BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
Member of WWPDB

BMRB Entry 20086

Title: Helical Agonist of Nociceptin (NOP) Receptor   PubMed: 21067234

Deposition date: 2009-07-23 Original release date: 2011-06-03

Authors: Hill, Timothy; Fairlie, David; Hoang, Huy

Citation: Harrison, Rosemary; Ruiz-Gomez, Gloria; Hill, Timothy; Chow, Shiao; Shepherd, Nicholas; Lohman, Rink-Jan; Abbenante, Giovanni; Hoang, Huy; Fairlie, David. "Novel Helix-Constrained Nociceptin Derivatives Are Potent Agonists and Antagonists of ERK Phosphorylation and Thermal Analgesia in Mice."  J. Med. Chem. 53, 8400-8408 (2010).

Assembly members:
Nociceptin_Antagonist, polymer, 18 residues, Formula weight is not available

Natural source:   Common Name: not available   Taxonomy ID: not available   Superkingdom: not available   Kingdom: not available   Genus/species: not available not available

Experimental source:   Production method: recombinant technology

Entity Sequences (FASTA):
Nociceptin_Antagonist: FGGFTGKRKSDRKKANQD

Data sets:
Data typeCount
1H chemical shifts82

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1Nociceptin Antagonist1

Entities:

Entity 1, Nociceptin Antagonist 18 residues - Formula weight is not available

1   PHEGLYGLYPHETHRGLYLYSARGLYSSER
2   ASPARGLYSLYSALAASNGLNASP

Samples:

sample_1: Nociceptin Antagonist 3 mM; H2O 90%; D2O 10%

sample_conditions_1: pH: 3.5; temperature: 288 K

Experiments:

NameSampleSample stateSample conditions
2D 1H-1H NOESYsample_1isotropicsample_conditions_1
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1
2D DQF-COSYsample_1isotropicsample_conditions_1

Software:

X-PLOR NIH, Schwieters, Kuszewski, Tjandra and Clore - geometry optimization

NMR spectrometers:

  • Bruker Avance 600 MHz