BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
Member of WWPDB

BMRB Entry 25206

Title: Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys

Deposition date: 2014-09-08 Original release date: 2015-09-21

Authors: Curtidor, Hernando; Torres, Mary Helena; Alba, Martha Patricia; Patarroyo, Manuel Elkin

Citation: Curtidor, Hernando; Torres, Mary Helena; Alba, Martha Patricia; Patarroyo, Manuel Elkin. "Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys"  Biol. Chem. 388, 25-36 (2007).

Assembly members:
entity, polymer, 20 residues, 2401.756 Da.

Natural source:   Common Name: not available   Taxonomy ID: not available   Superkingdom: not available   Kingdom: not available   Genus/species: not available not available

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):
entity: ESAKHMFDRIGKDVYDKVKE

Data sets:
Data typeCount
1H chemical shifts109

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1entity1

Entities:

Entity 1, entity 20 residues - 2401.756 Da.

1   GLUSERALALYSHISMETPHEASPARGILE
2   GLYLYSASPVALTYRASPLYSVALLYSGLU

Samples:

sample_1: entity8 – 10 mM; H2O 70%; trifluoroethanol 30%

sample_conditions_1: pH: 3.7; pressure: 1 atm; temperature: 295 K

Experiments:

NameSampleSample stateSample conditions
2D DQF-COSYsample_1isotropicsample_conditions_1
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1
2D 1H-1H NOESYsample_1isotropicsample_conditions_1

Software:

InsightII, Accelrys Software Inc. - geometry optimization, refinement

NMR spectrometers:

  • Bruker DRX 500 MHz

Related Database Links:

PDB
GB AAA75396 ABM88759 ETW19400 ETW37509 KOB84712