BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
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BMRB Entry 5508

Title: Native State Hydrogen Exchange Study of Suppressor and Pathogenic Variants of Transthyretin   PubMed: 12095258

Deposition date: 2002-08-25 Original release date: 2003-01-27

Authors: Liu, Kai; Kelly, Jeffery; Wemmer, David

Citation: Liu, Kai; Kelly, Jeffery; Wemmer, David. "Native State Hydrogen Exchange Study of Suppressor and Pathogenic Variants of Transthyretin"  J. Mol. Biol. 320, 821-832 (2002).

Assembly members:
Transthyretin, polymer, 128 residues, Formula weight is not available

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:   Production method: recombinant technology

Entity Sequences (FASTA):
Transthyretin: MGPTGTGESKCPLMVKVLDA VRGSPAINVAVHVFRKAADD TWEPFASGKTSESGELHGLT TEEEFVEGIYKVEIDTKSYW KALGISPFHEHAEVVFTAND SGPRRYTIAALLSPYSYSTM AVVTNPKE

Data sets:
  • assigned_chemical_shifts
Data typeCount
13C chemical shifts128
15N chemical shifts121
1H chemical shifts121

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1TTR subunit 11
2TTR subunit 21
3TTR subunit 31
4TTR subunit 41

Entities:

Entity 1, TTR subunit 1 128 residues - Formula weight is not available

1   METGLYPROTHRGLYTHRGLYGLUSERLYS
2   CYSPROLEUMETVALLYSVALLEUASPALA
3   VALARGGLYSERPROALAILEASNVALALA
4   VALHISVALPHEARGLYSALAALAASPASP
5   THRTRPGLUPROPHEALASERGLYLYSTHR
6   SERGLUSERGLYGLULEUHISGLYLEUTHR
7   THRGLUGLUGLUPHEVALGLUGLYILETYR
8   LYSVALGLUILEASPTHRLYSSERTYRTRP
9   LYSALALEUGLYILESERPROPHEHISGLU
10   HISALAGLUVALVALPHETHRALAASNASP
11   SERGLYPROARGARGTYRTHRILEALAALA
12   LEULEUSERPROTYRSERTYRSERTHRMET
13   ALAVALVALTHRASNPROLYSGLU

Samples:

sample_1: Transthyretin, [U-C13; U-N15], 0.3 – 1.5 mM; D2O 100%

sample_cond_1: pH: 7.0; temperature: 298 K

Experiments:

NameSampleSample stateSample conditions
HSQCnot availablenot availablenot available
HNCAnot availablenot availablenot available
HNCACBnot availablenot availablenot available
1H-15N NOESYnot availablenot availablenot available

Software:

No software information available

NMR spectrometers:

  • Bruker DRX 600 MHz

Related Database Links:

BMRB 2476 5507 5509 5510
PDB
DBJ BAA00059 BAG34987
EMBL CAA42087 CAG33189
GB AAA60011 AAA60012 AAA60013 AAA60018 AAA61181
PRF 0908191A 1008142A 1101213A 1709210A
REF NP_000362
SP P02766

Download simulated HSQC data in one of the following formats:
CSV: Backbone or all simulated shifts
SPARKY: Backbone or all simulated shifts