ATOM 1341 N ARG F 1 -5.345 -44.503 9.318 1.00 29.21 N ATOM 1342 CA ARG F 1 -4.064 -44.785 10.029 1.00 28.04 C ATOM 1343 C ARG F 1 -2.938 -45.269 9.114 1.00 26.92 C ATOM 1344 O ARG F 1 -1.844 -44.721 9.159 1.00 27.34 O ATOM 1345 CB ARG F 1 -4.271 -45.772 11.179 1.00 29.07 C ATOM 1346 CG ARG F 1 -5.130 -45.207 12.289 1.00 28.03 C ATOM 1347 CD ARG F 1 -5.261 -46.181 13.424 1.00 22.41 C ATOM 1348 NE ARG F 1 -4.105 -46.173 14.314 1.00 24.30 N ATOM 1349 CZ ARG F 1 -3.972 -46.987 15.357 1.00 20.85 C ATOM 1350 NH1 ARG F 1 -4.920 -47.868 15.629 1.00 26.84 N ATOM 1351 NH2 ARG F 1 -2.893 -46.925 16.125 1.00 25.20 N ATOM 1352 N MET F 2 -3.205 -46.295 8.304 1.00 27.71 N ATOM 1353 CA MET F 2 -2.178 -46.908 7.448 1.00 27.15 C ATOM 1354 C MET F 2 -1.639 -45.937 6.388 1.00 27.37 C ATOM 1355 O MET F 2 -0.432 -45.867 6.160 1.00 25.36 O ATOM 1356 CB MET F 2 -2.718 -48.165 6.772 1.00 27.47 C ATOM 1357 CG MET F 2 -1.645 -49.096 6.210 1.00 32.29 C ATOM 1358 SD MET F 2 -1.142 -50.340 7.420 1.00 47.86 S ATOM 1359 CE MET F 2 0.154 -49.516 8.317 1.00 47.46 C ATOM 1360 N LYS F 3 -2.540 -45.201 5.741 1.00 26.67 N ATOM 1361 CA LYS F 3 -2.146 -44.222 4.726 1.00 28.31 C ATOM 1362 C LYS F 3 -1.376 -43.050 5.337 1.00 26.21 C ATOM 1363 O LYS F 3 -0.428 -42.554 4.736 1.00 24.64 O ATOM 1364 CB LYS F 3 -3.371 -43.719 3.937 1.00 30.03 C ATOM 1365 CG LYS F 3 -3.039 -42.812 2.744 1.00 34.14 C ATOM 1366 CD LYS F 3 -2.118 -43.504 1.729 1.00 36.82 C ATOM 1367 CE LYS F 3 -1.695 -42.562 0.587 1.00 37.89 C ATOM 1368 NZ LYS F 3 -2.739 -42.317 -0.464 1.00 36.46 N ATOM 1369 N GLN F 4 -1.809 -42.591 6.512 1.00 27.63 N ATOM 1370 CA GLN F 4 -1.084 -41.558 7.263 1.00 27.48 C ATOM 1371 C GLN F 4 0.337 -42.019 7.586 1.00 24.54 C ATOM 1372 O GLN F 4 1.304 -41.274 7.417 1.00 23.72 O ATOM 1373 CB GLN F 4 -1.809 -41.256 8.571 1.00 27.13 C ATOM 1374 CG GLN F 4 -2.567 -39.965 8.591 1.00 32.53 C ATOM 1375 CD GLN F 4 -1.874 -38.899 9.424 1.00 38.91 C ATOM 1376 OE1 GLN F 4 -1.433 -37.884 8.898 1.00 34.65 O ATOM 1377 NE2 GLN F 4 -1.778 -39.128 10.737 1.00 39.37 N ATOM 1378 N LEU F 5 0.443 -43.250 8.069 1.00 22.07 N ATOM 1379 CA LEU F 5 1.727 -43.850 8.386 1.00 21.96 C ATOM 1380 C LEU F 5 2.602 -43.919 7.133 1.00 20.82 C ATOM 1381 O LEU F 5 3.779 -43.569 7.159 1.00 21.30 O ATOM 1382 CB LEU F 5 1.487 -45.240 8.970 1.00 22.79 C ATOM 1383 CG LEU F 5 2.353 -45.732 10.128 1.00 29.81 C ATOM 1384 CD1 LEU F 5 2.805 -44.615 11.043 1.00 20.60 C ATOM 1385 CD2 LEU F 5 1.563 -46.790 10.896 1.00 27.79 C ATOM 1386 N GLU F 6 1.995 -44.332 6.028 1.00 23.20 N ATOM 1387 CA GLU F 6 2.677 -44.447 4.748 1.00 23.38 C ATOM 1388 C GLU F 6 3.241 -43.090 4.297 1.00 23.67 C ATOM 1389 O GLU F 6 4.397 -42.982 3.882 1.00 18.51 O ATOM 1390 CB GLU F 6 1.685 -44.968 3.732 1.00 23.89 C ATOM 1391 CG GLU F 6 2.278 -45.791 2.620 1.00 37.13 C ATOM 1392 CD GLU F 6 1.224 -46.179 1.605 1.00 47.87 C ATOM 1393 OE1 GLU F 6 0.157 -46.693 2.017 1.00 52.36 O ATOM 1394 OE2 GLU F 6 1.460 -45.961 0.399 1.00 55.76 O ATOM 1395 N ASP F 7 2.411 -42.058 4.389 1.00 22.13 N ATOM 1396 CA ASP F 7 2.824 -40.719 4.008 1.00 21.09 C ATOM 1397 C ASP F 7 3.990 -40.228 4.853 1.00 18.12 C ATOM 1398 O ASP F 7 4.945 -39.681 4.327 1.00 18.84 O ATOM 1399 CB ASP F 7 1.642 -39.757 4.082 1.00 24.02 C ATOM 1400 CG ASP F 7 0.597 -40.046 3.015 1.00 27.13 C ATOM 1401 OD1 ASP F 7 0.835 -40.927 2.154 1.00 26.68 O ATOM 1402 OD2 ASP F 7 -0.454 -39.384 3.035 1.00 32.48 O ATOM 1403 N LYS F 8 3.921 -40.457 6.159 1.00 15.61 N ATOM 1404 CA LYS F 8 4.974 -39.989 7.049 1.00 15.07 C ATOM 1405 C LYS F 8 6.295 -40.710 6.838 1.00 13.90 C ATOM 1406 O LYS F 8 7.353 -40.084 6.878 1.00 14.65 O ATOM 1407 CB LYS F 8 4.543 -40.120 8.491 1.00 12.67 C ATOM 1408 CG LYS F 8 3.465 -39.105 8.863 1.00 18.03 C ATOM 1409 CD LYS F 8 2.894 -39.421 10.219 1.00 24.49 C ATOM 1410 CE LYS F 8 1.942 -38.309 10.676 1.00 27.11 C ATOM 1411 NZ LYS F 8 1.182 -38.690 11.892 1.00 34.38 N ATOM 1412 N VAL F 9 6.222 -42.023 6.644 1.00 14.76 N ATOM 1413 CA VAL F 9 7.411 -42.811 6.306 1.00 15.17 C ATOM 1414 C VAL F 9 8.024 -42.325 4.998 1.00 15.34 C ATOM 1415 O VAL F 9 9.241 -42.206 4.904 1.00 16.71 O ATOM 1416 CB VAL F 9 7.088 -44.318 6.257 1.00 15.95 C ATOM 1417 CG1 VAL F 9 8.214 -45.106 5.588 1.00 18.94 C ATOM 1418 CG2 VAL F 9 6.846 -44.833 7.677 1.00 13.44 C ATOM 1419 N GLU F 10 7.193 -42.029 3.997 1.00 14.28 N ATOM 1420 CA GLU F 10 7.723 -41.479 2.751 1.00 15.63 C ATOM 1421 C GLU F 10 8.407 -40.137 2.995 1.00 16.03 C ATOM 1422 O GLU F 10 9.484 -39.895 2.438 1.00 14.83 O ATOM 1423 CB GLU F 10 6.642 -41.364 1.668 1.00 16.77 C ATOM 1424 CG GLU F 10 6.239 -42.727 1.092 1.00 32.36 C ATOM 1425 CD GLU F 10 7.442 -43.598 0.707 1.00 36.95 C ATOM 1426 OE1 GLU F 10 8.319 -43.117 -0.051 1.00 43.23 O ATOM 1427 OE2 GLU F 10 7.506 -44.766 1.163 1.00 37.00 O ATOM 1428 N GLU F 11 7.818 -39.300 3.868 1.00 15.99 N ATOM 1429 CA GLU F 11 8.435 -38.006 4.206 1.00 16.32 C ATOM 1430 C GLU F 11 9.800 -38.235 4.830 1.00 15.28 C ATOM 1431 O GLU F 11 10.766 -37.566 4.474 1.00 12.83 O ATOM 1432 CB GLU F 11 7.590 -37.173 5.176 1.00 15.27 C ATOM 1433 CG GLU F 11 6.232 -36.776 4.652 1.00 18.89 C ATOM 1434 CD GLU F 11 5.334 -36.198 5.740 1.00 18.69 C ATOM 1435 OE1 GLU F 11 5.768 -36.101 6.918 1.00 17.24 O ATOM 1436 OE2 GLU F 11 4.192 -35.848 5.401 1.00 24.34 O ATOM 1437 N LEU F 12 9.866 -39.181 5.769 1.00 14.00 N ATOM 1438 CA LEU F 12 11.090 -39.511 6.468 1.00 16.34 C ATOM 1439 C LEU F 12 12.177 -40.059 5.559 1.00 15.40 C ATOM 1440 O LEU F 12 13.346 -39.703 5.729 1.00 16.23 O ATOM 1441 CB LEU F 12 10.803 -40.542 7.566 1.00 18.65 C ATOM 1442 CG LEU F 12 10.069 -39.992 8.781 1.00 21.67 C ATOM 1443 CD1 LEU F 12 9.627 -41.164 9.652 1.00 14.90 C ATOM 1444 CD2 LEU F 12 10.973 -39.019 9.531 1.00 20.02 C ATOM 1445 N LEU F 13 11.790 -40.937 4.629 1.00 13.33 N ATOM 1446 CA LEU F 13 12.718 -41.461 3.622 1.00 15.92 C ATOM 1447 C LEU F 13 13.340 -40.303 2.809 1.00 14.34 C ATOM 1448 O LEU F 13 14.570 -40.241 2.625 1.00 13.14 O ATOM 1449 CB LEU F 13 12.019 -42.471 2.703 1.00 15.98 C ATOM 1450 CG LEU F 13 11.630 -43.834 3.309 1.00 21.83 C ATOM 1451 CD1 LEU F 13 10.895 -44.653 2.300 1.00 24.37 C ATOM 1452 CD2 LEU F 13 12.846 -44.613 3.811 1.00 26.60 C ATOM 1453 N SER F 14 12.498 -39.387 2.350 1.00 13.93 N ATOM 1454 CA SER F 14 12.972 -38.222 1.590 1.00 14.16 C ATOM 1455 C SER F 14 13.867 -37.325 2.454 1.00 12.46 C ATOM 1456 O SER F 14 14.936 -36.860 2.023 1.00 12.83 O ATOM 1457 CB SER F 14 11.798 -37.417 1.034 1.00 15.77 C ATOM 1458 OG SER F 14 12.271 -36.211 0.453 1.00 15.00 O ATOM 1459 N LYS F 15 13.429 -37.070 3.676 1.00 12.66 N ATOM 1460 CA LYS F 15 14.197 -36.173 4.537 1.00 12.02 C ATOM 1461 C LYS F 15 15.542 -36.766 4.890 1.00 12.59 C ATOM 1462 O LYS F 15 16.543 -36.059 4.869 1.00 12.82 O ATOM 1463 CB LYS F 15 13.388 -35.749 5.745 1.00 7.40 C ATOM 1464 CG LYS F 15 12.200 -34.886 5.253 1.00 9.04 C ATOM 1465 CD LYS F 15 11.273 -34.375 6.313 1.00 17.90 C ATOM 1466 CE LYS F 15 10.326 -33.388 5.650 1.00 21.14 C ATOM 1467 NZ LYS F 15 9.113 -33.052 6.475 1.00 25.49 N ATOM 1468 N ASN F 16 15.575 -38.071 5.124 1.00 12.79 N ATOM 1469 CA ASN F 16 16.841 -38.743 5.410 1.00 12.84 C ATOM 1470 C ASN F 16 17.803 -38.642 4.224 1.00 11.45 C ATOM 1471 O ASN F 16 18.961 -38.334 4.422 1.00 12.82 O ATOM 1472 CB ASN F 16 16.643 -40.212 5.762 1.00 15.44 C ATOM 1473 CG ASN F 16 17.970 -40.981 5.792 1.00 13.62 C ATOM 1474 OD1 ASN F 16 18.816 -40.741 6.650 1.00 19.24 O ATOM 1475 ND2 ASN F 16 18.175 -41.844 4.813 1.00 19.25 N ATOM 1476 N TYR F 17 17.302 -38.903 3.018 1.00 9.39 N ATOM 1477 CA TYR F 17 18.083 -38.790 1.767 1.00 12.10 C ATOM 1478 C TYR F 17 18.728 -37.419 1.624 1.00 12.91 C ATOM 1479 O TYR F 17 19.941 -37.300 1.390 1.00 12.49 O ATOM 1480 CB TYR F 17 17.187 -39.024 0.541 1.00 14.08 C ATOM 1481 CG TYR F 17 17.856 -38.673 -0.783 1.00 15.60 C ATOM 1482 CD1 TYR F 17 18.850 -39.493 -1.342 1.00 20.31 C ATOM 1483 CD2 TYR F 17 17.489 -37.510 -1.482 1.00 16.87 C ATOM 1484 CE1 TYR F 17 19.477 -39.147 -2.549 1.00 13.37 C ATOM 1485 CE2 TYR F 17 18.087 -37.174 -2.685 1.00 21.31 C ATOM 1486 CZ TYR F 17 19.072 -37.992 -3.217 1.00 20.06 C ATOM 1487 OH TYR F 17 19.649 -37.621 -4.403 1.00 19.59 O ATOM 1488 N HIS F 18 17.908 -36.383 1.768 1.00 10.71 N ATOM 1489 CA HIS F 18 18.395 -35.020 1.616 1.00 10.21 C ATOM 1490 C HIS F 18 19.300 -34.601 2.779 1.00 11.11 C ATOM 1491 O HIS F 18 20.308 -33.936 2.575 1.00 10.37 O ATOM 1492 CB HIS F 18 17.243 -34.044 1.383 1.00 11.20 C ATOM 1493 CG HIS F 18 16.566 -34.224 0.053 1.00 10.22 C ATOM 1494 ND1 HIS F 18 17.183 -33.930 -1.144 1.00 11.15 N ATOM 1495 CD2 HIS F 18 15.328 -34.674 -0.267 1.00 12.38 C ATOM 1496 CE1 HIS F 18 16.363 -34.201 -2.146 1.00 10.73 C ATOM 1497 NE2 HIS F 18 15.233 -34.658 -1.639 1.00 10.42 N ATOM 1498 N LEU F 19 18.947 -34.976 4.004 1.00 11.38 N ATOM 1499 CA LEU F 19 19.820 -34.651 5.108 1.00 9.44 C ATOM 1500 C LEU F 19 21.153 -35.375 4.954 1.00 9.66 C ATOM 1501 O LEU F 19 22.213 -34.777 5.183 1.00 11.47 O ATOM 1502 CB LEU F 19 19.170 -34.961 6.454 1.00 8.22 C ATOM 1503 CG LEU F 19 19.921 -34.375 7.649 1.00 11.32 C ATOM 1504 CD1 LEU F 19 20.027 -32.825 7.602 1.00 9.95 C ATOM 1505 CD2 LEU F 19 19.229 -34.846 8.897 1.00 10.71 C ATOM 1506 N GLU F 20 21.123 -36.621 4.502 1.00 10.50 N ATOM 1507 CA GLU F 20 22.386 -37.325 4.302 1.00 10.28 C ATOM 1508 C GLU F 20 23.307 -36.624 3.293 1.00 12.79 C ATOM 1509 O GLU F 20 24.507 -36.492 3.541 1.00 9.75 O ATOM 1510 CB GLU F 20 22.185 -38.791 3.917 1.00 12.06 C ATOM 1511 CG GLU F 20 23.544 -39.461 3.632 1.00 11.03 C ATOM 1512 CD GLU F 20 23.468 -40.961 3.462 1.00 12.93 C ATOM 1513 OE1 GLU F 20 22.341 -41.523 3.505 1.00 13.63 O ATOM 1514 OE2 GLU F 20 24.554 -41.573 3.263 1.00 10.81 O ATOM 1515 N ASN F 21 22.742 -36.171 2.174 1.00 12.83 N ATOM 1516 CA ASN F 21 23.514 -35.405 1.194 1.00 13.29 C ATOM 1517 C ASN F 21 24.133 -34.154 1.782 1.00 10.74 C ATOM 1518 O ASN F 21 25.237 -33.768 1.408 1.00 9.17 O ATOM 1519 CB ASN F 21 22.673 -35.036 -0.024 1.00 15.49 C ATOM 1520 CG ASN F 21 22.336 -36.238 -0.868 1.00 17.03 C ATOM 1521 OD1 ASN F 21 22.975 -37.301 -0.766 1.00 17.59 O ATOM 1522 ND2 ASN F 21 21.324 -36.093 -1.690 1.00 15.71 N ATOM 1523 N ARG F 22 23.424 -33.510 2.687 1.00 11.82 N ATOM 1524 CA ARG F 22 23.980 -32.322 3.323 1.00 9.49 C ATOM 1525 C ARG F 22 25.146 -32.696 4.252 1.00 12.61 C ATOM 1526 O ARG F 22 26.168 -32.001 4.306 1.00 14.07 O ATOM 1527 CB ARG F 22 22.909 -31.607 4.112 1.00 11.11 C ATOM 1528 CG ARG F 22 22.011 -30.795 3.230 1.00 8.54 C ATOM 1529 CD ARG F 22 20.753 -30.389 3.966 1.00 11.93 C ATOM 1530 NE ARG F 22 21.056 -29.534 5.124 1.00 14.31 N ATOM 1531 CZ ARG F 22 20.151 -29.156 6.023 1.00 11.42 C ATOM 1532 NH1 ARG F 22 18.882 -29.552 5.898 1.00 15.30 N ATOM 1533 NH2 ARG F 22 20.496 -28.357 7.029 1.00 11.20 N ATOM 1534 N VAL F 23 24.960 -33.768 5.009 1.00 11.98 N ATOM 1535 CA VAL F 23 26.046 -34.352 5.807 1.00 11.94 C ATOM 1536 C VAL F 23 27.228 -34.742 4.916 1.00 11.48 C ATOM 1537 O VAL F 23 28.392 -34.484 5.258 1.00 11.54 O ATOM 1538 CB VAL F 23 25.551 -35.569 6.622 1.00 12.42 C ATOM 1539 CG1 VAL F 23 26.721 -36.277 7.365 1.00 13.11 C ATOM 1540 CG2 VAL F 23 24.450 -35.144 7.573 1.00 13.71 C ATOM 1541 N ALA F 24 26.953 -35.360 3.773 1.00 12.13 N ATOM 1542 CA ALA F 24 28.051 -35.726 2.858 1.00 13.83 C ATOM 1543 C ALA F 24 28.790 -34.486 2.345 1.00 14.09 C ATOM 1544 O ALA F 24 30.016 -34.495 2.184 1.00 12.91 O ATOM 1545 CB ALA F 24 27.539 -36.580 1.698 1.00 13.64 C ATOM 1546 N ARG F 25 28.049 -33.412 2.085 1.00 18.73 N ATOM 1547 CA ARG F 25 28.670 -32.153 1.665 1.00 16.74 C ATOM 1548 C ARG F 25 29.643 -31.636 2.751 1.00 15.44 C ATOM 1549 O ARG F 25 30.778 -31.212 2.462 1.00 15.23 O ATOM 1550 CB ARG F 25 27.580 -31.121 1.351 1.00 20.04 C ATOM 1551 CG ARG F 25 28.102 -29.906 0.632 1.00 27.69 C ATOM 1552 CD ARG F 25 27.071 -29.275 -0.291 1.00 44.03 C ATOM 1553 NE ARG F 25 27.730 -28.640 -1.430 1.00 49.72 N ATOM 1554 CZ ARG F 25 28.319 -27.447 -1.396 1.00 56.65 C ATOM 1555 NH1 ARG F 25 28.331 -26.729 -0.277 1.00 55.51 N ATOM 1556 NH2 ARG F 25 28.899 -26.970 -2.492 1.00 59.70 N ATOM 1557 N LEU F 26 29.187 -31.674 3.996 1.00 13.33 N ATOM 1558 CA LEU F 26 30.003 -31.252 5.135 1.00 15.43 C ATOM 1559 C LEU F 26 31.255 -32.106 5.247 1.00 16.49 C ATOM 1560 O LEU F 26 32.339 -31.592 5.483 1.00 15.96 O ATOM 1561 CB LEU F 26 29.206 -31.298 6.444 1.00 16.09 C ATOM 1562 CG LEU F 26 28.090 -30.264 6.629 1.00 16.25 C ATOM 1563 CD1 LEU F 26 27.195 -30.649 7.780 1.00 12.40 C ATOM 1564 CD2 LEU F 26 28.678 -28.845 6.842 1.00 19.67 C ATOM 1565 N GLU F 27 31.106 -33.413 5.058 1.00 14.84 N ATOM 1566 CA GLU F 27 32.274 -34.299 5.103 1.00 15.19 C ATOM 1567 C GLU F 27 33.309 -33.924 4.060 1.00 18.26 C ATOM 1568 O GLU F 27 34.509 -33.932 4.340 1.00 21.55 O ATOM 1569 CB GLU F 27 31.834 -35.754 4.966 1.00 13.94 C ATOM 1570 CG GLU F 27 31.094 -36.182 6.183 1.00 9.88 C ATOM 1571 CD GLU F 27 30.359 -37.474 6.019 1.00 20.25 C ATOM 1572 OE1 GLU F 27 30.094 -37.904 4.871 1.00 17.78 O ATOM 1573 OE2 GLU F 27 30.032 -38.039 7.069 1.00 11.51 O ATOM 1574 N LYS F 28 32.832 -33.580 2.866 1.00 22.56 N ATOM 1575 CA LYS F 28 33.697 -33.119 1.778 1.00 26.83 C ATOM 1576 C LYS F 28 34.384 -31.807 2.141 1.00 27.94 C ATOM 1577 O LYS F 28 35.586 -31.651 1.934 1.00 26.74 O ATOM 1578 CB LYS F 28 32.899 -32.972 0.484 1.00 27.95 C ATOM 1579 CG LYS F 28 33.760 -32.772 -0.752 1.00 36.97 C ATOM 1580 CD LYS F 28 33.108 -33.375 -1.983 1.00 45.33 C ATOM 1581 CE LYS F 28 33.265 -34.890 -2.014 1.00 41.52 C ATOM 1582 NZ LYS F 28 32.476 -35.473 -3.129 1.00 48.00 N ATOM 1583 N LEU F 29 33.608 -30.885 2.707 1.00 28.83 N ATOM 1584 CA LEU F 29 34.098 -29.567 3.101 1.00 31.30 C ATOM 1585 C LEU F 29 35.076 -29.604 4.284 1.00 33.20 C ATOM 1586 O LEU F 29 36.029 -28.826 4.331 1.00 35.60 O ATOM 1587 CB LEU F 29 32.924 -28.651 3.421 1.00 28.96 C ATOM 1588 CG LEU F 29 32.193 -27.950 2.273 1.00 30.42 C ATOM 1589 CD1 LEU F 29 30.810 -27.546 2.736 1.00 23.51 C ATOM 1590 CD2 LEU F 29 32.968 -26.724 1.827 1.00 36.02 C ATOM 1591 N VAL F 30 34.836 -30.496 5.241 1.00 34.51 N ATOM 1592 CA VAL F 30 35.753 -30.654 6.370 1.00 35.46 C ATOM 1593 C VAL F 30 36.910 -31.579 5.973 1.00 37.09 C ATOM 1594 O VAL F 30 37.866 -31.756 6.730 1.00 38.88 O ATOM 1595 CB VAL F 30 35.025 -31.150 7.648 1.00 35.71 C ATOM 1596 CG1 VAL F 30 35.989 -31.227 8.828 1.00 39.28 C ATOM 1597 CG2 VAL F 30 33.867 -30.222 7.996 1.00 35.63 C ATOM 1598 N GLY F 31 36.822 -32.141 4.769 1.00 37.68 N ATOM 1599 CA GLY F 31 37.837 -33.044 4.238 1.00 38.71 C ATOM 1600 C GLY F 31 37.949 -34.338 5.022 1.00 39.76 C ATOM 1601 O GLY F 31 38.949 -35.048 4.910 1.00 40.13 O