==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=19-AUG-2012 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE/HYDROLASE INHIBITOR 28-JUN-12 4FUJ . COMPND 2 MOLECULE: UROKINASE-TYPE PLASMINOGEN ACTIVATOR; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR Y.N.KANG,J.A.STUCKEY,V.NIENABER,V.GIRANDA . 246 1 5 5 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 11605.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 154 62.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 2 0.8 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 84 34.1 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 1 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 3 1.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 5 2.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 16 6.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 31 12.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 10 4.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 1 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 3 2 3 4 1 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 1 A I 0 0 0 0, 0.0 2,-0.4 0, 0.0 192,-0.2 0.000 360.0 360.0 360.0 122.6 -12.9 -15.2 0.5 2 2 A I B -A 192 0A 11 190,-2.1 190,-1.5 153,-0.1 142,-0.1 -0.751 360.0 -22.0 -87.0 127.4 -12.4 -18.5 -1.5 3 3 A G S S+ 0 0 32 140,-0.5 2,-0.1 -2,-0.4 188,-0.1 -0.422 94.7 105.8 69.2-145.1 -15.5 -19.2 -3.7 4 4 A G S S- 0 0 31 -2,-0.1 2,-0.3 154,-0.1 153,-0.2 -0.446 73.8 -67.0 73.3-148.9 -18.7 -17.6 -2.5 5 5 A E E -B 156 0B 139 151,-3.0 151,-2.6 -2,-0.1 2,-0.2 -0.963 36.5-105.1-139.9 160.4 -20.2 -14.6 -4.3 6 6 A F E +B 155 0B 97 -2,-0.3 149,-0.3 149,-0.2 2,-0.2 -0.523 48.1 173.1 -80.1 149.8 -19.4 -11.0 -5.1 7 7 A T - 0 0 11 147,-2.8 2,-0.3 57,-0.2 147,-0.2 -0.817 25.1-121.0-144.6-177.6 -21.6 -8.7 -3.0 8 8 A T > - 0 0 50 -2,-0.2 3,-1.7 145,-0.1 4,-0.5 -0.902 32.9-104.2-130.0 160.6 -22.1 -5.0 -2.2 9 9 A I G > S+ 0 0 2 -2,-0.3 3,-1.3 1,-0.3 6,-0.3 0.775 112.5 71.2 -53.7 -32.2 -22.0 -3.0 1.1 10 10 A E G 3 S+ 0 0 95 1,-0.3 -1,-0.3 2,-0.1 107,-0.0 0.779 101.4 46.3 -58.0 -25.8 -25.9 -2.7 1.2 11 11 A N G < S+ 0 0 92 -3,-1.7 -1,-0.3 1,-0.2 -2,-0.2 0.626 124.5 31.7 -89.4 -14.5 -26.0 -6.4 2.0 12 12 A Q S X S+ 0 0 4 -3,-1.3 3,-2.0 -4,-0.5 -1,-0.2 -0.549 71.8 160.6-134.9 58.6 -23.3 -6.2 4.7 13 13 A P T 3 S+ 0 0 5 0, 0.0 105,-1.4 0, 0.0 49,-0.3 0.646 72.1 58.8 -68.4 -12.1 -23.8 -2.6 6.1 14 14 A W T 3 S+ 0 0 19 103,-0.2 21,-2.4 105,-0.1 2,-0.3 0.485 81.1 120.3 -84.4 -10.2 -21.9 -3.3 9.4 15 15 A F E < -J 34 0C 1 -3,-2.0 47,-0.5 -6,-0.3 2,-0.4 -0.465 47.6-161.9 -69.1 123.6 -18.8 -4.2 7.3 16 16 A A E -JK 33 61C 0 17,-2.7 17,-1.3 -2,-0.3 2,-0.6 -0.879 8.0-150.3-107.0 132.3 -15.7 -2.0 8.0 17 17 A A E -JK 32 60C 1 43,-2.2 43,-2.5 -2,-0.4 2,-0.5 -0.913 17.0-161.4-101.6 113.4 -12.8 -1.8 5.5 18 18 A I E +JK 31 59C 0 13,-2.3 12,-3.1 -2,-0.6 13,-1.2 -0.911 12.6 174.8-109.2 126.2 -9.5 -1.1 7.4 19 19 A Y E -JK 29 58C 10 39,-3.0 39,-2.5 -2,-0.5 2,-0.4 -0.795 20.6-135.5-123.5 162.9 -6.4 0.2 5.7 20 20 A R E -JK 28 57C 33 8,-2.7 8,-2.2 -2,-0.3 2,-0.4 -0.982 10.0-139.7-126.6 133.9 -3.0 1.4 6.7 21 21 A R E -J 27 0C 79 35,-3.5 2,-0.3 -2,-0.4 6,-0.2 -0.767 22.9-155.9 -90.5 130.0 -1.0 4.4 5.6 22 22 A H > - 0 0 52 4,-3.2 3,-2.3 -2,-0.4 4,-0.2 -0.725 33.8 -81.8-102.5 161.4 2.7 3.8 5.1 23 23 A R T 3 S+ 0 0 110 1,-0.3 3,-0.3 -2,-0.3 -1,-0.1 -0.332 122.6 39.0 -59.6 133.5 5.6 6.3 5.2 24 24 A G T 3 S- 0 0 94 1,-0.2 -1,-0.3 -3,-0.1 -3,-0.0 0.186 127.1 -88.4 103.9 -16.2 5.6 7.9 1.8 25 25 A G S < S+ 0 0 50 -3,-2.3 2,-0.2 1,-0.3 -1,-0.2 0.424 78.4 142.3 96.9 2.9 1.8 8.0 1.7 26 26 A S - 0 0 69 -3,-0.3 -4,-3.2 -4,-0.2 2,-0.4 -0.535 36.5-150.1 -77.8 144.3 0.8 4.7 0.1 27 27 A V E -J 21 0C 69 -6,-0.2 2,-0.3 -2,-0.2 -6,-0.2 -0.963 14.9-177.4-118.2 128.9 -2.3 3.0 1.5 28 28 A T E -J 20 0C 62 -8,-2.2 -8,-2.7 -2,-0.4 2,-0.1 -0.946 32.2-104.3-125.5 152.0 -2.8 -0.8 1.7 29 29 A Y E +J 19 0C 25 -2,-0.3 -10,-0.3 -10,-0.2 3,-0.1 -0.451 37.2 173.4 -73.1 140.2 -5.8 -2.9 2.8 30 30 A V E - 0 0 27 -12,-3.1 2,-0.3 1,-0.4 -11,-0.2 0.768 49.3 -39.1-111.3 -64.3 -5.2 -4.6 6.2 31 31 A a E -J 18 0C 7 -13,-1.2 -13,-2.3 166,-0.1 -1,-0.4 -0.938 53.1 -96.1-157.3 175.0 -8.3 -6.4 7.5 32 32 A G E -J 17 0C 0 166,-2.3 12,-0.4 -2,-0.3 2,-0.3 -0.367 34.8-175.5 -95.7 171.8 -12.1 -6.3 7.9 33 33 A G E -J 16 0C 0 -17,-1.3 -17,-2.7 -2,-0.1 2,-0.4 -0.941 19.3-123.6-159.1 171.8 -14.1 -5.1 10.8 34 34 A S E -JL 15 42C 0 8,-2.2 8,-3.0 -2,-0.3 2,-0.6 -0.998 18.7-129.0-132.7 132.7 -17.7 -4.8 12.1 35 35 A L E + L 0 41C 0 -21,-2.4 85,-2.1 -2,-0.4 6,-0.2 -0.680 31.3 168.9 -77.9 116.1 -19.5 -1.7 13.3 36 36 A I E S- 0 0 23 4,-2.8 86,-0.2 -2,-0.6 -1,-0.2 0.621 72.5 -1.7-102.5 -20.7 -21.0 -2.6 16.8 37 37 A S E > S- L 0 40C 40 3,-1.1 3,-1.7 81,-0.1 -1,-0.4 -0.910 90.8 -90.1-158.5 159.2 -22.1 1.0 17.8 38 38 A P T 3 S+ 0 0 55 0, 0.0 73,-2.9 0, 0.0 3,-0.0 0.741 127.1 36.3 -50.6 -30.4 -21.6 4.3 15.8 39 39 A b T 3 S+ 0 0 35 71,-0.2 64,-2.4 1,-0.1 2,-0.5 0.421 110.2 76.1 -97.7 -7.4 -18.2 5.0 17.4 40 40 A W E < -LM 37 102C 21 -3,-1.7 -4,-2.8 62,-0.2 -3,-1.1 -0.932 47.0-178.3-127.6 124.0 -16.9 1.4 17.6 41 41 A V E -LM 35 101C 0 60,-2.6 60,-3.3 -2,-0.5 2,-0.4 -0.912 17.6-151.6-107.9 132.1 -15.5 -1.1 15.1 42 42 A I E +LM 34 100C 0 -8,-3.0 -8,-2.2 -2,-0.5 58,-0.2 -0.874 31.8 140.8-104.6 138.0 -14.6 -4.5 16.4 43 43 A S E - M 0 99C 0 56,-2.9 56,-1.9 -2,-0.4 2,-0.4 -0.587 51.3 -65.5-148.8-156.5 -11.9 -6.5 14.6 44 44 A A > - 0 0 0 -12,-0.4 3,-1.2 54,-0.3 4,-0.3 -0.932 26.7-138.7-113.3 135.8 -8.9 -8.9 15.4 45 45 A T G >> S+ 0 0 0 -2,-0.4 3,-2.4 1,-0.2 4,-1.8 0.864 100.0 68.8 -58.7 -36.3 -5.8 -7.8 17.4 46 46 A H G 34 S+ 0 0 45 1,-0.3 4,-0.3 2,-0.2 -1,-0.2 0.719 91.1 62.9 -57.3 -21.8 -3.5 -9.8 15.0 47 47 A a G <4 S+ 0 0 15 -3,-1.2 -1,-0.3 1,-0.2 -2,-0.2 0.697 119.4 22.1 -71.7 -24.2 -4.3 -7.3 12.3 48 48 A F T X4 S+ 0 0 0 -3,-2.4 3,-1.2 -4,-0.3 -2,-0.2 0.530 91.2 97.7-122.6 -16.3 -2.7 -4.4 14.3 49 49 A I T 3< S+ 0 0 65 -4,-1.8 -3,-0.1 1,-0.3 -2,-0.1 0.786 90.8 43.6 -51.2 -36.5 -0.2 -6.0 16.8 50 50 A D T 3 S+ 0 0 130 -4,-0.3 -1,-0.3 1,-0.3 -2,-0.1 0.609 125.3 33.8 -87.1 -13.8 2.9 -5.3 14.6 51 51 A Y S < S+ 0 0 123 -3,-1.2 -1,-0.3 1,-0.0 -2,-0.1 -0.645 72.4 165.9-136.7 71.7 1.9 -1.8 13.6 52 52 A P + 0 0 82 0, 0.0 2,-0.7 0, 0.0 29,-0.1 0.147 31.8 119.4 -85.1 25.5 0.1 -0.5 16.8 53 53 A K > - 0 0 123 1,-0.1 3,-1.4 -5,-0.1 4,-0.3 -0.802 51.6-156.5 -92.0 113.5 -0.0 3.2 15.9 54 54 A K G > S+ 0 0 99 -2,-0.7 3,-1.1 1,-0.2 24,-0.6 0.760 88.3 65.8 -58.3 -31.4 -3.6 4.3 15.7 55 55 A E G 3 S+ 0 0 137 1,-0.2 -1,-0.2 22,-0.1 -34,-0.0 0.704 91.8 64.9 -64.3 -25.7 -2.8 7.3 13.4 56 56 A D G < S+ 0 0 28 -3,-1.4 -35,-3.5 -5,-0.1 2,-0.3 0.648 87.3 90.2 -72.6 -20.0 -1.7 4.9 10.6 57 57 A Y E < -K 20 0C 1 -3,-1.1 21,-0.6 -4,-0.3 2,-0.4 -0.605 51.5-167.9 -93.8 144.5 -5.2 3.4 10.1 58 58 A I E -KN 19 77C 6 -39,-2.5 -39,-3.0 -2,-0.3 2,-0.4 -0.991 9.8-163.5-123.6 129.0 -8.1 4.4 7.9 59 59 A V E -KN 18 76C 0 17,-2.2 17,-2.8 -2,-0.4 2,-0.4 -0.967 3.2-166.9-116.5 130.0 -11.6 2.9 8.4 60 60 A Y E -KN 17 75C 23 -43,-2.5 -43,-2.2 -2,-0.4 2,-0.3 -0.931 4.4-170.2-115.5 143.3 -14.3 3.0 5.8 61 61 A L E S+KN 16 74C 0 13,-2.0 13,-2.5 -2,-0.4 -45,-0.1 -0.913 75.9 25.5-121.2 148.7 -18.0 2.3 6.3 62 62 A G S S+ 0 0 0 -47,-0.5 2,-0.5 54,-0.5 11,-0.1 0.695 86.3 139.3 69.7 21.0 -20.4 1.9 3.4 63 63 A R + 0 0 16 -48,-0.4 -1,-0.2 1,-0.1 6,-0.1 -0.874 27.5 175.7-100.8 124.7 -17.5 1.0 1.0 64 64 A S + 0 0 13 -2,-0.5 90,-2.1 4,-0.1 2,-0.3 0.555 64.2 50.9-101.5 -20.7 -18.2 -1.8 -1.5 65 65 A R B > S-P 153 0D 94 3,-0.4 3,-0.7 88,-0.2 88,-0.2 -0.945 73.4-131.2-128.7 146.8 -15.0 -1.8 -3.5 66 66 A L T 3 S+ 0 0 16 86,-2.8 87,-0.1 -2,-0.3 86,-0.1 0.827 109.7 21.6 -63.0 -34.2 -11.3 -1.9 -2.5 67 67 A N T 3 S+ 0 0 113 85,-0.4 2,-0.4 -3,-0.0 -1,-0.2 -0.041 106.5 89.8-129.7 31.3 -10.4 1.1 -4.7 68 68 A S S < S- 0 0 45 -3,-0.7 2,-1.2 84,-0.2 -3,-0.4 -0.973 71.1-129.5-128.3 145.4 -13.7 3.0 -5.2 69 69 A N - 0 0 132 -2,-0.4 2,-0.1 -6,-0.1 3,-0.1 -0.811 37.0-147.3 -91.4 89.8 -15.3 5.8 -3.2 70 70 A T > - 0 0 31 -2,-1.2 3,-2.3 -5,-0.2 2,-0.1 -0.423 25.5 -98.9 -61.8 136.6 -18.7 4.1 -3.0 71 71 A Q T 3 S+ 0 0 190 1,-0.3 -1,-0.1 -2,-0.1 -3,-0.0 -0.388 111.8 20.5 -58.3 128.3 -21.6 6.6 -2.9 72 72 A G T 3 S+ 0 0 48 1,-0.3 -1,-0.3 -3,-0.1 44,-0.1 0.375 91.1 143.0 89.8 -1.0 -22.6 7.1 0.7 73 73 A E < - 0 0 35 -3,-2.3 2,-0.4 -11,-0.1 -1,-0.3 -0.323 38.7-147.3 -71.5 156.2 -19.3 5.8 2.2 74 74 A M E -N 61 0C 47 -13,-2.5 -13,-2.0 31,-0.0 2,-0.4 -0.993 4.3-147.7-127.3 131.2 -17.8 7.4 5.3 75 75 A K E -N 60 0C 110 -2,-0.4 31,-0.3 -15,-0.2 2,-0.3 -0.839 22.0-179.0-101.4 136.5 -14.1 7.8 6.0 76 76 A F E -N 59 0C 4 -17,-2.8 -17,-2.2 -2,-0.4 2,-0.2 -0.929 22.9-142.4-135.8 160.3 -12.6 7.6 9.6 77 77 A E E -NO 58 104C 56 27,-3.3 27,-2.0 -2,-0.3 2,-0.7 -0.654 37.7-102.1-107.7 167.6 -9.5 7.8 11.6 78 78 A V E + O 0 103C 3 -24,-0.6 25,-0.2 -21,-0.6 3,-0.2 -0.867 32.7 179.0 -99.3 111.4 -8.8 5.8 14.7 79 79 A E E S+ 0 0 58 23,-2.8 2,-0.3 -2,-0.7 24,-0.2 0.785 79.4 11.4 -74.6 -36.8 -9.4 7.8 17.9 80 80 A N E - O 0 102C 71 22,-1.2 22,-3.3 -26,-0.1 2,-0.6 -0.952 63.8-160.2-149.7 123.8 -8.5 4.8 20.1 81 81 A L E - O 0 101C 24 -2,-0.3 2,-0.6 20,-0.2 20,-0.2 -0.948 15.5-168.6-107.4 111.4 -7.0 1.5 19.1 82 82 A I E - O 0 100C 20 18,-3.3 18,-2.4 -2,-0.6 2,-0.3 -0.900 3.6-173.7-108.3 112.4 -7.7 -1.2 21.8 83 83 A L E - O 0 99C 37 -2,-0.6 2,-0.3 16,-0.2 16,-0.2 -0.754 36.8-101.5 -99.9 144.4 -5.8 -4.4 21.5 84 84 A H > - 0 0 19 14,-1.2 3,-1.9 -2,-0.3 14,-0.0 -0.547 24.6-141.6 -68.8 126.7 -6.6 -7.3 23.9 85 85 A K T 3 S+ 0 0 188 -2,-0.3 -1,-0.2 1,-0.3 -2,-0.0 0.814 101.1 49.0 -57.7 -31.4 -3.9 -7.4 26.6 86 86 A D T 3 S+ 0 0 110 10,-0.1 -1,-0.3 2,-0.0 2,-0.1 0.197 79.7 135.9 -96.9 18.3 -3.8 -11.2 26.6 87 87 A Y < + 0 0 39 -3,-1.9 2,-0.3 9,-0.1 9,-0.2 -0.411 25.7 161.3 -62.9 139.0 -3.5 -11.5 22.8 88 88 A S E -Q 95 0E 54 7,-1.8 7,-3.1 -2,-0.1 2,-0.4 -0.971 28.6-140.4-155.9 158.5 -1.0 -14.2 21.7 89 89 A A E -Q 94 0E 56 -2,-0.3 5,-0.2 5,-0.2 2,-0.1 -0.995 12.4-174.6-129.1 129.7 -0.1 -16.3 18.7 90 90 A D - 0 0 98 3,-3.6 5,-0.0 -2,-0.4 -2,-0.0 -0.356 57.8 -73.8-100.0-172.2 1.0 -19.8 18.5 91 91 A T S S- 0 0 144 -2,-0.1 3,-0.1 1,-0.1 -2,-0.0 0.885 125.7 -8.2 -51.5 -42.2 2.2 -21.6 15.2 92 92 A L S S+ 0 0 38 1,-0.1 127,-0.2 81,-0.1 2,-0.1 0.717 119.4 79.4-120.3 -55.5 -1.5 -21.7 14.1 93 93 A A - 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