==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=6-DEC-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 20-DEC-01 1KO3 . COMPND 2 MOLECULE: VIM-2 METALLO-BETA-LACTAMASE; . SOURCE 2 ORGANISM_SCIENTIFIC: PSEUDOMONAS AERUGINOSA; . AUTHOR I.GARCIA-SAEZ,J.-D.DOCQUIER,G.M.ROSSOLINI,O.DIDEBERG . 230 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 9719.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 148 64.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 19 8.3 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 39 17.0 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 1 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 4 1.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 1 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 13 5.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 20 8.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 48 20.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 4 1.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 1 0 0 0 1 1 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 1 1 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 0 2 1 2 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 30 A E 0 0 209 0, 0.0 3,-0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 -62.4 15.1 36.2 42.5 2 31 A Y - 0 0 29 1,-0.1 209,-0.1 210,-0.1 14,-0.1 -0.602 360.0-115.4 -74.5 122.4 14.4 32.9 40.6 3 32 A P - 0 0 15 0, 0.0 2,-0.2 0, 0.0 207,-0.1 -0.249 35.3-172.8 -61.1 139.5 11.0 33.4 39.0 4 33 A T - 0 0 49 22,-0.1 3,-0.5 33,-0.0 4,-0.3 -0.608 49.4 -83.8-118.9 179.6 8.0 31.3 40.0 5 34 A V S > S+ 0 0 61 1,-0.2 3,-0.7 -2,-0.2 5,-0.1 0.744 125.5 68.7 -59.2 -19.0 4.5 30.9 38.7 6 35 A S T 3 S+ 0 0 97 1,-0.2 -1,-0.2 3,-0.1 0, 0.0 0.956 102.9 37.4 -63.7 -55.5 3.9 34.0 40.9 7 36 A E T 3 S+ 0 0 110 -3,-0.5 -1,-0.2 1,-0.1 -2,-0.2 0.267 112.1 75.0 -82.5 12.9 5.9 36.5 38.8 8 37 A I < - 0 0 5 -3,-0.7 2,-0.2 -4,-0.3 -1,-0.1 -0.932 67.7-151.5-134.9 113.6 4.8 34.8 35.6 9 38 A P > - 0 0 62 0, 0.0 3,-2.8 0, 0.0 19,-0.2 -0.579 41.1 -92.2 -80.3 140.1 1.4 35.1 33.9 10 39 A V T 3 S+ 0 0 87 1,-0.3 3,-0.1 -2,-0.2 19,-0.1 -0.292 118.2 29.4 -53.3 118.4 0.2 32.2 31.8 11 40 A G T 3 S+ 0 0 7 1,-0.5 -1,-0.3 17,-0.4 2,-0.2 0.243 105.7 97.0 111.4 -9.5 1.3 33.0 28.2 12 41 A E < - 0 0 82 -3,-2.8 -1,-0.5 51,-0.0 16,-0.4 -0.713 57.3-148.7-110.5 163.5 4.4 34.9 29.3 13 42 A V - 0 0 4 -2,-0.2 2,-0.4 50,-0.2 14,-0.2 -0.979 2.8-158.6-134.3 144.0 8.0 34.0 29.7 14 43 A R E -A 26 0A 73 12,-2.4 12,-3.0 -2,-0.4 2,-0.3 -0.947 10.4-145.0-122.0 141.6 10.8 35.3 32.1 15 44 A L E -A 25 0A 19 -2,-0.4 2,-0.4 10,-0.2 10,-0.2 -0.821 13.1-169.6-105.0 147.0 14.5 35.0 31.5 16 45 A Y E -A 24 0A 53 8,-2.3 8,-2.5 -2,-0.3 2,-0.5 -0.970 18.9-133.4-139.8 121.1 17.0 34.4 34.3 17 47 A Q E +A 23 0A 110 -2,-0.4 6,-0.3 6,-0.2 3,-0.1 -0.626 23.7 175.1 -79.3 121.8 20.8 34.7 34.1 18 48 A I E - 0 0 25 4,-1.9 2,-0.3 -2,-0.5 5,-0.2 0.791 68.4 -22.8 -91.7 -35.4 22.5 31.7 35.7 19 49 A A E > S-A 22 0A 20 3,-1.5 3,-1.9 143,-0.0 -1,-0.3 -0.902 99.7 -43.2-160.4-179.2 26.1 32.6 34.7 20 50 A D T 3 S- 0 0 144 1,-0.3 3,-0.1 -2,-0.3 24,-0.0 -0.406 128.2 -2.9 -61.1 124.3 27.9 34.7 32.1 21 51 A G T 3 S+ 0 0 12 -2,-0.2 23,-2.2 1,-0.1 2,-0.4 0.732 114.4 101.8 66.4 22.3 26.2 34.1 28.7 22 52 A V E < +AB 19 43A 0 -3,-1.9 -4,-1.9 21,-0.2 -3,-1.5 -0.987 41.7 167.0-140.2 128.1 23.8 31.5 30.1 23 53 A W E -AB 17 42A 31 19,-2.7 19,-2.8 -2,-0.4 2,-0.4 -0.920 26.3-139.1-134.1 160.0 20.1 32.0 31.0 24 54 A S E -AB 16 41A 0 -8,-2.5 -8,-2.3 -2,-0.3 2,-0.4 -0.870 18.5-142.5-113.3 149.0 17.2 29.8 31.8 25 55 A H E -AB 15 40A 1 15,-1.8 15,-1.8 -2,-0.4 2,-0.4 -0.949 15.1-158.6-112.2 139.3 13.8 30.6 30.3 26 56 A I E +AB 14 39A 1 -12,-3.0 -12,-2.4 -2,-0.4 2,-0.2 -0.977 18.7 159.4-124.1 129.7 10.8 30.1 32.5 27 57 A A E - B 0 38A 1 11,-2.1 11,-1.8 -2,-0.4 2,-0.3 -0.764 24.4-134.7-133.3 178.3 7.2 29.7 31.3 28 58 A T E - B 0 37A 0 -16,-0.4 -17,-0.4 -2,-0.2 2,-0.3 -0.933 14.1-174.9-136.9 161.4 4.0 28.2 32.8 29 59 A Q E - B 0 36A 53 7,-1.5 7,-2.4 -2,-0.3 2,-0.1 -0.956 26.8-121.6-158.1 135.5 1.3 25.9 31.6 30 60 A S E - B 0 35A 66 -2,-0.3 5,-0.3 5,-0.2 2,-0.2 -0.500 33.3-177.7 -74.1 150.7 -2.0 24.8 33.1 31 61 A F E > - B 0 34A 111 3,-3.6 3,-1.2 -2,-0.1 -2,-0.0 -0.709 61.7 -25.4-158.9 101.6 -2.2 21.0 33.3 32 62 A D T 3 S- 0 0 160 1,-0.3 3,-0.1 -2,-0.2 2,-0.1 0.896 129.1 -43.3 65.0 40.5 -5.1 19.0 34.6 33 63 A G T 3 S+ 0 0 82 1,-0.3 -1,-0.3 0, 0.0 2,-0.2 -0.168 125.1 85.5 99.7 -41.1 -6.4 21.9 36.7 34 64 A A E < S-B 31 0A 46 -3,-1.2 -3,-3.6 -2,-0.1 2,-0.5 -0.484 71.0-125.1 -96.0 166.3 -3.0 23.0 38.2 35 66 A V E -B 30 0A 66 -5,-0.3 -5,-0.2 -2,-0.2 -30,-0.1 -0.946 24.8-170.0-114.3 126.5 -0.3 25.3 36.9 36 67 A Y E -B 29 0A 84 -7,-2.4 -7,-1.5 -2,-0.5 2,-0.2 -0.870 17.0-132.7-116.4 147.4 3.3 24.2 36.5 37 68 A P E -B 28 0A 25 0, 0.0 2,-0.3 0, 0.0 -9,-0.2 -0.513 23.6-162.2 -89.8 165.6 6.5 26.2 35.8 38 69 A S E -B 27 0A 3 -11,-1.8 -11,-2.1 -2,-0.2 2,-0.3 -0.964 4.8-144.5-153.9 135.8 8.9 24.9 33.2 39 70 A N E +B 26 0A 1 169,-2.8 2,-0.3 -2,-0.3 -13,-0.2 -0.761 17.4 170.1-106.0 149.2 12.6 25.6 32.4 40 71 A G E -B 25 0A 0 -15,-1.8 -15,-1.8 -2,-0.3 2,-0.3 -0.800 28.5-118.6-138.5 173.9 14.6 25.8 29.2 41 72 A L E -BC 24 52A 0 11,-2.0 11,-3.2 -17,-0.3 2,-0.4 -0.885 14.6-163.7-123.8 154.9 18.1 27.0 28.6 42 73 A I E -BC 23 51A 1 -19,-2.8 -19,-2.7 -2,-0.3 2,-0.5 -0.992 11.1-174.8-135.7 125.3 19.7 29.9 26.5 43 74 A V E -BC 22 50A 2 7,-2.6 7,-2.1 -2,-0.4 -21,-0.2 -0.959 25.3-125.7-130.8 119.6 23.4 29.9 25.7 44 75 A R E - C 0 49A 109 -23,-2.2 2,-0.4 -2,-0.5 5,-0.2 -0.385 22.8-170.1 -61.7 129.2 25.4 32.6 24.0 45 76 A D E > - C 0 48A 37 3,-3.3 3,-1.0 -2,-0.1 2,-0.7 -0.765 60.7 -64.4-124.3 80.1 27.3 31.2 21.0 46 77 A G T 3 S- 0 0 55 -2,-0.4 -2,-0.0 1,-0.2 0, 0.0 -0.682 118.7 -16.9 77.2-114.1 29.6 34.0 19.8 47 78 A D T 3 S+ 0 0 121 -2,-0.7 -1,-0.2 -3,-0.1 2,-0.2 0.110 133.3 59.4-109.5 18.9 27.2 36.7 18.6 48 79 A E E < S-C 45 0A 71 -3,-1.0 -3,-3.3 26,-0.2 2,-0.4 -0.764 78.9-108.8-134.8-178.1 24.1 34.4 18.4 49 80 A L E -Cd 44 76A 0 26,-2.9 28,-1.8 -5,-0.2 29,-1.3 -0.932 7.3-152.7-125.9 143.6 22.1 32.2 20.7 50 81 A L E -Cd 43 78A 0 -7,-2.1 -7,-2.6 -2,-0.4 2,-0.4 -0.948 21.4-152.7-107.5 126.3 21.6 28.5 21.1 51 82 A L E -Cd 42 79A 1 27,-2.7 29,-2.4 -2,-0.5 2,-0.6 -0.847 3.8-155.2-103.2 134.2 18.1 27.7 22.6 52 83 A I E -Cd 41 80A 0 -11,-3.2 -11,-2.0 -2,-0.4 29,-0.2 -0.944 62.3 -21.3-111.7 113.9 17.6 24.5 24.6 53 84 A D S S- 0 0 2 27,-3.4 -1,-0.2 -2,-0.6 36,-0.1 0.463 77.2 -87.8 68.5 151.9 13.9 23.4 24.5 54 85 A T - 0 0 1 34,-1.2 37,-0.1 -3,-0.1 36,-0.1 -0.125 37.5-105.6 -79.8-179.8 10.7 25.3 23.7 55 86 A A - 0 0 1 2,-0.3 -27,-0.1 35,-0.2 33,-0.1 0.065 67.2 -91.0 -98.0 23.8 8.6 27.2 26.2 56 87 A W S S+ 0 0 29 34,-0.4 4,-0.2 31,-0.3 35,-0.2 0.995 95.8 17.2 67.2 69.5 6.0 24.5 26.2 57 88 A G S > S- 0 0 14 33,-2.8 4,-2.4 29,-0.4 -2,-0.3 -0.276 86.7 -88.6 121.3 154.4 3.5 25.5 23.4 58 89 A A H > S+ 0 0 54 2,-0.2 4,-2.1 1,-0.2 5,-0.2 0.917 123.2 45.7 -61.4 -48.3 3.2 27.8 20.4 59 90 A K H > S+ 0 0 137 1,-0.2 4,-1.9 2,-0.2 -1,-0.2 0.942 115.4 47.7 -62.3 -46.9 2.0 30.9 22.2 60 91 A N H > S+ 0 0 6 1,-0.2 4,-1.8 2,-0.2 -2,-0.2 0.888 112.3 49.3 -60.5 -40.7 4.6 30.5 24.9 61 92 A T H X S+ 0 0 0 -4,-2.4 4,-2.0 2,-0.2 -1,-0.2 0.837 107.3 53.4 -71.0 -32.5 7.4 30.0 22.4 62 93 A A H X S+ 0 0 48 -4,-2.1 4,-2.2 1,-0.2 -1,-0.2 0.906 111.7 47.3 -68.1 -36.6 6.4 33.0 20.4 63 94 A A H X S+ 0 0 23 -4,-1.9 4,-3.0 1,-0.2 -2,-0.2 0.838 107.3 57.3 -70.4 -34.3 6.6 35.0 23.7 64 95 A L H X S+ 0 0 0 -4,-1.8 4,-1.2 2,-0.2 -2,-0.2 0.919 109.5 44.1 -61.3 -45.7 9.9 33.4 24.4 65 96 A L H X S+ 0 0 29 -4,-2.0 4,-3.4 2,-0.2 3,-0.5 0.944 114.6 48.6 -65.7 -46.9 11.4 34.7 21.2 66 97 A A H X S+ 0 0 52 -4,-2.2 4,-1.9 1,-0.3 -2,-0.2 0.924 112.2 49.5 -57.9 -44.7 9.9 38.1 21.7 67 98 A E H < S+ 0 0 54 -4,-3.0 -1,-0.3 1,-0.2 -2,-0.2 0.729 114.3 46.0 -67.8 -22.3 11.2 38.2 25.2 68 99 A I H >X>S+ 0 0 2 -4,-1.2 4,-2.2 -3,-0.5 5,-1.6 0.888 109.7 52.9 -83.9 -43.6 14.6 37.2 23.9 69 100 A E H 3<5S+ 0 0 154 -4,-3.4 -2,-0.2 1,-0.3 -3,-0.2 0.816 114.7 42.6 -60.3 -33.1 14.6 39.7 21.1 70 102 A K T 3<5S+ 0 0 175 -4,-1.9 -1,-0.3 -5,-0.2 -2,-0.1 0.050 122.5 35.6-104.4 25.7 13.8 42.5 23.5 71 103 A Q T <45S+ 0 0 96 -3,-1.6 -2,-0.2 3,-0.1 -3,-0.1 0.480 132.3 16.8-148.3 -18.2 16.2 41.5 26.3 72 104 A I T <5S- 0 0 31 -4,-2.2 -3,-0.2 2,-0.1 -4,-0.1 0.482 78.8-153.2-128.9 -28.0 19.4 40.1 24.8 73 105 A G < + 0 0 53 -5,-1.6 -4,-0.2 1,-0.2 -3,-0.1 0.667 53.6 122.9 59.8 16.2 18.9 41.3 21.2 74 106 A L - 0 0 36 -6,-0.4 -1,-0.2 -26,-0.0 2,-0.2 -0.884 66.8-108.0-107.8 142.0 21.0 38.4 19.9 75 107 A P - 0 0 76 0, 0.0 -26,-2.9 0, 0.0 2,-0.9 -0.446 17.3-130.8 -73.8 139.1 19.5 36.1 17.3 76 109 A V E +d 49 0A 21 -28,-0.2 -26,-0.2 -2,-0.2 3,-0.1 -0.790 34.6 167.7 -86.4 108.9 18.4 32.5 18.1 77 110 A T E + 0 0 36 -28,-1.8 24,-2.5 -2,-0.9 2,-0.3 0.781 59.6 20.9 -95.7 -30.7 20.0 30.5 15.3 78 111 A R E -de 50 101A 54 -29,-1.3 -27,-2.7 22,-0.2 2,-0.3 -0.952 59.1-167.0-138.1 157.0 19.7 27.0 16.6 79 112 A A E -de 51 102A 3 22,-2.2 24,-2.8 -2,-0.3 2,-0.4 -0.996 5.0-158.7-143.7 145.9 17.5 25.1 19.1 80 113 A V E -de 52 103A 0 -29,-2.4 -27,-3.4 -2,-0.3 2,-0.5 -0.992 8.2-150.4-127.0 131.4 17.7 21.7 20.6 81 114 A S - 0 0 3 22,-2.1 24,-0.4 -2,-0.4 8,-0.1 -0.897 7.7-151.8-100.8 126.9 14.8 19.7 22.2 82 115 A T S S- 0 0 1 -2,-0.5 71,-1.9 1,-0.1 2,-0.3 0.626 72.9 -2.9 -76.0 -17.8 16.0 17.4 25.0 83 116 A H S S- 0 0 0 69,-0.2 -1,-0.1 2,-0.2 5,-0.1 -0.978 76.8 -96.3-163.9 168.7 13.2 14.9 24.5 84 117 A F S S+ 0 0 6 -2,-0.3 5,-0.1 4,-0.1 33,-0.1 0.513 77.2 114.6 -70.3 -6.9 10.0 14.2 22.5 85 118 A H S >> S- 0 0 22 1,-0.1 3,-2.5 3,-0.1 4,-1.9 -0.251 77.7-110.0 -70.7 155.2 7.4 15.5 24.9 86 119 A D H 3> S+ 0 0 78 1,-0.3 4,-1.6 2,-0.2 -29,-0.4 0.751 115.2 60.8 -51.8 -32.6 5.2 18.5 24.2 87 120 A D H 34 S+ 0 0 15 1,-0.2 -31,-0.3 -31,-0.2 -1,-0.3 0.558 114.8 36.0 -77.7 -2.3 6.9 20.7 26.8 88 121 A R H <4 S+ 0 0 0 -3,-2.5 -34,-1.2 -35,-0.1 -2,-0.2 0.646 131.5 24.5-116.8 -30.9 10.2 20.3 24.9 89 122 A V H >< S+ 0 0 0 -4,-1.9 3,-2.3 -36,-0.1 2,-0.8 0.474 89.7 111.7-112.6 -9.4 9.1 20.3 21.2 90 123 A G T 3< S+ 0 0 0 -4,-1.6 -33,-2.8 -5,-0.4 -34,-0.4 -0.580 83.9 29.7 -71.2 108.3 5.8 22.1 21.5 91 124 A G T 3> S+ 0 0 0 -2,-0.8 4,-2.1 -35,-0.2 3,-0.3 0.271 81.6 119.3 121.1 -2.9 6.5 25.4 19.8 92 125 A V H <> S+ 0 0 0 -3,-2.3 4,-2.6 1,-0.2 5,-0.2 0.837 72.8 56.9 -60.8 -34.3 9.1 24.0 17.3 93 126 A D H > S+ 0 0 85 -4,-0.3 4,-2.2 2,-0.2 -1,-0.2 0.872 107.5 49.6 -65.6 -34.0 6.9 25.0 14.4 94 127 A V H > S+ 0 0 39 -3,-0.3 4,-1.6 2,-0.2 -2,-0.2 0.915 110.3 48.9 -68.9 -45.0 7.0 28.6 15.7 95 128 A L H <>S+ 0 0 2 -4,-2.1 5,-2.6 1,-0.2 3,-0.2 0.929 112.1 49.5 -60.4 -46.0 10.8 28.4 16.0 96 129 A R H ><5S+ 0 0 89 -4,-2.6 3,-2.0 1,-0.2 -2,-0.2 0.914 107.5 53.7 -59.1 -46.0 11.1 27.1 12.5 97 130 A A H 3<5S+ 0 0 90 -4,-2.2 -1,-0.2 1,-0.3 -2,-0.2 0.818 106.2 54.2 -58.8 -33.0 8.8 29.8 11.1 98 131 A A T 3<5S- 0 0 67 -4,-1.6 -1,-0.3 -3,-0.2 -2,-0.2 0.365 125.7-101.7 -84.5 5.2 11.1 32.4 12.7 99 133 A G T < 5S+ 0 0 64 -3,-2.0 2,-0.3 1,-0.3 -3,-0.2 0.601 72.4 145.9 87.6 9.7 14.1 30.9 10.9 100 134 A V < - 0 0 8 -5,-2.6 2,-0.8 -6,-0.2 -1,-0.3 -0.659 50.8-127.9 -81.6 134.6 15.5 29.0 13.9 101 135 A A E -e 78 0A 29 -24,-2.5 -22,-2.2 -2,-0.3 2,-0.4 -0.766 28.6-151.4 -82.9 113.5 17.3 25.7 12.9 102 136 A T E -e 79 0A 3 -2,-0.8 20,-3.6 -24,-0.2 2,-0.3 -0.730 15.4-173.2 -92.9 135.2 15.6 23.1 15.2 103 137 A Y E +ef 80 122A 42 -24,-2.8 -22,-2.1 -2,-0.4 2,-0.3 -0.905 15.5 152.2-128.0 155.2 17.5 19.9 16.2 104 138 A A E - f 0 123A 0 18,-1.5 20,-2.2 -2,-0.3 -22,-0.1 -0.948 47.6 -88.7-168.6 160.8 16.9 16.7 18.1 105 139 A S > - 0 0 6 -24,-0.4 4,-2.5 -2,-0.3 5,-0.2 -0.352 41.6-110.3 -73.3 162.7 18.3 13.1 18.1 106 140 A P H > S+ 0 0 43 0, 0.0 4,-3.0 0, 0.0 5,-0.2 0.884 120.9 58.2 -61.2 -33.2 16.8 10.6 15.6 107 141 A S H > S+ 0 0 35 1,-0.2 4,-2.4 2,-0.2 5,-0.2 0.944 108.1 43.7 -61.2 -46.6 15.4 8.9 18.7 108 142 A T H > S+ 0 0 0 2,-0.2 4,-2.5 1,-0.2 -1,-0.2 0.911 113.8 50.9 -64.4 -43.2 13.5 12.0 19.8 109 143 A R H X S+ 0 0 77 -4,-2.5 4,-2.4 2,-0.2 -2,-0.2 0.923 111.0 49.3 -60.2 -45.3 12.3 12.7 16.2 110 144 A R H X S+ 0 0 150 -4,-3.0 4,-2.4 1,-0.2 -2,-0.2 0.934 114.0 44.3 -59.1 -49.9 11.1 9.2 15.9 111 145 A L H X S+ 0 0 41 -4,-2.4 4,-2.0 -5,-0.2 -1,-0.2 0.840 111.7 54.1 -65.7 -33.5 9.2 9.3 19.2 112 146 A A H X>S+ 0 0 0 -4,-2.5 5,-2.7 2,-0.2 4,-0.9 0.924 110.2 46.3 -65.9 -46.2 7.8 12.8 18.4 113 147 A E H ><5S+ 0 0 136 -4,-2.4 3,-1.0 2,-0.2 -2,-0.2 0.941 111.8 50.2 -62.8 -47.3 6.4 11.6 15.1 114 148 A V H 3<5S+ 0 0 111 -4,-2.4 -1,-0.2 1,-0.3 -2,-0.2 0.896 112.5 49.2 -58.3 -36.3 4.9 8.5 16.7 115 149 A E H 3<5S- 0 0 102 -4,-2.0 -1,-0.3 -5,-0.2 -2,-0.2 0.653 113.1-120.4 -77.8 -14.3 3.4 10.7 19.4 116 150 A G T <<5 + 0 0 67 -3,-1.0 -3,-0.2 -4,-0.9 -2,-0.1 0.662 68.2 138.0 82.0 15.4 2.0 13.1 16.7 117 165 A N < - 0 0 38 -5,-2.7 -1,-0.2 -6,-0.2 -32,-0.1 -0.353 65.1 -74.2 -87.5 173.1 4.0 15.9 18.2 118 166 A E - 0 0 43 -2,-0.1 -1,-0.2 -3,-0.1 -3,-0.1 -0.360 49.1-138.6 -65.6 147.4 6.0 18.6 16.4 119 167 A I - 0 0 46 -3,-0.1 -17,-0.1 -7,-0.1 -10,-0.1 -0.935 8.2-127.8-119.0 116.2 9.2 17.3 14.9 120 168 A P - 0 0 0 0, 0.0 -16,-0.1 0, 0.0 -17,-0.1 -0.316 21.7-135.2 -58.0 139.4 12.5 19.2 15.0 121 169 A T S S+ 0 0 68 -29,-0.1 -18,-0.2 -18,-0.1 2,-0.2 0.921 77.2 60.1 -65.6 -51.4 14.0 19.4 11.5 122 170 A H E S-f 103 0A 84 -20,-3.6 -18,-1.5 1,-0.0 2,-0.4 -0.494 74.9-130.0 -86.1 153.9 17.6 18.6 12.0 123 171 A S E -f 104 0A 46 -20,-0.2 2,-0.8 -2,-0.2 -18,-0.3 -0.845 3.4-147.1-106.6 134.9 19.1 15.4 13.4 124 172 A L - 0 0 8 -20,-2.2 3,-0.4 -2,-0.4 2,-0.1 -0.874 24.8-162.5-100.2 107.2 21.7 15.1 16.2 125 173 A E + 0 0 133 -2,-0.8 -20,-0.0 1,-0.2 0, 0.0 -0.442 61.8 41.3 -85.9 161.7 23.9 12.0 15.3 126 174 A G S S+ 0 0 44 -2,-0.1 -1,-0.2 1,-0.0 7,-0.1 0.683 84.6 95.0 77.7 21.2 26.1 10.2 17.7 127 175 A L + 0 0 7 -3,-0.4 5,-0.1 1,-0.1 4,-0.1 0.132 49.4 102.4-125.9 18.7 23.9 10.2 20.8 128 176 A S + 0 0 109 2,-0.1 2,-0.5 3,-0.1 -1,-0.1 0.658 69.3 66.6 -80.0 -16.7 22.2 6.8 20.4 129 177 A S S > S- 0 0 67 -3,-0.1 3,-2.9 16,-0.0 14,-0.2 -0.910 94.5-102.1-112.5 133.2 24.2 4.9 23.0 130 178 A S T 3 S+ 0 0 51 -2,-0.5 3,-0.1 1,-0.3 15,-0.1 -0.174 112.0 28.2 -45.6 133.3 24.1 5.5 26.7 131 179 A G T 3 S+ 0 0 31 12,-3.0 -1,-0.3 1,-0.3 2,-0.1 0.261 87.4 140.7 94.7 -14.5 27.1 7.5 27.7 132 180 A D < - 0 0 48 -3,-2.9 11,-2.5 11,-0.4 2,-0.3 -0.372 27.3-175.9 -65.7 142.1 27.5 9.2 24.3 133 181 A A E +G 142 0B 38 9,-0.2 2,-0.3 -7,-0.1 9,-0.2 -0.994 6.1 178.0-139.7 141.2 28.5 12.8 24.2 134 182 A V E -G 141 0B 38 7,-2.2 7,-3.2 -2,-0.3 2,-0.3 -0.994 29.1-115.2-143.4 147.6 28.8 15.3 21.3 135 183 A R E -G 140 0B 198 -2,-0.3 2,-0.3 5,-0.2 5,-0.2 -0.636 25.0-178.4 -85.5 140.2 29.7 18.9 21.1 136 184 A F E > -G 139 0B 20 3,-2.9 3,-1.8 -2,-0.3 -2,-0.0 -0.819 58.1 -74.0-137.5 92.7 27.1 21.4 19.8 137 185 A G T 3 S+ 0 0 18 -2,-0.3 -1,-0.2 1,-0.3 -92,-0.1 -0.313 118.0 1.9 57.7-125.3 28.6 24.9 19.7 138 186 A P T 3 S+ 0 0 27 0, 0.0 21,-0.4 0, 0.0 2,-0.3 0.327 129.5 53.5 -75.7 5.8 28.9 26.3 23.3 139 187 A V E < S-G 136 0B 1 -3,-1.8 -3,-2.9 18,-0.2 2,-0.4 -0.879 72.4-126.9-137.0 169.9 27.6 23.1 25.0 140 188 A E E -GH 135 156B 55 16,-2.5 16,-2.5 -2,-0.3 2,-0.4 -0.967 21.8-145.9-116.0 135.3 28.0 19.4 25.2 141 189 A L E -GH 134 155B 0 -7,-3.2 -7,-2.2 -2,-0.4 2,-0.4 -0.856 19.1-169.8-100.8 135.0 25.0 17.2 24.6 142 190 A F E -GH 133 154B 3 12,-2.4 12,-2.6 -2,-0.4 -9,-0.2 -0.990 20.7-157.1-133.7 132.0 24.9 14.0 26.6 143 191 A Y + 0 0 30 -11,-2.5 -12,-3.0 -2,-0.4 -11,-0.4 -0.917 13.7 179.6-106.0 105.6 22.7 10.9 26.4 144 192 A P - 0 0 0 0, 0.0 50,-0.2 0, 0.0 2,-0.2 0.593 50.2 -98.0 -81.0 -11.5 22.8 9.3 29.9 145 193 A G - 0 0 1 7,-0.5 4,-0.2 5,-0.1 -16,-0.0 -0.519 66.9 -27.0 113.9 173.5 20.5 6.5 29.0 146 194 A A S S+ 0 0 10 -2,-0.2 45,-0.3 1,-0.1 4,-0.3 -0.305 74.7 127.8 -61.9 136.8 16.8 6.1 29.6 147 195 A A S S+ 0 0 1 2,-2.0 37,-2.6 35,-0.1 41,-0.2 -0.058 81.6 5.1-148.7-102.6 15.3 8.0 32.6 148 196 A H S S+ 0 0 18 35,-0.2 2,-0.3 1,-0.2 34,-0.2 0.848 146.4 0.1 -62.7 -33.4 12.3 10.3 32.4 149 197 A S S > S- 0 0 0 -4,-0.2 -2,-2.0 34,-0.1 3,-0.8 -0.956 78.6-111.5-148.2 161.1 12.1 9.2 28.7 150 198 A T T 3 S+ 0 0 62 32,-0.5 -5,-0.1 -2,-0.3 33,-0.1 0.769 117.5 42.7 -68.7 -22.3 14.1 6.7 26.7 151 199 A D T 3 S+ 0 0 2 -44,-0.1 -1,-0.2 -43,-0.1 -43,-0.2 0.391 79.4 139.6-103.6 1.1 15.5 9.6 24.6 152 200 A N < - 0 0 2 -3,-0.8 -7,-0.5 -9,-0.1 2,-0.3 -0.183 30.3-166.5 -57.2 133.8 16.2 12.3 27.2 153 201 A L - 0 0 2 -71,-1.9 2,-0.3 -10,-0.2 -10,-0.2 -0.824 7.6-148.1-113.6 155.5 19.4 14.3 26.7 154 202 A V E -H 142 0B 0 -12,-2.6 -12,-2.4 -2,-0.3 2,-0.4 -0.894 12.3-139.7-121.2 154.7 21.1 16.6 29.2 155 203 A V E -HI 141 164B 0 9,-2.9 9,-4.0 -2,-0.3 2,-0.4 -0.957 12.4-167.9-121.8 133.9 23.1 19.7 28.3 156 204 A Y E -HI 140 163B 6 -16,-2.5 -16,-2.5 -2,-0.4 7,-0.2 -0.957 12.9-155.8-121.9 135.1 26.3 21.0 29.8 157 205 A V E >>> - I 0 162B 0 5,-2.8 4,-1.6 -2,-0.4 5,-1.3 -0.860 10.5-168.6-106.7 94.6 27.9 24.4 29.3 158 209 A P T 345S+ 0 0 78 0, 0.0 3,-0.2 0, 0.0 -1,-0.2 0.864 82.5 58.0 -52.9 -37.1 31.6 23.8 30.0 159 210 A S T 345S+ 0 0 103 -21,-0.4 -139,-0.1 1,-0.2 -20,-0.1 0.787 120.5 26.4 -65.8 -28.8 32.5 27.5 30.1 160 211 A A T <45S- 0 0 19 -3,-1.1 -1,-0.2 2,-0.1 43,-0.1 0.441 101.1-122.2-114.5 -0.8 30.0 28.2 32.9 161 215 A S T <5 + 0 0 36 -4,-1.6 42,-2.4 1,-0.2 43,-1.9 0.837 59.3 153.0 61.5 34.9 29.8 24.8 34.7 162 216 A V E < -Ij 157 204B 0 -5,-1.3 -5,-2.8 41,-0.2 2,-0.6 -0.852 29.4-165.4-101.0 125.9 26.1 24.7 34.1 163 217 A L E -Ij 156 205B 0 41,-3.2 43,-2.8 -2,-0.5 2,-0.7 -0.948 2.4-163.6-111.8 116.7 24.3 21.4 33.8 164 218 A Y E -Ij 155 206B 0 -9,-4.0 -9,-2.9 -2,-0.6 41,-0.1 -0.900 8.4-179.5-100.0 114.8 20.8 21.5 32.4 165 219 A G E > - 0 0 1 41,-2.6 3,-1.3 -2,-0.7 4,-0.1 0.616 16.4-160.2 -90.6 -13.4 19.1 18.2 33.2 166 220 A G E > - j 0 207B 1 40,-0.8 42,-1.8 1,-0.2 3,-1.6 -0.271 64.4 -27.8 62.9-155.7 15.7 18.7 31.6 167 221 A C T 3 S+ 0 0 6 1,-0.3 -1,-0.2 41,-0.2 -13,-0.1 0.526 127.3 77.5 -74.0 -4.2 13.0 16.5 32.9 168 222 A A T < S+ 0 0 1 -3,-1.3 2,-0.4 -15,-0.2 -1,-0.3 0.625 94.2 60.4 -75.6 -14.0 15.4 13.7 33.9 169 223 A I S < S- 0 0 2 -3,-1.6 39,-1.4 -4,-0.1 40,-0.5 -0.973 76.0-150.3-121.5 128.8 16.3 15.8 36.9 170 224 A Y - 0 0 15 -2,-0.4 51,-0.2 47,-0.4 2,-0.1 -0.623 18.6-117.4 -95.0 150.0 13.8 16.9 39.6 171 225 A E > - 0 0 26 38,-0.5 3,-1.4 -2,-0.2 -1,-0.1 -0.443 34.5-108.2 -77.7 160.0 13.9 20.1 41.8 172 226 A L T 3 S+ 0 0 93 39,-0.4 -1,-0.1 1,-0.3 38,-0.0 0.858 116.9 61.1 -58.7 -38.5 14.2 19.5 45.5 173 227 A S T 3 S+ 0 0 94 38,-0.1 2,-1.2 1,-0.1 -1,-0.3 0.676 81.7 91.2 -63.3 -20.4 10.6 20.6 46.2 174 228 A R < + 0 0 56 -3,-1.4 50,-0.1 1,-0.2 -1,-0.1 -0.686 50.9 171.2 -83.1 101.2 9.4 17.7 44.0 175 229 A T + 0 0 121 -2,-1.2 2,-0.3 2,-0.1 -1,-0.2 0.607 58.9 42.5 -86.4 -15.4 9.0 15.0 46.7 176 230 A S S S- 0 0 77 51,-0.0 49,-0.1 52,-0.0 48,-0.1 -0.921 95.6 -88.8-131.6 156.8 7.2 12.4 44.5 177 231 A A - 0 0 16 47,-0.4 3,-0.1 -2,-0.3 -2,-0.1 -0.333 40.0-151.7 -62.8 143.6 7.6 11.2 40.9 178 232 A G - 0 0 36 1,-0.3 2,-0.7 -4,-0.1 -1,-0.1 0.630 60.6 -20.2 -85.0-118.9 5.7 13.2 38.4 179 233 A N + 0 0 91 1,-0.1 -1,-0.3 3,-0.0 3,-0.1 -0.866 61.2 167.6 -95.0 120.0 4.5 11.6 35.1 180 234 A V > + 0 0 29 -2,-0.7 3,-1.4 -3,-0.1 5,-0.2 0.105 34.3 121.6-118.7 20.4 6.5 8.5 34.5 181 235 A A T 3 S+ 0 0 75 1,-0.3 -1,-0.1 3,-0.1 -32,-0.1 0.867 88.0 28.4 -50.6 -45.4 4.4 7.1 31.7 182 236 A D T 3 S+ 0 0 63 -34,-0.2 -32,-0.5 -3,-0.1 -1,-0.3 0.241 103.3 116.8-102.8 13.1 7.2 7.0 29.2 183 237 A A < - 0 0 22 -3,-1.4 2,-0.5 -34,-0.2 -35,-0.2 -0.286 62.6-140.2 -79.9 161.5 9.9 6.6 31.8 184 238 A D >> + 0 0 51 -37,-2.6 4,-1.9 1,-0.1 3,-0.8 -0.790 23.2 177.5-120.0 80.5 12.3 3.8 32.4 185 239 A L T 34 S+ 0 0 45 -2,-0.5 -1,-0.1 1,-0.2 44,-0.1 0.864 77.4 59.3 -53.8 -37.2 12.2 3.6 36.2 186 240 A A T 34 S+ 0 0 81 1,-0.2 4,-0.3 2,-0.1 -1,-0.2 0.871 115.9 32.1 -62.6 -36.0 14.6 0.6 36.1 187 241 A E T <> S+ 0 0 79 -3,-0.8 4,-2.4 1,-0.1 5,-0.2 0.613 94.4 91.2 -96.5 -14.6 17.3 2.5 34.2 188 242 A W H X S+ 0 0 0 -4,-1.9 4,-2.1 -41,-0.2 5,-0.2 0.900 87.2 46.9 -50.0 -51.2 16.8 6.0 35.7 189 243 A P H > S+ 0 0 26 0, 0.0 4,-2.1 0, 0.0 -1,-0.2 0.919 113.0 49.7 -60.0 -42.1 19.2 5.7 38.6 190 244 A T H > S+ 0 0 65 -4,-0.3 4,-1.7 1,-0.2 -2,-0.2 0.876 110.1 50.8 -63.4 -38.2 21.9 4.2 36.5 191 245 A S H X S+ 0 0 0 -4,-2.4 4,-1.4 -45,-0.3 -1,-0.2 0.871 108.1 52.5 -67.9 -36.0 21.5 7.1 33.9 192 246 A I H X S+ 0 0 4 -4,-2.1 4,-2.3 -5,-0.2 -2,-0.2 0.914 106.4 54.7 -64.3 -41.3 21.7 9.6 36.7 193 247 A E H X S+ 0 0 95 -4,-2.1 4,-3.0 1,-0.2 5,-0.2 0.879 104.0 53.1 -61.9 -38.0 25.0 8.0 37.8 194 248 A R H X S+ 0 0 75 -4,-1.7 4,-2.0 -50,-0.2 -1,-0.2 0.865 109.0 50.7 -65.0 -31.0 26.4 8.4 34.3 195 249 A I H X S+ 0 0 2 -4,-1.4 4,-2.0 -3,-0.2 -2,-0.2 0.905 111.1 49.3 -69.4 -40.3 25.5 12.1 34.6 196 250 A Q H < S+ 0 0 61 -4,-2.3 -2,-0.2 1,-0.2 -1,-0.2 0.946 112.7 45.6 -63.0 -49.2 27.3 12.2 37.9 197 251 A Q H < S+ 0 0 140 -4,-3.0 -1,-0.2 1,-0.2 -2,-0.2 0.859 116.3 45.9 -65.0 -34.1 30.4 10.5 36.6 198 252 A H H < S+ 0 0 79 -4,-2.0 -1,-0.2 -5,-0.2 -2,-0.2 0.778 123.6 29.2 -82.3 -26.4 30.6 12.7 33.5 199 253 A Y >< + 0 0 2 -4,-2.0 3,-1.6 -5,-0.1 -1,-0.2 -0.277 63.7 141.0-131.2 53.3 29.9 16.1 35.1 200 254 A P T 3 S+ 0 0 75 0, 0.0 -1,-0.1 0, 0.0 15,-0.1 0.691 74.7 61.4 -66.8 -14.5 31.3 16.0 38.7 201 255 A E T 3 S+ 0 0 92 -3,-0.1 -2,-0.1 14,-0.0 -3,-0.0 0.522 73.7 125.5 -88.9 -7.2 32.5 19.6 38.2 202 256 A A < + 0 0 3 -3,-1.6 13,-0.3 1,-0.1 -40,-0.2 -0.252 33.1 179.5 -54.8 136.5 29.0 21.0 37.6 203 257 A Q + 0 0 125 -42,-2.4 2,-0.4 1,-0.3 -41,-0.2 0.677 68.3 44.0-110.8 -29.7 28.2 23.9 39.9 204 258 A F E -j 162 0B 89 -43,-1.9 -41,-3.2 10,-0.1 2,-0.5 -0.981 66.0-168.8-121.9 127.0 24.7 24.9 38.8 205 259 A V E -jK 163 213B 0 8,-3.4 8,-2.6 -2,-0.4 -41,-0.2 -0.964 5.3-159.7-121.3 118.2 22.1 22.2 38.0 206 260 A I E -j 164 0B 0 -43,-2.8 -41,-2.6 -2,-0.5 -40,-0.8 -0.864 8.2-150.9-101.4 119.3 18.9 23.2 36.3 207 261 A P E -j 166 0B 0 0, 0.0 -40,-0.2 0, 0.0 -37,-0.2 -0.419 28.8-112.2 -81.1 159.3 15.9 20.8 36.6 208 262 A G S S+ 0 0 0 -42,-1.8 -169,-2.8 -39,-1.4 2,-0.4 0.807 105.7 25.1 -62.9 -25.8 13.3 20.6 33.9 209 263 A H S S- 0 0 29 -40,-0.5 -38,-0.5 -43,-0.3 -1,-0.2 -0.992 112.8 -7.6-142.3 130.2 10.8 22.2 36.3 210 264 A G S S+ 0 0 4 -2,-0.4 -172,-0.0 -3,-0.1 -174,-0.0 -0.443 94.9 9.1 96.1-164.2 11.4 24.5 39.3 211 265 A L - 0 0 86 -2,-0.1 -39,-0.4 1,-0.1 -38,-0.1 -0.341 62.8-128.6 -67.5 128.6 14.3 25.8 41.3 212 277 A P + 0 0 42 0, 0.0 -6,-0.2 0, 0.0 2,-0.2 -0.214 38.2 153.5 -69.6 163.6 17.9 25.3 40.2 213 278 A G B -K 205 0B 28 -8,-2.6 -8,-3.4 1,-0.1 2,-0.1 -0.714 38.8 -69.8-158.9-147.9 20.5 23.9 42.6 214 279 A G > - 0 0 21 -10,-0.2 3,-1.9 -2,-0.2 4,-0.2 -0.311 66.9 -67.3-110.9-163.8 23.7 21.9 42.8 215 280 A L T >> S+ 0 0 39 -13,-0.3 3,-1.9 1,-0.3 4,-0.7 0.643 117.0 83.5 -63.7 -14.9 24.7 18.3 42.0 216 281 A D H 3> S+ 0 0 93 1,-0.3 4,-2.1 2,-0.2 -1,-0.3 0.721 74.2 73.9 -61.8 -18.6 22.6 17.3 45.0 217 282 A L H <> S+ 0 0 0 -3,-1.9 4,-2.2 1,-0.2 -47,-0.4 0.801 90.5 58.6 -65.2 -24.8 19.6 17.4 42.7 218 283 A L H <> S+ 0 0 2 -3,-1.9 4,-2.4 2,-0.2 -1,-0.2 0.955 108.0 41.9 -68.2 -50.4 20.9 14.2 41.1 219 284 A K H X S+ 0 0 131 -4,-0.7 4,-2.8 1,-0.2 -2,-0.2 0.878 113.4 55.7 -64.4 -35.4 20.8 12.2 44.4 220 285 A H H X S+ 0 0 28 -4,-2.1 4,-2.5 2,-0.2 -1,-0.2 0.934 108.0 46.9 -61.2 -47.5 17.4 13.8 45.1 221 286 A T H X S+ 0 0 0 -4,-2.2 4,-3.2 1,-0.2 5,-0.2 0.920 111.9 51.3 -60.8 -45.0 16.0 12.6 41.8 222 287 A T H X S+ 0 0 14 -4,-2.4 4,-2.9 1,-0.2 5,-0.2 0.928 109.1 50.8 -57.8 -45.8 17.4 9.1 42.5 223 288 A N H X S+ 0 0 83 -4,-2.8 4,-2.4 1,-0.2 -2,-0.2 0.923 114.1 44.4 -56.7 -48.0 15.8 9.1 46.0 224 289 A V H X S+ 0 0 9 -4,-2.5 4,-2.0 2,-0.2 -47,-0.4 0.892 113.3 49.7 -66.0 -42.6 12.4 10.1 44.5 225 290 A V H X S+ 0 0 1 -4,-3.2 4,-2.6 2,-0.2 -2,-0.2 0.935 112.4 47.7 -62.9 -46.0 12.7 7.6 41.6 226 291 A K H X S+ 0 0 98 -4,-2.9 4,-1.9 -5,-0.2 -2,-0.2 0.942 110.5 51.5 -60.8 -47.9 13.6 4.7 44.0 227 292 A A H < S+ 0 0 69 -4,-2.4 -1,-0.2 -5,-0.2 -2,-0.2 0.882 112.6 46.1 -57.7 -39.3 10.8 5.6 46.4 228 293 A H H < S+ 0 0 81 -4,-2.0 -1,-0.2 1,-0.2 -2,-0.2 0.910 106.5 58.5 -69.7 -40.9 8.3 5.5 43.5 229 294 A T H < 0 0 73 -4,-2.6 -2,-0.2 1,-0.3 -1,-0.2 0.855 360.0 360.0 -54.9 -37.6 9.8 2.3 42.2 230 295 A N < 0 0 184 -4,-1.9 -1,-0.3 -5,-0.2 -2,-0.2 0.085 360.0 360.0 -93.4 360.0 8.9 0.8 45.6