==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=25-JAN-2013 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 20-OCT-99 1QNS . COMPND 2 MOLECULE: ENDO-1,4-B-D-MANNANASE; . SOURCE 2 ORGANISM_SCIENTIFIC: TRICHODERMA REESEI; . AUTHOR E.SABINI,H.SCHUBERT,G.MURSHUDOV,K.S.WILSON,M.SIIKA-AHO, . 344 1 4 4 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 12913.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 241 70.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 43 12.5 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 12 3.5 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 2 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 19 5.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 41 11.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 98 28.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 8 2.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 1 1 1 0 1 0 0 0 3 0 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 1 2 4 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 2 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 1 A A 0 0 116 0, 0.0 2,-0.3 0, 0.0 13,-0.0 0.000 360.0 360.0 360.0 173.3 -0.2 52.4 10.6 2 2 A S + 0 0 66 14,-0.0 2,-0.3 2,-0.0 157,-0.1 -0.870 360.0 148.5-140.7 95.1 2.2 49.9 9.1 3 3 A S - 0 0 43 -2,-0.3 12,-0.4 156,-0.2 2,-0.1 -0.790 55.3 -74.1-121.9-179.6 5.5 49.9 11.0 4 4 A F - 0 0 63 -2,-0.3 2,-0.3 1,-0.1 155,-0.1 -0.445 55.7-106.7 -79.3 143.8 8.0 47.2 11.7 5 5 A V + 0 0 1 156,-0.6 194,-0.4 154,-0.2 2,-0.2 -0.558 51.8 168.1 -70.1 130.7 6.9 44.6 14.3 6 6 A T E -A 13 0A 60 7,-1.8 7,-3.0 -2,-0.3 2,-0.5 -0.727 35.7-107.2-133.1 174.7 8.6 45.2 17.6 7 7 A I E -A 12 0A 53 5,-0.2 2,-0.5 -2,-0.2 5,-0.2 -0.964 25.6-174.8-107.3 129.6 8.5 44.1 21.3 8 8 A S E > -A 11 0A 55 3,-2.9 3,-2.5 -2,-0.5 2,-0.2 -0.989 69.8 -35.7-124.5 116.5 7.3 46.6 23.9 9 9 A G T 3 S- 0 0 69 -2,-0.5 -2,-0.0 1,-0.2 0, 0.0 -0.501 122.6 -36.5 67.4-136.2 7.6 45.2 27.4 10 10 A T T 3 S+ 0 0 21 -2,-0.2 2,-0.3 260,-0.1 -1,-0.2 -0.004 126.5 85.3-111.0 31.6 6.8 41.5 27.1 11 11 A Q E < S-A 8 0A 81 -3,-2.5 -3,-2.9 260,-0.1 2,-0.3 -0.826 80.8-108.4-123.5 163.0 4.2 42.1 24.5 12 12 A F E -A 7 0A 0 7,-0.3 7,-2.0 289,-0.3 2,-0.6 -0.671 18.1-148.2 -90.5 146.5 4.3 42.6 20.8 13 13 A N E -AB 6 18A 34 -7,-3.0 -7,-1.8 -2,-0.3 2,-0.6 -0.960 19.5-178.4-114.1 108.4 3.7 46.0 19.1 14 14 A I E > S- B 0 17A 8 3,-2.6 3,-2.0 -2,-0.6 -9,-0.1 -0.954 72.7 -22.4-113.7 110.8 1.9 45.4 15.7 15 15 A D T 3 S- 0 0 31 -2,-0.6 -1,-0.2 -12,-0.4 3,-0.1 0.849 129.4 -49.2 55.4 36.6 1.3 48.6 13.7 16 16 A G T 3 S+ 0 0 51 1,-0.2 2,-0.6 -3,-0.0 -1,-0.3 0.356 114.1 116.5 89.7 -8.2 1.4 50.6 16.9 17 17 A K E < -B 14 0A 146 -3,-2.0 -3,-2.6 2,-0.1 2,-0.6 -0.868 50.1-157.5 -98.2 120.5 -0.9 48.4 18.9 18 18 A V E +B 13 0A 66 -2,-0.6 2,-0.3 -5,-0.2 -5,-0.2 -0.804 46.2 77.7 -99.5 123.4 0.6 46.7 21.9 19 19 A G S S- 0 0 21 -7,-2.0 -7,-0.3 -2,-0.6 -5,-0.1 -0.922 79.3 -41.1 159.6 172.2 -1.2 43.6 23.1 20 20 A Y - 0 0 36 -2,-0.3 2,-0.3 323,-0.1 282,-0.2 -0.244 53.0-159.9 -59.6 144.8 -2.0 39.9 22.6 21 21 A F E -c 302 0B 4 280,-1.4 282,-1.6 29,-0.0 2,-0.4 -0.947 12.5-148.6-127.7 152.7 -2.5 38.6 19.1 22 22 A A E +c 303 0B 6 -2,-0.3 29,-2.6 27,-0.3 30,-0.7 -0.923 29.0 155.4-113.4 142.3 -4.1 35.6 17.4 23 23 A G E -cd 304 52B 1 280,-2.6 282,-1.1 -2,-0.4 2,-0.3 -0.757 25.2-129.6-142.7-164.9 -2.8 34.2 14.2 24 24 A T E -cd 305 53B 0 28,-2.1 30,-2.1 280,-0.3 2,-0.4 -0.980 18.1-110.6-151.3 161.4 -2.7 31.0 12.1 25 25 A N E + d 0 54B 0 280,-2.0 283,-2.9 -2,-0.3 282,-0.5 -0.832 32.5 165.1 -92.4 131.3 -0.4 28.6 10.3 26 26 A a > + 0 0 0 28,-3.2 3,-1.3 -2,-0.4 4,-0.5 -0.591 3.8 164.0-140.7 67.8 -0.8 28.5 6.5 27 27 A Y G > S+ 0 0 29 1,-0.3 29,-1.2 28,-0.2 3,-0.9 0.881 75.5 55.6 -55.6 -36.8 2.3 26.7 5.2 28 28 A W G > S+ 0 0 6 1,-0.2 3,-1.7 2,-0.2 4,-0.3 0.568 82.8 83.8 -78.5 -13.4 0.7 26.1 1.8 29 29 A a G X S+ 0 0 0 -3,-1.3 3,-1.2 1,-0.3 -1,-0.2 0.891 85.0 61.2 -58.4 -34.0 0.0 29.8 1.1 30 30 A S G < S+ 0 0 0 -3,-0.9 -1,-0.3 -4,-0.5 -2,-0.2 0.623 103.7 48.7 -66.4 -16.7 3.6 30.2 -0.1 31 31 A F G < S+ 0 0 29 -3,-1.7 2,-0.4 -4,-0.1 -1,-0.2 0.221 76.5 120.6-110.6 7.2 3.1 27.6 -2.9 32 32 A L < - 0 0 23 -3,-1.2 63,-0.1 -4,-0.3 6,-0.1 -0.621 41.5-168.6 -70.4 132.4 -0.1 28.9 -4.4 33 33 A T + 0 0 100 -2,-0.4 2,-0.7 1,-0.1 -1,-0.1 0.710 67.8 77.2 -98.0 -16.9 0.4 29.8 -8.1 34 34 A N >> - 0 0 83 1,-0.2 3,-1.6 2,-0.0 4,-1.0 -0.846 69.6-153.5 -93.1 114.8 -2.9 31.6 -8.7 35 35 A H H 3> S+ 0 0 96 -2,-0.7 4,-2.4 1,-0.3 3,-0.3 0.817 92.8 63.9 -52.7 -36.5 -2.6 35.1 -7.1 36 36 A A H 3> S+ 0 0 49 1,-0.2 4,-2.4 2,-0.2 -1,-0.3 0.829 99.1 54.0 -60.1 -31.7 -6.3 35.3 -6.6 37 37 A D H <> S+ 0 0 17 -3,-1.6 4,-1.8 2,-0.2 -1,-0.2 0.823 106.4 51.0 -76.3 -32.8 -6.1 32.3 -4.2 38 38 A V H X S+ 0 0 2 -4,-1.0 4,-2.7 -3,-0.3 5,-0.2 0.949 113.1 46.6 -63.3 -49.0 -3.5 34.1 -2.1 39 39 A D H X S+ 0 0 35 -4,-2.4 4,-2.6 1,-0.2 -2,-0.2 0.902 112.1 48.5 -64.3 -40.3 -5.8 37.2 -1.9 40 40 A S H X S+ 0 0 33 -4,-2.4 4,-2.1 2,-0.2 -1,-0.2 0.930 114.0 47.4 -65.3 -41.4 -9.0 35.2 -1.1 41 41 A T H X S+ 0 0 0 -4,-1.8 4,-2.3 1,-0.2 -2,-0.2 0.942 114.7 45.2 -63.5 -49.6 -7.2 33.3 1.7 42 42 A F H X S+ 0 0 0 -4,-2.7 4,-2.7 2,-0.2 5,-0.2 0.869 109.1 56.6 -62.8 -35.4 -5.6 36.4 3.2 43 43 A S H X S+ 0 0 54 -4,-2.6 4,-2.9 -5,-0.2 5,-0.2 0.935 109.4 46.4 -59.6 -42.2 -8.9 38.3 2.9 44 44 A H H X S+ 0 0 42 -4,-2.1 4,-1.6 1,-0.2 -2,-0.2 0.895 112.6 48.7 -67.9 -41.9 -10.6 35.6 5.0 45 45 A I H <>S+ 0 0 0 -4,-2.3 5,-1.8 2,-0.2 4,-0.4 0.940 115.0 45.7 -61.0 -47.9 -7.8 35.5 7.6 46 46 A S H ><5S+ 0 0 42 -4,-2.7 3,-1.6 1,-0.2 -2,-0.2 0.931 111.6 50.1 -60.5 -46.8 -7.8 39.3 7.9 47 47 A S H 3<5S+ 0 0 81 -4,-2.9 -1,-0.2 1,-0.3 -2,-0.2 0.816 104.0 60.8 -69.2 -21.5 -11.6 39.6 8.1 48 48 A S T 3<5S- 0 0 11 -4,-1.6 -1,-0.3 -5,-0.2 -2,-0.2 0.625 119.8-110.6 -75.4 -12.1 -11.6 36.9 10.9 49 49 A G T < 5 + 0 0 35 -3,-1.6 -27,-0.3 -4,-0.4 2,-0.2 0.530 69.8 140.8 94.7 6.3 -9.4 39.2 13.0 50 50 A L < - 0 0 6 -5,-1.8 -1,-0.3 1,-0.1 -27,-0.2 -0.588 30.8-170.0 -82.1 148.5 -6.2 37.3 12.9 51 51 A K + 0 0 86 -29,-2.6 54,-2.1 -2,-0.2 2,-0.4 0.596 61.2 48.5-111.8 -18.6 -3.1 39.4 12.5 52 52 A V E -de 23 105B 0 -30,-0.7 -28,-2.1 52,-0.2 2,-0.4 -0.988 55.3-167.4-134.6 136.3 -0.2 37.0 11.8 53 53 A V E -de 24 106B 0 52,-2.7 54,-2.1 -2,-0.4 2,-0.5 -0.989 13.4-146.0-125.3 134.2 0.3 34.1 9.4 54 54 A R E +de 25 107B 0 -30,-2.1 -28,-3.2 -2,-0.4 2,-0.3 -0.892 27.6 173.4-100.4 121.1 3.1 31.5 9.4 55 55 A V - 0 0 0 52,-2.1 2,-0.3 -2,-0.5 -28,-0.2 -0.912 38.0 -97.5-127.7 149.4 4.1 30.4 5.9 56 56 A W - 0 0 9 -29,-1.2 54,-0.1 -2,-0.3 52,-0.1 -0.531 24.8-167.8 -67.3 133.9 6.9 28.2 4.6 57 57 A G + 0 0 0 52,-1.5 2,-0.3 -2,-0.3 -1,-0.1 0.219 68.1 63.2-100.5 17.2 10.0 30.2 3.4 58 58 A F + 0 0 0 2,-0.0 2,-0.1 53,-0.0 53,-0.1 -0.937 40.8 170.3-137.7 157.7 11.4 27.1 1.8 59 59 A N - 0 0 15 -2,-0.3 13,-2.4 2,-0.1 14,-1.9 -0.564 27.1-173.4-169.5 88.0 10.8 24.5 -0.9 60 60 A D E +j 73 0C 5 57,-2.5 2,-0.3 12,-0.2 14,-0.2 -0.765 6.4 174.1 -99.1 135.8 13.9 22.4 -1.4 61 61 A V E -j 74 0C 26 12,-2.5 14,-2.9 -2,-0.4 3,-0.1 -0.915 30.9-159.5-133.4 160.4 14.5 19.8 -4.0 62 62 A N S S+ 0 0 49 1,-0.3 2,-0.4 -2,-0.3 -1,-0.1 0.615 92.1 37.1-106.7 -28.2 17.3 17.6 -5.3 63 63 A T S S- 0 0 108 13,-0.0 -1,-0.3 11,-0.0 12,-0.0 -0.978 98.1-107.0-122.8 137.9 15.8 17.0 -8.8 64 64 A Q - 0 0 109 -2,-0.4 7,-0.0 -3,-0.1 10,-0.0 -0.439 40.3-121.6 -65.4 140.9 14.0 19.8 -10.5 65 65 A P - 0 0 36 0, 0.0 3,-0.1 0, 0.0 -1,-0.1 -0.168 45.4 -63.7 -74.2 172.7 10.3 19.2 -10.5 66 66 A S S > S- 0 0 86 1,-0.2 3,-2.6 2,-0.1 0, 0.0 -0.215 75.1 -80.5 -51.9 143.9 8.2 18.9 -13.6 67 67 A P T 3 S+ 0 0 133 0, 0.0 -1,-0.2 0, 0.0 3,-0.1 -0.165 121.3 28.6 -48.8 128.1 8.1 22.1 -15.5 68 68 A G T 3 S+ 0 0 52 1,-0.4 2,-0.1 -3,-0.1 -2,-0.1 0.091 91.6 117.9 101.7 -22.0 5.6 24.5 -13.9 69 69 A Q < - 0 0 116 -3,-2.6 -1,-0.4 1,-0.1 2,-0.3 -0.461 69.9-105.6 -75.5 148.4 5.9 23.1 -10.4 70 70 A I + 0 0 19 -39,-0.2 2,-0.3 -2,-0.1 18,-0.2 -0.521 44.8 160.1 -80.6 137.2 7.2 25.4 -7.6 71 71 A W - 0 0 13 16,-2.2 -11,-0.2 -2,-0.3 3,-0.1 -0.935 21.9-171.7-149.2 136.2 10.7 25.1 -6.2 72 72 A F S S+ 0 0 0 -13,-2.4 11,-2.2 1,-0.3 2,-0.3 0.736 75.7 12.9 -99.4 -26.2 12.7 27.6 -4.3 73 73 A Q E -jK 60 82C 0 -14,-1.9 -12,-2.5 9,-0.2 2,-0.5 -0.976 55.5-153.0-153.6 137.1 16.1 25.9 -4.2 74 74 A K E -jK 61 81C 65 7,-2.9 7,-2.2 -2,-0.3 2,-0.6 -0.947 20.2-152.1-110.0 120.3 17.8 22.9 -5.8 75 75 A L + 0 0 2 -14,-2.9 2,-0.3 -2,-0.5 5,-0.1 -0.854 25.5 160.0-101.0 120.7 20.5 21.3 -3.7 76 76 A S > - 0 0 24 -2,-0.6 3,-1.7 1,-0.1 50,-0.1 -0.999 47.9-131.1-141.2 146.2 23.3 19.6 -5.5 77 77 A A T 3 S+ 0 0 79 -2,-0.3 3,-0.1 1,-0.3 -1,-0.1 0.659 110.9 51.1 -65.8 -18.3 26.9 18.5 -4.7 78 78 A T T 3 S- 0 0 135 1,-0.3 -1,-0.3 -3,-0.0 2,-0.0 0.173 133.9 -38.5-110.6 19.9 28.0 20.1 -7.9 79 79 A G < - 0 0 52 -3,-1.7 -1,-0.3 2,-0.0 2,-0.2 0.186 59.3-131.5 125.8 119.8 26.4 23.5 -7.5 80 80 A S - 0 0 26 -3,-0.1 2,-0.4 -5,-0.1 -5,-0.2 -0.503 15.3-144.9 -91.7 160.0 23.1 24.5 -6.0 81 81 A T E -K 74 0C 71 -7,-2.2 -7,-2.9 -2,-0.2 2,-0.6 -0.988 3.7-153.0-132.4 130.1 20.5 26.9 -7.6 82 82 A I E -K 73 0C 39 -2,-0.4 2,-0.8 -9,-0.2 -9,-0.2 -0.920 24.5-136.1-101.5 119.2 18.2 29.4 -5.8 83 83 A N + 0 0 17 -11,-2.2 6,-2.8 -2,-0.6 7,-0.1 -0.722 34.8 164.0 -86.1 107.2 15.1 29.9 -8.0 84 84 A T + 0 0 72 -2,-0.8 -1,-0.1 4,-0.2 -12,-0.1 0.234 47.7 103.1-104.6 17.5 14.1 33.6 -8.3 85 85 A G S > >S- 0 0 23 4,-0.1 3,-1.8 -13,-0.0 5,-1.6 -0.011 93.7 -80.2 -89.8-173.1 11.9 33.0 -11.4 86 86 A A T 3 5S+ 0 0 74 1,-0.3 -1,-0.0 4,-0.1 -16,-0.0 0.802 132.0 46.1 -61.4 -34.3 8.1 32.8 -11.7 87 87 A D T 3 5S+ 0 0 51 3,-0.1 -16,-2.2 -18,-0.1 -1,-0.3 0.135 120.7 45.4 -91.7 14.3 8.0 29.2 -10.5 88 88 A G T X>5S- 0 0 0 -3,-1.8 3,-2.5 -18,-0.2 4,-0.6 -0.055 123.0 -18.0-126.4-132.6 10.3 30.1 -7.6 89 89 A L H 3>5S+ 0 0 0 -6,-2.8 4,-2.2 1,-0.3 -5,-0.2 0.626 115.9 78.5 -62.0 -14.9 10.6 32.9 -5.1 90 90 A Q H 3> S+ 0 0 12 -3,-2.5 4,-1.4 -6,-0.3 -1,-0.2 0.933 107.1 45.2 -66.9 -43.1 5.5 33.1 -5.6 92 92 A L H X S+ 0 0 0 -4,-0.6 4,-2.5 1,-0.2 -2,-0.2 0.892 105.7 62.5 -67.9 -31.3 6.6 34.1 -2.1 93 93 A D H X S+ 0 0 34 -4,-2.2 4,-2.5 1,-0.2 -1,-0.2 0.921 103.1 48.5 -58.2 -41.9 7.0 37.7 -3.3 94 94 A Y H X S+ 0 0 51 -4,-1.5 4,-2.8 2,-0.2 -1,-0.2 0.877 107.8 55.8 -67.9 -33.8 3.3 37.9 -4.0 95 95 A V H X S+ 0 0 1 -4,-1.4 4,-2.3 2,-0.2 -2,-0.2 0.930 109.9 44.5 -59.7 -47.1 2.5 36.4 -0.6 96 96 A V H X S+ 0 0 2 -4,-2.5 4,-2.4 2,-0.2 -2,-0.2 0.938 113.3 51.5 -67.0 -40.4 4.5 39.2 1.1 97 97 A Q H X S+ 0 0 104 -4,-2.5 4,-2.3 2,-0.2 -2,-0.2 0.917 111.9 47.5 -58.6 -43.7 2.7 41.8 -1.2 98 98 A S H X S+ 0 0 0 -4,-2.8 4,-2.4 2,-0.2 -1,-0.2 0.864 108.8 52.6 -70.7 -34.4 -0.7 40.4 -0.3 99 99 A A H <>S+ 0 0 0 -4,-2.3 5,-2.6 -5,-0.2 4,-0.4 0.952 109.3 51.0 -63.3 -43.4 0.2 40.4 3.4 100 100 A E H ><5S+ 0 0 77 -4,-2.4 3,-0.9 1,-0.2 -2,-0.2 0.935 113.3 46.0 -58.9 -40.7 1.2 44.1 3.0 101 101 A Q H 3<5S+ 0 0 127 -4,-2.3 -1,-0.2 1,-0.2 -2,-0.2 0.876 115.4 44.7 -69.2 -42.5 -2.2 44.7 1.3 102 102 A H T 3<5S- 0 0 27 -4,-2.4 -1,-0.2 -5,-0.1 -2,-0.2 0.208 110.9-114.3 -88.5 5.7 -4.3 42.8 3.9 103 103 A N T < 5 + 0 0 111 -3,-0.9 2,-0.3 -4,-0.4 -3,-0.2 0.884 69.6 139.8 60.5 44.7 -2.6 44.3 6.9 104 104 A L < - 0 0 1 -5,-2.6 2,-0.3 -6,-0.2 -52,-0.2 -0.820 43.8-143.2-115.4 152.3 -1.1 40.9 7.9 105 105 A K E -e 52 0B 3 -54,-2.1 -52,-2.7 -2,-0.3 2,-0.4 -0.890 17.4-141.2-113.6 151.5 2.3 40.1 9.3 106 106 A L E -ef 53 161B 0 54,-2.3 56,-2.3 -2,-0.3 57,-1.4 -0.914 11.1-154.9-119.5 137.3 4.3 36.9 8.4 107 107 A I E -ef 54 163B 0 -54,-2.1 -52,-2.1 -2,-0.4 57,-0.2 -0.924 24.5-170.3-101.6 124.9 6.5 34.4 10.3 108 108 A I E - f 0 164B 0 55,-2.1 57,-2.1 -2,-0.5 2,-0.2 -0.903 9.9-161.7-126.6 104.2 8.8 32.8 7.8 109 109 A P E - f 0 165B 0 0, 0.0 -52,-1.5 0, 0.0 57,-0.2 -0.580 11.1-147.5 -78.0 150.0 11.1 29.8 8.6 110 110 A F S S+ 0 0 0 55,-1.8 2,-0.3 -2,-0.2 57,-0.2 0.641 73.0 14.3 -94.6 -17.4 14.0 29.1 6.2 111 111 A V S S- 0 0 4 54,-0.2 57,-2.6 55,-0.1 2,-0.5 -0.974 70.3-121.7-154.4 152.3 14.3 25.3 6.3 112 112 A N B -l 168 0D 2 -2,-0.3 8,-2.1 55,-0.2 9,-0.2 -0.846 3.9-151.8 -95.3 139.7 12.2 22.3 7.5 113 113 A N S S+ 0 0 25 55,-2.2 8,-0.3 -2,-0.5 -1,-0.1 0.907 86.9 64.4 -65.7 -39.4 13.6 19.9 10.2 114 114 A W S S- 0 0 86 54,-0.4 6,-0.2 6,-0.1 -2,-0.2 -0.372 96.7-111.3 -84.7 163.3 11.3 17.3 8.4 115 115 A S S > S+ 0 0 71 4,-0.1 3,-1.7 5,-0.1 2,-0.3 0.555 78.4 116.3 -81.3 1.1 11.5 16.0 4.9 116 116 A D T 3 S+ 0 0 100 1,-0.3 3,-0.2 2,-0.1 -56,-0.1 -0.465 91.8 6.0 -68.4 129.3 8.4 17.7 3.7 117 117 A Y T 3 S- 0 0 73 -2,-0.3 -57,-2.5 1,-0.2 2,-1.2 0.817 135.2 -66.8 57.5 38.6 9.4 20.2 1.0 118 118 A G S <> S+ 0 0 15 -3,-1.7 4,-1.0 -59,-0.2 3,-0.3 -0.554 77.3 175.0 94.6 -70.9 12.9 18.8 1.2 119 119 A G H >> - 0 0 0 -2,-1.2 3,-1.3 1,-0.2 4,-1.2 0.010 61.1 -32.9 67.2-168.1 14.1 19.8 4.6 120 120 A I H 3> S+ 0 0 5 -8,-2.1 4,-2.3 1,-0.3 3,-0.4 0.851 135.6 64.3 -53.2 -38.0 17.4 18.9 6.3 121 121 A N H 3> S+ 0 0 72 -3,-0.3 4,-2.3 -8,-0.3 -1,-0.3 0.840 96.7 55.2 -59.5 -33.8 17.1 15.5 4.3 122 122 A A H - 0 0 80 -2,-0.1 4,-1.3 -5,-0.0 -5,-0.0 -0.825 44.2 -74.8-146.7-175.5 23.1 12.8 8.4 131 131 A A T 4 S+ 0 0 59 -2,-0.2 4,-0.2 1,-0.2 40,-0.1 0.683 127.9 42.6 -64.7 -18.2 20.3 14.8 10.0 132 132 A T T >4 S+ 0 0 43 2,-0.1 3,-0.6 1,-0.1 -1,-0.2 0.782 112.0 51.5 -98.3 -28.0 22.2 15.5 13.2 133 133 A T G >> S+ 0 0 57 1,-0.2 3,-1.8 2,-0.1 4,-0.5 0.683 87.2 89.3 -80.8 -7.7 25.6 16.4 11.6 134 134 A W G >< S+ 0 0 3 -4,-1.3 3,-1.3 1,-0.3 -1,-0.2 0.867 77.2 63.0 -53.3 -40.8 23.7 18.8 9.3 135 135 A Y G <4 S+ 0 0 9 -3,-0.6 -1,-0.3 1,-0.3 -2,-0.1 0.741 115.7 29.7 -58.8 -26.7 24.2 21.6 11.9 136 136 A T G <4 S+ 0 0 107 -3,-1.8 2,-0.7 -4,-0.2 -1,-0.3 0.178 85.6 119.8-123.3 20.3 28.0 21.5 11.5 137 137 A N S+ 0 0 110 -2,-0.7 4,-2.5 1,-0.2 5,-0.2 0.924 90.6 46.0 -58.3 -46.1 30.2 23.1 6.2 139 139 A A H > S+ 0 0 50 2,-0.2 4,-2.0 1,-0.2 -1,-0.2 0.895 115.5 47.2 -62.4 -42.8 28.9 22.7 2.7 140 140 A A H > S+ 0 0 0 -13,-0.2 4,-2.7 2,-0.2 -2,-0.2 0.929 114.1 46.3 -65.3 -40.8 25.3 22.4 3.9 141 141 A Q H X S+ 0 0 20 -4,-2.9 4,-2.7 2,-0.2 -2,-0.2 0.874 109.2 55.7 -70.0 -35.5 25.6 25.4 6.2 142 142 A T H X S+ 0 0 80 -4,-2.5 4,-1.9 -5,-0.3 -1,-0.2 0.951 113.0 41.3 -63.7 -41.4 27.2 27.5 3.5 143 143 A Q H X S+ 0 0 18 -4,-2.0 4,-2.5 1,-0.2 -2,-0.2 0.910 112.3 54.5 -72.6 -42.3 24.3 26.8 1.1 144 144 A Y H X S+ 0 0 0 -4,-2.7 4,-2.9 1,-0.2 -1,-0.2 0.933 110.0 47.4 -54.7 -47.0 21.7 27.3 3.9 145 145 A R H X S+ 0 0 68 -4,-2.7 4,-2.6 2,-0.2 -1,-0.2 0.883 108.8 54.2 -65.7 -31.9 23.2 30.7 4.7 146 146 A K H X S+ 0 0 116 -4,-1.9 4,-1.9 2,-0.2 -1,-0.2 0.901 110.9 46.9 -63.7 -40.1 23.2 31.6 0.9 147 147 A Y H X S+ 0 0 0 -4,-2.5 4,-2.1 2,-0.2 5,-0.2 0.927 109.2 53.0 -69.7 -41.4 19.5 30.7 0.9 148 148 A V H X S+ 0 0 0 -4,-2.9 4,-3.0 1,-0.2 5,-0.3 0.932 110.4 48.7 -54.0 -50.0 18.9 32.8 4.1 149 149 A Q H X S+ 0 0 83 -4,-2.6 4,-2.5 1,-0.2 -1,-0.2 0.919 108.5 54.0 -58.8 -38.2 20.5 35.8 2.4 150 150 A A H < S+ 0 0 16 -4,-1.9 4,-0.4 2,-0.2 -1,-0.2 0.851 116.2 37.1 -65.8 -37.4 18.4 35.2 -0.7 151 151 A V H >X S+ 0 0 0 -4,-2.1 3,-1.2 2,-0.2 4,-0.9 0.952 117.3 48.7 -81.9 -49.6 15.2 35.3 1.2 152 152 A V H >X S+ 0 0 0 -4,-3.0 4,-1.2 1,-0.3 3,-1.0 0.898 106.5 57.1 -58.5 -39.5 16.0 38.0 3.8 153 153 A S H 3< S+ 0 0 65 -4,-2.5 -1,-0.3 -5,-0.3 4,-0.2 0.731 102.2 56.7 -66.9 -21.6 17.4 40.4 1.2 154 154 A R H <4 S+ 0 0 85 -3,-1.2 -1,-0.3 -4,-0.4 -2,-0.2 0.767 122.9 21.1 -72.2 -35.1 14.1 40.4 -0.7 155 155 A Y H X< S+ 0 0 12 -3,-1.0 3,-2.0 -4,-0.9 6,-0.2 0.247 82.6 115.6-121.3 12.0 12.0 41.5 2.3 156 156 A A T 3< S+ 0 0 9 -4,-1.2 41,-0.2 1,-0.3 -3,-0.1 0.779 86.8 40.1 -57.0 -30.3 14.3 43.2 4.7 157 157 A N T 3 S+ 0 0 132 -4,-0.2 2,-0.4 -3,-0.1 -1,-0.3 0.269 90.5 110.5-105.2 12.5 12.6 46.5 4.4 158 158 A S X - 0 0 12 -3,-2.0 3,-1.0 1,-0.1 -3,-0.1 -0.707 59.5-149.3 -86.7 135.7 9.1 45.3 4.3 159 159 A T T 3 S+ 0 0 32 -2,-0.4 -154,-0.2 1,-0.2 -156,-0.2 0.541 87.8 77.8 -79.1 -1.6 6.8 46.0 7.3 160 160 A A T 3 + 0 0 0 -55,-0.1 -54,-2.3 -5,-0.1 2,-0.6 0.471 67.5 97.9 -87.2 -1.5 4.9 42.8 6.6 161 161 A I E < -f 106 0B 0 -3,-1.0 -156,-0.6 -56,-0.2 38,-0.2 -0.761 47.0-176.1 -88.5 120.1 7.5 40.5 8.2 162 162 A F E - 0 0 0 -56,-2.3 37,-0.7 -2,-0.6 2,-0.3 0.945 68.6 -29.2 -70.1 -54.4 6.6 39.6 11.8 163 163 A A E -fg 107 199B 0 -57,-1.4 -55,-2.1 35,-0.1 -1,-0.3 -0.965 53.0-117.6-162.2 151.1 9.9 37.6 12.3 164 164 A W E -fg 108 200B 0 35,-2.2 37,-2.3 -2,-0.3 2,-0.4 -0.684 33.5-154.2 -82.1 145.9 12.5 35.5 10.5 165 165 A E E -fg 109 201B 0 -57,-2.1 -55,-1.8 -2,-0.3 37,-0.2 -0.983 14.8-141.2-132.3 127.1 12.6 31.9 11.8 166 166 A L S S- 0 0 0 35,-2.3 2,-0.3 -2,-0.4 37,-0.2 0.903 74.9 -32.7 -61.6 -38.5 15.6 29.7 11.7 167 167 A G - 0 0 2 35,-1.7 2,-0.8 -57,-0.2 -55,-0.2 -0.978 63.6 -88.6-164.6 172.0 13.7 26.6 10.9 168 168 A N B S-l 112 0D 5 -57,-2.6 -55,-2.2 -2,-0.3 -54,-0.4 -0.843 102.3 -28.0 -91.7 112.4 10.5 24.7 11.3 169 169 A E S S- 0 0 16 34,-2.4 35,-0.2 -2,-0.8 -1,-0.2 0.854 78.6-157.5 53.9 48.7 10.8 22.5 14.5 170 170 A P + 0 0 6 0, 0.0 35,-0.3 0, 0.0 2,-0.3 -0.285 18.5 172.4 -55.6 136.6 14.6 22.0 14.4 171 171 A R - 0 0 46 -40,-0.1 2,-0.3 33,-0.1 52,-0.2 -0.938 29.7-160.0-137.8 159.9 15.7 18.9 16.4 172 172 A b > - 0 0 1 50,-2.8 3,-2.3 -2,-0.3 2,-0.1 -0.760 30.9-139.4-138.7 84.9 19.0 17.1 16.9 173 173 A N T 3 S- 0 0 101 -2,-0.3 49,-0.3 1,-0.3 3,-0.1 -0.323 79.5 -7.1 -55.1 122.7 17.9 13.6 18.0 174 174 A G T 3 S+ 0 0 64 47,-2.3 -1,-0.3 1,-0.2 48,-0.1 0.418 104.8 132.8 72.8 2.6 20.1 12.3 20.8 175 175 A b < - 0 0 26 -3,-2.3 48,-0.3 46,-0.1 -1,-0.2 -0.355 69.6 -92.2 -84.1 162.9 22.6 15.2 20.5 176 176 A S > - 0 0 78 1,-0.1 3,-1.6 -3,-0.1 4,-0.5 -0.501 38.3-124.4 -58.3 141.8 24.1 17.4 23.1 177 177 A T T 3> S+ 0 0 27 1,-0.3 4,-1.7 2,-0.2 48,-0.3 0.713 104.9 75.3 -68.1 -14.2 21.7 20.4 23.4 178 178 A D H 3> S+ 0 0 78 1,-0.2 4,-2.8 2,-0.2 5,-0.3 0.709 80.0 70.2 -69.4 -22.8 24.8 22.7 22.8 179 179 A V H <> S+ 0 0 44 -3,-1.6 4,-2.2 2,-0.2 -1,-0.2 0.984 106.3 36.9 -59.4 -53.2 24.7 21.8 19.0 180 180 A I H > S+ 0 0 0 43,-0.5 4,-3.1 -4,-0.5 5,-0.3 0.882 114.3 58.1 -68.8 -33.8 21.5 23.7 18.4 181 181 A V H X S+ 0 0 17 -4,-1.7 4,-2.2 1,-0.2 -2,-0.2 0.965 111.8 40.2 -58.5 -48.8 22.6 26.4 20.9 182 182 A Q H X S+ 0 0 103 -4,-2.8 4,-2.3 2,-0.2 -1,-0.2 0.890 117.9 47.1 -67.2 -40.2 25.7 27.2 19.0 183 183 A W H X S+ 0 0 16 -4,-2.2 4,-3.1 -5,-0.3 5,-0.3 0.945 113.7 47.9 -64.0 -48.4 24.1 26.9 15.5 184 184 A A H X S+ 0 0 0 -4,-3.1 4,-2.4 1,-0.2 5,-0.3 0.879 111.2 51.8 -63.1 -35.9 21.2 29.1 16.6 185 185 A T H X S+ 0 0 32 -4,-2.2 4,-2.0 -5,-0.3 -1,-0.2 0.964 114.7 41.7 -60.0 -53.6 23.5 31.7 18.1 186 186 A S H X S+ 0 0 49 -4,-2.3 4,-2.0 1,-0.2 -2,-0.2 0.923 117.1 45.5 -64.6 -45.1 25.6 31.9 14.9 187 187 A V H X S+ 0 0 0 -4,-3.1 4,-2.5 2,-0.2 -1,-0.2 0.913 112.4 50.3 -71.9 -36.7 22.7 31.9 12.4 188 188 A S H X S+ 0 0 0 -4,-2.4 4,-2.5 -5,-0.3 -1,-0.2 0.890 109.4 52.4 -68.1 -38.1 20.6 34.4 14.3 189 189 A Q H X S+ 0 0 117 -4,-2.0 4,-1.7 -5,-0.3 -1,-0.2 0.937 109.4 50.7 -54.7 -42.6 23.6 36.7 14.5 190 190 A Y H X S+ 0 0 54 -4,-2.0 4,-0.9 2,-0.2 -2,-0.2 0.937 108.9 49.7 -61.6 -48.2 23.9 36.3 10.7 191 191 A V H >X S+ 0 0 0 -4,-2.5 3,-1.3 1,-0.2 4,-1.2 0.941 109.1 52.3 -58.6 -42.1 20.2 37.2 10.1 192 192 A K H 3< S+ 0 0 64 -4,-2.5 -1,-0.2 1,-0.3 -2,-0.2 0.827 104.8 57.3 -63.5 -29.1 20.6 40.3 12.3 193 193 A S H 3< S+ 0 0 85 -4,-1.7 -1,-0.3 1,-0.2 -2,-0.2 0.716 111.2 42.7 -72.1 -19.4 23.6 41.3 10.1 194 194 A L H << S+ 0 0 54 -3,-1.3 2,-0.3 -4,-0.9 -1,-0.2 0.582 127.8 20.6 -95.6 -20.9 21.4 41.2 7.1 195 195 A D < + 0 0 7 -4,-1.2 -1,-0.3 -5,-0.1 3,-0.1 -0.866 48.7 178.1-157.4 115.2 18.4 43.0 8.5 196 196 A S S S+ 0 0 110 -2,-0.3 -4,-0.1 1,-0.2 -3,-0.1 0.316 78.2 69.5-101.5 7.1 18.2 45.2 11.6 197 197 A N S S+ 0 0 50 -41,-0.2 2,-0.3 2,-0.1 -1,-0.2 0.745 89.7 67.4 -92.4 -25.6 14.5 45.9 11.2 198 198 A H S S- 0 0 4 -3,-0.1 -35,-0.1 -194,-0.1 -3,-0.1 -0.720 73.9-116.8-112.9 152.6 13.0 42.6 12.1 199 199 A L E -g 163 0B 14 -37,-0.7 -35,-2.2 -194,-0.4 2,-0.3 -0.318 28.3-151.7 -70.1 150.8 12.6 40.2 15.0 200 200 A V E +g 164 0B 1 -37,-0.2 36,-2.8 -35,-0.0 37,-0.6 -0.995 16.0 174.7-128.9 141.5 14.2 36.7 14.8 201 201 A T E -g 165 0B 0 -37,-2.3 -35,-2.3 -2,-0.3 -34,-0.2 -0.935 34.2-123.8-141.9 165.8 13.1 33.4 16.5 202 202 A L - 0 0 3 35,-0.5 -35,-1.7 -2,-0.3 -1,-0.1 0.909 28.4-140.4 -80.2 -46.7 14.2 29.7 16.5 203 203 A G + 0 0 0 1,-0.2 -34,-2.4 -37,-0.2 -38,-0.1 0.571 47.0 149.0 93.0 5.2 11.0 27.9 15.4 204 204 A D - 0 0 3 -35,-0.2 -1,-0.2 -36,-0.2 -33,-0.1 -0.238 57.7-120.4 -68.1 164.4 11.5 25.0 17.8 205 205 A E - 0 0 6 -35,-0.3 36,-2.1 35,-0.2 -1,-0.1 0.562 50.1-108.5 -78.7 -11.9 8.7 23.0 19.5 206 206 A G + 0 0 0 34,-0.2 20,-0.2 1,-0.2 34,-0.1 0.573 58.9 164.9 91.8 13.6 9.9 23.9 23.0 207 207 A L + 0 0 6 18,-0.1 19,-0.4 19,-0.1 -1,-0.2 -0.295 45.1 45.6 -67.6 148.1 11.2 20.5 23.9 208 208 A G + 0 0 0 9,-2.0 18,-2.6 11,-0.3 19,-0.5 0.923 61.2 147.0 87.0 88.6 13.5 20.1 26.9 209 209 A L > - 0 0 8 9,-2.0 3,-0.9 16,-0.2 5,-0.3 -0.923 35.7-153.0-155.2 121.4 12.3 22.0 30.0 210 210 A S T 3 S+ 0 0 97 -2,-0.3 8,-0.1 1,-0.2 9,-0.0 0.540 83.6 73.9 -81.8 -3.6 12.9 20.9 33.6 211 211 A T T 3 S+ 0 0 100 49,-0.1 -1,-0.2 7,-0.1 50,-0.0 0.373 84.8 85.5 -91.6 7.0 9.9 22.5 35.2 212 212 A G S < S- 0 0 31 -3,-0.9 45,-0.0 6,-0.1 -2,-0.0 0.077 96.0 -85.7 -89.6-157.4 7.4 20.0 33.8 213 213 A D - 0 0 105 2,-0.0 -3,-0.1 -2,-0.0 -2,-0.0 0.201 62.6-102.6-102.7 9.7 6.1 16.6 34.7 214 214 A G + 0 0 57 -5,-0.3 5,-0.1 1,-0.2 -4,-0.0 0.438 68.6 148.8 83.0 1.9 8.8 14.5 33.1 215 215 A A >> - 0 0 24 1,-0.1 3,-2.1 3,-0.1 4,-0.8 -0.270 66.3 -95.4 -61.3 156.6 6.8 13.4 30.1 216 216 A Y G >4 S+ 0 0 120 1,-0.3 3,-1.6 2,-0.2 5,-0.4 0.830 122.2 60.4 -48.1 -41.8 9.1 12.9 27.0 217 217 A P G 34 S+ 0 0 5 0, 0.0 -9,-2.0 0, 0.0 -1,-0.3 0.786 105.0 50.6 -61.4 -27.1 8.5 16.4 25.5 218 218 A Y G <4 S+ 0 0 10 -3,-2.1 -9,-2.0 -11,-0.2 -2,-0.2 0.655 99.2 84.2 -81.3 -14.3 10.0 17.9 28.7 219 219 A T S << S- 0 0 66 -3,-1.6 3,-0.3 -4,-0.8 -11,-0.3 -0.124 88.8-111.0 -80.5 179.9 13.1 15.6 28.6 220 220 A Y S S+ 0 0 82 1,-0.2 3,-0.2 -12,-0.1 -1,-0.1 -0.370 76.6 115.3-110.3 51.0 16.3 16.3 26.5 221 221 A G S S+ 0 0 18 -5,-0.4 -47,-2.3 -2,-0.2 -1,-0.2 0.602 72.3 54.7 -92.4 -12.0 16.1 13.5 23.9 222 222 A E S S- 0 0 17 -3,-0.3 -50,-2.8 -49,-0.3 -1,-0.1 0.198 112.0-106.7-111.9 17.8 15.7 15.9 20.9 223 223 A G S S+ 0 0 0 -48,-0.3 -43,-0.5 -3,-0.2 2,-0.4 0.617 81.6 114.3 73.4 11.3 18.7 18.0 21.3 224 224 A T - 0 0 4 -44,-0.1 2,-0.5 -45,-0.1 -2,-0.2 -0.923 43.1-170.3-121.5 143.9 16.9 21.1 22.5 225 225 A D > - 0 0 22 -2,-0.4 4,-2.5 -48,-0.3 -17,-0.2 -0.957 12.6-159.3-126.6 105.1 17.0 23.0 25.9 226 226 A F H > S+ 0 0 0 -18,-2.6 4,-2.5 -2,-0.5 5,-0.2 0.892 88.7 47.7 -55.1 -50.7 14.2 25.6 25.9 227 227 A A H > S+ 0 0 30 -19,-0.5 4,-0.9 1,-0.2 -1,-0.2 0.889 113.5 48.9 -63.6 -36.4 15.6 27.8 28.6 228 228 A K H 4 S+ 0 0 111 1,-0.2 3,-0.5 2,-0.2 4,-0.4 0.921 112.8 48.2 -67.4 -43.0 19.1 27.8 27.1 229 229 A N H >< S+ 0 0 2 -4,-2.5 3,-1.7 1,-0.2 -2,-0.2 0.947 107.6 52.8 -67.0 -41.0 17.7 28.7 23.6 230 230 A V H 3< S+ 0 0 7 -4,-2.5 -1,-0.2 1,-0.3 -2,-0.2 0.679 100.7 63.0 -73.1 -13.0 15.5 31.5 24.7 231 231 A Q T 3< S+ 0 0 110 -4,-0.9 -1,-0.3 -3,-0.5 -2,-0.2 0.543 72.7 117.7 -82.9 -7.4 18.4 33.2 26.5 232 232 A I X - 0 0 13 -3,-1.7 3,-1.6 -4,-0.4 -3,-0.0 -0.406 66.0-139.2 -61.8 127.7 20.3 33.6 23.2 233 233 A K T 3 S+ 0 0 194 1,-0.3 -1,-0.1 -2,-0.2 -48,-0.0 0.818 97.8 54.0 -63.5 -35.6 20.7 37.4 22.7 234 234 A S T 3 S+ 0 0 16 -49,-0.1 2,-0.5 -35,-0.0 -1,-0.3 0.247 92.2 82.4 -88.2 9.9 20.0 37.4 19.0 235 235 A L < - 0 0 4 -3,-1.6 -34,-0.2 -6,-0.1 3,-0.1 -0.971 62.7-166.5-109.0 125.6 16.6 35.5 19.4 236 236 A D + 0 0 38 -36,-2.8 2,-0.3 -2,-0.5 -35,-0.2 0.690 64.2 6.4 -90.2 -20.7 13.9 38.0 20.4 237 237 A F S S- 0 0 3 -37,-0.6 -35,-0.5 33,-0.1 2,-0.2 -0.975 73.3-109.5-156.3 160.4 11.1 35.7 21.6 238 238 A G E -h 272 0B 2 33,-2.2 35,-2.4 -2,-0.3 2,-0.4 -0.608 22.9-156.8 -97.2 153.4 10.5 32.0 22.2 239 239 A T E +h 273 0B 0 -2,-0.2 2,-0.3 33,-0.2 35,-0.2 -0.983 12.1 175.3-121.4 148.2 8.3 29.6 20.3 240 240 A F E -h 274 0B 0 33,-1.9 35,-1.7 -2,-0.4 36,-0.8 -0.990 11.5-156.6-150.6 149.8 6.7 26.4 21.3 241 241 A H E -h 276 0B 0 -36,-2.1 2,-0.3 -2,-0.3 36,-0.2 -0.723 7.2-148.8-118.7 168.8 4.3 23.9 19.6 242 242 A L E +h 277 0B 0 34,-1.0 36,-1.5 -2,-0.2 -36,-0.0 -0.902 26.1 154.2-153.0 115.0 1.8 21.4 21.1 243 243 A Y >> + 0 0 17 -2,-0.3 4,-1.6 34,-0.2 3,-1.4 -0.581 5.4 173.0-141.1 79.8 0.6 18.0 19.8 244 244 A P H 3>>S+ 0 0 1 0, 0.0 5,-1.4 0, 0.0 4,-1.2 0.871 82.5 58.4 -54.1 -36.5 -0.6 15.6 22.5 245 245 A D H 345S+ 0 0 58 33,-0.4 34,-0.1 1,-0.2 5,-0.0 0.762 112.8 38.6 -66.1 -26.8 -1.9 13.1 19.9 246 246 A S H <45S+ 0 0 77 -3,-1.4 -1,-0.2 1,-0.1 -4,-0.0 0.660 118.9 48.9 -91.4 -20.5 1.6 12.8 18.4 247 247 A W H <5S- 0 0 41 -4,-1.6 -2,-0.2 -3,-0.2 -31,-0.2 0.409 106.3-115.1-105.3 0.1 3.4 12.9 21.7 248 248 A G T <5S+ 0 0 76 -4,-1.2 2,-0.3 1,-0.3 -3,-0.2 0.739 75.3 118.3 74.1 21.5 1.5 10.3 23.8 249 249 A T < - 0 0 29 -5,-1.4 -1,-0.3 -6,-0.2 -2,-0.1 -0.753 67.4-104.1-109.4 168.3 0.1 12.8 26.3 250 250 A N - 0 0 99 -2,-0.3 4,-0.3 1,-0.1 3,-0.3 -0.363 32.8-110.7 -86.6 169.0 -3.5 13.7 27.1 251 251 A Y S > S+ 0 0 38 1,-0.2 3,-2.0 2,-0.2 4,-0.3 0.926 113.3 58.5 -68.5 -39.6 -5.0 17.0 25.8 252 252 A T T >> S+ 0 0 97 1,-0.3 3,-1.8 2,-0.2 4,-0.6 0.806 90.4 72.2 -66.1 -22.7 -5.4 18.6 29.3 253 253 A W H 3> S+ 0 0 29 -3,-0.3 4,-1.7 1,-0.3 -1,-0.3 0.711 81.7 76.6 -59.0 -23.7 -1.6 18.2 29.8 254 254 A G H <> S+ 0 0 0 -3,-2.0 4,-2.2 -4,-0.3 -1,-0.3 0.807 83.3 62.5 -60.5 -28.8 -1.3 21.0 27.2 255 255 A N H <> S+ 0 0 32 -3,-1.8 4,-2.4 -4,-0.3 -1,-0.2 0.951 105.8 44.5 -62.8 -46.6 -2.3 23.7 29.8 256 256 A G H X S+ 0 0 26 -4,-0.6 4,-2.7 2,-0.2 5,-0.3 0.870 108.8 58.1 -66.5 -33.3 0.7 22.9 31.9 257 257 A W H X S+ 0 0 0 -4,-1.7 4,-1.7 1,-0.2 5,-0.2 0.936 109.5 44.8 -61.4 -41.8 2.9 22.9 28.7 258 258 A I H X S+ 0 0 0 -4,-2.2 4,-2.7 1,-0.2 -2,-0.2 0.949 113.9 49.7 -65.9 -47.1 1.8 26.5 28.0 259 259 A Q H X S+ 0 0 103 -4,-2.4 4,-2.1 1,-0.2 -2,-0.2 0.903 111.2 47.3 -61.9 -43.0 2.3 27.6 31.6 260 260 A T H X S+ 0 0 25 -4,-2.7 4,-1.7 1,-0.2 -1,-0.2 0.895 114.5 46.2 -68.9 -39.5 5.8 26.2 31.9 261 261 A H H X S+ 0 0 0 -4,-1.7 4,-2.6 -5,-0.3 5,-0.2 0.935 110.4 53.3 -68.4 -44.5 7.0 27.7 28.6 262 262 A A H X S+ 0 0 0 -4,-2.7 4,-2.8 1,-0.2 -2,-0.2 0.924 108.7 50.2 -54.5 -43.6 5.4 31.1 29.3 263 263 A A H X S+ 0 0 59 -4,-2.1 4,-2.4 1,-0.2 -1,-0.2 0.866 109.2 51.0 -64.5 -38.4 7.3 31.2 32.6 264 264 A A H X S+ 0 0 15 -4,-1.7 4,-1.3 2,-0.2 -2,-0.2 0.910 111.2 48.0 -68.0 -37.2 10.6 30.4 30.9 265 265 A c H ><>S+ 0 0 0 -4,-2.6 5,-2.3 2,-0.2 3,-0.7 0.961 113.0 48.0 -63.6 -47.6 10.1 33.1 28.3 266 266 A L H ><5S+ 0 0 64 -4,-2.8 3,-1.3 1,-0.3 -2,-0.2 0.899 107.9 55.2 -64.6 -35.0 9.2 35.7 31.1 267 267 A A H 3<5S+ 0 0 88 -4,-2.4 -1,-0.3 1,-0.3 -2,-0.2 0.790 108.5 48.8 -65.5 -30.0 12.2 34.6 33.1 268 268 A A T <<5S- 0 0 25 -4,-1.3 -1,-0.3 -3,-0.7 -2,-0.2 0.358 120.7-113.7 -87.4 3.2 14.4 35.4 30.0 269 269 A G T < 5S+ 0 0 53 -3,-1.3 -3,-0.2 -4,-0.3 -2,-0.1 0.700 79.9 101.7 75.1 22.9 12.6 38.7 29.7 270 270 A K S - 0 0 108 -2,-0.5 4,-2.7 1,-0.1 5,-0.3 0.890 68.9-177.7 42.7 63.0 -12.9 17.0 19.3 283 283 A P H >>S+ 0 0 27 0, 0.0 4,-2.7 0, 0.0 5,-0.5 0.856 75.8 54.6 -63.2 -35.3 -10.8 20.1 18.6 284 284 A d H >5S+ 0 0 45 1,-0.2 4,-1.3 2,-0.2 -2,-0.1 0.972 115.6 39.2 -64.9 -46.2 -13.4 22.6 19.8 285 285 A T H 45S+ 0 0 102 1,-0.2 -1,-0.2 2,-0.1 -3,-0.1 0.899 124.3 37.9 -63.7 -45.4 -13.6 20.9 23.2 286 286 A N H <5S+ 0 0 34 -4,-2.7 4,-0.3 -5,-0.2 -2,-0.2 0.761 119.5 41.8 -83.1 -30.7 -9.9 20.1 23.6 287 287 A E H >X5S+ 0 0 1 -4,-2.7 4,-2.0 -5,-0.3 3,-0.5 0.733 96.7 73.9 -92.2 -27.2 -8.3 23.2 22.1 288 288 A A H 3X S+ 0 0 56 0, 0.0 4,-2.6 0, 0.0 -1,-0.2 0.880 107.2 53.4 -61.3 -35.5 -9.0 25.6 27.0 290 290 A W H <> S+ 0 0 1 -3,-0.5 4,-2.9 -4,-0.3 -2,-0.2 0.910 106.9 51.1 -63.6 -41.5 -5.5 26.0 25.6 291 291 A Q H X S+ 0 0 5 -4,-2.0 4,-2.5 1,-0.2 -1,-0.2 0.936 112.1 47.3 -62.8 -41.1 -6.5 29.2 23.9 292 292 A T H X S+ 0 0 84 -4,-2.4 4,-2.0 -5,-0.2 -2,-0.2 0.931 110.8 51.2 -66.9 -42.1 -7.8 30.5 27.2 293 293 A T H < S+ 0 0 19 -4,-2.6 4,-0.5 -5,-0.2 -2,-0.2 0.952 112.3 46.9 -59.7 -45.7 -4.7 29.4 29.1 294 294 A S H >< S+ 0 0 0 -4,-2.9 3,-1.2 1,-0.2 6,-0.2 0.944 111.5 50.3 -62.3 -43.9 -2.5 31.2 26.6 295 295 A L H 3< S+ 0 0 51 -4,-2.5 -1,-0.2 1,-0.3 -2,-0.2 0.843 117.0 41.2 -63.5 -31.2 -4.6 34.4 26.6 296 296 A T T 3< S+ 0 0 105 -4,-2.0 2,-0.5 -5,-0.2 -1,-0.3 0.265 93.6 95.7-105.3 11.3 -4.5 34.6 30.4 297 297 A T S X S- 0 0 30 -3,-1.2 3,-1.9 -4,-0.5 2,-0.1 -0.887 74.5-122.2-109.5 125.8 -0.9 33.6 31.2 298 298 A R T 3 S+ 0 0 171 -2,-0.5 -32,-0.2 1,-0.2 3,-0.1 -0.415 98.1 36.8 -60.6 139.4 1.8 36.2 31.8 299 299 A G T 3 S+ 0 0 3 1,-0.3 -27,-2.2 -289,-0.1 2,-0.6 0.081 88.0 114.1 103.2 -22.3 4.7 35.8 29.3 300 300 A M E < + i 0 272B 15 -3,-1.9 -1,-0.3 -6,-0.2 -27,-0.2 -0.770 36.9 177.7 -87.1 124.1 2.5 34.8 26.4 301 301 A G E - 0 0 2 -29,-3.1 -280,-1.4 -2,-0.6 -289,-0.3 0.640 61.6 -33.9 -94.9 -18.4 2.4 37.3 23.5 302 302 A G E -ci 21 273B 0 -30,-0.8 -28,-2.4 -282,-0.2 -1,-0.3 -0.956 50.8-125.2 174.2 172.6 0.1 35.4 21.1 303 303 A D E -ci 22 274B 1 -282,-1.6 -280,-2.6 -2,-0.3 2,-0.3 -0.976 8.7-166.0-144.8 148.0 -1.0 32.1 19.7 304 304 A M E -c 23 0B 0 -30,-2.9 -280,-0.3 -2,-0.3 -27,-0.2 -0.896 16.8-145.1-139.3 106.6 -1.3 30.5 16.2 305 305 A F E -c 24 0B 3 -282,-1.1 -280,-2.0 -2,-0.3 2,-0.6 -0.330 29.5 -96.6 -69.6 154.3 -3.3 27.3 15.6 306 306 A W S S+ 0 0 23 -29,-2.5 -280,-0.1 1,-0.2 -30,-0.1 -0.969 86.1 16.3-105.8 113.5 -2.3 24.6 13.1 307 307 A Q - 0 0 0 -2,-0.6 18,-2.8 -282,-0.5 -1,-0.2 0.691 42.6-160.2-156.7 161.3 -3.8 25.1 10.6 308 308 A W E -m 325 0E 1 -283,-2.9 2,-0.4 -3,-0.3 18,-0.2 -0.469 23.1-168.6 -67.4 139.0 -5.9 27.3 8.3 309 309 A G E +m 326 0E 0 16,-1.9 18,-2.4 -2,-0.2 2,-0.3 -0.974 14.6 162.6-123.1 143.3 -8.0 25.5 5.6 310 310 A D - 0 0 5 -2,-0.4 8,-2.8 9,-0.3 2,-0.3 -0.925 27.1-132.2-151.3 174.4 -9.6 27.4 2.7 311 311 A T B -N 317 0F 78 -2,-0.3 6,-0.2 6,-0.2 2,-0.2 -0.900 21.7-130.0-135.1 157.8 -11.2 26.9 -0.7 312 312 A F > - 0 0 22 4,-2.6 3,-2.3 -2,-0.3 -275,-0.1 -0.661 28.0-100.6-114.4 167.5 -10.7 28.9 -4.0 313 313 A A T 3 S+ 0 0 102 1,-0.3 -1,-0.0 -2,-0.2 -276,-0.0 0.781 119.2 56.1 -62.1 -28.0 -12.8 30.5 -6.7 314 314 A N T 3 S- 0 0 125 2,-0.1 -1,-0.3 1,-0.0 3,-0.1 0.419 121.0-104.3 -83.1 0.5 -12.4 27.5 -9.0 315 315 A G S < S+ 0 0 67 -3,-2.3 2,-0.2 1,-0.3 -2,-0.1 0.455 78.2 132.0 92.6 -2.2 -13.8 25.1 -6.4 316 316 A A - 0 0 41 1,-0.0 -4,-2.6 -5,-0.0 -1,-0.3 -0.571 48.7-135.7 -79.9 151.2 -10.5 23.5 -5.4 317 317 A Q B -N 311 0F 124 -6,-0.2 -6,-0.2 -2,-0.2 3,-0.1 -0.693 20.8-107.2 -98.9 157.4 -9.6 23.2 -1.7 318 318 A S - 0 0 6 -8,-2.8 -1,-0.1 -2,-0.3 -289,-0.0 -0.242 47.8 -77.4 -69.4 165.5 -6.3 23.9 -0.1 319 319 A N + 0 0 78 -291,-0.0 2,-0.3 -10,-0.0 -9,-0.3 -0.256 64.7 174.1 -53.7 150.9 -3.9 21.4 1.2 320 320 A S - 0 0 53 -3,-0.1 -11,-0.1 -11,-0.1 -12,-0.0 -0.963 24.6-167.2-157.7 170.9 -5.1 20.0 4.5 321 321 A D > - 0 0 52 -2,-0.3 3,-1.7 -14,-0.1 0, 0.0 -0.865 54.0 -75.0-150.2-176.3 -4.5 17.4 7.3 322 322 A P T 3 S+ 0 0 92 0, 0.0 -43,-0.1 0, 0.0 -2,-0.0 0.677 127.9 55.1 -67.2 -11.6 -6.6 16.1 10.3 323 323 A Y T 3 S+ 0 0 22 -45,-0.1 -44,-0.2 2,-0.1 -46,-0.0 0.567 78.0 128.3 -94.2 -9.5 -5.9 19.4 12.2 324 324 A T < - 0 0 16 -3,-1.7 2,-0.6 1,-0.1 -16,-0.2 -0.164 45.7-156.6 -54.9 133.9 -7.2 21.7 9.5 325 325 A V E -m 308 0E 3 -18,-2.8 -16,-1.9 -20,-0.1 2,-0.3 -0.947 20.6-140.7-109.5 110.1 -9.8 24.3 10.7 326 326 A W E > -m 309 0E 80 -2,-0.6 3,-2.1 -18,-0.2 6,-0.4 -0.498 23.4-102.1 -78.9 131.2 -11.8 25.2 7.5 327 327 A Y T 3 S+ 0 0 54 -18,-2.4 -1,-0.1 -2,-0.3 3,-0.1 -0.238 104.3 11.7 -51.0 137.1 -12.8 28.8 7.1 328 328 A N T 3 S+ 0 0 108 1,-0.2 -1,-0.3 -284,-0.1 2,-0.1 0.409 100.0 126.0 73.7 4.0 -16.4 29.5 7.9 329 329 A S S <> S- 0 0 39 -3,-2.1 4,-2.1 1,-0.1 -1,-0.2 -0.262 79.3 -99.1 -81.9 176.1 -16.9 26.1 9.5 330 330 A S H > S+ 0 0 89 1,-0.2 4,-2.2 2,-0.2 5,-0.1 0.861 127.2 51.0 -62.2 -37.5 -18.3 25.3 13.0 331 331 A N H > S+ 0 0 50 2,-0.2 4,-2.9 1,-0.2 5,-0.3 0.815 105.3 56.2 -74.8 -28.0 -14.7 24.8 14.2 332 332 A W H >>S+ 0 0 36 -6,-0.4 4,-2.0 2,-0.2 5,-1.9 0.913 108.3 48.9 -61.7 -41.6 -13.8 28.3 12.7 333 333 A Q H <>S+ 0 0 115 -4,-2.1 5,-2.5 3,-0.2 -2,-0.2 0.952 118.1 40.1 -62.7 -46.0 -16.6 29.7 14.9 334 334 A d H <5S+ 0 0 19 -4,-2.2 -2,-0.2 1,-0.2 -1,-0.2 0.887 129.1 25.3 -70.8 -45.1 -15.3 27.9 18.0 335 335 A L H <5S+ 0 0 1 -4,-2.9 -3,-0.2 3,-0.1 -1,-0.2 0.505 133.4 26.1-102.8 -9.4 -11.6 28.4 17.6 336 336 A V T X5S+ 0 0 1 -4,-2.0 4,-2.9 -5,-0.3 5,-0.3 0.650 124.8 33.5-116.7 -67.2 -11.2 31.5 15.4 337 337 A K H > S+ 0 0 10 -6,-0.2 4,-1.5 2,-0.2 3,-0.3 0.942 111.2 47.6 -70.1 -47.0 -11.2 33.4 20.4 340 340 A V H X S+ 0 0 23 -4,-2.9 4,-1.9 1,-0.2 3,-0.2 0.901 111.0 54.2 -58.6 -37.2 -10.7 36.7 18.5 341 341 A D H < S+ 0 0 80 -4,-2.3 -1,-0.2 -5,-0.3 -2,-0.2 0.863 107.7 49.8 -65.0 -35.1 -13.8 38.0 20.3 342 342 A A H < S+ 0 0 67 -4,-1.3 -1,-0.2 -3,-0.3 -2,-0.2 0.761 109.4 50.9 -74.6 -29.2 -12.4 37.0 23.7 343 343 A I H < 0 0 37 -4,-1.5 -2,-0.2 -3,-0.2 -1,-0.2 0.891 360.0 360.0 -72.8 -38.4 -9.1 38.8 22.9 344 344 A N < 0 0 190 -4,-1.9 -4,-0.0 -5,-0.2 -1,-0.0 -0.457 360.0 360.0 174.3 360.0 -10.9 41.9 21.9