==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=5-JAN-2010 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER METALLOPROTEASE INHIBITOR 26-MAY-98 2TMP . COMPND 2 MOLECULE: TISSUE INHIBITOR OF METALLOPROTEINASES-2; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR F.W.MUSKETT,T.A.FRENKIEL,J.FEENEY,R.B.FREEDMAN,M.D.CARR, . 127 1 3 3 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 7039.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 52 40.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 2 1.6 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 10 7.9 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 2 1.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 12 9.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 5 3.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 6 4.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 3 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 1 A a 0 0 78 0, 0.0 71,-0.2 0, 0.0 70,-0.1 0.000 360.0 360.0 360.0 -15.1 -9.9 -11.2 1.0 2 2 A S + 0 0 109 69,-2.0 70,-0.1 71,-0.0 69,-0.1 0.767 360.0 176.2 52.7 26.3 -8.4 -11.8 4.4 3 3 A b - 0 0 49 68,-0.7 70,-0.1 1,-0.1 -1,-0.0 0.140 33.5-105.7 -50.0 177.5 -5.3 -12.6 2.4 4 4 A S - 0 0 85 97,-0.1 2,-0.3 -3,-0.0 -1,-0.1 -0.942 26.7-145.2-119.6 109.5 -2.1 -13.5 4.3 5 5 A P + 0 0 90 0, 0.0 2,-0.2 0, 0.0 96,-0.1 -0.554 45.8 117.4 -75.0 131.4 0.6 -10.8 4.3 6 6 A V + 0 0 96 -2,-0.3 5,-0.1 95,-0.3 0, 0.0 -0.477 12.6 109.0-155.1-133.4 4.2 -12.1 4.2 7 7 A H > - 0 0 47 1,-0.2 4,-0.6 -2,-0.2 -1,-0.2 0.903 42.8-162.9 37.7 85.6 7.2 -12.0 1.8 8 8 A P T 4 S+ 0 0 64 0, 0.0 109,-0.2 0, 0.0 -1,-0.2 0.414 91.5 14.9 -75.0 2.5 9.4 -9.8 3.9 9 9 A Q T >> S+ 0 0 28 107,-0.1 3,-1.3 108,-0.0 4,-0.7 0.486 116.5 65.7-139.7 -44.0 11.4 -9.3 0.7 10 10 A Q T 34 S+ 0 0 100 1,-0.3 4,-0.4 2,-0.2 93,-0.1 0.542 96.8 66.6 -63.9 -5.2 9.3 -10.5 -2.2 11 11 A A T 3X S+ 0 0 5 -4,-0.6 4,-1.9 2,-0.2 92,-0.4 0.840 102.9 41.2 -83.0 -37.6 7.0 -7.6 -1.2 12 12 A F T <4 S+ 0 0 1 -3,-1.3 111,-0.8 1,-0.2 -2,-0.2 0.481 116.2 51.8 -87.0 -4.7 9.6 -4.9 -2.1 13 13 A c T < S+ 0 0 17 -4,-0.7 -1,-0.2 109,-0.1 -2,-0.2 0.546 113.8 42.9-103.5 -15.1 10.4 -6.9 -5.2 14 14 A N T 4 S+ 0 0 102 -4,-0.4 -2,-0.2 -5,-0.2 -3,-0.2 0.813 99.5 82.3 -96.3 -41.6 6.8 -7.2 -6.3 15 15 A A < - 0 0 0 -4,-1.9 74,-0.3 72,-0.2 3,-0.1 0.076 54.9-167.2 -54.9 174.9 5.8 -3.6 -5.6 16 16 A D S S+ 0 0 52 72,-2.1 73,-0.1 38,-0.1 -1,-0.1 0.134 75.3 45.9-153.4 15.6 6.5 -0.9 -8.1 17 17 A V - 0 0 0 38,-0.2 2,-0.7 68,-0.1 71,-0.5 -0.501 61.5-179.5-166.5 86.5 5.8 2.2 -6.0 18 18 A V B +A 87 0A 3 103,-0.2 36,-2.6 69,-0.2 2,-0.4 -0.845 14.2 160.3 -97.1 117.3 7.3 2.4 -2.5 19 19 A I - 0 0 2 66,-2.5 2,-1.3 67,-1.3 33,-0.3 -0.982 40.6-143.4-141.4 125.1 6.4 5.7 -0.7 20 20 A R + 0 0 52 -2,-0.4 65,-0.3 65,-0.2 32,-0.2 -0.137 52.0 153.7 -78.1 41.5 6.5 6.3 3.0 21 21 A T - 0 0 0 -2,-1.3 63,-3.0 63,-0.4 2,-0.5 -0.055 43.1-122.6 -64.6 171.9 3.4 8.5 2.5 22 22 A K - 0 0 46 61,-0.3 26,-1.8 63,-0.1 2,-0.9 -0.981 11.6-148.9-126.1 120.1 0.9 9.0 5.3 23 23 A A B +B 47 0B 0 -2,-0.5 24,-0.2 24,-0.3 56,-0.2 -0.789 38.5 144.2 -90.9 108.1 -2.7 8.2 4.9 24 24 A V + 0 0 57 -2,-0.9 2,-0.3 22,-0.6 -1,-0.2 0.701 65.4 37.3-110.1 -36.5 -4.8 10.6 6.9 25 25 A S + 0 0 40 21,-1.4 21,-0.3 -3,-0.2 2,-0.3 -0.736 64.6 179.8-115.7 165.0 -7.8 11.0 4.7 26 26 A E - 0 0 58 19,-0.3 2,-0.3 -2,-0.3 19,-0.2 -0.842 22.1-128.6-149.4-176.4 -9.7 8.6 2.4 27 27 A K - 0 0 100 -2,-0.3 17,-2.2 17,-0.2 2,-1.5 -0.882 15.3-139.5-149.7 111.9 -12.7 8.3 0.1 28 28 A E + 0 0 139 -2,-0.3 2,-0.6 15,-0.3 15,-0.1 -0.572 33.0 173.4 -74.1 92.1 -15.4 5.7 0.3 29 29 A V - 0 0 43 -2,-1.5 13,-2.6 13,-0.1 -2,-0.1 -0.915 27.4-131.0-107.7 114.8 -15.8 4.9 -3.3 30 30 A D - 0 0 113 -2,-0.6 3,-0.1 11,-0.2 -1,-0.0 -0.097 20.2-174.0 -56.8 160.1 -18.2 2.0 -4.0 31 31 A S - 0 0 30 1,-0.3 -1,-0.1 10,-0.0 -2,-0.0 0.118 44.3-107.0-144.1 16.8 -17.0 -0.8 -6.3 32 32 A G - 0 0 36 8,-0.1 8,-4.8 7,-0.0 9,-0.4 -0.080 51.7 -50.7 78.1 177.6 -20.1 -2.9 -6.6 33 33 A N B -C 39 0C 108 6,-0.3 5,-0.1 7,-0.1 2,-0.1 -0.426 53.3-128.8 -85.0 162.6 -20.7 -6.3 -5.1 34 34 A D > - 0 0 86 4,-3.5 3,-1.0 -2,-0.1 -1,-0.1 -0.041 42.8 -78.5 -93.7-161.2 -18.4 -9.2 -5.4 35 35 A I T 3 S+ 0 0 158 1,-0.2 -2,-0.0 2,-0.1 -1,-0.0 0.425 131.8 57.6 -81.6 0.6 -19.1 -12.8 -6.4 36 36 A Y T 3 S- 0 0 202 2,-0.2 -1,-0.2 0, 0.0 -3,-0.0 0.370 118.2-110.0-108.6 -0.6 -20.5 -13.3 -3.0 37 37 A G S < S+ 0 0 53 -3,-1.0 -2,-0.1 1,-0.4 3,-0.0 0.296 79.5 129.9 87.6 -8.4 -23.1 -10.6 -3.2 38 38 A N - 0 0 67 1,-0.1 -4,-3.5 -5,-0.1 -1,-0.4 -0.446 68.6 -98.3 -78.3 152.7 -21.1 -8.6 -0.8 39 39 A P B -C 33 0C 88 0, 0.0 -6,-0.3 0, 0.0 -1,-0.1 -0.558 27.7-156.4 -75.0 130.3 -20.2 -4.9 -1.5 40 40 A I + 0 0 62 -8,-4.8 -7,-0.1 -2,-0.3 -10,-0.1 0.993 23.1 171.5 -66.4 -79.6 -16.7 -4.4 -2.8 41 41 A K - 0 0 19 -9,-0.4 -11,-0.2 1,-0.1 2,-0.1 0.660 23.9-152.4 69.5 126.9 -15.9 -0.9 -1.9 42 42 A R - 0 0 120 -13,-2.6 24,-0.2 24,-0.2 23,-0.2 -0.559 14.3-152.6-131.4 67.5 -12.4 0.5 -2.4 43 43 A I - 0 0 23 -2,-0.1 22,-1.7 21,-0.1 -15,-0.3 -0.009 20.2-123.0 -39.1 140.9 -11.9 3.2 0.1 44 44 A Q E -D 64 0D 3 -17,-2.2 -17,-0.2 20,-0.2 20,-0.2 -0.165 6.1-132.1 -82.2-179.8 -9.4 5.8 -1.1 45 45 A Y E -D 63 0D 0 18,-1.4 2,-3.8 -19,-0.2 18,-1.2 -0.545 17.1-174.4-137.4 69.1 -6.2 6.9 0.6 46 46 A E E +D 62 0D 77 -21,-0.3 -21,-1.4 16,-0.2 -22,-0.6 -0.308 26.4 174.3 -64.4 67.5 -6.0 10.6 0.5 47 47 A I B -B 23 0B 9 -2,-3.8 -24,-0.3 14,-0.8 14,-0.1 0.102 38.2-131.4 -64.6-174.5 -2.5 10.5 2.0 48 48 A K - 0 0 120 -26,-1.8 -25,-0.1 12,-0.1 13,-0.1 0.377 39.3-126.1-120.5 -5.2 -0.4 13.6 2.5 49 49 A Q + 0 0 47 -27,-0.4 -28,-0.1 11,-0.2 3,-0.1 0.838 40.1 168.1 56.7 113.5 2.8 12.2 1.0 50 50 A I + 0 0 62 1,-0.5 2,-0.3 0, 0.0 -29,-0.2 0.577 65.7 9.9-123.2 -30.5 5.8 12.4 3.2 51 51 A K - 0 0 86 33,-0.2 -1,-0.5 0, 0.0 -30,-0.2 -0.965 49.7-159.6-149.5 160.8 8.3 10.2 1.4 52 52 A M + 0 0 95 -2,-0.3 -33,-0.3 -33,-0.3 -34,-0.1 -0.512 16.8 168.9-145.8 70.8 8.6 8.4 -1.9 53 53 A F S S- 0 0 48 1,-0.1 2,-0.3 -36,-0.1 -34,-0.2 0.950 71.9 -4.8 -44.7 -74.7 11.2 5.6 -1.7 54 54 A K S S+ 0 0 47 -36,-2.6 -1,-0.1 31,-0.2 -38,-0.1 -0.862 101.7 56.9-124.7 159.0 10.4 3.9 -5.0 55 55 A G S S- 0 0 15 -38,-0.3 -38,-0.2 -2,-0.3 38,-0.1 -0.970 88.4 -4.0 129.0-143.4 7.8 4.5 -7.7 56 56 A P - 0 0 28 0, 0.0 4,-0.1 0, 0.0 37,-0.1 0.045 61.0-117.6 -75.0-171.2 6.9 7.6 -9.7 57 57 A E S S+ 0 0 180 2,-0.1 36,-0.0 -3,-0.0 -5,-0.0 0.747 105.8 44.4 -99.5 -33.7 8.4 11.1 -9.4 58 58 A K S S- 0 0 164 1,-0.1 2,-0.2 0, 0.0 35,-0.0 0.970 102.8-118.7 -72.8 -84.0 5.3 12.9 -8.4 59 59 A D - 0 0 4 3,-0.0 35,-0.9 36,-0.0 2,-0.5 -0.785 7.8-103.0 153.6 165.5 3.5 10.8 -5.8 60 60 A I + 0 0 0 -2,-0.2 -13,-0.3 34,-0.1 3,-0.2 -0.683 39.4 162.9-117.7 74.8 0.3 8.9 -5.1 61 61 A E S S+ 0 0 89 -2,-0.5 -14,-0.8 1,-0.2 2,-0.4 0.581 75.8 54.5 -66.9 -8.9 -1.6 11.2 -2.7 62 62 A F E S+D 46 0D 64 32,-0.3 34,-0.4 -16,-0.2 -1,-0.2 -0.816 73.5 169.9-131.3 92.0 -4.5 9.0 -3.7 63 63 A I E -D 45 0D 0 -18,-1.2 -18,-1.4 -2,-0.4 2,-0.4 -0.492 24.7-128.9 -96.1 168.4 -4.0 5.3 -3.1 64 64 A Y E +De 44 97D 74 32,-0.8 34,-1.3 -20,-0.2 2,-0.3 -0.926 37.5 135.4-122.1 145.8 -6.6 2.5 -3.3 65 65 A T - 0 0 9 -22,-1.7 8,-0.1 -2,-0.4 34,-0.1 -0.875 49.8 -67.2-162.7-168.3 -7.4 -0.2 -0.8 66 66 A A - 0 0 7 -2,-0.3 9,-0.2 -24,-0.2 -24,-0.2 -0.672 44.3-121.0 -99.1 154.7 -10.2 -2.1 0.9 67 67 A P S > S+ 0 0 27 0, 0.0 4,-0.7 0, 0.0 5,-0.3 0.186 72.7 47.9 -75.0-161.0 -12.6 -0.7 3.5 68 68 A S T 4 S- 0 0 98 1,-0.2 3,-0.1 2,-0.1 -2,-0.0 0.015 121.3 -42.4 56.3-169.8 -13.1 -1.9 7.1 69 69 A S T 4 S- 0 0 109 1,-0.2 -1,-0.2 2,-0.0 2,-0.1 0.852 117.3 -55.1 -56.2 -36.7 -10.1 -2.5 9.3 70 70 A A T 4 + 0 0 35 -3,-0.2 -1,-0.2 4,-0.0 -2,-0.1 -0.082 65.0 159.8 151.9 103.1 -8.4 -4.1 6.4 71 71 A V S < S+ 0 0 55 -4,-0.7 -69,-2.0 -3,-0.1 -68,-0.7 0.743 95.5 7.9-105.7 -39.1 -9.8 -7.0 4.3 72 72 A a S S+ 0 0 34 -5,-0.3 2,-0.2 -71,-0.2 30,-0.1 -0.040 136.9 23.1-132.4 26.8 -7.7 -6.5 1.1 73 73 A G S S- 0 0 2 26,-0.4 26,-0.1 -6,-0.1 -8,-0.1 -0.805 87.0 -92.7-162.2-158.2 -5.4 -3.9 2.5 74 74 A V - 0 0 45 -2,-0.2 25,-0.1 24,-0.1 -4,-0.0 0.347 46.3-143.1-116.1 -1.4 -3.9 -2.4 5.6 75 75 A S - 0 0 17 -9,-0.2 2,-0.4 1,-0.2 -30,-0.0 0.867 23.7-166.7 32.4 84.9 -6.5 0.3 6.0 76 76 A L + 0 0 3 1,-0.1 -1,-0.2 5,-0.0 -2,-0.1 -0.864 27.7 168.1-103.9 133.4 -4.3 3.1 7.3 77 77 A D - 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