data_1757 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; 1H NMR and Circular Dichroism Studies of the N-Terminal Domain of Cyclic GMP Dependent Protein Kinase: A Leucine/Isoleucine Zipper ; _BMRB_accession_number 1757 _BMRB_flat_file_name bmr1757.str _Entry_type update _Submission_date 1995-07-31 _Accession_date 1996-03-25 _Entry_origination BMRB _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details . loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Atkinson R. Andrew . 2 Saudek Vladimir . . 3 Huggins John P. . 4 Pelton John T. . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 247 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 1995-07-31 original BMRB 'Last release in original BMRB flat-file format' 1996-03-25 reformat BMRB 'Converted to the BMRB 1996-03-01 STAR flat-file format' 1999-06-14 revision BMRB 'Converted to BMRB NMR-STAR V 2.1 format' stop_ save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full ; Atkinson, R. Andrew, Saudek, Vladimir, Huggins, John P., Pelton, John T., "1H NMR and Circular Dichroism Studies of the N-Terminal Domain of Cyclic GMP Dependent Protein Kinase: A Leucine/Isoleucine Zipper," Biochemistry 30 (39), 9387-9395 (1991). ; _Citation_title ; 1H NMR and Circular Dichroism Studies of the N-Terminal Domain of Cyclic GMP Dependent Protein Kinase: A Leucine/Isoleucine Zipper ; _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID ? loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Atkinson R. Andrew . 2 Saudek Vladimir . . 3 Huggins John P. . 4 Pelton John T. . stop_ _Journal_abbreviation Biochemistry _Journal_volume 30 _Journal_issue 39 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 9387 _Page_last 9395 _Year 1991 _Details . save_ ################################## # Molecular system description # ################################## save_system_cGMP-dependent_protein_kinase _Saveframe_category molecular_system _Mol_system_name 'cGMP-dependent protein kinase' _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label 'cGMP-dependent protein kinase' $cGMP-dependent_protein_kinase stop_ _System_molecular_weight . _System_oligomer_state ? _System_paramagnetic ? _System_thiol_state . _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_cGMP-dependent_protein_kinase _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common 'cGMP-dependent protein kinase' _Name_variant 'residues 1-39' _Molecular_mass . _Mol_thiol_state . _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 39 _Mol_residue_sequence ; SELEEDFAKILMLKEERIKE LEKRLSEKEEEIQELKRKL ; loop_ _Residue_seq_code _Residue_label 1 SER 2 GLU 3 LEU 4 GLU 5 GLU 6 ASP 7 PHE 8 ALA 9 LYS 10 ILE 11 LEU 12 MET 13 LEU 14 LYS 15 GLU 16 GLU 17 ARG 18 ILE 19 LYS 20 GLU 21 LEU 22 GLU 23 LYS 24 ARG 25 LEU 26 SER 27 GLU 28 LYS 29 GLU 30 GLU 31 GLU 32 ILE 33 GLN 34 GLU 35 LEU 36 LYS 37 ARG 38 LYS 39 LEU stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date 2015-10-14 loop_ _Database_name _Database_accession_code _Database_entry_mol_name _Sequence_query_to_submitted_percentage _Sequence_subject_length _Sequence_identity _Sequence_positive _Sequence_homology_expectation_value PDB 1ZXA "Solution Structure Of The Coiled-Coil Domain Of Cgmp- Dependent Protein Kinase Ia" 100.00 67 100.00 100.00 1.23e-13 PDB 4R4L "Crystal Structure Of Wt Cgmp Dependent Protein Kinase I Alpha (pkgi Alpha) Leucine Zipper" 100.00 49 100.00 100.00 6.31e-13 PDB 4R4M "Crystal Structure Of C42l Cgmp Dependent Protein Kinase I Alpha (pkgi Alpha) Leucine Zipper" 100.00 49 100.00 100.00 6.73e-13 DBJ BAA08297 "cGMP-dependent protein kinase type I alpha [Homo sapiens]" 100.00 671 100.00 100.00 5.11e-12 DBJ BAC34693 "unnamed protein product [Mus musculus]" 100.00 105 100.00 100.00 3.83e-13 DBJ BAC39087 "unnamed protein product [Mus musculus]" 100.00 671 100.00 100.00 5.11e-12 DBJ BAG61905 "unnamed protein product [Homo sapiens]" 100.00 210 100.00 100.00 8.24e-13 EMBL CAA34214 "unnamed protein product [Bos taurus]" 100.00 671 100.00 100.00 5.01e-12 EMBL CAB07436 "cGMP-dependent protein kinase type I alpha [Homo sapiens]" 100.00 671 100.00 100.00 5.11e-12 GB AAC31192 "cGMP-dependent protein kinase type 1 alpha [Oryctolagus cuniculus]" 100.00 671 100.00 100.00 4.96e-12 GB AAZ75707 "cGMP-dependent protein kinase type I [Sus scrofa]" 100.00 671 100.00 100.00 5.16e-12 GB ABX38843 "cyclic GMP-dependent protein kinase [Rattus norvegicus]" 100.00 671 100.00 100.00 5.26e-12 GB EAW54141 "protein kinase, cGMP-dependent, type I, isoform CRA_b [Homo sapiens]" 100.00 671 100.00 100.00 5.11e-12 GB EDL41712 "mCG145655, partial [Mus musculus]" 100.00 155 100.00 100.00 1.97e-13 PRF 1511094A "cGMP dependent protein kinase I alpha" 100.00 671 100.00 100.00 5.01e-12 REF NP_001013855 "cGMP-dependent protein kinase 1 alpha isoform [Mus musculus]" 100.00 671 100.00 100.00 5.11e-12 REF NP_001038039 "cGMP-dependent protein kinase 1 [Sus scrofa]" 100.00 671 100.00 100.00 5.16e-12 REF NP_001075511 "cGMP-dependent protein kinase 1 [Oryctolagus cuniculus]" 100.00 671 100.00 100.00 4.96e-12 REF NP_001091982 "cGMP-dependent protein kinase 1 isoform 1 [Homo sapiens]" 100.00 671 100.00 100.00 5.11e-12 REF NP_001099201 "cGMP-dependent protein kinase 1 [Rattus norvegicus]" 100.00 671 100.00 100.00 5.16e-12 SP O77676 "RecName: Full=cGMP-dependent protein kinase 1; Short=cGK 1; Short=cGK1" 100.00 671 100.00 100.00 4.96e-12 SP P00516 "RecName: Full=cGMP-dependent protein kinase 1; Short=cGK 1; Short=cGK1; AltName: Full=cGMP-dependent protein kinase I; Short=cG" 100.00 671 100.00 100.00 5.01e-12 SP P0C605 "RecName: Full=cGMP-dependent protein kinase 1; Short=cGK 1; Short=cGK1; AltName: Full=cGMP-dependent protein kinase I; Short=cG" 100.00 671 100.00 100.00 5.11e-12 SP Q13976 "RecName: Full=cGMP-dependent protein kinase 1; Short=cGK 1; Short=cGK1; AltName: Full=cGMP-dependent protein kinase I; Short=cG" 100.00 671 100.00 100.00 5.11e-12 TPG DAA14966 "TPA: cGMP-dependent protein kinase 1 [Bos taurus]" 100.00 671 100.00 100.00 5.01e-12 stop_ save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $cGMP-dependent_protein_kinase . . . . . . stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $cGMP-dependent_protein_kinase 'not available' . . . . . stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_one _Saveframe_category sample _Sample_type solution _Details . save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_list _Saveframe_category NMR_spectrometer _Manufacturer unknown _Model unknown _Field_strength 0 _Details 'spectrometer information not available' save_ ####################### # Sample conditions # ####################### save_sample_condition_set_one _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units pH 4 . na temperature 323 . K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chem_shift_reference_par_set_one _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis TSP H . . ppm 0 . . . . . stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_chemical_shift_assignment_data_set_one _Saveframe_category assigned_chemical_shifts _Details . loop_ _Sample_label $sample_one stop_ _Sample_conditions_label $sample_condition_set_one _Chem_shift_reference_set_label $chem_shift_reference_par_set_one _Mol_system_component_name 'cGMP-dependent protein kinase' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 . 2 GLU HA H 4.29 . 1 2 . 2 GLU HB2 H 2.03 . 2 3 . 2 GLU HB3 H 1.95 . 2 4 . 2 GLU HG2 H 2.32 . 1 5 . 2 GLU HG3 H 2.32 . 1 6 . 3 LEU H H 8.12 . 1 7 . 3 LEU HA H 4.09 . 1 8 . 3 LEU HB2 H 1.56 . 2 9 . 3 LEU HB3 H 1.48 . 2 10 . 3 LEU HG H 1.48 . 1 11 . 3 LEU HD1 H .82 . 2 12 . 3 LEU HD2 H .8 . 2 13 . 4 GLU H H 8.05 . 1 14 . 4 GLU HA H 3.95 . 1 15 . 4 GLU HB2 H 2.01 . 1 16 . 4 GLU HB3 H 2.01 . 1 17 . 4 GLU HG2 H 2.32 . 1 18 . 4 GLU HG3 H 2.32 . 1 19 . 5 GLU H H 7.87 . 1 20 . 5 GLU HA H 4.1 . 1 21 . 5 GLU HB2 H 1.95 . 1 22 . 5 GLU HB3 H 1.95 . 1 23 . 5 GLU HG2 H 2.3 . 1 24 . 5 GLU HG3 H 2.3 . 1 25 . 6 ASP H H 8.08 . 1 26 . 6 ASP HA H 4.47 . 1 27 . 6 ASP HB2 H 2.75 . 2 28 . 6 ASP HB3 H 2.66 . 2 29 . 7 PHE H H 7.9 . 1 30 . 7 PHE HA H 4.07 . 1 31 . 7 PHE HB2 H 2.78 . 2 32 . 7 PHE HB3 H 2.61 . 2 33 . 7 PHE HD1 H 6.77 . 1 34 . 7 PHE HD2 H 6.77 . 1 35 . 7 PHE HE1 H 7.11 . 1 36 . 7 PHE HE2 H 7.11 . 1 37 . 8 ALA H H 8.07 . 1 38 . 8 ALA HA H 3.83 . 1 39 . 8 ALA HB H 1.42 . 1 40 . 9 LYS H H 7.61 . 1 41 . 9 LYS HA H 3.98 . 1 42 . 9 LYS HB2 H 1.94 . 2 43 . 9 LYS HB3 H 1.87 . 2 44 . 9 LYS HG2 H 1.45 . 1 45 . 9 LYS HG3 H 1.45 . 1 46 . 9 LYS HD2 H 1.63 . 1 47 . 9 LYS HD3 H 1.63 . 1 48 . 9 LYS HE2 H 2.93 . 1 49 . 9 LYS HE3 H 2.93 . 1 50 . 10 ILE H H 7.69 . 1 51 . 10 ILE HA H 3.7 . 1 52 . 10 ILE HB H 1.92 . 1 53 . 10 ILE HD1 H .75 . 1 54 . 11 LEU H H 8.25 . 1 55 . 11 LEU HA H 3.79 . 1 56 . 11 LEU HB2 H 1.54 . 2 57 . 11 LEU HB3 H 1.49 . 2 58 . 11 LEU HG H 1.7 . 1 59 . 11 LEU HD1 H .85 . 2 60 . 11 LEU HD2 H .78 . 2 61 . 12 MET H H 7.89 . 1 62 . 12 MET HA H 4.01 . 1 63 . 12 MET HB2 H 2.27 . 2 64 . 12 MET HB3 H 2.15 . 2 65 . 12 MET HG2 H 2.55 . 1 66 . 12 MET HG3 H 2.55 . 1 67 . 12 MET HE H 2.03 . 1 68 . 13 LEU H H 7.82 . 1 69 . 13 LEU HA H 4.08 . 1 70 . 13 LEU HB2 H 1.62 . 2 71 . 13 LEU HB3 H 1.57 . 2 72 . 13 LEU HG H 1.79 . 1 73 . 13 LEU HD1 H .84 . 2 74 . 13 LEU HD2 H .82 . 2 75 . 14 LYS H H 8.12 . 1 76 . 14 LYS HA H 4.05 . 1 77 . 14 LYS HB2 H 2.1 . 1 78 . 14 LYS HB3 H 2.1 . 1 79 . 14 LYS HG2 H 1.71 . 2 80 . 14 LYS HG3 H 1.59 . 2 81 . 14 LYS HD2 H 1.42 . 1 82 . 14 LYS HD3 H 1.42 . 1 83 . 14 LYS HE2 H 2.85 . 2 84 . 14 LYS HE3 H 2.71 . 2 85 . 15 GLU H H 8.4 . 1 86 . 15 GLU HA H 4.09 . 1 87 . 15 GLU HB2 H 2.18 . 2 88 . 15 GLU HB3 H 2.09 . 2 89 . 15 GLU HG2 H 2.35 . 1 90 . 15 GLU HG3 H 2.35 . 1 91 . 16 GLU H H 8.24 . 1 92 . 16 GLU HA H 4 . 1 93 . 16 GLU HB2 H 2.2 . 2 94 . 16 GLU HB3 H 2.12 . 2 95 . 16 GLU HG2 H 2.53 . 2 96 . 16 GLU HG3 H 2.43 . 2 97 . 17 ARG H H 7.66 . 1 98 . 17 ARG HA H 4.12 . 1 99 . 17 ARG HB2 H 2.08 . 2 100 . 17 ARG HB3 H 2 . 2 101 . 17 ARG HG2 H 1.77 . 2 102 . 17 ARG HG3 H 1.63 . 2 103 . 17 ARG HD2 H 3.3 . 2 104 . 17 ARG HD3 H 3.12 . 2 105 . 17 ARG HE H 7.01 . 1 106 . 18 ILE H H 8.02 . 1 107 . 18 ILE HA H 3.38 . 1 108 . 18 ILE HB H 1.95 . 1 109 . 18 ILE HD1 H .91 . 1 110 . 19 LYS H H 7.98 . 1 111 . 19 LYS HA H 4 . 1 112 . 19 LYS HB2 H 1.91 . 2 113 . 19 LYS HB3 H 1.87 . 2 114 . 19 LYS HG2 H 1.44 . 2 115 . 19 LYS HG3 H 1.26 . 2 116 . 19 LYS HD2 H 1.64 . 2 117 . 19 LYS HD3 H 1.58 . 2 118 . 19 LYS HE2 H 2.92 . 1 119 . 19 LYS HE3 H 2.92 . 1 120 . 20 GLU H H 8.07 . 1 121 . 20 GLU HA H 4.04 . 1 122 . 20 GLU HB2 H 2.22 . 2 123 . 20 GLU HB3 H 2.16 . 2 124 . 21 LEU H H 8.4 . 1 125 . 21 LEU HA H 3.95 . 1 126 . 21 LEU HB2 H 2.11 . 2 127 . 21 LEU HB3 H 1.21 . 2 128 . 21 LEU HG H 1.84 . 1 129 . 21 LEU HD1 H .91 . 2 130 . 21 LEU HD2 H .78 . 2 131 . 22 GLU H H 8.72 . 1 132 . 22 GLU HA H 3.91 . 1 133 . 22 GLU HB2 H 2.23 . 2 134 . 22 GLU HB3 H 1.98 . 2 135 . 22 GLU HG2 H 2.66 . 2 136 . 22 GLU HG3 H 2.24 . 2 137 . 23 LYS H H 7.87 . 1 138 . 23 LYS HA H 4.1 . 1 139 . 23 LYS HB2 H 1.99 . 2 140 . 23 LYS HB3 H 1.93 . 2 141 . 23 LYS HG2 H 1.52 . 1 142 . 23 LYS HG3 H 1.52 . 1 143 . 24 ARG H H 8.18 . 1 144 . 24 ARG HA H 4.09 . 1 145 . 24 ARG HB2 H 1.99 . 2 146 . 24 ARG HB3 H 1.86 . 2 147 . 24 ARG HG2 H 1.84 . 2 148 . 24 ARG HG3 H 1.67 . 2 149 . 24 ARG HD2 H 3.15 . 1 150 . 24 ARG HD3 H 3.15 . 1 151 . 24 ARG HE H 7.44 . 1 152 . 25 LEU H H 8.67 . 1 153 . 25 LEU HA H 3.89 . 1 154 . 25 LEU HB2 H 1.78 . 2 155 . 25 LEU HB3 H 1.67 . 2 156 . 25 LEU HG H 1.6 . 1 157 . 25 LEU HD1 H .84 . 2 158 . 25 LEU HD2 H .82 . 2 159 . 26 SER H H 7.89 . 1 160 . 26 SER HA H 4.21 . 1 161 . 26 SER HB2 H 4.01 . 1 162 . 26 SER HB3 H 4.01 . 1 163 . 27 GLU H H 7.89 . 1 164 . 27 GLU HA H 4.1 . 1 165 . 27 GLU HB2 H 2.31 . 2 166 . 27 GLU HB3 H 2.27 . 2 167 . 27 GLU HG2 H 2.15 . 1 168 . 27 GLU HG3 H 2.15 . 1 169 . 28 LYS H H 8.29 . 1 170 . 28 LYS HA H 4.13 . 1 171 . 28 LYS HB2 H 2.08 . 1 172 . 28 LYS HB3 H 2.08 . 1 173 . 28 LYS HG2 H 1.63 . 1 174 . 28 LYS HG3 H 1.63 . 1 175 . 28 LYS HD2 H 1.46 . 1 176 . 28 LYS HD3 H 1.46 . 1 177 . 28 LYS HE2 H 2.92 . 2 178 . 28 LYS HE3 H 2.8 . 2 179 . 29 GLU H H 8.36 . 1 180 . 29 GLU HA H 4.1 . 1 181 . 29 GLU HB2 H 2.17 . 2 182 . 29 GLU HB3 H 2.08 . 2 183 . 29 GLU HG2 H 2.41 . 2 184 . 29 GLU HG3 H 2.32 . 2 185 . 30 GLU H H 7.78 . 1 186 . 30 GLU HA H 4.07 . 1 187 . 30 GLU HB2 H 2.19 . 1 188 . 30 GLU HB3 H 2.19 . 1 189 . 30 GLU HG2 H 2.5 . 2 190 . 30 GLU HG3 H 2.44 . 2 191 . 31 GLU H H 7.83 . 1 192 . 31 GLU HA H 4 . 1 193 . 31 GLU HB2 H 2.23 . 2 194 . 31 GLU HB3 H 2.14 . 2 195 . 31 GLU HG2 H 2.53 . 2 196 . 31 GLU HG3 H 2.51 . 2 197 . 32 ILE H H 8.15 . 1 198 . 32 ILE HA H 3.42 . 1 199 . 32 ILE HB H 1.93 . 1 200 . 32 ILE HD1 H .9 . 1 201 . 33 GLN H H 7.83 . 1 202 . 33 GLN HA H 3.9 . 1 203 . 33 GLN HB2 H 2.16 . 2 204 . 33 GLN HB3 H 2.11 . 2 205 . 33 GLN HG2 H 2.49 . 2 206 . 33 GLN HG3 H 2.42 . 2 207 . 33 GLN HE21 H 7.28 . 2 208 . 33 GLN HE22 H 6.7 . 2 209 . 34 GLU H H 7.94 . 1 210 . 34 GLU HA H 4.01 . 1 211 . 34 GLU HB2 H 2.18 . 2 212 . 34 GLU HB3 H 2.09 . 2 213 . 34 GLU HG2 H 2.5 . 2 214 . 34 GLU HG3 H 2.35 . 2 215 . 35 LEU H H 8.22 . 1 216 . 35 LEU HA H 3.95 . 1 217 . 35 LEU HB2 H 1.97 . 2 218 . 35 LEU HB3 H 1.24 . 2 219 . 35 LEU HG H 1.87 . 1 220 . 35 LEU HD1 H .87 . 2 221 . 35 LEU HD2 H .76 . 2 222 . 36 LYS H H 8.5 . 1 223 . 36 LYS HA H 3.83 . 1 224 . 36 LYS HB2 H 1.82 . 2 225 . 36 LYS HB3 H 1.8 . 2 226 . 36 LYS HG2 H 1.29 . 1 227 . 36 LYS HG3 H 1.29 . 1 228 . 36 LYS HD2 H 1.57 . 1 229 . 36 LYS HD3 H 1.57 . 1 230 . 36 LYS HE2 H 2.87 . 2 231 . 36 LYS HE3 H 2.81 . 2 232 . 37 ARG H H 7.62 . 1 233 . 37 ARG HA H 4.03 . 1 234 . 37 ARG HB2 H 1.91 . 1 235 . 37 ARG HB3 H 1.91 . 1 236 . 37 ARG HG2 H 1.79 . 2 237 . 37 ARG HG3 H 1.62 . 2 238 . 37 ARG HD2 H 3.18 . 1 239 . 37 ARG HD3 H 3.18 . 1 240 . 37 ARG HE H 7.16 . 1 241 . 39 LEU H H 7.59 . 1 242 . 39 LEU HA H 4.09 . 1 243 . 39 LEU HB2 H 1.67 . 2 244 . 39 LEU HB3 H 1.57 . 2 245 . 39 LEU HG H 1.64 . 1 246 . 39 LEU HD1 H .83 . 2 247 . 39 LEU HD2 H .8 . 2 stop_ save_