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   <PDBx:audit_authorCategory>
      <PDBx:audit_author pdbx_ordinal="1">
         <PDBx:name>Macias, M.J.</PDBx:name>
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      <PDBx:audit_author pdbx_ordinal="2">
         <PDBx:name>Aragon, E.</PDBx:name>
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         <PDBx:name>Xi, Q.</PDBx:name>
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         <PDBx:name>Massague, J.</PDBx:name>
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      <PDBx:chem_comp id="SER">
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         <PDBx:type>L-peptide linking</PDBx:type>
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         <PDBx:name>GLUTAMINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
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      <PDBx:chem_comp id="ARG">
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         <PDBx:formula_weight>175.210</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
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         <PDBx:type>L-peptide linking</PDBx:type>
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      <PDBx:chem_comp id="TYR">
         <PDBx:formula>C9 H11 N O3</PDBx:formula>
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         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
         <PDBx:name>TYROSINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="PHE">
         <PDBx:formula>C9 H11 N O2</PDBx:formula>
         <PDBx:formula_weight>165.191</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
         <PDBx:name>PHENYLALANINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="ASN">
         <PDBx:formula>C4 H8 N2 O3</PDBx:formula>
         <PDBx:formula_weight>132.119</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
         <PDBx:name>ASPARAGINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="HIS">
         <PDBx:formula>C6 H10 N3 O2 1</PDBx:formula>
         <PDBx:formula_weight>156.164</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
         <PDBx:name>HISTIDINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="ILE">
         <PDBx:formula>C6 H13 N O2</PDBx:formula>
         <PDBx:formula_weight>131.174</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
         <PDBx:name>ISOLEUCINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="TPO">
         <PDBx:formula>C4 H10 N O6 P</PDBx:formula>
         <PDBx:formula_weight>199.100</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>n</PDBx:mon_nstd_flag>
         <PDBx:name>PHOSPHOTHREONINE</PDBx:name>
         <PDBx:pdbx_synonyms>PHOSPHONOTHREONINE</PDBx:pdbx_synonyms>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="SEP">
         <PDBx:formula>C3 H8 N O6 P</PDBx:formula>
         <PDBx:formula_weight>185.073</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>n</PDBx:mon_nstd_flag>
         <PDBx:name>PHOSPHOSERINE</PDBx:name>
         <PDBx:pdbx_synonyms>PHOSPHONOSERINE</PDBx:pdbx_synonyms>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
   </PDBx:chem_compCategory>
   <PDBx:citationCategory>
      <PDBx:citation id="primary">
         <PDBx:country>US</PDBx:country>
         <PDBx:journal_abbrev>Genes Dev.</PDBx:journal_abbrev>
         <PDBx:journal_id_ASTM>GEDEEP</PDBx:journal_id_ASTM>
         <PDBx:journal_id_CSD>2056</PDBx:journal_id_CSD>
         <PDBx:journal_id_ISSN>0890-9369</PDBx:journal_id_ISSN>
         <PDBx:journal_volume>25</PDBx:journal_volume>
         <PDBx:page_first>1275</PDBx:page_first>
         <PDBx:page_last>1288</PDBx:page_last>
         <PDBx:pdbx_database_id_DOI>10.1101/gad.2060811</PDBx:pdbx_database_id_DOI>
         <PDBx:pdbx_database_id_PubMed>21685363</PDBx:pdbx_database_id_PubMed>
         <PDBx:title>A Smad action turnover switch operated by WW domain readers of a phosphoserine code.</PDBx:title>
         <PDBx:year>2011</PDBx:year>
      </PDBx:citation>
   </PDBx:citationCategory>
   <PDBx:citation_authorCategory>
      <PDBx:citation_author citation_id="primary" name="Aragon, E." ordinal="1"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Goerner, N." ordinal="2"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Zaromytidou, A.I." ordinal="3"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Xi, Q." ordinal="4"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Escobedo, A." ordinal="5"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Massague, J." ordinal="6"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Macias, M.J." ordinal="7"></PDBx:citation_author>
   </PDBx:citation_authorCategory>
   <PDBx:database_2Category>
      <PDBx:database_2 database_code="2LAX" database_id="PDB"></PDBx:database_2>
      <PDBx:database_2 database_code="RCSB102173" database_id="RCSB"></PDBx:database_2>
      <PDBx:database_2 database_code="17539" database_id="BMRB"></PDBx:database_2>
   </PDBx:database_2Category>
   <PDBx:database_PDB_revCategory>
      <PDBx:database_PDB_rev num="1">
         <PDBx:date>2011-07-06</PDBx:date>
         <PDBx:date_original>2011-03-22</PDBx:date_original>
         <PDBx:mod_type>0</PDBx:mod_type>
         <PDBx:replaces>2LAX</PDBx:replaces>
      </PDBx:database_PDB_rev>
   </PDBx:database_PDB_revCategory>
   <PDBx:entityCategory>
      <PDBx:entity id="1">
         <PDBx:formula_weight>4540.073</PDBx:formula_weight>
         <PDBx:pdbx_description>Yorkie homolog</PDBx:pdbx_description>
         <PDBx:pdbx_fragment>first WW domain, residues 170-205</PDBx:pdbx_fragment>
         <PDBx:pdbx_number_of_molecules>1</PDBx:pdbx_number_of_molecules>
         <PDBx:src_method>man</PDBx:src_method>
         <PDBx:type>polymer</PDBx:type>
      </PDBx:entity>
      <PDBx:entity id="2">
         <PDBx:formula_weight>1136.976</PDBx:formula_weight>
         <PDBx:pdbx_description>Mothers against decapentaplegic homolog 1</PDBx:pdbx_description>
         <PDBx:pdbx_fragment>residues 201-209</PDBx:pdbx_fragment>
         <PDBx:pdbx_number_of_molecules>1</PDBx:pdbx_number_of_molecules>
         <PDBx:src_method>syn</PDBx:src_method>
         <PDBx:type>polymer</PDBx:type>
      </PDBx:entity>
   </PDBx:entityCategory>
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      <PDBx:entity_keywords entity_id="1">
      </PDBx:entity_keywords>
      <PDBx:entity_keywords entity_id="2">
      </PDBx:entity_keywords>
   </PDBx:entity_keywordsCategory>
   <PDBx:entity_name_comCategory>
      <PDBx:entity_name_com entity_id="1">
         <PDBx:name>65 kDa Yes-associated protein, YAP65</PDBx:name>
      </PDBx:entity_name_com>
      <PDBx:entity_name_com entity_id="2">
         <PDBx:name>MAD homolog 1, Mothers against DPP homolog 1, JV4-1, Mad-related protein 1, SMAD family member 1, SMAD 1, Smad1, hSMAD1, Transforming growth factor-beta-signaling protein 1, BSP-1</PDBx:name>
      </PDBx:entity_name_com>
   </PDBx:entity_name_comCategory>
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      <PDBx:entity_poly entity_id="1">
         <PDBx:nstd_linkage>no</PDBx:nstd_linkage>
         <PDBx:nstd_monomer>no</PDBx:nstd_monomer>
         <PDBx:pdbx_seq_one_letter_code>GAMEDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKA</PDBx:pdbx_seq_one_letter_code>
         <PDBx:pdbx_seq_one_letter_code_can>GAMEDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKA</PDBx:pdbx_seq_one_letter_code_can>
         <PDBx:pdbx_strand_id>A</PDBx:pdbx_strand_id>
         <PDBx:type>polypeptide(L)</PDBx:type>
      </PDBx:entity_poly>
      <PDBx:entity_poly entity_id="2">
         <PDBx:nstd_linkage>no</PDBx:nstd_linkage>
         <PDBx:nstd_monomer>yes</PDBx:nstd_monomer>
         <PDBx:pdbx_seq_one_letter_code>S(TPO)YPH(SEP)PTS</PDBx:pdbx_seq_one_letter_code>
         <PDBx:pdbx_seq_one_letter_code_can>STYPHSPTS</PDBx:pdbx_seq_one_letter_code_can>
         <PDBx:pdbx_strand_id>B</PDBx:pdbx_strand_id>
         <PDBx:type>polypeptide(L)</PDBx:type>
      </PDBx:entity_poly>
   </PDBx:entity_polyCategory>
   <PDBx:entity_poly_seqCategory>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLY" num="1">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ALA" num="2">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="MET" num="3">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLU" num="4">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ASP" num="5">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="VAL" num="6">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="PRO" num="7">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LEU" num="8">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="PRO" num="9">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ALA" num="10">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLY" num="11">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="TRP" num="12">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLU" num="13">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="MET" num="14">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ALA" num="15">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LYS" num="16">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="THR" num="17">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="SER" num="18">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="SER" num="19">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLY" num="20">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLN" num="21">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ARG" num="22">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="TYR" num="23">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="PHE" num="24">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LEU" num="25">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ASN" num="26">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="HIS" num="27">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ILE" num="28">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ASP" num="29">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLN" num="30">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="THR" num="31">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="THR" num="32">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="THR" num="33">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="TRP" num="34">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLN" num="35">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ASP" num="36">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="PRO" num="37">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ARG" num="38">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LYS" num="39">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ALA" num="40">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="2" mon_id="SER" num="1">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="2" mon_id="TPO" num="2">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="2" mon_id="TYR" num="3">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="2" mon_id="PRO" num="4">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="2" mon_id="HIS" num="5">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="2" mon_id="SEP" num="6">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="2" mon_id="PRO" num="7">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="2" mon_id="THR" num="8">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="2" mon_id="SER" num="9">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
   </PDBx:entity_poly_seqCategory>
   <PDBx:entity_src_genCategory>
      <PDBx:entity_src_gen entity_id="1">
         <PDBx:gene_src_common_name>human</PDBx:gene_src_common_name>
         <PDBx:pdbx_gene_src_gene>YAP1, YAP65</PDBx:pdbx_gene_src_gene>
         <PDBx:pdbx_gene_src_ncbi_taxonomy_id>9606</PDBx:pdbx_gene_src_ncbi_taxonomy_id>
         <PDBx:pdbx_gene_src_scientific_name>Homo sapiens</PDBx:pdbx_gene_src_scientific_name>
         <PDBx:pdbx_host_org_ncbi_taxonomy_id>562</PDBx:pdbx_host_org_ncbi_taxonomy_id>
         <PDBx:pdbx_host_org_scientific_name>Escherichia coli</PDBx:pdbx_host_org_scientific_name>
         <PDBx:pdbx_host_org_vector>petM11</PDBx:pdbx_host_org_vector>
      </PDBx:entity_src_gen>
   </PDBx:entity_src_genCategory>
   <PDBx:entryCategory>
      <PDBx:entry id="2LAX"></PDBx:entry>
   </PDBx:entryCategory>
   <PDBx:exptlCategory>
      <PDBx:exptl entry_id="2LAX" method="SOLUTION NMR">
         <PDBx:details>Structure of first WW domain of human YAP in complex with a human Smad1 doubly-phosphorilated derived peptide.</PDBx:details>
      </PDBx:exptl>
   </PDBx:exptlCategory>
   <PDBx:pdbx_database_relatedCategory>
      <PDBx:pdbx_database_related content_type="unspecified" db_id="17539" db_name="BMRB">
         <PDBx:details xsi:nil="true" />
      </PDBx:pdbx_database_related>
      <PDBx:pdbx_database_related content_type="unspecified" db_id="2LAW" db_name="PDB">
         <PDBx:details xsi:nil="true" />
      </PDBx:pdbx_database_related>
      <PDBx:pdbx_database_related content_type="unspecified" db_id="2LAY" db_name="PDB">
         <PDBx:details xsi:nil="true" />
      </PDBx:pdbx_database_related>
      <PDBx:pdbx_database_related content_type="unspecified" db_id="2LAZ" db_name="PDB">
         <PDBx:details xsi:nil="true" />
      </PDBx:pdbx_database_related>
      <PDBx:pdbx_database_related content_type="unspecified" db_id="2LB0" db_name="PDB">
         <PDBx:details xsi:nil="true" />
      </PDBx:pdbx_database_related>
      <PDBx:pdbx_database_related content_type="unspecified" db_id="2LB1" db_name="PDB">
         <PDBx:details xsi:nil="true" />
      </PDBx:pdbx_database_related>
      <PDBx:pdbx_database_related content_type="unspecified" db_id="2LB2" db_name="PDB">
         <PDBx:details xsi:nil="true" />
      </PDBx:pdbx_database_related>
      <PDBx:pdbx_database_related content_type="unspecified" db_id="2LB3" db_name="PDB">
         <PDBx:details xsi:nil="true" />
      </PDBx:pdbx_database_related>
   </PDBx:pdbx_database_relatedCategory>
   <PDBx:pdbx_database_statusCategory>
      <PDBx:pdbx_database_status entry_id="2LAX">
         <PDBx:deposit_site>BMRB</PDBx:deposit_site>
         <PDBx:process_site>RCSB</PDBx:process_site>
         <PDBx:status_code>REL</PDBx:status_code>
         <PDBx:status_code_cs>REL</PDBx:status_code_cs>
         <PDBx:status_code_mr>REL</PDBx:status_code_mr>
      </PDBx:pdbx_database_status>
   </PDBx:pdbx_database_statusCategory>
   <PDBx:pdbx_entity_src_synCategory>
      <PDBx:pdbx_entity_src_syn entity_id="2">
         <PDBx:ncbi_taxonomy_id>9606</PDBx:ncbi_taxonomy_id>
         <PDBx:organism_common_name>human</PDBx:organism_common_name>
         <PDBx:organism_scientific>Homo sapiens</PDBx:organism_scientific>
      </PDBx:pdbx_entity_src_syn>
   </PDBx:pdbx_entity_src_synCategory>
   <PDBx:pdbx_nmr_constraintsCategory>
      <PDBx:pdbx_nmr_constraints entry_id="2LAX">
         <PDBx:NOE_constraints_total>600</PDBx:NOE_constraints_total>
         <PDBx:NOE_intraresidue_total_count>0</PDBx:NOE_intraresidue_total_count>
         <PDBx:NOE_long_range_total_count>248</PDBx:NOE_long_range_total_count>
         <PDBx:NOE_medium_range_total_count>81</PDBx:NOE_medium_range_total_count>
         <PDBx:NOE_sequential_total_count>170</PDBx:NOE_sequential_total_count>
         <PDBx:hydrogen_bond_constraints_total_count>10</PDBx:hydrogen_bond_constraints_total_count>
      </PDBx:pdbx_nmr_constraints>
   </PDBx:pdbx_nmr_constraintsCategory>
   <PDBx:pdbx_nmr_ensembleCategory>
      <PDBx:pdbx_nmr_ensemble entry_id="2LAX">
         <PDBx:conformer_selection_criteria>structures with acceptable covalent geometry</PDBx:conformer_selection_criteria>
         <PDBx:conformers_calculated_total_number>300</PDBx:conformers_calculated_total_number>
         <PDBx:conformers_submitted_total_number>20</PDBx:conformers_submitted_total_number>
      </PDBx:pdbx_nmr_ensemble>
   </PDBx:pdbx_nmr_ensembleCategory>
   <PDBx:pdbx_nmr_exptlCategory>
      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="1" solution_id="1">
         <PDBx:type>2D 1H-1H NOESY</PDBx:type>
      </PDBx:pdbx_nmr_exptl>
      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="2" solution_id="1">
         <PDBx:type>2D 1H-1H TOCSY</PDBx:type>
      </PDBx:pdbx_nmr_exptl>
      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="3" solution_id="3">
         <PDBx:type>3D CBCA(CO)NH</PDBx:type>
      </PDBx:pdbx_nmr_exptl>
      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="4" solution_id="3">
         <PDBx:type>3D HNCACB</PDBx:type>
      </PDBx:pdbx_nmr_exptl>
      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="5" solution_id="2">
         <PDBx:type>2D 1H-15N HSQC</PDBx:type>
      </PDBx:pdbx_nmr_exptl>
   </PDBx:pdbx_nmr_exptlCategory>
   <PDBx:pdbx_nmr_exptl_sampleCategory>
      <PDBx:pdbx_nmr_exptl_sample component="NEDD4LWW3-1" solution_id="1">
         <PDBx:concentration>1</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="SMAD3-2" solution_id="1">
         <PDBx:concentration>3</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium phosphate-3" solution_id="1">
         <PDBx:concentration>20</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium chloride-4" solution_id="1">
         <PDBx:concentration>100</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium azide-5" solution_id="1">
         <PDBx:concentration>2</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="NEDD4LWW3-6" solution_id="2">
         <PDBx:concentration>1</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
         <PDBx:isotopic_labeling>[U-100&#37; 15N]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="SMAD3-7" solution_id="2">
         <PDBx:concentration>3</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium phosphate-8" solution_id="2">
         <PDBx:concentration>20</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium chloride-9" solution_id="2">
         <PDBx:concentration>100</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium azide-10" solution_id="2">
         <PDBx:concentration>2</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="NEDD4LWW3-11" solution_id="3">
         <PDBx:concentration>1</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
         <PDBx:isotopic_labeling>[U-100&#37; 13C; U-100&#37; 15N]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="SMAD3-12" solution_id="3">
         <PDBx:concentration>3</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium phosphate-13" solution_id="3">
         <PDBx:concentration>20</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium chloride-14" solution_id="3">
         <PDBx:concentration>100</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium azide-15" solution_id="3">
         <PDBx:concentration>2</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
   </PDBx:pdbx_nmr_exptl_sampleCategory>
   <PDBx:pdbx_nmr_exptl_sample_conditionsCategory>
      <PDBx:pdbx_nmr_exptl_sample_conditions conditions_id="1">
         <PDBx:ionic_strength>0.420</PDBx:ionic_strength>
         <PDBx:pH>7</PDBx:pH>
         <PDBx:pressure>ambient</PDBx:pressure>
         <PDBx:temperature>285</PDBx:temperature>
      </PDBx:pdbx_nmr_exptl_sample_conditions>
   </PDBx:pdbx_nmr_exptl_sample_conditionsCategory>
   <PDBx:pdbx_nmr_refineCategory>
      <PDBx:pdbx_nmr_refine entry_id="2LAX">
         <PDBx:method>simulated annealing</PDBx:method>
      </PDBx:pdbx_nmr_refine>
   </PDBx:pdbx_nmr_refineCategory>
   <PDBx:pdbx_nmr_representativeCategory>
      <PDBx:pdbx_nmr_representative entry_id="2LAX">
         <PDBx:conformer_id>1</PDBx:conformer_id>
         <PDBx:selection_criteria>lowest energy</PDBx:selection_criteria>
      </PDBx:pdbx_nmr_representative>
   </PDBx:pdbx_nmr_representativeCategory>
   <PDBx:pdbx_nmr_sample_detailsCategory>
      <PDBx:pdbx_nmr_sample_details solution_id="1">
         <PDBx:contents>1 mM NEDD4LWW3, 3 mM SMAD3, 20 mM sodium phosphate, 100 mM sodium chloride, 2 mM sodium azide, 90&#37; H2O/10&#37; D2O</PDBx:contents>
         <PDBx:solvent_system>90&#37; H2O/10&#37; D2O</PDBx:solvent_system>
      </PDBx:pdbx_nmr_sample_details>
      <PDBx:pdbx_nmr_sample_details solution_id="2">
         <PDBx:contents>1 mM [U-100&#37; 15N] NEDD4LWW3, 3 mM SMAD3, 20 mM sodium phosphate, 100 mM sodium chloride, 2 mM sodium azide, 90&#37; H2O/10&#37; D2O</PDBx:contents>
         <PDBx:solvent_system>90&#37; H2O/10&#37; D2O</PDBx:solvent_system>
      </PDBx:pdbx_nmr_sample_details>
      <PDBx:pdbx_nmr_sample_details solution_id="3">
         <PDBx:contents>1 mM [U-100&#37; 13C; U-100&#37; 15N] NEDD4LWW3, 3 mM SMAD3, 20 mM sodium phosphate, 100 mM sodium chloride, 2 mM sodium azide, 90&#37; H2O/10&#37; D2O</PDBx:contents>
         <PDBx:solvent_system>90&#37; H2O/10&#37; D2O</PDBx:solvent_system>
      </PDBx:pdbx_nmr_sample_details>
   </PDBx:pdbx_nmr_sample_detailsCategory>
   <PDBx:pdbx_nmr_softwareCategory>
      <PDBx:pdbx_nmr_software ordinal="1">
         <PDBx:authors>Brunger, Adams, Clore, Gros, Nilges and Read</PDBx:authors>
         <PDBx:classification>structure solution</PDBx:classification>
         <PDBx:name>CNS</PDBx:name>
         <PDBx:version>1.3</PDBx:version>
      </PDBx:pdbx_nmr_software>
      <PDBx:pdbx_nmr_software ordinal="2">
         <PDBx:authors>Bartels et al.</PDBx:authors>
         <PDBx:classification>chemical shift assignment</PDBx:classification>
         <PDBx:name>XEASY</PDBx:name>
      </PDBx:pdbx_nmr_software>
      <PDBx:pdbx_nmr_software ordinal="3">
         <PDBx:authors>Bruker Biospin</PDBx:authors>
         <PDBx:classification>collection</PDBx:classification>
         <PDBx:name>TOPSPIN</PDBx:name>
      </PDBx:pdbx_nmr_software>
      <PDBx:pdbx_nmr_software ordinal="4">
         <PDBx:authors>Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax</PDBx:authors>
         <PDBx:classification>processing</PDBx:classification>
         <PDBx:name>NMRPipe</PDBx:name>
      </PDBx:pdbx_nmr_software>
      <PDBx:pdbx_nmr_software ordinal="5">
         <PDBx:classification>refinement</PDBx:classification>
         <PDBx:name>CNS</PDBx:name>
      </PDBx:pdbx_nmr_software>
   </PDBx:pdbx_nmr_softwareCategory>
   <PDBx:pdbx_nmr_spectrometerCategory>
      <PDBx:pdbx_nmr_spectrometer spectrometer_id="1">
         <PDBx:field_strength>600</PDBx:field_strength>
         <PDBx:manufacturer>Bruker</PDBx:manufacturer>
         <PDBx:model>DRX</PDBx:model>
         <PDBx:type>Bruker DRX</PDBx:type>
      </PDBx:pdbx_nmr_spectrometer>
   </PDBx:pdbx_nmr_spectrometerCategory>
   <PDBx:pdbx_poly_seq_schemeCategory>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLY" seq_id="1">
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>1</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_seq_num>166</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ALA" seq_id="2">
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>2</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_seq_num>167</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="MET" seq_id="3">
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>3</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_seq_num>168</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLU" seq_id="4">
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>4</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_seq_num>169</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASP" seq_id="5">
         <PDBx:auth_mon_id>ASP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>170</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>5</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>170</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="VAL" seq_id="6">
         <PDBx:auth_mon_id>VAL</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>171</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>6</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>VAL</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>171</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PRO" seq_id="7">
         <PDBx:auth_mon_id>PRO</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>172</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>7</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PRO</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>172</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="8">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>173</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>8</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>173</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PRO" seq_id="9">
         <PDBx:auth_mon_id>PRO</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>174</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>9</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PRO</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>174</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ALA" seq_id="10">
         <PDBx:auth_mon_id>ALA</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>175</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>10</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ALA</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>175</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLY" seq_id="11">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>176</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>11</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>176</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="TRP" seq_id="12">
         <PDBx:auth_mon_id>TRP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>177</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>12</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>TRP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>177</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLU" seq_id="13">
         <PDBx:auth_mon_id>GLU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>178</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>13</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>178</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="MET" seq_id="14">
         <PDBx:auth_mon_id>MET</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>179</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>14</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>MET</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>179</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ALA" seq_id="15">
         <PDBx:auth_mon_id>ALA</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>180</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>15</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ALA</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>180</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LYS" seq_id="16">
         <PDBx:auth_mon_id>LYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>181</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>16</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>181</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="THR" seq_id="17">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>182</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>17</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>182</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="18">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>183</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>18</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>183</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="19">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>184</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>19</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>184</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLY" seq_id="20">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>185</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>20</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>185</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLN" seq_id="21">
         <PDBx:auth_mon_id>GLN</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>186</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>21</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLN</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>186</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ARG" seq_id="22">
         <PDBx:auth_mon_id>ARG</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>187</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>22</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ARG</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>187</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="TYR" seq_id="23">
         <PDBx:auth_mon_id>TYR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>188</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>23</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>TYR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>188</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PHE" seq_id="24">
         <PDBx:auth_mon_id>PHE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>189</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>24</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PHE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>189</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="25">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>190</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>25</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>190</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASN" seq_id="26">
         <PDBx:auth_mon_id>ASN</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>191</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>26</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASN</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>191</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="HIS" seq_id="27">
         <PDBx:auth_mon_id>HIS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>192</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>27</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HIS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>192</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ILE" seq_id="28">
         <PDBx:auth_mon_id>ILE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>193</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>28</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ILE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>193</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASP" seq_id="29">
         <PDBx:auth_mon_id>ASP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>194</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>29</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>194</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLN" seq_id="30">
         <PDBx:auth_mon_id>GLN</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>195</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>30</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLN</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>195</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="THR" seq_id="31">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>196</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>31</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>196</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="THR" seq_id="32">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>197</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>32</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>197</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="THR" seq_id="33">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>198</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>33</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>198</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="TRP" seq_id="34">
         <PDBx:auth_mon_id>TRP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>199</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>34</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>TRP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>199</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLN" seq_id="35">
         <PDBx:auth_mon_id>GLN</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>200</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>35</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLN</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>200</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASP" seq_id="36">
         <PDBx:auth_mon_id>ASP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>201</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>36</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>201</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PRO" seq_id="37">
         <PDBx:auth_mon_id>PRO</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>202</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>37</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PRO</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>202</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ARG" seq_id="38">
         <PDBx:auth_mon_id>ARG</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>203</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>38</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ARG</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>203</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LYS" seq_id="39">
         <PDBx:auth_mon_id>LYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>204</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>39</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>204</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ALA" seq_id="40">
         <PDBx:auth_mon_id>ALA</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>205</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>40</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ALA</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>205</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="2" mon_id="SER" seq_id="1">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>201</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>1</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>201</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="2" mon_id="TPO" seq_id="2">
         <PDBx:auth_mon_id>TPO</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>202</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>2</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>TPO</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>202</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="2" mon_id="TYR" seq_id="3">
         <PDBx:auth_mon_id>TYR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>203</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>3</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>TYR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>203</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="2" mon_id="PRO" seq_id="4">
         <PDBx:auth_mon_id>PRO</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>204</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>4</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PRO</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>204</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="2" mon_id="HIS" seq_id="5">
         <PDBx:auth_mon_id>HIS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>205</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>5</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HIS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>205</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="2" mon_id="SEP" seq_id="6">
         <PDBx:auth_mon_id>SEP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>206</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>6</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SEP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>206</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="2" mon_id="PRO" seq_id="7">
         <PDBx:auth_mon_id>PRO</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>207</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>7</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PRO</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>207</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="2" mon_id="THR" seq_id="8">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>208</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>8</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>208</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="2" mon_id="SER" seq_id="9">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>209</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>9</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>209</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
   </PDBx:pdbx_poly_seq_schemeCategory>
   <PDBx:pdbx_struct_assemblyCategory>
      <PDBx:pdbx_struct_assembly id="1">
         <PDBx:details>author_defined_assembly</PDBx:details>
         <PDBx:oligomeric_count>2</PDBx:oligomeric_count>
         <PDBx:oligomeric_details>dimeric</PDBx:oligomeric_details>
      </PDBx:pdbx_struct_assembly>
   </PDBx:pdbx_struct_assemblyCategory>
   <PDBx:pdbx_struct_assembly_genCategory>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="1"></PDBx:pdbx_struct_assembly_gen>
   </PDBx:pdbx_struct_assembly_genCategory>
   <PDBx:pdbx_struct_mod_residueCategory>
      <PDBx:pdbx_struct_mod_residue id="1">
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TPO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>202</PDBx:auth_seq_id>
         <PDBx:details>PHOSPHOTHREONINE</PDBx:details>
         <PDBx:label_asym_id>B</PDBx:label_asym_id>
         <PDBx:label_comp_id>TPO</PDBx:label_comp_id>
         <PDBx:label_seq_id>2</PDBx:label_seq_id>
         <PDBx:parent_comp_id>THR</PDBx:parent_comp_id>
      </PDBx:pdbx_struct_mod_residue>
      <PDBx:pdbx_struct_mod_residue id="2">
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>SEP</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>206</PDBx:auth_seq_id>
         <PDBx:details>PHOSPHOSERINE</PDBx:details>
         <PDBx:label_asym_id>B</PDBx:label_asym_id>
         <PDBx:label_comp_id>SEP</PDBx:label_comp_id>
         <PDBx:label_seq_id>6</PDBx:label_seq_id>
         <PDBx:parent_comp_id>SER</PDBx:parent_comp_id>
      </PDBx:pdbx_struct_mod_residue>
   </PDBx:pdbx_struct_mod_residueCategory>
   <PDBx:pdbx_struct_oper_listCategory>
      <PDBx:pdbx_struct_oper_list id="1">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_555</PDBx:name>
         <PDBx:symmetry_operation>x,y,z</PDBx:symmetry_operation>
         <PDBx:type>identity operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>0.0000000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
   </PDBx:pdbx_struct_oper_listCategory>
   <PDBx:pdbx_struct_sheet_hbondCategory>
      <PDBx:pdbx_struct_sheet_hbond range_id_1="1" range_id_2="2" sheet_id="A">
         <PDBx:range_1_auth_asym_id>A</PDBx:range_1_auth_asym_id>
         <PDBx:range_1_auth_atom_id>N</PDBx:range_1_auth_atom_id>
         <PDBx:range_1_auth_comp_id>THR</PDBx:range_1_auth_comp_id>
         <PDBx:range_1_auth_seq_id>182</PDBx:range_1_auth_seq_id>
         <PDBx:range_1_label_asym_id>A</PDBx:range_1_label_asym_id>
         <PDBx:range_1_label_atom_id>N</PDBx:range_1_label_atom_id>
         <PDBx:range_1_label_comp_id>THR</PDBx:range_1_label_comp_id>
         <PDBx:range_1_label_seq_id>17</PDBx:range_1_label_seq_id>
         <PDBx:range_2_auth_asym_id>A</PDBx:range_2_auth_asym_id>
         <PDBx:range_2_auth_atom_id>O</PDBx:range_2_auth_atom_id>
         <PDBx:range_2_auth_comp_id>GLN</PDBx:range_2_auth_comp_id>
         <PDBx:range_2_auth_seq_id>186</PDBx:range_2_auth_seq_id>
         <PDBx:range_2_label_asym_id>A</PDBx:range_2_label_asym_id>
         <PDBx:range_2_label_atom_id>O</PDBx:range_2_label_atom_id>
         <PDBx:range_2_label_comp_id>GLN</PDBx:range_2_label_comp_id>
         <PDBx:range_2_label_seq_id>21</PDBx:range_2_label_seq_id>
      </PDBx:pdbx_struct_sheet_hbond>
      <PDBx:pdbx_struct_sheet_hbond range_id_1="2" range_id_2="3" sheet_id="A">
         <PDBx:range_1_auth_asym_id>A</PDBx:range_1_auth_asym_id>
         <PDBx:range_1_auth_atom_id>N</PDBx:range_1_auth_atom_id>
         <PDBx:range_1_auth_comp_id>PHE</PDBx:range_1_auth_comp_id>
         <PDBx:range_1_auth_seq_id>189</PDBx:range_1_auth_seq_id>
         <PDBx:range_1_label_asym_id>A</PDBx:range_1_label_asym_id>
         <PDBx:range_1_label_atom_id>N</PDBx:range_1_label_atom_id>
         <PDBx:range_1_label_comp_id>PHE</PDBx:range_1_label_comp_id>
         <PDBx:range_1_label_seq_id>24</PDBx:range_1_label_seq_id>
         <PDBx:range_2_auth_asym_id>A</PDBx:range_2_auth_asym_id>
         <PDBx:range_2_auth_atom_id>O</PDBx:range_2_auth_atom_id>
         <PDBx:range_2_auth_comp_id>THR</PDBx:range_2_auth_comp_id>
         <PDBx:range_2_auth_seq_id>198</PDBx:range_2_auth_seq_id>
         <PDBx:range_2_label_asym_id>A</PDBx:range_2_label_asym_id>
         <PDBx:range_2_label_atom_id>O</PDBx:range_2_label_atom_id>
         <PDBx:range_2_label_comp_id>THR</PDBx:range_2_label_comp_id>
         <PDBx:range_2_label_seq_id>33</PDBx:range_2_label_seq_id>
      </PDBx:pdbx_struct_sheet_hbond>
   </PDBx:pdbx_struct_sheet_hbondCategory>
   <PDBx:pdbx_unobs_or_zero_occ_atomsCategory>
      <PDBx:pdbx_unobs_or_zero_occ_atoms id="1">
         <PDBx:PDB_model_num>1</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_atom_id>HOP2</PDBx:auth_atom_id>
         <PDBx:auth_comp_id>TPO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>202</PDBx:auth_seq_id>
         <PDBx:occupancy_flag>1</PDBx:occupancy_flag>
         <PDBx:polymer_flag>Y</PDBx:polymer_flag>
      </PDBx:pdbx_unobs_or_zero_occ_atoms>
      <PDBx:pdbx_unobs_or_zero_occ_atoms id="2">
         <PDBx:PDB_model_num>1</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_atom_id>HOP3</PDBx:auth_atom_id>
         <PDBx:auth_comp_id>TPO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>202</PDBx:auth_seq_id>
         <PDBx:occupancy_flag>1</PDBx:occupancy_flag>
         <PDBx:polymer_flag>Y</PDBx:polymer_flag>
      </PDBx:pdbx_unobs_or_zero_occ_atoms>
      <PDBx:pdbx_unobs_or_zero_occ_atoms id="3">
         <PDBx:PDB_model_num>1</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_atom_id>HOP2</PDBx:auth_atom_id>
         <PDBx:auth_comp_id>SEP</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>206</PDBx:auth_seq_id>
         <PDBx:occupancy_flag>1</PDBx:occupancy_flag>
         <PDBx:polymer_flag>Y</PDBx:polymer_flag>
      </PDBx:pdbx_unobs_or_zero_occ_atoms>
      <PDBx:pdbx_unobs_or_zero_occ_atoms id="4">
         <PDBx:PDB_model_num>1</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_atom_id>HOP3</PDBx:auth_atom_id>
         <PDBx:auth_comp_id>SEP</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>206</PDBx:auth_seq_id>
         <PDBx:occupancy_flag>1</PDBx:occupancy_flag>
         <PDBx:polymer_flag>Y</PDBx:polymer_flag>
      </PDBx:pdbx_unobs_or_zero_occ_atoms>
      <PDBx:pdbx_unobs_or_zero_occ_atoms id="5">
         <PDBx:PDB_model_num>2</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_atom_id>HOP2</PDBx:auth_atom_id>
         <PDBx:auth_comp_id>TPO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>202</PDBx:auth_seq_id>
         <PDBx:occupancy_flag>1</PDBx:occupancy_flag>
         <PDBx:polymer_flag>Y</PDBx:polymer_flag>
      </PDBx:pdbx_unobs_or_zero_occ_atoms>
      <PDBx:pdbx_unobs_or_zero_occ_atoms id="6">
         <PDBx:PDB_model_num>2</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_atom_id>HOP3</PDBx:auth_atom_id>
         <PDBx:auth_comp_id>TPO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>202</PDBx:auth_seq_id>
         <PDBx:occupancy_flag>1</PDBx:occupancy_flag>
         <PDBx:polymer_flag>Y</PDBx:polymer_flag>
      </PDBx:pdbx_unobs_or_zero_occ_atoms>
      <PDBx:pdbx_unobs_or_zero_occ_atoms id="7">
         <PDBx:PDB_model_num>2</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_atom_id>HOP2</PDBx:auth_atom_id>
         <PDBx:auth_comp_id>SEP</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>206</PDBx:auth_seq_id>
         <PDBx:occupancy_flag>1</PDBx:occupancy_flag>
         <PDBx:polymer_flag>Y</PDBx:polymer_flag>
      </PDBx:pdbx_unobs_or_zero_occ_atoms>
      <PDBx:pdbx_unobs_or_zero_occ_atoms id="8">
         <PDBx:PDB_model_num>2</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_atom_id>HOP3</PDBx:auth_atom_id>
         <PDBx:auth_comp_id>SEP</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>206</PDBx:auth_seq_id>
         <PDBx:occupancy_flag>1</PDBx:occupancy_flag>
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         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.47</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="23">
         <PDBx:PDB_model_num>8</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.54</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="24">
         <PDBx:PDB_model_num>8</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HG22</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>THR</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>GLN</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>198</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>200</PDBx:auth_seq_id_2>
         <PDBx:dist>1.55</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="25">
         <PDBx:PDB_model_num>9</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.33</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="26">
         <PDBx:PDB_model_num>9</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HG22</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>THR</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>GLN</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>198</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>200</PDBx:auth_seq_id_2>
         <PDBx:dist>1.43</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="27">
         <PDBx:PDB_model_num>10</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.39</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="28">
         <PDBx:PDB_model_num>10</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>B</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>PRO</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.45</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="29">
         <PDBx:PDB_model_num>10</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HE1</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HG2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>TRP</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>PRO</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>199</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>207</PDBx:auth_seq_id_2>
         <PDBx:dist>1.55</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="30">
         <PDBx:PDB_model_num>10</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>OE1</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HE2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>192</PDBx:auth_seq_id_2>
         <PDBx:dist>1.59</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="31">
         <PDBx:PDB_model_num>10</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>OD2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HG1</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>ASP</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>THR</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>194</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>196</PDBx:auth_seq_id_2>
         <PDBx:dist>1.60</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="32">
         <PDBx:PDB_model_num>11</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.43</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="33">
         <PDBx:PDB_model_num>11</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>B</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>PRO</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.46</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="34">
         <PDBx:PDB_model_num>11</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HZ1</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>OXT</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>LYS</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>ALA</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.59</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="35">
         <PDBx:PDB_model_num>12</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.52</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="36">
         <PDBx:PDB_model_num>12</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>B</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>PRO</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.54</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="37">
         <PDBx:PDB_model_num>13</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>B</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>PRO</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.51</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="38">
         <PDBx:PDB_model_num>13</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.52</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="39">
         <PDBx:PDB_model_num>14</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HZ3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HG22</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>TRP</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>THR</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>177</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>198</PDBx:auth_seq_id_2>
         <PDBx:dist>1.38</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="40">
         <PDBx:PDB_model_num>14</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>B</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>PRO</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.39</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="41">
         <PDBx:PDB_model_num>14</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HG1</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>THR</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>GLN</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>182</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>186</PDBx:auth_seq_id_2>
         <PDBx:dist>1.42</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="42">
         <PDBx:PDB_model_num>14</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HG1</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>ASP</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>THR</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>194</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>196</PDBx:auth_seq_id_2>
         <PDBx:dist>1.47</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="43">
         <PDBx:PDB_model_num>14</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.56</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="44">
         <PDBx:PDB_model_num>15</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.41</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="45">
         <PDBx:PDB_model_num>15</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>B</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>PRO</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.42</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="46">
         <PDBx:PDB_model_num>16</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.35</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="47">
         <PDBx:PDB_model_num>16</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>B</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>PRO</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.50</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="48">
         <PDBx:PDB_model_num>16</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HG3</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>THR</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>PRO</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>197</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>207</PDBx:auth_seq_id_2>
         <PDBx:dist>1.50</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="49">
         <PDBx:PDB_model_num>17</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>B</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>PRO</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.43</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="50">
         <PDBx:PDB_model_num>17</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.50</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="51">
         <PDBx:PDB_model_num>17</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HG1</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>ASP</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>THR</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>194</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>196</PDBx:auth_seq_id_2>
         <PDBx:dist>1.50</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="52">
         <PDBx:PDB_model_num>17</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HG1</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>THR</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>GLN</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>182</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>186</PDBx:auth_seq_id_2>
         <PDBx:dist>1.57</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="53">
         <PDBx:PDB_model_num>18</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.43</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="54">
         <PDBx:PDB_model_num>18</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>B</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>PRO</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.46</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="55">
         <PDBx:PDB_model_num>18</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HG1</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>THR</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>GLN</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>182</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>186</PDBx:auth_seq_id_2>
         <PDBx:dist>1.49</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="56">
         <PDBx:PDB_model_num>18</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>ASP</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>THR</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>194</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>196</PDBx:auth_seq_id_2>
         <PDBx:dist>1.51</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="57">
         <PDBx:PDB_model_num>18</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HG22</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>THR</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>GLN</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>198</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>200</PDBx:auth_seq_id_2>
         <PDBx:dist>1.57</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="58">
         <PDBx:PDB_model_num>19</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>B</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>H</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>PRO</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HIS</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>204</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>205</PDBx:auth_seq_id_2>
         <PDBx:dist>1.46</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="59">
         <PDBx:PDB_model_num>19</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.46</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="60">
         <PDBx:PDB_model_num>19</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HG21</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>ASN</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>THR</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>191</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>196</PDBx:auth_seq_id_2>
         <PDBx:dist>1.47</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="61">
         <PDBx:PDB_model_num>20</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>GLU</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>LEU</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>178</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>190</PDBx:auth_seq_id_2>
         <PDBx:dist>1.44</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="62">
         <PDBx:PDB_model_num>20</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HG1</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB2</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>THR</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>GLN</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>182</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>186</PDBx:auth_seq_id_2>
         <PDBx:dist>1.46</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="63">
         <PDBx:PDB_model_num>20</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>B</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HE1</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>ALA</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>TYR</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>180</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>203</PDBx:auth_seq_id_2>
         <PDBx:dist>1.56</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="64">
         <PDBx:PDB_model_num>20</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>HB3</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HB</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>ASP</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>THR</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>194</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>196</PDBx:auth_seq_id_2>
         <PDBx:dist>1.58</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
      <PDBx:pdbx_validate_close_contact id="65">
         <PDBx:PDB_model_num>20</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>OD2</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>HG1</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>ASP</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>THR</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>194</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>196</PDBx:auth_seq_id_2>
         <PDBx:dist>1.59</PDBx:dist>
      </PDBx:pdbx_validate_close_contact>
   </PDBx:pdbx_validate_close_contactCategory>
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      <PDBx:pdbx_validate_torsion id="1">
         <PDBx:PDB_model_num>1</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-80.35</PDBx:phi>
         <PDBx:psi>-133.80</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="2">
         <PDBx:PDB_model_num>2</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-73.41</PDBx:phi>
         <PDBx:psi>-141.80</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="3">
         <PDBx:PDB_model_num>2</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>THR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>208</PDBx:auth_seq_id>
         <PDBx:phi>-117.77</PDBx:phi>
         <PDBx:psi>-110.01</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="4">
         <PDBx:PDB_model_num>3</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-86.51</PDBx:phi>
         <PDBx:psi>-128.48</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="5">
         <PDBx:PDB_model_num>4</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-69.00</PDBx:phi>
         <PDBx:psi>-166.61</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="6">
         <PDBx:PDB_model_num>4</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>THR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>208</PDBx:auth_seq_id>
         <PDBx:phi>-89.90</PDBx:phi>
         <PDBx:psi>-94.33</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="7">
         <PDBx:PDB_model_num>5</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TYR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>203</PDBx:auth_seq_id>
         <PDBx:phi>69.61</PDBx:phi>
         <PDBx:psi>107.90</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="8">
         <PDBx:PDB_model_num>5</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-84.95</PDBx:phi>
         <PDBx:psi>-121.61</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="9">
         <PDBx:PDB_model_num>6</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TYR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>203</PDBx:auth_seq_id>
         <PDBx:phi>-175.53</PDBx:phi>
         <PDBx:psi>119.02</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="10">
         <PDBx:PDB_model_num>6</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-75.47</PDBx:phi>
         <PDBx:psi>-134.03</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="11">
         <PDBx:PDB_model_num>7</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-78.38</PDBx:phi>
         <PDBx:psi>-131.09</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="12">
         <PDBx:PDB_model_num>8</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TYR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>203</PDBx:auth_seq_id>
         <PDBx:phi>66.88</PDBx:phi>
         <PDBx:psi>108.72</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="13">
         <PDBx:PDB_model_num>10</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-84.59</PDBx:phi>
         <PDBx:psi>-127.77</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="14">
         <PDBx:PDB_model_num>11</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-82.26</PDBx:phi>
         <PDBx:psi>-133.24</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="15">
         <PDBx:PDB_model_num>12</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>GLN</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>195</PDBx:auth_seq_id>
         <PDBx:phi>64.58</PDBx:phi>
         <PDBx:psi>74.96</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="16">
         <PDBx:PDB_model_num>12</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-82.02</PDBx:phi>
         <PDBx:psi>-145.81</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="17">
         <PDBx:PDB_model_num>13</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TPO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>202</PDBx:auth_seq_id>
         <PDBx:phi>63.40</PDBx:phi>
         <PDBx:psi>95.08</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="18">
         <PDBx:PDB_model_num>13</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-78.04</PDBx:phi>
         <PDBx:psi>-113.70</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="19">
         <PDBx:PDB_model_num>14</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-82.38</PDBx:phi>
         <PDBx:psi>-126.20</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="20">
         <PDBx:PDB_model_num>15</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TPO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>202</PDBx:auth_seq_id>
         <PDBx:phi>-124.86</PDBx:phi>
         <PDBx:psi>-97.44</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="21">
         <PDBx:PDB_model_num>15</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TYR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>203</PDBx:auth_seq_id>
         <PDBx:phi>-179.35</PDBx:phi>
         <PDBx:psi>128.85</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="22">
         <PDBx:PDB_model_num>15</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-78.59</PDBx:phi>
         <PDBx:psi>-128.89</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="23">
         <PDBx:PDB_model_num>15</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>HIS</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>205</PDBx:auth_seq_id>
         <PDBx:phi>-150.08</PDBx:phi>
         <PDBx:psi>5.54</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="24">
         <PDBx:PDB_model_num>15</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>SEP</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>206</PDBx:auth_seq_id>
         <PDBx:phi>51.39</PDBx:phi>
         <PDBx:psi>135.53</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="25">
         <PDBx:PDB_model_num>16</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TYR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>203</PDBx:auth_seq_id>
         <PDBx:phi>-129.78</PDBx:phi>
         <PDBx:psi>-55.06</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="26">
         <PDBx:PDB_model_num>16</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-96.63</PDBx:phi>
         <PDBx:psi>-143.51</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="27">
         <PDBx:PDB_model_num>17</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>GLN</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>195</PDBx:auth_seq_id>
         <PDBx:phi>72.08</PDBx:phi>
         <PDBx:psi>31.82</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="28">
         <PDBx:PDB_model_num>17</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-75.56</PDBx:phi>
         <PDBx:psi>-126.11</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="29">
         <PDBx:PDB_model_num>18</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TYR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>203</PDBx:auth_seq_id>
         <PDBx:phi>73.36</PDBx:phi>
         <PDBx:psi>122.64</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="30">
         <PDBx:PDB_model_num>18</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-77.07</PDBx:phi>
         <PDBx:psi>-129.30</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="31">
         <PDBx:PDB_model_num>19</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>ARG</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>203</PDBx:auth_seq_id>
         <PDBx:phi>-99.11</PDBx:phi>
         <PDBx:psi>-66.17</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="32">
         <PDBx:PDB_model_num>19</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TPO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>202</PDBx:auth_seq_id>
         <PDBx:phi>-139.39</PDBx:phi>
         <PDBx:psi>-33.98</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="33">
         <PDBx:PDB_model_num>19</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-81.45</PDBx:phi>
         <PDBx:psi>-124.49</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="34">
         <PDBx:PDB_model_num>20</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>PRO</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>204</PDBx:auth_seq_id>
         <PDBx:phi>-72.42</PDBx:phi>
         <PDBx:psi>-139.66</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="35">
         <PDBx:PDB_model_num>20</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>HIS</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>205</PDBx:auth_seq_id>
         <PDBx:phi>-150.11</PDBx:phi>
         <PDBx:psi>56.66</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="36">
         <PDBx:PDB_model_num>20</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>SEP</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>206</PDBx:auth_seq_id>
         <PDBx:phi>61.28</PDBx:phi>
         <PDBx:psi>150.40</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
   </PDBx:pdbx_validate_torsionCategory>
   <PDBx:pdbx_versionCategory>
      <PDBx:pdbx_version entry_id="2LAX" major_version="3" minor_version="2" revision_type="Version format compliance">
         <PDBx:details>compliance with PDB format V.3.20</PDBx:details>
         <PDBx:revision_date>2011-04-07</PDBx:revision_date>
      </PDBx:pdbx_version>
      <PDBx:pdbx_version entry_id="2LAX" major_version="4" minor_version="0000" revision_type="Version format compliance">
         <PDBx:details>compliance with PDB Exchange Dictionary V4</PDBx:details>
         <PDBx:revision_date>2011-07-13</PDBx:revision_date>
      </PDBx:pdbx_version>
   </PDBx:pdbx_versionCategory>
   <PDBx:structCategory>
      <PDBx:struct entry_id="2LAX">
         <PDBx:pdbx_CASP_flag>N</PDBx:pdbx_CASP_flag>
         <PDBx:pdbx_descriptor>Yorkie homolog, Mothers against decapentaplegic homolog 1</PDBx:pdbx_descriptor>
         <PDBx:pdbx_model_details>lowest energy, model 1</PDBx:pdbx_model_details>
         <PDBx:title>Structure of first WW domain of human YAP in complex with a human Smad1 doubly-phosphorilated derived peptide.</PDBx:title>
      </PDBx:struct>
   </PDBx:structCategory>
   <PDBx:struct_asymCategory>
      <PDBx:struct_asym id="A">
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="B">
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
   </PDBx:struct_asymCategory>
   <PDBx:struct_biolCategory>
      <PDBx:struct_biol id="1">
      </PDBx:struct_biol>
   </PDBx:struct_biolCategory>
   <PDBx:struct_connCategory>
      <PDBx:struct_conn id="covale1">
         <PDBx:conn_type_id>covale</PDBx:conn_type_id>
         <PDBx:pdbx_dist_value>1.324</PDBx:pdbx_dist_value>
         <PDBx:ptnr1_auth_asym_id>B</PDBx:ptnr1_auth_asym_id>
         <PDBx:ptnr1_auth_comp_id>SER</PDBx:ptnr1_auth_comp_id>
         <PDBx:ptnr1_auth_seq_id>201</PDBx:ptnr1_auth_seq_id>
         <PDBx:ptnr1_label_asym_id>B</PDBx:ptnr1_label_asym_id>
         <PDBx:ptnr1_label_atom_id>C</PDBx:ptnr1_label_atom_id>
         <PDBx:ptnr1_label_comp_id>SER</PDBx:ptnr1_label_comp_id>
         <PDBx:ptnr1_label_seq_id>1</PDBx:ptnr1_label_seq_id>
         <PDBx:ptnr1_symmetry>1_555</PDBx:ptnr1_symmetry>
         <PDBx:ptnr2_auth_asym_id>B</PDBx:ptnr2_auth_asym_id>
         <PDBx:ptnr2_auth_comp_id>TPO</PDBx:ptnr2_auth_comp_id>
         <PDBx:ptnr2_auth_seq_id>202</PDBx:ptnr2_auth_seq_id>
         <PDBx:ptnr2_label_asym_id>B</PDBx:ptnr2_label_asym_id>
         <PDBx:ptnr2_label_atom_id>N</PDBx:ptnr2_label_atom_id>
         <PDBx:ptnr2_label_comp_id>TPO</PDBx:ptnr2_label_comp_id>
         <PDBx:ptnr2_label_seq_id>2</PDBx:ptnr2_label_seq_id>
         <PDBx:ptnr2_symmetry>1_555</PDBx:ptnr2_symmetry>
      </PDBx:struct_conn>
      <PDBx:struct_conn id="covale2">
         <PDBx:conn_type_id>covale</PDBx:conn_type_id>
         <PDBx:pdbx_dist_value>1.331</PDBx:pdbx_dist_value>
         <PDBx:ptnr1_auth_asym_id>B</PDBx:ptnr1_auth_asym_id>
         <PDBx:ptnr1_auth_comp_id>TPO</PDBx:ptnr1_auth_comp_id>
         <PDBx:ptnr1_auth_seq_id>202</PDBx:ptnr1_auth_seq_id>
         <PDBx:ptnr1_label_asym_id>B</PDBx:ptnr1_label_asym_id>
         <PDBx:ptnr1_label_atom_id>C</PDBx:ptnr1_label_atom_id>
         <PDBx:ptnr1_label_comp_id>TPO</PDBx:ptnr1_label_comp_id>
         <PDBx:ptnr1_label_seq_id>2</PDBx:ptnr1_label_seq_id>
         <PDBx:ptnr1_symmetry>1_555</PDBx:ptnr1_symmetry>
         <PDBx:ptnr2_auth_asym_id>B</PDBx:ptnr2_auth_asym_id>
         <PDBx:ptnr2_auth_comp_id>TYR</PDBx:ptnr2_auth_comp_id>
         <PDBx:ptnr2_auth_seq_id>203</PDBx:ptnr2_auth_seq_id>
         <PDBx:ptnr2_label_asym_id>B</PDBx:ptnr2_label_asym_id>
         <PDBx:ptnr2_label_atom_id>N</PDBx:ptnr2_label_atom_id>
         <PDBx:ptnr2_label_comp_id>TYR</PDBx:ptnr2_label_comp_id>
         <PDBx:ptnr2_label_seq_id>3</PDBx:ptnr2_label_seq_id>
         <PDBx:ptnr2_symmetry>1_555</PDBx:ptnr2_symmetry>
      </PDBx:struct_conn>
      <PDBx:struct_conn id="covale3">
         <PDBx:conn_type_id>covale</PDBx:conn_type_id>
         <PDBx:pdbx_dist_value>1.325</PDBx:pdbx_dist_value>
         <PDBx:ptnr1_auth_asym_id>B</PDBx:ptnr1_auth_asym_id>
         <PDBx:ptnr1_auth_comp_id>HIS</PDBx:ptnr1_auth_comp_id>
         <PDBx:ptnr1_auth_seq_id>205</PDBx:ptnr1_auth_seq_id>
         <PDBx:ptnr1_label_asym_id>B</PDBx:ptnr1_label_asym_id>
         <PDBx:ptnr1_label_atom_id>C</PDBx:ptnr1_label_atom_id>
         <PDBx:ptnr1_label_comp_id>HIS</PDBx:ptnr1_label_comp_id>
         <PDBx:ptnr1_label_seq_id>5</PDBx:ptnr1_label_seq_id>
         <PDBx:ptnr1_symmetry>1_555</PDBx:ptnr1_symmetry>
         <PDBx:ptnr2_auth_asym_id>B</PDBx:ptnr2_auth_asym_id>
         <PDBx:ptnr2_auth_comp_id>SEP</PDBx:ptnr2_auth_comp_id>
         <PDBx:ptnr2_auth_seq_id>206</PDBx:ptnr2_auth_seq_id>
         <PDBx:ptnr2_label_asym_id>B</PDBx:ptnr2_label_asym_id>
         <PDBx:ptnr2_label_atom_id>N</PDBx:ptnr2_label_atom_id>
         <PDBx:ptnr2_label_comp_id>SEP</PDBx:ptnr2_label_comp_id>
         <PDBx:ptnr2_label_seq_id>6</PDBx:ptnr2_label_seq_id>
         <PDBx:ptnr2_symmetry>1_555</PDBx:ptnr2_symmetry>
      </PDBx:struct_conn>
      <PDBx:struct_conn id="covale4">
         <PDBx:conn_type_id>covale</PDBx:conn_type_id>
         <PDBx:pdbx_dist_value>1.347</PDBx:pdbx_dist_value>
         <PDBx:ptnr1_auth_asym_id>B</PDBx:ptnr1_auth_asym_id>
         <PDBx:ptnr1_auth_comp_id>SEP</PDBx:ptnr1_auth_comp_id>
         <PDBx:ptnr1_auth_seq_id>206</PDBx:ptnr1_auth_seq_id>
         <PDBx:ptnr1_label_asym_id>B</PDBx:ptnr1_label_asym_id>
         <PDBx:ptnr1_label_atom_id>C</PDBx:ptnr1_label_atom_id>
         <PDBx:ptnr1_label_comp_id>SEP</PDBx:ptnr1_label_comp_id>
         <PDBx:ptnr1_label_seq_id>6</PDBx:ptnr1_label_seq_id>
         <PDBx:ptnr1_symmetry>1_555</PDBx:ptnr1_symmetry>
         <PDBx:ptnr2_auth_asym_id>B</PDBx:ptnr2_auth_asym_id>
         <PDBx:ptnr2_auth_comp_id>PRO</PDBx:ptnr2_auth_comp_id>
         <PDBx:ptnr2_auth_seq_id>207</PDBx:ptnr2_auth_seq_id>
         <PDBx:ptnr2_label_asym_id>B</PDBx:ptnr2_label_asym_id>
         <PDBx:ptnr2_label_atom_id>N</PDBx:ptnr2_label_atom_id>
         <PDBx:ptnr2_label_comp_id>PRO</PDBx:ptnr2_label_comp_id>
         <PDBx:ptnr2_label_seq_id>7</PDBx:ptnr2_label_seq_id>
         <PDBx:ptnr2_symmetry>1_555</PDBx:ptnr2_symmetry>
      </PDBx:struct_conn>
   </PDBx:struct_connCategory>
   <PDBx:struct_conn_typeCategory>
      <PDBx:struct_conn_type id="covale">
      </PDBx:struct_conn_type>
   </PDBx:struct_conn_typeCategory>
   <PDBx:struct_keywordsCategory>
      <PDBx:struct_keywords entry_id="2LAX">
         <PDBx:pdbx_keywords>SIGNALING PROTEIN/TRANSCRIPTION</PDBx:pdbx_keywords>
         <PDBx:text>YAP, SMAD, CDK, signal transduction, SIGNALING PROTEIN-TRANSCRIPTION complex</PDBx:text>
      </PDBx:struct_keywords>
   </PDBx:struct_keywordsCategory>
   <PDBx:struct_refCategory>
      <PDBx:struct_ref id="1">
         <PDBx:biol_id xsi:nil="true" />
         <PDBx:db_code>YAP1_HUMAN</PDBx:db_code>
         <PDBx:db_name>UNP</PDBx:db_name>
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_align_begin>170</PDBx:pdbx_align_begin>
         <PDBx:pdbx_db_accession>P46937</PDBx:pdbx_db_accession>
         <PDBx:pdbx_seq_one_letter_code>DVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKA</PDBx:pdbx_seq_one_letter_code>
      </PDBx:struct_ref>
      <PDBx:struct_ref id="2">
         <PDBx:biol_id xsi:nil="true" />
         <PDBx:db_code>SMAD1_HUMAN</PDBx:db_code>
         <PDBx:db_name>UNP</PDBx:db_name>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:pdbx_align_begin>201</PDBx:pdbx_align_begin>
         <PDBx:pdbx_db_accession>Q15797</PDBx:pdbx_db_accession>
         <PDBx:pdbx_seq_one_letter_code>STYPHSPTS</PDBx:pdbx_seq_one_letter_code>
      </PDBx:struct_ref>
   </PDBx:struct_refCategory>
   <PDBx:struct_ref_seqCategory>
      <PDBx:struct_ref_seq align_id="1">
         <PDBx:db_align_beg>170</PDBx:db_align_beg>
         <PDBx:db_align_end>205</PDBx:db_align_end>
         <PDBx:pdbx_PDB_id_code>2LAX</PDBx:pdbx_PDB_id_code>
         <PDBx:pdbx_auth_seq_align_beg>170</PDBx:pdbx_auth_seq_align_beg>
         <PDBx:pdbx_auth_seq_align_end>205</PDBx:pdbx_auth_seq_align_end>
         <PDBx:pdbx_db_accession>P46937</PDBx:pdbx_db_accession>
         <PDBx:pdbx_strand_id>A</PDBx:pdbx_strand_id>
         <PDBx:ref_id>1</PDBx:ref_id>
         <PDBx:seq_align_beg>5</PDBx:seq_align_beg>
         <PDBx:seq_align_end>40</PDBx:seq_align_end>
      </PDBx:struct_ref_seq>
      <PDBx:struct_ref_seq align_id="2">
         <PDBx:db_align_beg>201</PDBx:db_align_beg>
         <PDBx:db_align_end>209</PDBx:db_align_end>
         <PDBx:pdbx_PDB_id_code>2LAX</PDBx:pdbx_PDB_id_code>
         <PDBx:pdbx_auth_seq_align_beg>201</PDBx:pdbx_auth_seq_align_beg>
         <PDBx:pdbx_auth_seq_align_end>209</PDBx:pdbx_auth_seq_align_end>
         <PDBx:pdbx_db_accession>Q15797</PDBx:pdbx_db_accession>
         <PDBx:pdbx_strand_id>B</PDBx:pdbx_strand_id>
         <PDBx:ref_id>2</PDBx:ref_id>
         <PDBx:seq_align_beg>1</PDBx:seq_align_beg>
         <PDBx:seq_align_end>9</PDBx:seq_align_end>
      </PDBx:struct_ref_seq>
   </PDBx:struct_ref_seqCategory>
   <PDBx:struct_ref_seq_difCategory>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="1">
         <PDBx:align_id>1</PDBx:align_id>
         <PDBx:details>EXPRESSION TAG</PDBx:details>
         <PDBx:mon_id>GLY</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>166</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>2LAX</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>A</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>P46937</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:seq_num>1</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="2">
         <PDBx:align_id>1</PDBx:align_id>
         <PDBx:details>EXPRESSION TAG</PDBx:details>
         <PDBx:mon_id>ALA</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>167</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>2LAX</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>A</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>P46937</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:seq_num>2</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="3">
         <PDBx:align_id>1</PDBx:align_id>
         <PDBx:details>EXPRESSION TAG</PDBx:details>
         <PDBx:mon_id>MET</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>168</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>2LAX</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>A</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>P46937</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:seq_num>3</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="4">
         <PDBx:align_id>1</PDBx:align_id>
         <PDBx:details>EXPRESSION TAG</PDBx:details>
         <PDBx:mon_id>GLU</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>169</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>2LAX</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>A</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>P46937</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:seq_num>4</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
   </PDBx:struct_ref_seq_difCategory>
   <PDBx:struct_sheetCategory>
      <PDBx:struct_sheet id="A">
         <PDBx:number_strands>3</PDBx:number_strands>
      </PDBx:struct_sheet>
   </PDBx:struct_sheetCategory>
   <PDBx:struct_sheet_orderCategory>
      <PDBx:struct_sheet_order range_id_1="1" range_id_2="2" sheet_id="A">
         <PDBx:sense>anti-parallel</PDBx:sense>
      </PDBx:struct_sheet_order>
      <PDBx:struct_sheet_order range_id_1="2" range_id_2="3" sheet_id="A">
         <PDBx:sense>anti-parallel</PDBx:sense>
      </PDBx:struct_sheet_order>
   </PDBx:struct_sheet_orderCategory>
   <PDBx:struct_sheet_rangeCategory>
      <PDBx:struct_sheet_range id="1" sheet_id="A">
         <PDBx:beg_auth_asym_id>A</PDBx:beg_auth_asym_id>
         <PDBx:beg_auth_comp_id>TRP</PDBx:beg_auth_comp_id>
         <PDBx:beg_auth_seq_id>177</PDBx:beg_auth_seq_id>
         <PDBx:beg_label_asym_id>A</PDBx:beg_label_asym_id>
         <PDBx:beg_label_comp_id>TRP</PDBx:beg_label_comp_id>
         <PDBx:beg_label_seq_id>12</PDBx:beg_label_seq_id>
         <PDBx:end_auth_asym_id>A</PDBx:end_auth_asym_id>
         <PDBx:end_auth_comp_id>THR</PDBx:end_auth_comp_id>
         <PDBx:end_auth_seq_id>182</PDBx:end_auth_seq_id>
         <PDBx:end_label_asym_id>A</PDBx:end_label_asym_id>
         <PDBx:end_label_comp_id>THR</PDBx:end_label_comp_id>
         <PDBx:end_label_seq_id>17</PDBx:end_label_seq_id>
      </PDBx:struct_sheet_range>
      <PDBx:struct_sheet_range id="2" sheet_id="A">
         <PDBx:beg_auth_asym_id>A</PDBx:beg_auth_asym_id>
         <PDBx:beg_auth_comp_id>GLN</PDBx:beg_auth_comp_id>
         <PDBx:beg_auth_seq_id>186</PDBx:beg_auth_seq_id>
         <PDBx:beg_label_asym_id>A</PDBx:beg_label_asym_id>
         <PDBx:beg_label_comp_id>GLN</PDBx:beg_label_comp_id>
         <PDBx:beg_label_seq_id>21</PDBx:beg_label_seq_id>
         <PDBx:end_auth_asym_id>A</PDBx:end_auth_asym_id>
         <PDBx:end_auth_comp_id>ASN</PDBx:end_auth_comp_id>
         <PDBx:end_auth_seq_id>191</PDBx:end_auth_seq_id>
         <PDBx:end_label_asym_id>A</PDBx:end_label_asym_id>
         <PDBx:end_label_comp_id>ASN</PDBx:end_label_comp_id>
         <PDBx:end_label_seq_id>26</PDBx:end_label_seq_id>
      </PDBx:struct_sheet_range>
      <PDBx:struct_sheet_range id="3" sheet_id="A">
         <PDBx:beg_auth_asym_id>A</PDBx:beg_auth_asym_id>
         <PDBx:beg_auth_comp_id>THR</PDBx:beg_auth_comp_id>
         <PDBx:beg_auth_seq_id>196</PDBx:beg_auth_seq_id>
         <PDBx:beg_label_asym_id>A</PDBx:beg_label_asym_id>
         <PDBx:beg_label_comp_id>THR</PDBx:beg_label_comp_id>
         <PDBx:beg_label_seq_id>31</PDBx:beg_label_seq_id>
         <PDBx:end_auth_asym_id>A</PDBx:end_auth_asym_id>
         <PDBx:end_auth_comp_id>THR</PDBx:end_auth_comp_id>
         <PDBx:end_auth_seq_id>198</PDBx:end_auth_seq_id>
         <PDBx:end_label_asym_id>A</PDBx:end_label_asym_id>
         <PDBx:end_label_comp_id>THR</PDBx:end_label_comp_id>
         <PDBx:end_label_seq_id>33</PDBx:end_label_seq_id>
      </PDBx:struct_sheet_range>
   </PDBx:struct_sheet_rangeCategory>
</PDBx:datablock>
