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         <PDBx:name>Esaki, K.</PDBx:name>
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         <PDBx:name>Terasawa, H.</PDBx:name>
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         <PDBx:type>L-peptide linking</PDBx:type>
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         <PDBx:type>L-peptide linking</PDBx:type>
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         <PDBx:name>ISOLEUCINE</PDBx:name>
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         <PDBx:name>THREONINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
   </PDBx:chem_compCategory>
   <PDBx:citationCategory>
      <PDBx:citation id="primary">
         <PDBx:country>UK</PDBx:country>
         <PDBx:journal_abbrev>Febs J.</PDBx:journal_abbrev>
         <PDBx:journal_id_ISSN>1742-464X</PDBx:journal_id_ISSN>
         <PDBx:pdbx_database_id_DOI>10.1111/febs.13096</PDBx:pdbx_database_id_DOI>
         <PDBx:pdbx_database_id_PubMed>25283965</PDBx:pdbx_database_id_PubMed>
         <PDBx:title>Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT</PDBx:title>
         <PDBx:year>2014</PDBx:year>
      </PDBx:citation>
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      <PDBx:citation_author citation_id="primary" name="Esaki, K." ordinal="1"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Yoshinaga, S." ordinal="2"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Tsuji, T." ordinal="3"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Toda, E." ordinal="4"></PDBx:citation_author>
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      <PDBx:citation_author citation_id="primary" name="Ueda, T." ordinal="10"></PDBx:citation_author>
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      <PDBx:database_PDB_rev num="1">
         <PDBx:date>2014-10-08</PDBx:date>
         <PDBx:date_original>2014-03-04</PDBx:date_original>
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      <PDBx:database_PDB_rev num="2">
         <PDBx:date>2014-10-29</PDBx:date>
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         <PDBx:pdbx_description>MCP-1 receptor</PDBx:pdbx_description>
         <PDBx:pdbx_fragment>C-Terminal region, UNP residues 90-105</PDBx:pdbx_fragment>
         <PDBx:pdbx_number_of_molecules>1</PDBx:pdbx_number_of_molecules>
         <PDBx:src_method>man</PDBx:src_method>
         <PDBx:type>polymer</PDBx:type>
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      </PDBx:entity_keywords>
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         <PDBx:name>CCR2, CHEMOKINE_(C-C_MOTIF)_RECEPTOR_2</PDBx:name>
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         <PDBx:nstd_linkage>no</PDBx:nstd_linkage>
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         <PDBx:pdbx_seq_one_letter_code>EKFRRYLSVFFRKHIT</PDBx:pdbx_seq_one_letter_code>
         <PDBx:pdbx_seq_one_letter_code_can>EKFRRYLSVFFRKHIT</PDBx:pdbx_seq_one_letter_code_can>
         <PDBx:pdbx_strand_id>A</PDBx:pdbx_strand_id>
         <PDBx:type>polypeptide(L)</PDBx:type>
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         <PDBx:hetero>n</PDBx:hetero>
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         <PDBx:hetero>n</PDBx:hetero>
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         <PDBx:hetero>n</PDBx:hetero>
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         <PDBx:hetero>n</PDBx:hetero>
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         <PDBx:hetero>n</PDBx:hetero>
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         <PDBx:hetero>n</PDBx:hetero>
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         <PDBx:hetero>n</PDBx:hetero>
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         <PDBx:gene_src_common_name>human</PDBx:gene_src_common_name>
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         <PDBx:pdbx_gene_src_ncbi_taxonomy_id>9606</PDBx:pdbx_gene_src_ncbi_taxonomy_id>
         <PDBx:pdbx_gene_src_scientific_name>Homo sapiens</PDBx:pdbx_gene_src_scientific_name>
         <PDBx:pdbx_host_org_ncbi_taxonomy_id>562</PDBx:pdbx_host_org_ncbi_taxonomy_id>
         <PDBx:pdbx_host_org_scientific_name>Escherichia Coli</PDBx:pdbx_host_org_scientific_name>
         <PDBx:pdbx_host_org_vector>Ptkk19</PDBx:pdbx_host_org_vector>
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      <PDBx:pdbx_entity_name entity_id="1" name="CCR2" name_type="RCSB_NAME"></PDBx:pdbx_entity_name>
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         <PDBx:conformer_selection_criteria>TARGET FUNCTION</PDBx:conformer_selection_criteria>
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         <PDBx:conformers_submitted_total_number>20</PDBx:conformers_submitted_total_number>
         <PDBx:representative_conformer>1</PDBx:representative_conformer>
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      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="1" solution_id="1">
         <PDBx:type>3D 1H-15N NOESY</PDBx:type>
      </PDBx:pdbx_nmr_exptl>
      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="2" solution_id="1">
         <PDBx:type>3D HNHA</PDBx:type>
      </PDBx:pdbx_nmr_exptl>
      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="3" solution_id="2">
         <PDBx:type>3D 1H-13C NOESY</PDBx:type>
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      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="4" solution_id="3">
         <PDBx:type>3D CBCA(CO)NH</PDBx:type>
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      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="5" solution_id="3">
         <PDBx:type>3D HNCACB</PDBx:type>
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      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="6" solution_id="3">
         <PDBx:type>3D HBHA(CO)NH</PDBx:type>
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      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="7" solution_id="2">
         <PDBx:type>3D HCCH- TOCSY</PDBx:type>
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      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="8" solution_id="1">
         <PDBx:type>2D 1H-15N HSQC</PDBx:type>
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      <PDBx:pdbx_nmr_exptl conditions_id="1" experiment_id="9" solution_id="2">
         <PDBx:type>2D 1H-13C HSQC</PDBx:type>
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      <PDBx:pdbx_nmr_exptl_sample component="CCR2_Pro-C-1" solution_id="1">
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         <PDBx:isotopic_labeling>[U-100&#37; 15N]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium phosphate-2" solution_id="1">
         <PDBx:concentration>20</PDBx:concentration>
         <PDBx:concentration_units>uM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium chloride-3" solution_id="1">
         <PDBx:concentration>50</PDBx:concentration>
         <PDBx:concentration_units>uM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="DPC-4" solution_id="1">
         <PDBx:concentration>10</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
         <PDBx:isotopic_labeling>[U-99&#37; 2H]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="D2O-5" solution_id="1">
         <PDBx:concentration>5</PDBx:concentration>
         <PDBx:concentration_units>&#37;</PDBx:concentration_units>
         <PDBx:isotopic_labeling>[U-100&#37; 2H]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="H2O-6" solution_id="1">
         <PDBx:concentration>95</PDBx:concentration>
         <PDBx:concentration_units>&#37;</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="CCR2_Pro-C-7" solution_id="2">
         <PDBx:concentration>200</PDBx:concentration>
         <PDBx:concentration_units>uM</PDBx:concentration_units>
         <PDBx:isotopic_labeling>[U-100&#37; 13C; U-100&#37; 15N]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium phosphate-8" solution_id="2">
         <PDBx:concentration>20</PDBx:concentration>
         <PDBx:concentration_units>uM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium chloride-9" solution_id="2">
         <PDBx:concentration>50</PDBx:concentration>
         <PDBx:concentration_units>uM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="DPC-10" solution_id="2">
         <PDBx:concentration>10</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
         <PDBx:isotopic_labeling>[U-99&#37; 2H]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="D2O-11" solution_id="2">
         <PDBx:concentration>100</PDBx:concentration>
         <PDBx:concentration_units>&#37;</PDBx:concentration_units>
         <PDBx:isotopic_labeling>[U-100&#37; 2H]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="CCR2_Pro-C-12" solution_id="3">
         <PDBx:concentration>200</PDBx:concentration>
         <PDBx:concentration_units>uM</PDBx:concentration_units>
         <PDBx:isotopic_labeling>[U-100&#37; 13C; U-100&#37; 15N]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium phosphate-13" solution_id="3">
         <PDBx:concentration>20</PDBx:concentration>
         <PDBx:concentration_units>uM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="sodium chloride-14" solution_id="3">
         <PDBx:concentration>50</PDBx:concentration>
         <PDBx:concentration_units>uM</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="DPC-15" solution_id="3">
         <PDBx:concentration>10</PDBx:concentration>
         <PDBx:concentration_units>mM</PDBx:concentration_units>
         <PDBx:isotopic_labeling>[U-99&#37; 2H]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="D2O-16" solution_id="3">
         <PDBx:concentration>5</PDBx:concentration>
         <PDBx:concentration_units>&#37;</PDBx:concentration_units>
         <PDBx:isotopic_labeling>[U-100&#37; 2H]</PDBx:isotopic_labeling>
      </PDBx:pdbx_nmr_exptl_sample>
      <PDBx:pdbx_nmr_exptl_sample component="H2O-17" solution_id="3">
         <PDBx:concentration>95</PDBx:concentration>
         <PDBx:concentration_units>&#37;</PDBx:concentration_units>
      </PDBx:pdbx_nmr_exptl_sample>
   </PDBx:pdbx_nmr_exptl_sampleCategory>
   <PDBx:pdbx_nmr_exptl_sample_conditionsCategory>
      <PDBx:pdbx_nmr_exptl_sample_conditions conditions_id="1">
         <PDBx:pH>6.5</PDBx:pH>
         <PDBx:pressure>AMBIENT</PDBx:pressure>
         <PDBx:temperature>298</PDBx:temperature>
      </PDBx:pdbx_nmr_exptl_sample_conditions>
   </PDBx:pdbx_nmr_exptl_sample_conditionsCategory>
   <PDBx:pdbx_nmr_representativeCategory>
      <PDBx:pdbx_nmr_representative entry_id="2MLO">
         <PDBx:conformer_id>1</PDBx:conformer_id>
         <PDBx:selection_criteria>lowest energy</PDBx:selection_criteria>
      </PDBx:pdbx_nmr_representative>
   </PDBx:pdbx_nmr_representativeCategory>
   <PDBx:pdbx_nmr_sample_detailsCategory>
      <PDBx:pdbx_nmr_sample_details solution_id="1">
         <PDBx:contents>200 uM [U-100&#37; 15N] CCR2_Pro-C-1, 20 uM sodium phosphate-2, 50 uM sodium chloride-3, 10 mM [U-99&#37; 2H] DPC-4, 5 &#37; [U-100&#37; 2H] D2O-5, 95 &#37; H2O-6</PDBx:contents>
         <PDBx:solvent_system>95&#37; H2O/5&#37; D2O</PDBx:solvent_system>
      </PDBx:pdbx_nmr_sample_details>
      <PDBx:pdbx_nmr_sample_details solution_id="2">
         <PDBx:contents>200 uM [U-100&#37; 13C; U-100&#37; 15N] CCR2_Pro-C-7, 20 uM sodium phosphate-8, 50 uM sodium chloride-9, 10 mM [U-99&#37; 2H] DPC-10, 100 &#37; [U-100&#37; 2H] D2O-11</PDBx:contents>
         <PDBx:solvent_system>100&#37; D2O</PDBx:solvent_system>
      </PDBx:pdbx_nmr_sample_details>
      <PDBx:pdbx_nmr_sample_details solution_id="3">
         <PDBx:contents>200 uM [U-100&#37; 13C; U-100&#37; 15N] CCR2_Pro-C-12, 20 uM sodium phosphate-13, 50 uM sodium chloride-14, 10 mM [U-99&#37; 2H] DPC-15, 5 &#37; [U-100&#37; 2H] D2O-16, 95 &#37; H2O-17</PDBx:contents>
         <PDBx:solvent_system>95&#37; H2O/5&#37; D2O</PDBx:solvent_system>
      </PDBx:pdbx_nmr_sample_details>
   </PDBx:pdbx_nmr_sample_detailsCategory>
   <PDBx:pdbx_nmr_softwareCategory>
      <PDBx:pdbx_nmr_software ordinal="1">
         <PDBx:authors>GUNTERT, MUMENTHALER</PDBx:authors>
         <PDBx:classification>structure solution</PDBx:classification>
         <PDBx:name>CYANA</PDBx:name>
      </PDBx:pdbx_nmr_software>
      <PDBx:pdbx_nmr_software ordinal="2">
         <PDBx:authors>GUNTERT, MUMENTHALER</PDBx:authors>
         <PDBx:classification>refinement</PDBx:classification>
         <PDBx:name>CYANA</PDBx:name>
      </PDBx:pdbx_nmr_software>
   </PDBx:pdbx_nmr_softwareCategory>
   <PDBx:pdbx_nmr_spectrometerCategory>
      <PDBx:pdbx_nmr_spectrometer spectrometer_id="1">
         <PDBx:field_strength>600</PDBx:field_strength>
         <PDBx:manufacturer>BRUKER</PDBx:manufacturer>
         <PDBx:model>AVANCE III</PDBx:model>
         <PDBx:type>BRUKER AVANCE III</PDBx:type>
      </PDBx:pdbx_nmr_spectrometer>
      <PDBx:pdbx_nmr_spectrometer spectrometer_id="2">
         <PDBx:field_strength>600</PDBx:field_strength>
         <PDBx:manufacturer>Bruker</PDBx:manufacturer>
         <PDBx:model>Avance</PDBx:model>
         <PDBx:type>Bruker Avance</PDBx:type>
      </PDBx:pdbx_nmr_spectrometer>
   </PDBx:pdbx_nmr_spectrometerCategory>
   <PDBx:pdbx_poly_seq_schemeCategory>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLU" seq_id="1">
         <PDBx:auth_mon_id>GLU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>1</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>1</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LYS" seq_id="2">
         <PDBx:auth_mon_id>LYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>2</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>2</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>2</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PHE" seq_id="3">
         <PDBx:auth_mon_id>PHE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>3</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>3</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PHE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>3</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ARG" seq_id="4">
         <PDBx:auth_mon_id>ARG</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>4</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>4</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ARG</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>4</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ARG" seq_id="5">
         <PDBx:auth_mon_id>ARG</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>5</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>5</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ARG</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>5</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="TYR" seq_id="6">
         <PDBx:auth_mon_id>TYR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>6</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>6</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>TYR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>6</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="7">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>7</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>7</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>7</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="8">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>8</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>8</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>8</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="VAL" seq_id="9">
         <PDBx:auth_mon_id>VAL</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>9</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>9</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>VAL</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>9</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PHE" seq_id="10">
         <PDBx:auth_mon_id>PHE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>10</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>10</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PHE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>10</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PHE" seq_id="11">
         <PDBx:auth_mon_id>PHE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>11</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>11</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PHE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>11</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ARG" seq_id="12">
         <PDBx:auth_mon_id>ARG</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>12</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>12</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ARG</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>12</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LYS" seq_id="13">
         <PDBx:auth_mon_id>LYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>13</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>13</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>13</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="HIS" seq_id="14">
         <PDBx:auth_mon_id>HIS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>14</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>14</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HIS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>14</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ILE" seq_id="15">
         <PDBx:auth_mon_id>ILE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>15</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>15</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ILE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>15</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="THR" seq_id="16">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>16</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>16</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>16</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
   </PDBx:pdbx_poly_seq_schemeCategory>
   <PDBx:pdbx_struct_assemblyCategory>
      <PDBx:pdbx_struct_assembly id="1">
         <PDBx:details>author_defined_assembly</PDBx:details>
         <PDBx:oligomeric_count>1</PDBx:oligomeric_count>
         <PDBx:oligomeric_details>monomeric</PDBx:oligomeric_details>
      </PDBx:pdbx_struct_assembly>
   </PDBx:pdbx_struct_assemblyCategory>
   <PDBx:pdbx_struct_assembly_genCategory>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A" oper_expression="1"></PDBx:pdbx_struct_assembly_gen>
   </PDBx:pdbx_struct_assembly_genCategory>
   <PDBx:pdbx_struct_oper_listCategory>
      <PDBx:pdbx_struct_oper_list id="1">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_555</PDBx:name>
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      <PDBx:pdbx_validate_torsion id="2">
         <PDBx:PDB_model_num>2</PDBx:PDB_model_num>
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      <PDBx:pdbx_validate_torsion id="9">
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      <PDBx:pdbx_validate_torsion id="10">
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      <PDBx:pdbx_validate_torsion id="13">
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         <PDBx:PDB_model_num>14</PDBx:PDB_model_num>
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      <PDBx:pdbx_validate_torsion id="18">
         <PDBx:PDB_model_num>15</PDBx:PDB_model_num>
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      <PDBx:pdbx_validate_torsion id="19">
         <PDBx:PDB_model_num>15</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>ILE</PDBx:auth_comp_id>
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      <PDBx:pdbx_validate_torsion id="20">
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      <PDBx:pdbx_validate_torsion id="21">
         <PDBx:PDB_model_num>16</PDBx:PDB_model_num>
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      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="22">
         <PDBx:PDB_model_num>17</PDBx:PDB_model_num>
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      <PDBx:pdbx_validate_torsion id="23">
         <PDBx:PDB_model_num>17</PDBx:PDB_model_num>
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      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="24">
         <PDBx:PDB_model_num>18</PDBx:PDB_model_num>
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         <PDBx:auth_comp_id>HIS</PDBx:auth_comp_id>
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      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="25">
         <PDBx:PDB_model_num>19</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>HIS</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>14</PDBx:auth_seq_id>
         <PDBx:phi>-94.85</PDBx:phi>
         <PDBx:psi>-62.31</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
      <PDBx:pdbx_validate_torsion id="26">
         <PDBx:PDB_model_num>20</PDBx:PDB_model_num>
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>HIS</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>14</PDBx:auth_seq_id>
         <PDBx:phi>-98.55</PDBx:phi>
         <PDBx:psi>-63.94</PDBx:psi>
      </PDBx:pdbx_validate_torsion>
   </PDBx:pdbx_validate_torsionCategory>
   <PDBx:pdbx_versionCategory>
      <PDBx:pdbx_version entry_id="2MLO" major_version="4" minor_version="0000" revision_type="Initial release">
         <PDBx:details>Initial release</PDBx:details>
         <PDBx:revision_date>2014-10-08</PDBx:revision_date>
      </PDBx:pdbx_version>
      <PDBx:pdbx_version entry_id="2MLO" major_version="4" minor_version="0000" revision_type="Citation">
         <PDBx:details>Citation update</PDBx:details>
         <PDBx:revision_date>2014-10-08</PDBx:revision_date>
      </PDBx:pdbx_version>
      <PDBx:pdbx_version entry_id="2MLO" major_version="4" minor_version="0001" revision_type="Citation">
         <PDBx:details>Citation update</PDBx:details>
         <PDBx:revision_date>2014-10-29</PDBx:revision_date>
      </PDBx:pdbx_version>
   </PDBx:pdbx_versionCategory>
   <PDBx:structCategory>
      <PDBx:struct entry_id="2MLO">
         <PDBx:pdbx_descriptor>MCP-1 receptor</PDBx:pdbx_descriptor>
         <PDBx:pdbx_model_details>lowest energy, model1</PDBx:pdbx_model_details>
         <PDBx:title>Human CCR2 Membrane-Proximal C-Terminal Region (PRO-C) in a Membrane bound form</PDBx:title>
      </PDBx:struct>
   </PDBx:structCategory>
   <PDBx:struct_asymCategory>
      <PDBx:struct_asym id="A">
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
   </PDBx:struct_asymCategory>
   <PDBx:struct_biolCategory>
      <PDBx:struct_biol id="1">
      </PDBx:struct_biol>
   </PDBx:struct_biolCategory>
   <PDBx:struct_confCategory>
      <PDBx:struct_conf id="HELX_P1">
         <PDBx:beg_auth_asym_id>A</PDBx:beg_auth_asym_id>
         <PDBx:beg_auth_comp_id>PHE</PDBx:beg_auth_comp_id>
         <PDBx:beg_auth_seq_id>3</PDBx:beg_auth_seq_id>
         <PDBx:beg_label_asym_id>A</PDBx:beg_label_asym_id>
         <PDBx:beg_label_comp_id>PHE</PDBx:beg_label_comp_id>
         <PDBx:beg_label_seq_id>3</PDBx:beg_label_seq_id>
         <PDBx:conf_type_id>HELX_P</PDBx:conf_type_id>
         <PDBx:end_auth_asym_id>A</PDBx:end_auth_asym_id>
         <PDBx:end_auth_comp_id>LYS</PDBx:end_auth_comp_id>
         <PDBx:end_auth_seq_id>13</PDBx:end_auth_seq_id>
         <PDBx:end_label_asym_id>A</PDBx:end_label_asym_id>
         <PDBx:end_label_comp_id>LYS</PDBx:end_label_comp_id>
         <PDBx:end_label_seq_id>13</PDBx:end_label_seq_id>
         <PDBx:pdbx_PDB_helix_class>1</PDBx:pdbx_PDB_helix_class>
         <PDBx:pdbx_PDB_helix_id>1</PDBx:pdbx_PDB_helix_id>
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      </PDBx:struct_conf>
   </PDBx:struct_confCategory>
   <PDBx:struct_conf_typeCategory>
      <PDBx:struct_conf_type id="HELX_P">
      </PDBx:struct_conf_type>
   </PDBx:struct_conf_typeCategory>
   <PDBx:struct_keywordsCategory>
      <PDBx:struct_keywords entry_id="2MLO">
         <PDBx:pdbx_keywords>SIGNALING PROTEIN</PDBx:pdbx_keywords>
         <PDBx:text>CCR2, PRO-C, SIGNALING PROTEIN</PDBx:text>
      </PDBx:struct_keywords>
   </PDBx:struct_keywordsCategory>
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      <PDBx:struct_ref id="1">
         <PDBx:biol_id xsi:nil="true" />
         <PDBx:db_code>O95950_HUMAN</PDBx:db_code>
         <PDBx:db_name>UNP</PDBx:db_name>
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_align_begin>90</PDBx:pdbx_align_begin>
         <PDBx:pdbx_db_accession>O95950</PDBx:pdbx_db_accession>
         <PDBx:pdbx_seq_one_letter_code>EKFRRYLSVFFRKHIT</PDBx:pdbx_seq_one_letter_code>
      </PDBx:struct_ref>
   </PDBx:struct_refCategory>
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      <PDBx:struct_ref_seq align_id="1">
         <PDBx:db_align_beg>90</PDBx:db_align_beg>
         <PDBx:db_align_end>105</PDBx:db_align_end>
         <PDBx:pdbx_PDB_id_code>2MLO</PDBx:pdbx_PDB_id_code>
         <PDBx:pdbx_auth_seq_align_beg>1</PDBx:pdbx_auth_seq_align_beg>
         <PDBx:pdbx_auth_seq_align_end>16</PDBx:pdbx_auth_seq_align_end>
         <PDBx:pdbx_db_accession>O95950</PDBx:pdbx_db_accession>
         <PDBx:pdbx_strand_id>A</PDBx:pdbx_strand_id>
         <PDBx:ref_id>1</PDBx:ref_id>
         <PDBx:seq_align_beg>1</PDBx:seq_align_beg>
         <PDBx:seq_align_end>16</PDBx:seq_align_end>
      </PDBx:struct_ref_seq>
   </PDBx:struct_ref_seqCategory>
</PDBx:datablock>
