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         <PDBx:name>Yu, L.</PDBx:name>
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         <PDBx:title>Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.</PDBx:title>
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         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="C" ndb_seq_num="5">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>4</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>1205</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="D" ndb_seq_num="1">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>2</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>201</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="D" ndb_seq_num="2">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>202</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="D" ndb_seq_num="3">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>3</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>203</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="D" ndb_seq_num="4">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>7</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>204</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
   </PDBx:pdbx_nonpoly_schemeCategory>
   <PDBx:pdbx_poly_seq_schemeCategory>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLY" seq_id="1">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>127</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>1</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>127</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="TYR" seq_id="2">
         <PDBx:auth_mon_id>TYR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>128</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>2</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>TYR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>128</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="MET" seq_id="3">
         <PDBx:auth_mon_id>MET</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>129</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>3</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>MET</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>129</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="4">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>130</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>4</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>130</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLY" seq_id="5">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>131</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>5</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>131</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="6">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>132</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>6</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>132</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ALA" seq_id="7">
         <PDBx:auth_mon_id>ALA</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1133</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>7</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ALA</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>1133</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="GLY" seq_id="1">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>127</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>1</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>127</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="TYR" seq_id="2">
         <PDBx:auth_mon_id>TYR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>128</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>2</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>TYR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>128</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="MET" seq_id="3">
         <PDBx:auth_mon_id>MET</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>129</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>3</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>MET</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>129</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="LEU" seq_id="4">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>130</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>4</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>130</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="GLY" seq_id="5">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>131</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>5</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>131</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="SER" seq_id="6">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>132</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>6</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>132</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="ALA" seq_id="7">
         <PDBx:auth_mon_id>ALA</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>133</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>7</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ALA</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>133</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
   </PDBx:pdbx_poly_seq_schemeCategory>
   <PDBx:pdbx_struct_assemblyCategory>
      <PDBx:pdbx_struct_assembly id="1">
         <PDBx:details>author_defined_assembly</PDBx:details>
         <PDBx:oligomeric_count>8</PDBx:oligomeric_count>
      </PDBx:pdbx_struct_assembly>
   </PDBx:pdbx_struct_assemblyCategory>
   <PDBx:pdbx_struct_assembly_genCategory>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,C" oper_expression="1,2,3,4"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="B,D" oper_expression="1,2,5,6"></PDBx:pdbx_struct_assembly_gen>
   </PDBx:pdbx_struct_assembly_genCategory>
   <PDBx:pdbx_struct_oper_listCategory>
      <PDBx:pdbx_struct_oper_list id="1">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_555</PDBx:name>
         <PDBx:type>identity operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>0.0000000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="2">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_655</PDBx:name>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>9.4670000000</PDBx:vector1>
         <PDBx:vector2>0.0000000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="3">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_665</PDBx:name>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>13.5877311168</PDBx:vector1>
         <PDBx:vector2>9.5912614427</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="4">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_565</PDBx:name>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>4.1207311168</PDBx:vector1>
         <PDBx:vector2>9.5912614427</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="5">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_545</PDBx:name>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>-4.1207311168</PDBx:vector1>
         <PDBx:vector2>-9.5912614427</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="6">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_645</PDBx:name>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>5.3462688832</PDBx:vector1>
         <PDBx:vector2>-9.5912614427</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
   </PDBx:pdbx_struct_oper_listCategory>
   <PDBx:pdbx_versionCategory>
      <PDBx:pdbx_version entry_id="4W5Y" major_version="4" minor_version="0000" revision_type="Initial release">
         <PDBx:details>Initial release</PDBx:details>
         <PDBx:revision_date>2015-05-27</PDBx:revision_date>
      </PDBx:pdbx_version>
      <PDBx:pdbx_version entry_id="4W5Y" major_version="4" minor_version="0001" revision_type="Biological assembly">
         <PDBx:details>Biological assembly</PDBx:details>
         <PDBx:revision_date>2015-06-10</PDBx:revision_date>
      </PDBx:pdbx_version>
      <PDBx:pdbx_version entry_id="4W5Y" major_version="4" minor_version="0002" revision_type="Citation">
         <PDBx:details>Citation</PDBx:details>
         <PDBx:revision_date>2015-07-01</PDBx:revision_date>
      </PDBx:pdbx_version>
   </PDBx:pdbx_versionCategory>
   <PDBx:refineCategory>
      <PDBx:refine entry_id="4W5Y" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:B_iso_max>8.990</PDBx:B_iso_max>
         <PDBx:B_iso_mean>2.7084</PDBx:B_iso_mean>
         <PDBx:B_iso_min>0.930</PDBx:B_iso_min>
         <PDBx:ls_R_factor_R_free>0.1000</PDBx:ls_R_factor_R_free>
         <PDBx:ls_R_factor_R_work>0.0812</PDBx:ls_R_factor_R_work>
         <PDBx:ls_R_factor_obs>0.0822</PDBx:ls_R_factor_obs>
         <PDBx:ls_d_res_high>1.1220</PDBx:ls_d_res_high>
         <PDBx:ls_d_res_low>10.7840</PDBx:ls_d_res_low>
         <PDBx:ls_number_reflns_R_free>130</PDBx:ls_number_reflns_R_free>
         <PDBx:ls_number_reflns_R_work>2744</PDBx:ls_number_reflns_R_work>
         <PDBx:ls_number_reflns_obs>2874</PDBx:ls_number_reflns_obs>
         <PDBx:ls_percent_reflns_R_free>4.5200</PDBx:ls_percent_reflns_R_free>
         <PDBx:ls_percent_reflns_obs>98.7300</PDBx:ls_percent_reflns_obs>
         <PDBx:overall_SU_ML>0.0000</PDBx:overall_SU_ML>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_ls_cross_valid_method>FREE R-VALUE</PDBx:pdbx_ls_cross_valid_method>
         <PDBx:pdbx_ls_sigma_F>2.210</PDBx:pdbx_ls_sigma_F>
         <PDBx:pdbx_method_to_determine_struct>AB INITIO PHASING</PDBx:pdbx_method_to_determine_struct>
         <PDBx:pdbx_overall_phase_error>10.1300</PDBx:pdbx_overall_phase_error>
         <PDBx:pdbx_solvent_shrinkage_radii>0.9000</PDBx:pdbx_solvent_shrinkage_radii>
         <PDBx:pdbx_solvent_vdw_probe_radii>1.1100</PDBx:pdbx_solvent_vdw_probe_radii>
         <PDBx:pdbx_stereochemistry_target_values>ML</PDBx:pdbx_stereochemistry_target_values>
         <PDBx:solvent_model_details>FLAT BULK SOLVENT MODEL</PDBx:solvent_model_details>
      </PDBx:refine>
   </PDBx:refineCategory>
   <PDBx:refine_histCategory>
      <PDBx:refine_hist cycle_id="final" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:d_res_high>1.1220</PDBx:d_res_high>
         <PDBx:d_res_low>10.7840</PDBx:d_res_low>
         <PDBx:number_atoms_solvent>9</PDBx:number_atoms_solvent>
         <PDBx:number_atoms_total>105</PDBx:number_atoms_total>
         <PDBx:pdbx_B_iso_mean_solvent>7.03</PDBx:pdbx_B_iso_mean_solvent>
         <PDBx:pdbx_number_atoms_ligand>0</PDBx:pdbx_number_atoms_ligand>
         <PDBx:pdbx_number_atoms_nucleic_acid>0</PDBx:pdbx_number_atoms_nucleic_acid>
         <PDBx:pdbx_number_atoms_protein>96</PDBx:pdbx_number_atoms_protein>
         <PDBx:pdbx_number_residues_total>14</PDBx:pdbx_number_residues_total>
      </PDBx:refine_hist>
   </PDBx:refine_histCategory>
   <PDBx:refine_ls_restrCategory>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="f_bond_d">
         <PDBx:dev_ideal>0.009</PDBx:dev_ideal>
         <PDBx:number>102</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="f_angle_d">
         <PDBx:dev_ideal>1.259</PDBx:dev_ideal>
         <PDBx:number>135</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="f_chiral_restr">
         <PDBx:dev_ideal>0.053</PDBx:dev_ideal>
         <PDBx:number>13</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="f_plane_restr">
         <PDBx:dev_ideal>0.004</PDBx:dev_ideal>
         <PDBx:number>17</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="f_dihedral_angle_d">
         <PDBx:dev_ideal>12.237</PDBx:dev_ideal>
         <PDBx:number>37</PDBx:number>
      </PDBx:refine_ls_restr>
   </PDBx:refine_ls_restrCategory>
   <PDBx:refine_ls_shellCategory>
      <PDBx:refine_ls_shell d_res_high="1.1224" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:R_factor_R_free>0.1000</PDBx:R_factor_R_free>
         <PDBx:R_factor_R_work>0.0812</PDBx:R_factor_R_work>
         <PDBx:d_res_low>10.7844</PDBx:d_res_low>
         <PDBx:number_reflns_R_free>130</PDBx:number_reflns_R_free>
         <PDBx:number_reflns_R_work>2744</PDBx:number_reflns_R_work>
         <PDBx:number_reflns_all>2874</PDBx:number_reflns_all>
         <PDBx:pdbx_total_number_of_bins_used>1</PDBx:pdbx_total_number_of_bins_used>
         <PDBx:percent_reflns_obs>99.0000</PDBx:percent_reflns_obs>
      </PDBx:refine_ls_shell>
   </PDBx:refine_ls_shellCategory>
   <PDBx:reflnsCategory>
      <PDBx:reflns pdbx_ordinal="1">
         <PDBx:B_iso_Wilson_estimate>1.890</PDBx:B_iso_Wilson_estimate>
         <PDBx:d_resolution_high>1.120</PDBx:d_resolution_high>
         <PDBx:d_resolution_low>50.000</PDBx:d_resolution_low>
         <PDBx:entry_id>4W5Y</PDBx:entry_id>
         <PDBx:number_obs>2879</PDBx:number_obs>
         <PDBx:pdbx_Rmerge_I_obs>0.056</PDBx:pdbx_Rmerge_I_obs>
         <PDBx:pdbx_chi_squared>1.000</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_netI_over_av_sigmaI>41.126</PDBx:pdbx_netI_over_av_sigmaI>
         <PDBx:pdbx_netI_over_sigmaI>17.200</PDBx:pdbx_netI_over_sigmaI>
         <PDBx:pdbx_number_measured_all>28915</PDBx:pdbx_number_measured_all>
         <PDBx:pdbx_redundancy>10.000</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_obs>98.400</PDBx:percent_possible_obs>
      </PDBx:reflns>
   </PDBx:reflnsCategory>
   <PDBx:reflns_shellCategory>
      <PDBx:reflns_shell pdbx_ordinal="1">
         <PDBx:Rmerge_I_obs>0.083</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.120</PDBx:d_res_high>
         <PDBx:d_res_low>1.160</PDBx:d_res_low>
         <PDBx:number_unique_all>273</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>0.975</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>6.900</PDBx:pdbx_redundancy>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>90.700</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="2">
         <PDBx:Rmerge_I_obs>0.088</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.160</PDBx:d_res_high>
         <PDBx:d_res_low>1.210</PDBx:d_res_low>
         <PDBx:number_unique_all>295</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.003</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>9.600</PDBx:pdbx_redundancy>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>98.300</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="3">
         <PDBx:Rmerge_I_obs>0.088</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.210</PDBx:d_res_high>
         <PDBx:d_res_low>1.260</PDBx:d_res_low>
         <PDBx:number_unique_all>278</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.005</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>10.000</PDBx:pdbx_redundancy>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>98.900</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="4">
         <PDBx:Rmerge_I_obs>0.070</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.260</PDBx:d_res_high>
         <PDBx:d_res_low>1.330</PDBx:d_res_low>
         <PDBx:number_unique_all>293</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.009</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>9.400</PDBx:pdbx_redundancy>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>99.300</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="5">
         <PDBx:Rmerge_I_obs>0.077</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.330</PDBx:d_res_high>
         <PDBx:d_res_low>1.410</PDBx:d_res_low>
         <PDBx:number_unique_all>281</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.000</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>10.100</PDBx:pdbx_redundancy>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>99.600</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="6">
         <PDBx:Rmerge_I_obs>0.062</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.410</PDBx:d_res_high>
         <PDBx:d_res_low>1.520</PDBx:d_res_low>
         <PDBx:number_unique_all>301</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.000</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>10.400</PDBx:pdbx_redundancy>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="7">
         <PDBx:Rmerge_I_obs>0.062</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.520</PDBx:d_res_high>
         <PDBx:d_res_low>1.670</PDBx:d_res_low>
         <PDBx:number_unique_all>284</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>0.996</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>11.000</PDBx:pdbx_redundancy>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>99.300</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="8">
         <PDBx:Rmerge_I_obs>0.051</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.670</PDBx:d_res_high>
         <PDBx:d_res_low>1.920</PDBx:d_res_low>
         <PDBx:number_unique_all>301</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>0.991</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>10.800</PDBx:pdbx_redundancy>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="9">
         <PDBx:Rmerge_I_obs>0.044</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.920</PDBx:d_res_high>
         <PDBx:d_res_low>2.410</PDBx:d_res_low>
         <PDBx:number_unique_all>289</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.007</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>11.400</PDBx:pdbx_redundancy>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>99.700</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="10">
         <PDBx:Rmerge_I_obs>0.040</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.410</PDBx:d_res_high>
         <PDBx:d_res_low>50.000</PDBx:d_res_low>
         <PDBx:number_unique_all>284</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.008</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>10.700</PDBx:pdbx_redundancy>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>98.300</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
   </PDBx:reflns_shellCategory>
   <PDBx:softwareCategory>
      <PDBx:software pdbx_ordinal="1">
         <PDBx:classification>data reduction</PDBx:classification>
         <PDBx:name>HKL-2000</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="2">
         <PDBx:classification>data extraction</PDBx:classification>
         <PDBx:name>PDB_EXTRACT</PDBx:name>
         <PDBx:version>3.15</PDBx:version>
      </PDBx:software>
      <PDBx:software pdbx_ordinal="3">
         <PDBx:classification>phasing</PDBx:classification>
         <PDBx:name>SHELX</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="4">
         <PDBx:classification>refinement</PDBx:classification>
         <PDBx:name>PHENIX</PDBx:name>
         <PDBx:version>(phenix.refine: 1.9_1692)</PDBx:version>
      </PDBx:software>
      <PDBx:software pdbx_ordinal="5">
         <PDBx:classification>data scaling</PDBx:classification>
         <PDBx:name>HKL</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
   </PDBx:softwareCategory>
   <PDBx:structCategory>
      <PDBx:struct entry_id="4W5Y">
         <PDBx:pdbx_descriptor>GLY-TYR-MET-LEU-GLY-SER-ALA</PDBx:pdbx_descriptor>
         <PDBx:title>Crystal structure of Prp pepttide</PDBx:title>
      </PDBx:struct>
   </PDBx:structCategory>
   <PDBx:struct_asymCategory>
      <PDBx:struct_asym id="A">
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="B">
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="C">
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="D">
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
   </PDBx:struct_asymCategory>
   <PDBx:struct_biolCategory>
      <PDBx:struct_biol id="1">
         <PDBx:details>BIOLOGICAL UNIT DISPLAYS ONLY A PORTION OF THE CRYSTAL       
LATTICE TO DEMONSTRATE THE CRYSTAL PACKING CONTENT. THE CRYSTAL      
PACKING IS FORMED BY A REPETITION IN BOTH DIRECTIONS OF THE PORTION   INDICATED IN REMARK 350.</PDBx:details>
      </PDBx:struct_biol>
   </PDBx:struct_biolCategory>
   <PDBx:struct_keywordsCategory>
      <PDBx:struct_keywords entry_id="4W5Y">
         <PDBx:pdbx_keywords>de novo protein, membrane protein</PDBx:pdbx_keywords>
         <PDBx:text>prion peptide, membrane protein, de novo protein</PDBx:text>
      </PDBx:struct_keywords>
   </PDBx:struct_keywordsCategory>
   <PDBx:struct_refCategory>
      <PDBx:struct_ref id="1">
         <PDBx:db_code>4W5Y</PDBx:db_code>
         <PDBx:db_name>PDB</PDBx:db_name>
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_align_begin>1</PDBx:pdbx_align_begin>
         <PDBx:pdbx_db_accession>4W5Y</PDBx:pdbx_db_accession>
      </PDBx:struct_ref>
   </PDBx:struct_refCategory>
   <PDBx:struct_ref_seqCategory>
      <PDBx:struct_ref_seq align_id="1">
         <PDBx:db_align_beg>127</PDBx:db_align_beg>
         <PDBx:db_align_end>1133</PDBx:db_align_end>
         <PDBx:pdbx_PDB_id_code>4W5Y</PDBx:pdbx_PDB_id_code>
         <PDBx:pdbx_auth_seq_align_beg>127</PDBx:pdbx_auth_seq_align_beg>
         <PDBx:pdbx_auth_seq_align_end>1133</PDBx:pdbx_auth_seq_align_end>
         <PDBx:pdbx_db_accession>4W5Y</PDBx:pdbx_db_accession>
         <PDBx:pdbx_strand_id>A</PDBx:pdbx_strand_id>
         <PDBx:ref_id>1</PDBx:ref_id>
         <PDBx:seq_align_beg>1</PDBx:seq_align_beg>
         <PDBx:seq_align_end>7</PDBx:seq_align_end>
      </PDBx:struct_ref_seq>
      <PDBx:struct_ref_seq align_id="2">
         <PDBx:db_align_beg>127</PDBx:db_align_beg>
         <PDBx:db_align_end>133</PDBx:db_align_end>
         <PDBx:pdbx_PDB_id_code>4W5Y</PDBx:pdbx_PDB_id_code>
         <PDBx:pdbx_auth_seq_align_beg>127</PDBx:pdbx_auth_seq_align_beg>
         <PDBx:pdbx_auth_seq_align_end>133</PDBx:pdbx_auth_seq_align_end>
         <PDBx:pdbx_db_accession>4W5Y</PDBx:pdbx_db_accession>
         <PDBx:pdbx_strand_id>B</PDBx:pdbx_strand_id>
         <PDBx:ref_id>1</PDBx:ref_id>
         <PDBx:seq_align_beg>1</PDBx:seq_align_beg>
         <PDBx:seq_align_end>7</PDBx:seq_align_end>
      </PDBx:struct_ref_seq>
   </PDBx:struct_ref_seqCategory>
   <PDBx:symmetryCategory>
      <PDBx:symmetry entry_id="4W5Y">
         <PDBx:Int_Tables_number>1</PDBx:Int_Tables_number>
         <PDBx:space_group_name_H-M>P 1</PDBx:space_group_name_H-M>
      </PDBx:symmetry>
   </PDBx:symmetryCategory>
</PDBx:datablock>
