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         <PDBx:journal_id_ASTM>NATUAS</PDBx:journal_id_ASTM>
         <PDBx:journal_id_CSD>0006</PDBx:journal_id_CSD>
         <PDBx:journal_id_ISSN>1476-4687</PDBx:journal_id_ISSN>
         <PDBx:journal_volume>525</PDBx:journal_volume>
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         <PDBx:page_last>490</PDBx:page_last>
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         <PDBx:pdbx_database_id_PubMed>26352473</PDBx:pdbx_database_id_PubMed>
         <PDBx:title>Structure of the toxic core of alpha-synuclein from invisible crystals.</PDBx:title>
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         <PDBx:detector>CMOS</PDBx:detector>
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         <PDBx:pdbx_monochromatic_or_laue_m_l>M</PDBx:pdbx_monochromatic_or_laue_m_l>
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         <PDBx:source>ELECTRON MICROSCOPE</PDBx:source>
         <PDBx:type>OTHER</PDBx:type>
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         <PDBx:type>TVIPS F416 CMOS CAMERA by TIETZ</PDBx:type>
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         <PDBx:name>Human alpha-synuclein</PDBx:name>
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         <PDBx:illumination_mode>FLOOD BEAM</PDBx:illumination_mode>
         <PDBx:microscope_model>FEI TECNAI F20</PDBx:microscope_model>
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      <PDBx:entity_name_com entity_id="1">
         <PDBx:name>Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,NACP</PDBx:name>
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      <PDBx:pdbx_audit_support ordinal="1">
         <PDBx:country>United States</PDBx:country>
         <PDBx:funding_organization>National Institutes of Health</PDBx:funding_organization>
         <PDBx:grant_number>1R01-AG029430</PDBx:grant_number>
      </PDBx:pdbx_audit_support>
      <PDBx:pdbx_audit_support ordinal="2">
         <PDBx:country>United States</PDBx:country>
         <PDBx:funding_organization>National Institutes of Health</PDBx:funding_organization>
         <PDBx:grant_number>NIH-016570</PDBx:grant_number>
      </PDBx:pdbx_audit_support>
   </PDBx:pdbx_audit_supportCategory>
   <PDBx:pdbx_database_relatedCategory>
      <PDBx:pdbx_database_related content_type="unspecified" db_id="4RIL" db_name="PDB">
         <PDBx:details>Another segment from alpha-synuclein</PDBx:details>
      </PDBx:pdbx_database_related>
      <PDBx:pdbx_database_related content_type="associated EM volume" db_id="EMD-3001" db_name="EMDB">
         <PDBx:details xsi:nil="true" />
      </PDBx:pdbx_database_related>
   </PDBx:pdbx_database_relatedCategory>
   <PDBx:pdbx_database_statusCategory>
      <PDBx:pdbx_database_status entry_id="4ZNN">
         <PDBx:SG_entry>N</PDBx:SG_entry>
         <PDBx:date_begin_release_preparation xsi:nil="true" />
         <PDBx:deposit_site>RCSB</PDBx:deposit_site>
         <PDBx:pdb_format_compatible>Y</PDBx:pdb_format_compatible>
         <PDBx:process_site>RCSB</PDBx:process_site>
         <PDBx:status_code>REL</PDBx:status_code>
         <PDBx:status_code_sf>REL</PDBx:status_code_sf>
      </PDBx:pdbx_database_status>
   </PDBx:pdbx_database_statusCategory>
   <PDBx:pdbx_entity_nonpolyCategory>
      <PDBx:pdbx_entity_nonpoly entity_id="2">
         <PDBx:comp_id>HOH</PDBx:comp_id>
         <PDBx:name>water</PDBx:name>
      </PDBx:pdbx_entity_nonpoly>
   </PDBx:pdbx_entity_nonpolyCategory>
   <PDBx:pdbx_entity_src_synCategory>
      <PDBx:pdbx_entity_src_syn entity_id="1" pdbx_src_id="1">
         <PDBx:details>Synthetic peptide GVVHGVTTVA corresponding to segment 47-56 of human alpha-synuclein</PDBx:details>
         <PDBx:ncbi_taxonomy_id>9606</PDBx:ncbi_taxonomy_id>
         <PDBx:organism_common_name>Human</PDBx:organism_common_name>
         <PDBx:organism_scientific>Homo sapiens</PDBx:organism_scientific>
         <PDBx:pdbx_alt_source_flag>sample</PDBx:pdbx_alt_source_flag>
         <PDBx:pdbx_beg_seq_num>1</PDBx:pdbx_beg_seq_num>
         <PDBx:pdbx_end_seq_num>10</PDBx:pdbx_end_seq_num>
      </PDBx:pdbx_entity_src_syn>
   </PDBx:pdbx_entity_src_synCategory>
   <PDBx:pdbx_nonpoly_schemeCategory>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="1">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>101</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="2">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>2</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>102</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="3">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>3</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>103</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="4">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>4</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>104</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
   </PDBx:pdbx_nonpoly_schemeCategory>
   <PDBx:pdbx_phasing_MRCategory>
      <PDBx:pdbx_phasing_MR entry_id="4ZNN">
         <PDBx:model_details>Phaser MODE: MR_AUTO</PDBx:model_details>
      </PDBx:pdbx_phasing_MR>
   </PDBx:pdbx_phasing_MRCategory>
   <PDBx:pdbx_poly_seq_schemeCategory>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLY" seq_id="1">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>47</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>1</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>47</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="VAL" seq_id="2">
         <PDBx:auth_mon_id>VAL</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>48</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>2</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>VAL</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>48</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="VAL" seq_id="3">
         <PDBx:auth_mon_id>VAL</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>49</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>3</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>VAL</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>49</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="HIS" seq_id="4">
         <PDBx:auth_mon_id>HIS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>50</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>4</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HIS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>50</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLY" seq_id="5">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>51</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>5</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>51</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="VAL" seq_id="6">
         <PDBx:auth_mon_id>VAL</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>52</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>6</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>VAL</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>52</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="THR" seq_id="7">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>53</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>7</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>53</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="THR" seq_id="8">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>54</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>8</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>54</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="VAL" seq_id="9">
         <PDBx:auth_mon_id>VAL</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>55</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>9</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>VAL</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>55</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ALA" seq_id="10">
         <PDBx:auth_mon_id>ALA</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>56</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>10</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ALA</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>56</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
   </PDBx:pdbx_poly_seq_schemeCategory>
   <PDBx:pdbx_struct_assemblyCategory>
      <PDBx:pdbx_struct_assembly id="1">
         <PDBx:details>author_defined_assembly</PDBx:details>
         <PDBx:oligomeric_count>10</PDBx:oligomeric_count>
         <PDBx:oligomeric_details>decameric</PDBx:oligomeric_details>
      </PDBx:pdbx_struct_assembly>
   </PDBx:pdbx_struct_assemblyCategory>
   <PDBx:pdbx_struct_assembly_genCategory>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="1"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="2"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="3"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="4"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="5"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="6"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="7"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="8"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="9"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="10"></PDBx:pdbx_struct_assembly_gen>
   </PDBx:pdbx_struct_assembly_genCategory>
   <PDBx:pdbx_struct_oper_listCategory>
      <PDBx:pdbx_struct_oper_list id="1">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_555</PDBx:name>
         <PDBx:symmetry_operation>x,y,z</PDBx:symmetry_operation>
         <PDBx:type>identity operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>0.0000000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="2">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_565</PDBx:name>
         <PDBx:symmetry_operation>x,y+1,z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>4.7100000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="3">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_575</PDBx:name>
         <PDBx:symmetry_operation>x,y+2,z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>9.4200000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="4">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_585</PDBx:name>
         <PDBx:symmetry_operation>x,y+3,z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>14.1300000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="5">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_595</PDBx:name>
         <PDBx:symmetry_operation>x,y+4,z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>18.8400000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="6">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>2_556</PDBx:name>
         <PDBx:symmetry_operation>-x,y+1/2,-z+1</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>-2.4937927927</PDBx:vector1>
         <PDBx:vector2>2.3550000000</PDBx:vector2>
         <PDBx:vector3>32.9357237283</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="7">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>2_566</PDBx:name>
         <PDBx:symmetry_operation>-x,y+3/2,-z+1</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>-2.4937927927</PDBx:vector1>
         <PDBx:vector2>7.0650000000</PDBx:vector2>
         <PDBx:vector3>32.9357237283</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="8">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>2_576</PDBx:name>
         <PDBx:symmetry_operation>-x,y+5/2,-z+1</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>-2.4937927927</PDBx:vector1>
         <PDBx:vector2>11.7750000000</PDBx:vector2>
         <PDBx:vector3>32.9357237283</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="9">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>2_586</PDBx:name>
         <PDBx:symmetry_operation>-x,y+7/2,-z+1</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>-2.4937927927</PDBx:vector1>
         <PDBx:vector2>16.4850000000</PDBx:vector2>
         <PDBx:vector3>32.9357237283</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="10">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>2_596</PDBx:name>
         <PDBx:symmetry_operation>-x,y+9/2,-z+1</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>-2.4937927927</PDBx:vector1>
         <PDBx:vector2>21.1950000000</PDBx:vector2>
         <PDBx:vector3>32.9357237283</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
   </PDBx:pdbx_struct_oper_listCategory>
   <PDBx:pdbx_versionCategory>
      <PDBx:pdbx_version entry_id="4ZNN" major_version="4" minor_version="0000" revision_type="Initial release">
         <PDBx:details>Initial release</PDBx:details>
         <PDBx:revision_date>2015-09-09</PDBx:revision_date>
      </PDBx:pdbx_version>
      <PDBx:pdbx_version entry_id="4ZNN" major_version="4" minor_version="0001" revision_type="Citation">
         <PDBx:details>Citation</PDBx:details>
         <PDBx:revision_date>2015-09-23</PDBx:revision_date>
      </PDBx:pdbx_version>
      <PDBx:pdbx_version entry_id="4ZNN" major_version="4" minor_version="0002" revision_type="Citation">
         <PDBx:details>Citation</PDBx:details>
         <PDBx:revision_date>2015-10-07</PDBx:revision_date>
      </PDBx:pdbx_version>
      <PDBx:pdbx_version entry_id="4ZNN" major_version="4" minor_version="0003" revision_type="Experimental method">
         <PDBx:details>Correct data collection</PDBx:details>
         <PDBx:revision_date>2016-11-30</PDBx:revision_date>
      </PDBx:pdbx_version>
   </PDBx:pdbx_versionCategory>
   <PDBx:phasingCategory>
      <PDBx:phasing method="MR"></PDBx:phasing>
   </PDBx:phasingCategory>
   <PDBx:refineCategory>
      <PDBx:refine entry_id="4ZNN" pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY">
         <PDBx:B_iso_max>50.340</PDBx:B_iso_max>
         <PDBx:B_iso_mean>18.3710</PDBx:B_iso_mean>
         <PDBx:B_iso_min>11.230</PDBx:B_iso_min>
         <PDBx:aniso_B11>1.0800</PDBx:aniso_B11>
         <PDBx:aniso_B12>0.0000</PDBx:aniso_B12>
         <PDBx:aniso_B13>0.0100</PDBx:aniso_B13>
         <PDBx:aniso_B22>-1.1300</PDBx:aniso_B22>
         <PDBx:aniso_B23>-0.0000</PDBx:aniso_B23>
         <PDBx:aniso_B33>0.0500</PDBx:aniso_B33>
         <PDBx:correlation_coeff_Fo_to_Fc>0.9530</PDBx:correlation_coeff_Fo_to_Fc>
         <PDBx:correlation_coeff_Fo_to_Fc_free>0.9580</PDBx:correlation_coeff_Fo_to_Fc_free>
         <PDBx:details>HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES      : REFINED INDIVIDUALLY</PDBx:details>
         <PDBx:ls_R_factor_R_free>0.2817</PDBx:ls_R_factor_R_free>
         <PDBx:ls_R_factor_R_work>0.2347</PDBx:ls_R_factor_R_work>
         <PDBx:ls_R_factor_obs>0.2396</PDBx:ls_R_factor_obs>
         <PDBx:ls_d_res_high>1.4100</PDBx:ls_d_res_high>
         <PDBx:ls_d_res_low>16.4700</PDBx:ls_d_res_low>
         <PDBx:ls_number_reflns_R_free>112</PDBx:ls_number_reflns_R_free>
         <PDBx:ls_number_reflns_obs>1006</PDBx:ls_number_reflns_obs>
         <PDBx:ls_percent_reflns_R_free>10.0000</PDBx:ls_percent_reflns_R_free>
         <PDBx:ls_percent_reflns_obs>86.7300</PDBx:ls_percent_reflns_obs>
         <PDBx:ls_wR_factor_R_free>0.2879</PDBx:ls_wR_factor_R_free>
         <PDBx:ls_wR_factor_R_work>0.2427</PDBx:ls_wR_factor_R_work>
         <PDBx:overall_FOM_work_R_set>0.6203</PDBx:overall_FOM_work_R_set>
         <PDBx:overall_SU_B>3.4910</PDBx:overall_SU_B>
         <PDBx:overall_SU_ML>0.1110</PDBx:overall_SU_ML>
         <PDBx:overall_SU_R_Cruickshank_DPI>0.1115</PDBx:overall_SU_R_Cruickshank_DPI>
         <PDBx:overall_SU_R_free>0.1137</PDBx:overall_SU_R_free>
         <PDBx:pdbx_R_Free_selection_details>RANDOM</PDBx:pdbx_R_Free_selection_details>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_ls_cross_valid_method>THROUGHOUT</PDBx:pdbx_ls_cross_valid_method>
         <PDBx:pdbx_ls_sigma_F>0.000</PDBx:pdbx_ls_sigma_F>
         <PDBx:pdbx_method_to_determine_struct>MOLECULAR REPLACEMENT</PDBx:pdbx_method_to_determine_struct>
         <PDBx:pdbx_overall_ESU_R>0.1120</PDBx:pdbx_overall_ESU_R>
         <PDBx:pdbx_overall_ESU_R_Free>0.1140</PDBx:pdbx_overall_ESU_R_Free>
         <PDBx:pdbx_solvent_ion_probe_radii>0.8000</PDBx:pdbx_solvent_ion_probe_radii>
         <PDBx:pdbx_solvent_shrinkage_radii>0.8000</PDBx:pdbx_solvent_shrinkage_radii>
         <PDBx:pdbx_solvent_vdw_probe_radii>1.2000</PDBx:pdbx_solvent_vdw_probe_radii>
         <PDBx:pdbx_starting_model>Ideal model</PDBx:pdbx_starting_model>
         <PDBx:pdbx_stereochemistry_target_values>MAXIMUM LIKELIHOOD</PDBx:pdbx_stereochemistry_target_values>
         <PDBx:solvent_model_details>MASK</PDBx:solvent_model_details>
      </PDBx:refine>
   </PDBx:refineCategory>
   <PDBx:refine_histCategory>
      <PDBx:refine_hist cycle_id="final" pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY">
         <PDBx:d_res_high>1.4100</PDBx:d_res_high>
         <PDBx:d_res_low>16.4700</PDBx:d_res_low>
         <PDBx:number_atoms_solvent>4</PDBx:number_atoms_solvent>
         <PDBx:number_atoms_total>70</PDBx:number_atoms_total>
         <PDBx:pdbx_B_iso_mean_solvent>24.58</PDBx:pdbx_B_iso_mean_solvent>
         <PDBx:pdbx_number_atoms_ligand>0</PDBx:pdbx_number_atoms_ligand>
         <PDBx:pdbx_number_atoms_nucleic_acid>0</PDBx:pdbx_number_atoms_nucleic_acid>
         <PDBx:pdbx_number_atoms_protein>66</PDBx:pdbx_number_atoms_protein>
         <PDBx:pdbx_number_residues_total>10</PDBx:pdbx_number_residues_total>
      </PDBx:refine_hist>
   </PDBx:refine_histCategory>
   <PDBx:refine_ls_restrCategory>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_bond_refined_d">
         <PDBx:dev_ideal>0.020</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.019</PDBx:dev_ideal_target>
         <PDBx:number>66</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_bond_other_d">
         <PDBx:dev_ideal>0.154</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.020</PDBx:dev_ideal_target>
         <PDBx:number>69</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_angle_refined_deg">
         <PDBx:dev_ideal>1.977</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>1.905</PDBx:dev_ideal_target>
         <PDBx:number>91</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_angle_other_deg">
         <PDBx:dev_ideal>3.442</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>3.000</PDBx:dev_ideal_target>
         <PDBx:number>155</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_dihedral_angle_1_deg">
         <PDBx:dev_ideal>5.506</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>5.000</PDBx:dev_ideal_target>
         <PDBx:number>9</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_dihedral_angle_2_deg">
         <PDBx:dev_ideal>75.764</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>20.000</PDBx:dev_ideal_target>
         <PDBx:number>1</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_dihedral_angle_3_deg">
         <PDBx:dev_ideal>6.335</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>15.000</PDBx:dev_ideal_target>
         <PDBx:number>7</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_chiral_restr">
         <PDBx:dev_ideal>0.065</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.200</PDBx:dev_ideal_target>
         <PDBx:number>14</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_gen_planes_refined">
         <PDBx:dev_ideal>0.006</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.020</PDBx:dev_ideal_target>
         <PDBx:number>73</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_gen_planes_other">
         <PDBx:dev_ideal>0.001</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.020</PDBx:dev_ideal_target>
         <PDBx:number>13</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_mcbond_it">
         <PDBx:dev_ideal>3.934</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>1.542</PDBx:dev_ideal_target>
         <PDBx:number>39</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_mcbond_other">
         <PDBx:dev_ideal>1.925</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>1.468</PDBx:dev_ideal_target>
         <PDBx:number>38</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY" type="r_mcangle_it">
         <PDBx:dev_ideal>5.296</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>2.279</PDBx:dev_ideal_target>
         <PDBx:number>42</PDBx:number>
      </PDBx:refine_ls_restr>
   </PDBx:refine_ls_restrCategory>
   <PDBx:refine_ls_shellCategory>
      <PDBx:refine_ls_shell d_res_high="1.4090" pdbx_refine_id="ELECTRON CRYSTALLOGRAPHY">
         <PDBx:R_factor_R_free>0.3290</PDBx:R_factor_R_free>
         <PDBx:R_factor_R_work>0.3360</PDBx:R_factor_R_work>
         <PDBx:d_res_low>1.5740</PDBx:d_res_low>
         <PDBx:number_reflns_R_free>26</PDBx:number_reflns_R_free>
         <PDBx:number_reflns_R_work>239</PDBx:number_reflns_R_work>
         <PDBx:number_reflns_all>265</PDBx:number_reflns_all>
         <PDBx:pdbx_total_number_of_bins_used>5</PDBx:pdbx_total_number_of_bins_used>
         <PDBx:percent_reflns_obs>70.6700</PDBx:percent_reflns_obs>
      </PDBx:refine_ls_shell>
   </PDBx:refine_ls_shellCategory>
   <PDBx:reflnsCategory>
      <PDBx:reflns pdbx_ordinal="1">
         <PDBx:B_iso_Wilson_estimate>22.483</PDBx:B_iso_Wilson_estimate>
         <PDBx:Rmerge_F_obs>0.967</PDBx:Rmerge_F_obs>
         <PDBx:d_resolution_high>1.410</PDBx:d_resolution_high>
         <PDBx:d_resolution_low>16.5</PDBx:d_resolution_low>
         <PDBx:entry_id>4ZNN</PDBx:entry_id>
         <PDBx:number_obs>1120</PDBx:number_obs>
         <PDBx:observed_criterion_sigma_I>-3.000</PDBx:observed_criterion_sigma_I>
         <PDBx:pdbx_Rmerge_I_obs>0.236</PDBx:pdbx_Rmerge_I_obs>
         <PDBx:pdbx_Rrim_I_all>0.264</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_chi_squared>0.831</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_netI_over_sigmaI>4.620</PDBx:pdbx_netI_over_sigmaI>
         <PDBx:pdbx_number_measured_all>4110</PDBx:pdbx_number_measured_all>
         <PDBx:pdbx_redundancy>3.7</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_obs>86.900</PDBx:percent_possible_obs>
      </PDBx:reflns>
   </PDBx:reflnsCategory>
   <PDBx:reflns_shellCategory>
      <PDBx:reflns_shell pdbx_ordinal="1">
         <PDBx:Rmerge_F_obs>0.628</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.780</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.410</PDBx:d_res_high>
         <PDBx:d_res_low>1.480</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>1.080</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>323</PDBx:number_measured_obs>
         <PDBx:number_possible>171</PDBx:number_possible>
         <PDBx:number_unique_obs>100</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.895</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>58.500</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="2">
         <PDBx:Rmerge_F_obs>0.664</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.503</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.480</PDBx:d_res_high>
         <PDBx:d_res_low>1.560</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>2.170</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>523</PDBx:number_measured_obs>
         <PDBx:number_possible>175</PDBx:number_possible>
         <PDBx:number_unique_obs>140</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.572</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>80.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="3">
         <PDBx:Rmerge_F_obs>0.824</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.417</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.560</PDBx:d_res_high>
         <PDBx:d_res_low>1.650</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>2.370</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>417</PDBx:number_measured_obs>
         <PDBx:number_possible>137</PDBx:number_possible>
         <PDBx:number_unique_obs>125</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.480</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>91.200</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="4">
         <PDBx:Rmerge_F_obs>0.826</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.417</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.650</PDBx:d_res_high>
         <PDBx:d_res_low>1.770</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>2.330</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>375</PDBx:number_measured_obs>
         <PDBx:number_possible>121</PDBx:number_possible>
         <PDBx:number_unique_obs>116</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.496</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>95.900</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="5">
         <PDBx:Rmerge_F_obs>0.937</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.290</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.770</PDBx:d_res_high>
         <PDBx:d_res_low>1.910</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>3.780</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>443</PDBx:number_measured_obs>
         <PDBx:number_possible>124</PDBx:number_possible>
         <PDBx:number_unique_obs>116</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.334</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>93.500</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="6">
         <PDBx:Rmerge_F_obs>0.975</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.262</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.910</PDBx:d_res_high>
         <PDBx:d_res_low>2.090</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>5.190</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>530</PDBx:number_measured_obs>
         <PDBx:number_possible>133</PDBx:number_possible>
         <PDBx:number_unique_obs>126</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.298</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>94.700</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="7">
         <PDBx:Rmerge_F_obs>0.941</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.269</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.090</PDBx:d_res_high>
         <PDBx:d_res_low>2.340</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>6.270</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>552</PDBx:number_measured_obs>
         <PDBx:number_possible>129</PDBx:number_possible>
         <PDBx:number_unique_obs>122</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.303</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>94.600</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="8">
         <PDBx:Rmerge_F_obs>0.969</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.203</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.340</PDBx:d_res_high>
         <PDBx:d_res_low>2.700</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>6.330</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>263</PDBx:number_measured_obs>
         <PDBx:number_possible>85</PDBx:number_possible>
         <PDBx:number_unique_obs>78</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.237</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>91.800</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="9">
         <PDBx:Rmerge_F_obs>0.991</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.144</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.700</PDBx:d_res_high>
         <PDBx:d_res_low>3.310</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>8.020</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>263</PDBx:number_measured_obs>
         <PDBx:number_possible>88</PDBx:number_possible>
         <PDBx:number_unique_obs>81</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.170</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>92.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="10">
         <PDBx:Rmerge_F_obs>0.949</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.256</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>3.310</PDBx:d_res_high>
         <PDBx:d_res_low>4.680</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>11.770</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>337</PDBx:number_measured_obs>
         <PDBx:number_possible>85</PDBx:number_possible>
         <PDBx:number_unique_obs>80</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.279</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>94.100</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="11">
         <PDBx:Rmerge_F_obs>0.987</PDBx:Rmerge_F_obs>
         <PDBx:Rmerge_I_obs>0.078</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>4.680</PDBx:d_res_high>
         <PDBx:d_res_low>16.5</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>7.180</PDBx:meanI_over_sigI_obs>
         <PDBx:number_measured_obs>84</PDBx:number_measured_obs>
         <PDBx:number_possible>41</PDBx:number_possible>
         <PDBx:number_unique_obs>36</PDBx:number_unique_obs>
         <PDBx:pdbx_Rrim_I_all>0.100</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_rejects>0</PDBx:pdbx_rejects>
         <PDBx:percent_possible_all>87.800</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
   </PDBx:reflns_shellCategory>
   <PDBx:softwareCategory>
      <PDBx:software pdbx_ordinal="1">
         <PDBx:classification>data scaling</PDBx:classification>
         <PDBx:name>XSCALE</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="2">
         <PDBx:classification>phasing</PDBx:classification>
         <PDBx:name>PHASER</PDBx:name>
         <PDBx:version>2.5.6</PDBx:version>
      </PDBx:software>
      <PDBx:software pdbx_ordinal="3">
         <PDBx:classification>refinement</PDBx:classification>
         <PDBx:name>REFMAC</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="4">
         <PDBx:classification>data extraction</PDBx:classification>
         <PDBx:name>PDB_EXTRACT</PDBx:name>
         <PDBx:version>3.15</PDBx:version>
      </PDBx:software>
      <PDBx:software pdbx_ordinal="5">
         <PDBx:classification>data reduction</PDBx:classification>
         <PDBx:name>XDS</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="6">
         <PDBx:classification>model building</PDBx:classification>
         <PDBx:name>Coot</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
   </PDBx:softwareCategory>
   <PDBx:structCategory>
      <PDBx:struct entry_id="4ZNN">
         <PDBx:pdbx_descriptor>Alpha-synuclein</PDBx:pdbx_descriptor>
         <PDBx:title>MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson&apos;s disease protein, alpha-synuclein residues 47-56</PDBx:title>
      </PDBx:struct>
   </PDBx:structCategory>
   <PDBx:struct_asymCategory>
      <PDBx:struct_asym id="A">
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="B">
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
   </PDBx:struct_asymCategory>
   <PDBx:struct_keywordsCategory>
      <PDBx:struct_keywords entry_id="4ZNN">
         <PDBx:pdbx_keywords>LIPID BINDING PROTEIN</PDBx:pdbx_keywords>
         <PDBx:text>Amyloid, alpha-synuclein, Parkinson&apos;s Disease, Toxic Core, NACore, LIPID BINDING PROTEIN</PDBx:text>
      </PDBx:struct_keywords>
   </PDBx:struct_keywordsCategory>
   <PDBx:struct_refCategory>
      <PDBx:struct_ref id="1">
         <PDBx:db_code>SYUA_HUMAN</PDBx:db_code>
         <PDBx:db_name>UNP</PDBx:db_name>
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_align_begin>47</PDBx:pdbx_align_begin>
         <PDBx:pdbx_db_accession>P37840</PDBx:pdbx_db_accession>
         <PDBx:pdbx_seq_one_letter_code>GVVHGVATVA</PDBx:pdbx_seq_one_letter_code>
      </PDBx:struct_ref>
   </PDBx:struct_refCategory>
   <PDBx:struct_ref_seqCategory>
      <PDBx:struct_ref_seq align_id="1">
         <PDBx:db_align_beg>47</PDBx:db_align_beg>
         <PDBx:db_align_end>56</PDBx:db_align_end>
         <PDBx:pdbx_PDB_id_code>4ZNN</PDBx:pdbx_PDB_id_code>
         <PDBx:pdbx_auth_seq_align_beg>47</PDBx:pdbx_auth_seq_align_beg>
         <PDBx:pdbx_auth_seq_align_end>56</PDBx:pdbx_auth_seq_align_end>
         <PDBx:pdbx_db_accession>P37840</PDBx:pdbx_db_accession>
         <PDBx:pdbx_strand_id>A</PDBx:pdbx_strand_id>
         <PDBx:ref_id>1</PDBx:ref_id>
         <PDBx:seq_align_beg>1</PDBx:seq_align_beg>
         <PDBx:seq_align_end>10</PDBx:seq_align_end>
      </PDBx:struct_ref_seq>
   </PDBx:struct_ref_seqCategory>
   <PDBx:struct_ref_seq_difCategory>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="1">
         <PDBx:align_id>1</PDBx:align_id>
         <PDBx:db_mon_id>ALA</PDBx:db_mon_id>
         <PDBx:details>engineered mutation</PDBx:details>
         <PDBx:mon_id>THR</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>53</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>4ZNN</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>A</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>P37840</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:pdbx_seq_db_seq_num>53</PDBx:pdbx_seq_db_seq_num>
         <PDBx:seq_num>7</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
   </PDBx:struct_ref_seq_difCategory>
   <PDBx:symmetryCategory>
      <PDBx:symmetry entry_id="4ZNN">
         <PDBx:Int_Tables_number>4</PDBx:Int_Tables_number>
         <PDBx:space_group_name_H-M>P 1 21 1</PDBx:space_group_name_H-M>
      </PDBx:symmetry>
   </PDBx:symmetryCategory>
</PDBx:datablock>
