data_1MP6
# 
_entry.id   1MP6 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    4.007 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
PDB  1MP6       
RCSB RCSB017074 
# 
loop_
_database_PDB_rev.num 
_database_PDB_rev.date 
_database_PDB_rev.date_original 
_database_PDB_rev.status 
_database_PDB_rev.replaces 
_database_PDB_rev.mod_type 
1 2002-09-25 2002-09-11 ? 1MP6 0 
2 2009-02-24 ?          ? 1MP6 1 
# 
_database_PDB_rev_record.rev_num   2 
_database_PDB_rev_record.type      VERSN 
_database_PDB_rev_record.details   ? 
# 
_pdbx_database_status.status_code    REL 
_pdbx_database_status.entry_id       1MP6 
_pdbx_database_status.deposit_site   RCSB 
_pdbx_database_status.process_site   RCSB 
_pdbx_database_status.SG_entry       . 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
'Wang, J.'    1 
'Kim, S.'     2 
'Kovacs, F.'  3 
'Cross, T.A.' 4 
# 
loop_
_citation.id 
_citation.title 
_citation.journal_abbrev 
_citation.journal_volume 
_citation.page_first 
_citation.page_last 
_citation.year 
_citation.journal_id_ASTM 
_citation.country 
_citation.journal_id_ISSN 
_citation.journal_id_CSD 
_citation.book_publisher 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_DOI 
primary 'Structure of the transmembrane region of the M2 protein H(+) channel.'                     'Protein Sci.' 10  2241 2250 
2001 PRCIEI US 0961-8368 0795 ? 11604531 10.1110/ps.17901       
1       'Helix tilt of the M2 transmembrane peptide from influenza A virus: an intrinsic property.' J.Mol.Biol.    295 117  125  
2000 JMOBAK UK 0022-2836 0070 ? ?        10.1006/jmbi.1999.3322 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
primary 'Wang, J.'    1 
primary 'Kim, S.'     2 
primary 'Kovacs, F.'  3 
primary 'Cross, T.A.' 4 
1       'Kovacs, F.'  5 
1       'Denny, J.K.' 6 
1       'Song, Z.'    7 
1       'Quine, J.R.' 8 
1       'Cross, T.A.' 9 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 syn 
_entity.pdbx_description           'Matrix protein M2' 
_entity.formula_weight             2730.321 
_entity.pdbx_number_of_molecules   1 
_entity.details                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              'transmembrane peptide (residues 22-46)' 
_entity.pdbx_ec                    ? 
# 
_entity_keywords.entity_id   1 
_entity_keywords.text        ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'M2 protein' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       SSDPLVVAASIIGILHLILWILDRL 
_entity_poly.pdbx_seq_one_letter_code_can   SSDPLVVAASIIGILHLILWILDRL 
_entity_poly.pdbx_strand_id                 A 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1  SER n 
1 2  SER n 
1 3  ASP n 
1 4  PRO n 
1 5  LEU n 
1 6  VAL n 
1 7  VAL n 
1 8  ALA n 
1 9  ALA n 
1 10 SER n 
1 11 ILE n 
1 12 ILE n 
1 13 GLY n 
1 14 ILE n 
1 15 LEU n 
1 16 HIS n 
1 17 LEU n 
1 18 ILE n 
1 19 LEU n 
1 20 TRP n 
1 21 ILE n 
1 22 LEU n 
1 23 ASP n 
1 24 ARG n 
1 25 LEU n 
# 
_pdbx_entity_src_syn.entity_id              1 
_pdbx_entity_src_syn.organism_scientific    ? 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       ? 
_pdbx_entity_src_syn.details                
;This sequence occurs naturally in the Influenza A virus (Udorn/72 strain). The M2 transmembrane peptide was synthesized using solid phase peptide synthesis.
;
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    VMT2_IAUDO 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   SSDPLVVAASIIGILHLILWILDRL 
_struct_ref.pdbx_align_begin           22 
_struct_ref.biol_id                    . 
_struct_ref.pdbx_db_accession          P03490 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              1MP6 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 25 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P03490 
_struct_ref_seq.db_align_beg                  22 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  46 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       22 
_struct_ref_seq.pdbx_auth_seq_align_end       46 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.104 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.132 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.174 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.147 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.094  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.174 
GLY 'PEPTIDE LINKING'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.164 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.228 
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.210 
# 
_pdbx_nmr_exptl.experiment_id   1 
_pdbx_nmr_exptl.solution_id     1 
_pdbx_nmr_exptl.conditions_id   1 
_pdbx_nmr_exptl.type            'SOLID STATE NMR PISEMA' 
# 
_pdbx_nmr_exptl_sample_conditions.conditions_id    1 
_pdbx_nmr_exptl_sample_conditions.temperature      303.00 
_pdbx_nmr_exptl_sample_conditions.pressure         ambient 
_pdbx_nmr_exptl_sample_conditions.pH               7.0 
_pdbx_nmr_exptl_sample_conditions.ionic_strength   none 
_pdbx_nmr_exptl_sample_conditions.pressure_units   ? 
# 
_pdbx_nmr_sample_details.solution_id      1 
_pdbx_nmr_sample_details.contents         
;Oriented samples of the peptide in hydrated lipid bilayers were prepared by first co-dissolving M2-TMP and dimyristoylphosphatidylcholine (DMPC) in trifluoroethanol (TFE). The solution was then spread onto approximately 60 glass plates. After vacuum drying to remove TFE, 2 microliters of sterile-filtered water was added to each plate, and the plates were then stacked into a glass tube and placed in a chamber containing a saturated solution of K2SO4 for hydration.
;
_pdbx_nmr_sample_details.solvent_system   
;Oriented bilayers formed after equilibrating the sample in this chamber at 42C overnight. This sample container was then sealed with a microscope cover glass and epoxy to maintain sample hydration during the experiments.
;
# 
_pdbx_nmr_spectrometer.spectrometer_id   1 
_pdbx_nmr_spectrometer.type              ? 
_pdbx_nmr_spectrometer.manufacturer      'Home built' 
_pdbx_nmr_spectrometer.model             Chemagnetics 
_pdbx_nmr_spectrometer.field_strength    400 
# 
_pdbx_nmr_refine.entry_id   1MP6 
_pdbx_nmr_refine.method     'simulated annealing' 
_pdbx_nmr_refine.details    
;The refined M2-TMP monomer structure was obtained by a geometrical search using a search algorithm to obtain a minimum of the global penalty function that incorporates all the orientational restraints and the CHARMM empirical function.  The orientational restraints imposed on the structure during refinement are 15 15N chemical shifts and 15 15N-1H dipolar couplings from PISEMA experiments. The observed chemical shifts are compared to calculated values from the molecular coordinates and the known tensor element magnitudes and assumed tensor orientations. The refinement was carried out in vacuo with the initial coordinates of an ideal a-helix structure (3.6 residues per turn) having a range of tilt and rotational orientations with respect to the bilayer spanning the values obtained from the PISA wheels.
;
# 
_pdbx_nmr_details.entry_id   1MP6 
_pdbx_nmr_details.text       
'15N CHEMICAL SHIFT, 1H-15N DIPOLAR COUPLING FREQUENCIES WERE MEASURED FROM SOLID STATE NMR PISEMA EXPERIMENT' 
# 
_pdbx_nmr_ensemble.entry_id                                      1MP6 
_pdbx_nmr_ensemble.conformers_calculated_total_number            30 
_pdbx_nmr_ensemble.conformers_submitted_total_number             1 
_pdbx_nmr_ensemble.conformer_selection_criteria                  
;The lowest energy conformer with backbone and C beta atoms is deposited, preferred rotameric states of side chains were used during the backbone structure refinement but the side chain atoms were not included in the pdb file.
;
_pdbx_nmr_ensemble.average_constraints_per_residue               ? 
_pdbx_nmr_ensemble.average_constraint_violations_per_residue     ? 
_pdbx_nmr_ensemble.maximum_distance_constraint_violation         ? 
_pdbx_nmr_ensemble.average_distance_constraint_violation         ? 
_pdbx_nmr_ensemble.maximum_upper_distance_constraint_violation   ? 
_pdbx_nmr_ensemble.maximum_lower_distance_constraint_violation   ? 
_pdbx_nmr_ensemble.distance_constraint_violation_method          ? 
_pdbx_nmr_ensemble.maximum_torsion_angle_constraint_violation    ? 
_pdbx_nmr_ensemble.average_torsion_angle_constraint_violation    ? 
_pdbx_nmr_ensemble.torsion_angle_constraint_violation_method     ? 
# 
_pdbx_nmr_representative.entry_id             1MP6 
_pdbx_nmr_representative.conformer_id         1 
_pdbx_nmr_representative.selection_criteria   'lowest energy' 
# 
_pdbx_nmr_software.name             TORC 
_pdbx_nmr_software.version          v5.4 
_pdbx_nmr_software.classification   refinement 
_pdbx_nmr_software.authors          KETCHEM,ROUX,CROSS 
_pdbx_nmr_software.ordinal          1 
# 
_exptl.entry_id          1MP6 
_exptl.method            'SOLID-STATE NMR' 
_exptl.crystals_number   ? 
# 
_exptl_crystal.id   1 
# 
_diffrn.id           1 
_diffrn.crystal_id   1 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   . 
_diffrn_radiation_wavelength.wt           1.0 
# 
_struct.entry_id                  1MP6 
_struct.title                     
'Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy' 
_struct.pdbx_descriptor           'Matrix protein M2' 
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        1MP6 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
_struct_keywords.text            
'INFLUENZA A VIRUS, MEMBRANE PROTEIN STRUCTURE, M2 PROTON CHANNEL, SOLID STATE NMR, MEMBRANE PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_biol.id   1 
# 
_struct_conf.conf_type_id            HELX_P 
_struct_conf.id                      HELX_P1 
_struct_conf.pdbx_PDB_helix_id       1 
_struct_conf.beg_label_comp_id       SER 
_struct_conf.beg_label_asym_id       A 
_struct_conf.beg_label_seq_id        1 
_struct_conf.pdbx_beg_PDB_ins_code   ? 
_struct_conf.end_label_comp_id       LEU 
_struct_conf.end_label_asym_id       A 
_struct_conf.end_label_seq_id        25 
_struct_conf.pdbx_end_PDB_ins_code   ? 
_struct_conf.beg_auth_comp_id        SER 
_struct_conf.beg_auth_asym_id        A 
_struct_conf.beg_auth_seq_id         22 
_struct_conf.end_auth_comp_id        LEU 
_struct_conf.end_auth_asym_id        A 
_struct_conf.end_auth_seq_id         46 
_struct_conf.pdbx_PDB_helix_class    1 
_struct_conf.details                 ? 
_struct_conf.pdbx_PDB_helix_length   25 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_database_PDB_matrix.entry_id          1MP6 
_database_PDB_matrix.origx[1][1]       1.000000 
_database_PDB_matrix.origx[1][2]       0.000000 
_database_PDB_matrix.origx[1][3]       0.000000 
_database_PDB_matrix.origx[2][1]       0.000000 
_database_PDB_matrix.origx[2][2]       1.000000 
_database_PDB_matrix.origx[2][3]       0.000000 
_database_PDB_matrix.origx[3][1]       0.000000 
_database_PDB_matrix.origx[3][2]       0.000000 
_database_PDB_matrix.origx[3][3]       1.000000 
_database_PDB_matrix.origx_vector[1]   0.00000 
_database_PDB_matrix.origx_vector[2]   0.00000 
_database_PDB_matrix.origx_vector[3]   0.00000 
# 
_atom_sites.entry_id                    1MP6 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
N 
C 
O 
H 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.Cartn_x_esd 
_atom_site.Cartn_y_esd 
_atom_site.Cartn_z_esd 
_atom_site.occupancy_esd 
_atom_site.B_iso_or_equiv_esd 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1   N N  . SER A 1 1  ? 14.173  -2.599 -18.189 1.00 0.00 ? ? ? ? ? ? 22 SER A N  1 
ATOM 2   C CA . SER A 1 1  ? 14.220  -1.411 -19.139 1.00 0.00 ? ? ? ? ? ? 22 SER A CA 1 
ATOM 3   C C  . SER A 1 1  ? 13.334  -0.242 -18.721 1.00 0.00 ? ? ? ? ? ? 22 SER A C  1 
ATOM 4   O O  . SER A 1 1  ? 12.640  -0.276 -17.708 1.00 0.00 ? ? ? ? ? ? 22 SER A O  1 
ATOM 5   C CB . SER A 1 1  ? 13.867  -1.898 -20.575 1.00 0.00 ? ? ? ? ? ? 22 SER A CB 1 
ATOM 6   H HA . SER A 1 1  ? 15.236  -1.041 -19.133 1.00 0.00 ? ? ? ? ? ? 22 SER A HA 1 
ATOM 7   N N  . SER A 1 2  ? 13.303  0.863  -19.493 1.00 0.00 ? ? ? ? ? ? 23 SER A N  1 
ATOM 8   C CA . SER A 1 2  ? 12.584  2.078  -19.096 1.00 0.00 ? ? ? ? ? ? 23 SER A CA 1 
ATOM 9   C C  . SER A 1 2  ? 11.081  1.905  -19.027 1.00 0.00 ? ? ? ? ? ? 23 SER A C  1 
ATOM 10  O O  . SER A 1 2  ? 10.402  2.475  -18.177 1.00 0.00 ? ? ? ? ? ? 23 SER A O  1 
ATOM 11  C CB . SER A 1 2  ? 12.894  3.266  -20.046 1.00 0.00 ? ? ? ? ? ? 23 SER A CB 1 
ATOM 12  H H  . SER A 1 2  ? 13.822  0.908  -20.339 1.00 0.00 ? ? ? ? ? ? 23 SER A H  1 
ATOM 13  H HA . SER A 1 2  ? 12.897  2.345  -18.093 1.00 0.00 ? ? ? ? ? ? 23 SER A HA 1 
ATOM 14  N N  . ASP A 1 3  ? 10.517  1.074  -19.927 1.00 0.00 ? ? ? ? ? ? 24 ASP A N  1 
ATOM 15  C CA . ASP A 1 3  ? 9.122   0.693  -19.927 1.00 0.00 ? ? ? ? ? ? 24 ASP A CA 1 
ATOM 16  C C  . ASP A 1 3  ? 8.797   -0.284 -18.769 1.00 0.00 ? ? ? ? ? ? 24 ASP A C  1 
ATOM 17  O O  . ASP A 1 3  ? 7.878   0.016  -18.007 1.00 0.00 ? ? ? ? ? ? 24 ASP A O  1 
ATOM 18  C CB . ASP A 1 3  ? 8.748   0.263  -21.377 1.00 0.00 ? ? ? ? ? ? 24 ASP A CB 1 
ATOM 19  H H  . ASP A 1 3  ? 11.099  0.637  -20.599 1.00 0.00 ? ? ? ? ? ? 24 ASP A H  1 
ATOM 20  H HA . ASP A 1 3  ? 8.542   1.586  -19.716 1.00 0.00 ? ? ? ? ? ? 24 ASP A HA 1 
ATOM 21  N N  . PRO A 1 4  ? 9.492   -1.397 -18.528 1.00 0.00 ? ? ? ? ? ? 25 PRO A N  1 
ATOM 22  C CA . PRO A 1 4  ? 9.231   -2.235 -17.358 1.00 0.00 ? ? ? ? ? ? 25 PRO A CA 1 
ATOM 23  C C  . PRO A 1 4  ? 9.429   -1.603 -15.986 1.00 0.00 ? ? ? ? ? ? 25 PRO A C  1 
ATOM 24  O O  . PRO A 1 4  ? 8.707   -1.976 -15.062 1.00 0.00 ? ? ? ? ? ? 25 PRO A O  1 
ATOM 25  C CB . PRO A 1 4  ? 10.211  -3.393 -17.553 1.00 0.00 ? ? ? ? ? ? 25 PRO A CB 1 
ATOM 26  H HA . PRO A 1 4  ? 8.196   -2.532 -17.404 1.00 0.00 ? ? ? ? ? ? 25 PRO A HA 1 
ATOM 27  N N  . LEU A 1 5  ? 10.374  -0.658 -15.800 1.00 0.00 ? ? ? ? ? ? 26 LEU A N  1 
ATOM 28  C CA . LEU A 1 5  ? 10.615  -0.022 -14.509 1.00 0.00 ? ? ? ? ? ? 26 LEU A CA 1 
ATOM 29  C C  . LEU A 1 5  ? 9.457   0.862  -14.083 1.00 0.00 ? ? ? ? ? ? 26 LEU A C  1 
ATOM 30  O O  . LEU A 1 5  ? 8.983   0.777  -12.954 1.00 0.00 ? ? ? ? ? ? 26 LEU A O  1 
ATOM 31  C CB . LEU A 1 5  ? 11.927  0.816  -14.483 1.00 0.00 ? ? ? ? ? ? 26 LEU A CB 1 
ATOM 32  H H  . LEU A 1 5  ? 10.986  -0.476 -16.574 1.00 0.00 ? ? ? ? ? ? 26 LEU A H  1 
ATOM 33  H HA . LEU A 1 5  ? 10.689  -0.802 -13.765 1.00 0.00 ? ? ? ? ? ? 26 LEU A HA 1 
ATOM 34  N N  . VAL A 1 6  ? 8.953   1.723  -15.001 1.00 0.00 ? ? ? ? ? ? 27 VAL A N  1 
ATOM 35  C CA . VAL A 1 6  ? 7.827   2.599  -14.708 1.00 0.00 ? ? ? ? ? ? 27 VAL A CA 1 
ATOM 36  C C  . VAL A 1 6  ? 6.540   1.806  -14.394 1.00 0.00 ? ? ? ? ? ? 27 VAL A C  1 
ATOM 37  O O  . VAL A 1 6  ? 5.811   2.105  -13.444 1.00 0.00 ? ? ? ? ? ? 27 VAL A O  1 
ATOM 38  C CB . VAL A 1 6  ? 7.649   3.672  -15.801 1.00 0.00 ? ? ? ? ? ? 27 VAL A CB 1 
ATOM 39  H H  . VAL A 1 6  ? 9.400   1.843  -15.885 1.00 0.00 ? ? ? ? ? ? 27 VAL A H  1 
ATOM 40  H HA . VAL A 1 6  ? 8.088   3.120  -13.801 1.00 0.00 ? ? ? ? ? ? 27 VAL A HA 1 
ATOM 41  N N  . VAL A 1 7  ? 6.288   0.703  -15.140 1.00 0.00 ? ? ? ? ? ? 28 VAL A N  1 
ATOM 42  C CA . VAL A 1 7  ? 5.187   -0.222 -14.867 1.00 0.00 ? ? ? ? ? ? 28 VAL A CA 1 
ATOM 43  C C  . VAL A 1 7  ? 5.290   -0.869 -13.484 1.00 0.00 ? ? ? ? ? ? 28 VAL A C  1 
ATOM 44  O O  . VAL A 1 7  ? 4.337   -0.831 -12.699 1.00 0.00 ? ? ? ? ? ? 28 VAL A O  1 
ATOM 45  C CB . VAL A 1 7  ? 5.085   -1.276 -15.972 1.00 0.00 ? ? ? ? ? ? 28 VAL A CB 1 
ATOM 46  H H  . VAL A 1 7  ? 6.886   0.442  -15.892 1.00 0.00 ? ? ? ? ? ? 28 VAL A H  1 
ATOM 47  H HA . VAL A 1 7  ? 4.268   0.351  -14.842 1.00 0.00 ? ? ? ? ? ? 28 VAL A HA 1 
ATOM 48  N N  . ALA A 1 8  ? 6.478   -1.409 -13.110 1.00 0.00 ? ? ? ? ? ? 29 ALA A N  1 
ATOM 49  C CA . ALA A 1 8  ? 6.732   -1.986 -11.806 1.00 0.00 ? ? ? ? ? ? 29 ALA A CA 1 
ATOM 50  C C  . ALA A 1 8  ? 6.484   -1.025 -10.652 1.00 0.00 ? ? ? ? ? ? 29 ALA A C  1 
ATOM 51  O O  . ALA A 1 8  ? 5.800   -1.353 -9.688  1.00 0.00 ? ? ? ? ? ? 29 ALA A O  1 
ATOM 52  C CB . ALA A 1 8  ? 8.189   -2.503 -11.746 1.00 0.00 ? ? ? ? ? ? 29 ALA A CB 1 
ATOM 53  H H  . ALA A 1 8  ? 7.277   -1.422 -13.712 1.00 0.00 ? ? ? ? ? ? 29 ALA A H  1 
ATOM 54  H HA . ALA A 1 8  ? 6.047   -2.810 -11.676 1.00 0.00 ? ? ? ? ? ? 29 ALA A HA 1 
ATOM 55  N N  . ALA A 1 9  ? 7.010   0.211  -10.758 1.00 0.00 ? ? ? ? ? ? 30 ALA A N  1 
ATOM 56  C CA . ALA A 1 9  ? 6.819   1.286  -9.801  1.00 0.00 ? ? ? ? ? ? 30 ALA A CA 1 
ATOM 57  C C  . ALA A 1 9  ? 5.351   1.647  -9.606  1.00 0.00 ? ? ? ? ? ? 30 ALA A C  1 
ATOM 58  O O  . ALA A 1 9  ? 4.871   1.826  -8.484  1.00 0.00 ? ? ? ? ? ? 30 ALA A O  1 
ATOM 59  C CB . ALA A 1 9  ? 7.612   2.521  -10.267 1.00 0.00 ? ? ? ? ? ? 30 ALA A CB 1 
ATOM 60  H H  . ALA A 1 9  ? 7.522   0.418  -11.591 1.00 0.00 ? ? ? ? ? ? 30 ALA A H  1 
ATOM 61  H HA . ALA A 1 9  ? 7.182   0.960  -8.837  1.00 0.00 ? ? ? ? ? ? 30 ALA A HA 1 
ATOM 62  N N  . SER A 1 10 ? 4.589   1.700  -10.717 1.00 0.00 ? ? ? ? ? ? 31 SER A N  1 
ATOM 63  C CA . SER A 1 10 ? 3.160   1.973  -10.714 1.00 0.00 ? ? ? ? ? ? 31 SER A CA 1 
ATOM 64  C C  . SER A 1 10 ? 2.355   0.917  -9.962  1.00 0.00 ? ? ? ? ? ? 31 SER A C  1 
ATOM 65  O O  . SER A 1 10 ? 1.521   1.245  -9.117  1.00 0.00 ? ? ? ? ? ? 31 SER A O  1 
ATOM 66  C CB . SER A 1 10 ? 2.588   2.095  -12.146 1.00 0.00 ? ? ? ? ? ? 31 SER A CB 1 
ATOM 67  H H  . SER A 1 10 ? 5.025   1.556  -11.610 1.00 0.00 ? ? ? ? ? ? 31 SER A H  1 
ATOM 68  H HA . SER A 1 10 ? 3.012   2.915  -10.201 1.00 0.00 ? ? ? ? ? ? 31 SER A HA 1 
ATOM 69  N N  . ILE A 1 11 ? 2.624   -0.382 -10.216 1.00 0.00 ? ? ? ? ? ? 32 ILE A N  1 
ATOM 70  C CA . ILE A 1 11 ? 2.009   -1.516 -9.510  1.00 0.00 ? ? ? ? ? ? 32 ILE A CA 1 
ATOM 71  C C  . ILE A 1 11 ? 2.306   -1.493 -7.992  1.00 0.00 ? ? ? ? ? ? 32 ILE A C  1 
ATOM 72  O O  . ILE A 1 11 ? 1.436   -1.681 -7.149  1.00 0.00 ? ? ? ? ? ? 32 ILE A O  1 
ATOM 73  C CB . ILE A 1 11 ? 2.486   -2.819 -10.169 1.00 0.00 ? ? ? ? ? ? 32 ILE A CB 1 
ATOM 74  H H  . ILE A 1 11 ? 3.313   -0.621 -10.901 1.00 0.00 ? ? ? ? ? ? 32 ILE A H  1 
ATOM 75  H HA . ILE A 1 11 ? 0.938   -1.427 -9.606  1.00 0.00 ? ? ? ? ? ? 32 ILE A HA 1 
ATOM 76  N N  . ILE A 1 12 ? 3.587   -1.194 -7.691  1.00 0.00 ? ? ? ? ? ? 33 ILE A N  1 
ATOM 77  C CA . ILE A 1 12 ? 3.986   -1.055 -6.269  1.00 0.00 ? ? ? ? ? ? 33 ILE A CA 1 
ATOM 78  C C  . ILE A 1 12 ? 3.202   0.036  -5.520  1.00 0.00 ? ? ? ? ? ? 33 ILE A C  1 
ATOM 79  O O  . ILE A 1 12 ? 2.627   -0.207 -4.454  1.00 0.00 ? ? ? ? ? ? 33 ILE A O  1 
ATOM 80  C CB . ILE A 1 12 ? 5.501   -0.907 -6.088  1.00 0.00 ? ? ? ? ? ? 33 ILE A CB 1 
ATOM 81  H H  . ILE A 1 12 ? 4.241   -1.046 -8.431  1.00 0.00 ? ? ? ? ? ? 33 ILE A H  1 
ATOM 82  H HA . ILE A 1 12 ? 3.708   -1.975 -5.765  1.00 0.00 ? ? ? ? ? ? 33 ILE A HA 1 
ATOM 83  N N  . GLY A 1 13 ? 3.111   1.251  -6.106  1.00 0.00 ? ? ? ? ? ? 34 GLY A N  1 
ATOM 84  C CA . GLY A 1 13 ? 2.302   2.357  -5.576  1.00 0.00 ? ? ? ? ? ? 34 GLY A CA 1 
ATOM 85  C C  . GLY A 1 13 ? 0.834   2.045  -5.380  1.00 0.00 ? ? ? ? ? ? 34 GLY A C  1 
ATOM 86  O O  . GLY A 1 13 ? 0.251   2.342  -4.336  1.00 0.00 ? ? ? ? ? ? 34 GLY A O  1 
ATOM 87  H H  . GLY A 1 13 ? 3.593   1.412  -6.968  1.00 0.00 ? ? ? ? ? ? 34 GLY A H  1 
ATOM 88  N N  . ILE A 1 14 ? 0.217   1.402  -6.393  1.00 0.00 ? ? ? ? ? ? 35 ILE A N  1 
ATOM 89  C CA . ILE A 1 14 ? -1.177  0.962  -6.319  1.00 0.00 ? ? ? ? ? ? 35 ILE A CA 1 
ATOM 90  C C  . ILE A 1 14 ? -1.433  -0.019 -5.172  1.00 0.00 ? ? ? ? ? ? 35 ILE A C  1 
ATOM 91  O O  . ILE A 1 14 ? -2.350  0.175  -4.378  1.00 0.00 ? ? ? ? ? ? 35 ILE A O  1 
ATOM 92  C CB . ILE A 1 14 ? -1.646  0.415  -7.674  1.00 0.00 ? ? ? ? ? ? 35 ILE A CB 1 
ATOM 93  H H  . ILE A 1 14 ? 0.727   1.109  -7.209  1.00 0.00 ? ? ? ? ? ? 35 ILE A H  1 
ATOM 94  H HA . ILE A 1 14 ? -1.782  1.822  -6.089  1.00 0.00 ? ? ? ? ? ? 35 ILE A HA 1 
ATOM 95  N N  . LEU A 1 15 ? -0.594  -1.072 -5.016  1.00 0.00 ? ? ? ? ? ? 36 LEU A N  1 
ATOM 96  C CA . LEU A 1 15 ? -0.660  -2.025 -3.914  1.00 0.00 ? ? ? ? ? ? 36 LEU A CA 1 
ATOM 97  C C  . LEU A 1 15 ? -0.553  -1.374 -2.538  1.00 0.00 ? ? ? ? ? ? 36 LEU A C  1 
ATOM 98  O O  . LEU A 1 15 ? -1.360  -1.642 -1.646  1.00 0.00 ? ? ? ? ? ? 36 LEU A O  1 
ATOM 99  C CB . LEU A 1 15 ? 0.463   -3.095 -4.021  1.00 0.00 ? ? ? ? ? ? 36 LEU A CB 1 
ATOM 100 H H  . LEU A 1 15 ? 0.138   -1.198 -5.681  1.00 0.00 ? ? ? ? ? ? 36 LEU A H  1 
ATOM 101 H HA . LEU A 1 15 ? -1.626  -2.501 -3.947  1.00 0.00 ? ? ? ? ? ? 36 LEU A HA 1 
ATOM 102 N N  . HIS A 1 16 ? 0.425   -0.462 -2.346  1.00 0.00 ? ? ? ? ? ? 37 HIS A N  1 
ATOM 103 C CA . HIS A 1 16 ? 0.561   0.304  -1.115  1.00 0.00 ? ? ? ? ? ? 37 HIS A CA 1 
ATOM 104 C C  . HIS A 1 16 ? -0.679  1.131  -0.763  1.00 0.00 ? ? ? ? ? ? 37 HIS A C  1 
ATOM 105 O O  . HIS A 1 16 ? -1.155  1.106  0.372   1.00 0.00 ? ? ? ? ? ? 37 HIS A O  1 
ATOM 106 C CB . HIS A 1 16 ? 1.793   1.241  -1.190  1.00 0.00 ? ? ? ? ? ? 37 HIS A CB 1 
ATOM 107 H H  . HIS A 1 16 ? 1.069   -0.264 -3.088  1.00 0.00 ? ? ? ? ? ? 37 HIS A H  1 
ATOM 108 H HA . HIS A 1 16 ? 0.693   -0.391 -0.302  1.00 0.00 ? ? ? ? ? ? 37 HIS A HA 1 
ATOM 109 N N  . LEU A 1 17 ? -1.245  1.877  -1.732  1.00 0.00 ? ? ? ? ? ? 38 LEU A N  1 
ATOM 110 C CA . LEU A 1 17 ? -2.481  2.630  -1.563  1.00 0.00 ? ? ? ? ? ? 38 LEU A CA 1 
ATOM 111 C C  . LEU A 1 17 ? -3.677  1.770  -1.145  1.00 0.00 ? ? ? ? ? ? 38 LEU A C  1 
ATOM 112 O O  . LEU A 1 17 ? -4.383  2.099  -0.194  1.00 0.00 ? ? ? ? ? ? 38 LEU A O  1 
ATOM 113 C CB . LEU A 1 17 ? -2.786  3.385  -2.881  1.00 0.00 ? ? ? ? ? ? 38 LEU A CB 1 
ATOM 114 H H  . LEU A 1 17 ? -0.793  1.938  -2.624  1.00 0.00 ? ? ? ? ? ? 38 LEU A H  1 
ATOM 115 H HA . LEU A 1 17 ? -2.323  3.336  -0.757  1.00 0.00 ? ? ? ? ? ? 38 LEU A HA 1 
ATOM 116 N N  . ILE A 1 18 ? -3.900  0.620  -1.819  1.00 0.00 ? ? ? ? ? ? 39 ILE A N  1 
ATOM 117 C CA . ILE A 1 18 ? -4.934  -0.355 -1.470  1.00 0.00 ? ? ? ? ? ? 39 ILE A CA 1 
ATOM 118 C C  . ILE A 1 18 ? -4.801  -0.870 -0.038  1.00 0.00 ? ? ? ? ? ? 39 ILE A C  1 
ATOM 119 O O  . ILE A 1 18 ? -5.771  -0.877 0.725   1.00 0.00 ? ? ? ? ? ? 39 ILE A O  1 
ATOM 120 C CB . ILE A 1 18 ? -4.967  -1.498 -2.494  1.00 0.00 ? ? ? ? ? ? 39 ILE A CB 1 
ATOM 121 H H  . ILE A 1 18 ? -3.314  0.385  -2.594  1.00 0.00 ? ? ? ? ? ? 39 ILE A H  1 
ATOM 122 H HA . ILE A 1 18 ? -5.893  0.148  -1.500  1.00 0.00 ? ? ? ? ? ? 39 ILE A HA 1 
ATOM 123 N N  . LEU A 1 19 ? -3.578  -1.267 0.368   1.00 0.00 ? ? ? ? ? ? 40 LEU A N  1 
ATOM 124 C CA . LEU A 1 19 ? -3.295  -1.678 1.747   1.00 0.00 ? ? ? ? ? ? 40 LEU A CA 1 
ATOM 125 C C  . LEU A 1 19 ? -3.640  -0.596 2.777   1.00 0.00 ? ? ? ? ? ? 40 LEU A C  1 
ATOM 126 O O  . LEU A 1 19 ? -4.332  -0.855 3.759   1.00 0.00 ? ? ? ? ? ? 40 LEU A O  1 
ATOM 127 C CB . LEU A 1 19 ? -1.806  -2.086 1.920   1.00 0.00 ? ? ? ? ? ? 40 LEU A CB 1 
ATOM 128 H H  . LEU A 1 19 ? -2.812  -1.340 -0.273  1.00 0.00 ? ? ? ? ? ? 40 LEU A H  1 
ATOM 129 H HA . LEU A 1 19 ? -3.927  -2.518 1.984   1.00 0.00 ? ? ? ? ? ? 40 LEU A HA 1 
ATOM 130 N N  . TRP A 1 20 ? -3.220  0.662  2.532   1.00 0.00 ? ? ? ? ? ? 41 TRP A N  1 
ATOM 131 C CA . TRP A 1 20 ? -3.524  1.806  3.382   1.00 0.00 ? ? ? ? ? ? 41 TRP A CA 1 
ATOM 132 C C  . TRP A 1 20 ? -5.033  2.057  3.559   1.00 0.00 ? ? ? ? ? ? 41 TRP A C  1 
ATOM 133 O O  . TRP A 1 20 ? -5.527  2.217  4.671   1.00 0.00 ? ? ? ? ? ? 41 TRP A O  1 
ATOM 134 C CB . TRP A 1 20 ? -2.796  3.047  2.804   1.00 0.00 ? ? ? ? ? ? 41 TRP A CB 1 
ATOM 135 H H  . TRP A 1 20 ? -2.745  0.873  1.681   1.00 0.00 ? ? ? ? ? ? 41 TRP A H  1 
ATOM 136 H HA . TRP A 1 20 ? -3.140  1.577  4.369   1.00 0.00 ? ? ? ? ? ? 41 TRP A HA 1 
ATOM 137 N N  . ILE A 1 21 ? -5.818  2.029  2.462   1.00 0.00 ? ? ? ? ? ? 42 ILE A N  1 
ATOM 138 C CA . ILE A 1 21 ? -7.281  2.144  2.454   1.00 0.00 ? ? ? ? ? ? 42 ILE A CA 1 
ATOM 139 C C  . ILE A 1 21 ? -7.948  1.037  3.261   1.00 0.00 ? ? ? ? ? ? 42 ILE A C  1 
ATOM 140 O O  . ILE A 1 21 ? -8.870  1.276  4.048   1.00 0.00 ? ? ? ? ? ? 42 ILE A O  1 
ATOM 141 C CB . ILE A 1 21 ? -7.803  2.177  1.010   1.00 0.00 ? ? ? ? ? ? 42 ILE A CB 1 
ATOM 142 H H  . ILE A 1 21 ? -5.349  1.874  1.596   1.00 0.00 ? ? ? ? ? ? 42 ILE A H  1 
ATOM 143 H HA . ILE A 1 21 ? -7.527  3.066  2.953   1.00 0.00 ? ? ? ? ? ? 42 ILE A HA 1 
ATOM 144 N N  . LEU A 1 22 ? -7.465  -0.217 3.137   1.00 0.00 ? ? ? ? ? ? 43 LEU A N  1 
ATOM 145 C CA . LEU A 1 22 ? -7.937  -1.350 3.916   1.00 0.00 ? ? ? ? ? ? 43 LEU A CA 1 
ATOM 146 C C  . LEU A 1 22 ? -7.688  -1.189 5.413   1.00 0.00 ? ? ? ? ? ? 43 LEU A C  1 
ATOM 147 O O  . LEU A 1 22 ? -8.541  -1.512 6.236   1.00 0.00 ? ? ? ? ? ? 43 LEU A O  1 
ATOM 148 C CB . LEU A 1 22 ? -7.265  -2.638 3.376   1.00 0.00 ? ? ? ? ? ? 43 LEU A CB 1 
ATOM 149 H H  . LEU A 1 22 ? -6.745  -0.438 2.475   1.00 0.00 ? ? ? ? ? ? 43 LEU A H  1 
ATOM 150 H HA . LEU A 1 22 ? -9.006  -1.406 3.778   1.00 0.00 ? ? ? ? ? ? 43 LEU A HA 1 
ATOM 151 N N  . ASP A 1 23 ? -6.519  -0.642 5.807   1.00 0.00 ? ? ? ? ? ? 44 ASP A N  1 
ATOM 152 C CA . ASP A 1 23 ? -6.231  -0.290 7.195   1.00 0.00 ? ? ? ? ? ? 44 ASP A CA 1 
ATOM 153 C C  . ASP A 1 23 ? -7.122  0.817  7.761   1.00 0.00 ? ? ? ? ? ? 44 ASP A C  1 
ATOM 154 O O  . ASP A 1 23 ? -7.556  0.738  8.903   1.00 0.00 ? ? ? ? ? ? 44 ASP A O  1 
ATOM 155 C CB . ASP A 1 23 ? -4.763  0.179  7.370   1.00 0.00 ? ? ? ? ? ? 44 ASP A CB 1 
ATOM 156 H H  . ASP A 1 23 ? -5.830  -0.407 5.116   1.00 0.00 ? ? ? ? ? ? 44 ASP A H  1 
ATOM 157 H HA . ASP A 1 23 ? -6.446  -1.156 7.805   1.00 0.00 ? ? ? ? ? ? 44 ASP A HA 1 
ATOM 158 N N  . ARG A 1 24 ? -7.412  1.876  6.981   1.00 0.00 ? ? ? ? ? ? 45 ARG A N  1 
ATOM 159 C CA . ARG A 1 24 ? -8.308  2.944  7.392   1.00 0.00 ? ? ? ? ? ? 45 ARG A CA 1 
ATOM 160 C C  . ARG A 1 24 ? -9.751  2.487  7.590   1.00 0.00 ? ? ? ? ? ? 45 ARG A C  1 
ATOM 161 O O  . ARG A 1 24 ? -10.450 2.957  8.482   1.00 0.00 ? ? ? ? ? ? 45 ARG A O  1 
ATOM 162 C CB . ARG A 1 24 ? -8.279  4.093  6.354   1.00 0.00 ? ? ? ? ? ? 45 ARG A CB 1 
ATOM 163 H H  . ARG A 1 24 ? -7.007  1.950  6.066   1.00 0.00 ? ? ? ? ? ? 45 ARG A H  1 
ATOM 164 H HA . ARG A 1 24 ? -7.992  3.314  8.358   1.00 0.00 ? ? ? ? ? ? 45 ARG A HA 1 
ATOM 165 N N  . LEU A 1 25 ? -10.239 1.548  6.757   1.00 0.00 ? ? ? ? ? ? 46 LEU A N  1 
ATOM 166 C CA . LEU A 1 25 ? -11.564 0.972  6.866   1.00 0.00 ? ? ? ? ? ? 46 LEU A CA 1 
ATOM 167 C C  . LEU A 1 25 ? -11.714 0.086  8.100   1.00 0.00 ? ? ? ? ? ? 46 LEU A C  1 
ATOM 168 O O  . LEU A 1 25 ? -12.742 0.113  8.784   1.00 0.00 ? ? ? ? ? ? 46 LEU A O  1 
ATOM 169 C CB . LEU A 1 25 ? -11.832 0.136  5.597   1.00 0.00 ? ? ? ? ? ? 46 LEU A CB 1 
ATOM 170 H H  . LEU A 1 25 ? -9.666  1.223  6.002   1.00 0.00 ? ? ? ? ? ? 46 LEU A H  1 
ATOM 171 H HA . LEU A 1 25 ? -12.282 1.774  6.962   1.00 0.00 ? ? ? ? ? ? 46 LEU A HA 1 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1  SER 1  22 22 SER SER A . n 
A 1 2  SER 2  23 23 SER SER A . n 
A 1 3  ASP 3  24 24 ASP ASP A . n 
A 1 4  PRO 4  25 25 PRO PRO A . n 
A 1 5  LEU 5  26 26 LEU LEU A . n 
A 1 6  VAL 6  27 27 VAL VAL A . n 
A 1 7  VAL 7  28 28 VAL VAL A . n 
A 1 8  ALA 8  29 29 ALA ALA A . n 
A 1 9  ALA 9  30 30 ALA ALA A . n 
A 1 10 SER 10 31 31 SER SER A . n 
A 1 11 ILE 11 32 32 ILE ILE A . n 
A 1 12 ILE 12 33 33 ILE ILE A . n 
A 1 13 GLY 13 34 34 GLY GLY A . n 
A 1 14 ILE 14 35 35 ILE ILE A . n 
A 1 15 LEU 15 36 36 LEU LEU A . n 
A 1 16 HIS 16 37 37 HIS HIS A . n 
A 1 17 LEU 17 38 38 LEU LEU A . n 
A 1 18 ILE 18 39 39 ILE ILE A . n 
A 1 19 LEU 19 40 40 LEU LEU A . n 
A 1 20 TRP 20 41 41 TRP TRP A . n 
A 1 21 ILE 21 42 42 ILE ILE A . n 
A 1 22 LEU 22 43 43 LEU LEU A . n 
A 1 23 ASP 23 44 44 ASP ASP A . n 
A 1 24 ARG 24 45 45 ARG ARG A . n 
A 1 25 LEU 25 46 46 LEU LEU A . n 
# 
_pdbx_prerelease_seq.entity_id             1 
_pdbx_prerelease_seq.seq_one_letter_code   SSDPLVVAASIIGILHLILWILDRL 
# 
loop_
_pdbx_version.entry_id 
_pdbx_version.revision_date 
_pdbx_version.major_version 
_pdbx_version.minor_version 
_pdbx_version.revision_type 
_pdbx_version.details 
1MP6 2008-04-28 3 2    'Version format compliance' 'compliance with PDB format V.3.15'          
1MP6 2011-07-13 4 0000 'Version format compliance' 'compliance with PDB Exchange Dictionary V4' 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
1   Y 1 1 A SER 22 ? OG   ? 
2   Y 1 1 A SER 22 ? HB2  ? 
3   Y 1 1 A SER 22 ? HB3  ? 
4   Y 1 1 A SER 22 ? HG   ? 
5   Y 1 1 A SER 23 ? OG   ? 
6   Y 1 1 A SER 23 ? HB2  ? 
7   Y 1 1 A SER 23 ? HB3  ? 
8   Y 1 1 A SER 23 ? HG   ? 
9   Y 1 1 A ASP 24 ? CG   ? 
10  Y 1 1 A ASP 24 ? OD1  ? 
11  Y 1 1 A ASP 24 ? OD2  ? 
12  Y 1 1 A ASP 24 ? HB2  ? 
13  Y 1 1 A ASP 24 ? HB3  ? 
14  Y 1 1 A PRO 25 ? CG   ? 
15  Y 1 1 A PRO 25 ? CD   ? 
16  Y 1 1 A PRO 25 ? HB2  ? 
17  Y 1 1 A PRO 25 ? HB3  ? 
18  Y 1 1 A PRO 25 ? HG2  ? 
19  Y 1 1 A PRO 25 ? HG3  ? 
20  Y 1 1 A PRO 25 ? HD2  ? 
21  Y 1 1 A PRO 25 ? HD3  ? 
22  Y 1 1 A LEU 26 ? CG   ? 
23  Y 1 1 A LEU 26 ? CD1  ? 
24  Y 1 1 A LEU 26 ? CD2  ? 
25  Y 1 1 A LEU 26 ? HB2  ? 
26  Y 1 1 A LEU 26 ? HB3  ? 
27  Y 1 1 A LEU 26 ? HG   ? 
28  Y 1 1 A LEU 26 ? HD11 ? 
29  Y 1 1 A LEU 26 ? HD12 ? 
30  Y 1 1 A LEU 26 ? HD13 ? 
31  Y 1 1 A LEU 26 ? HD21 ? 
32  Y 1 1 A LEU 26 ? HD22 ? 
33  Y 1 1 A LEU 26 ? HD23 ? 
34  Y 1 1 A VAL 27 ? CG1  ? 
35  Y 1 1 A VAL 27 ? CG2  ? 
36  Y 1 1 A VAL 27 ? HB   ? 
37  Y 1 1 A VAL 27 ? HG11 ? 
38  Y 1 1 A VAL 27 ? HG12 ? 
39  Y 1 1 A VAL 27 ? HG13 ? 
40  Y 1 1 A VAL 27 ? HG21 ? 
41  Y 1 1 A VAL 27 ? HG22 ? 
42  Y 1 1 A VAL 27 ? HG23 ? 
43  Y 1 1 A VAL 28 ? CG1  ? 
44  Y 1 1 A VAL 28 ? CG2  ? 
45  Y 1 1 A VAL 28 ? HB   ? 
46  Y 1 1 A VAL 28 ? HG11 ? 
47  Y 1 1 A VAL 28 ? HG12 ? 
48  Y 1 1 A VAL 28 ? HG13 ? 
49  Y 1 1 A VAL 28 ? HG21 ? 
50  Y 1 1 A VAL 28 ? HG22 ? 
51  Y 1 1 A VAL 28 ? HG23 ? 
52  Y 1 1 A ALA 29 ? HB1  ? 
53  Y 1 1 A ALA 29 ? HB2  ? 
54  Y 1 1 A ALA 29 ? HB3  ? 
55  Y 1 1 A ALA 30 ? HB1  ? 
56  Y 1 1 A ALA 30 ? HB2  ? 
57  Y 1 1 A ALA 30 ? HB3  ? 
58  Y 1 1 A SER 31 ? OG   ? 
59  Y 1 1 A SER 31 ? HB2  ? 
60  Y 1 1 A SER 31 ? HB3  ? 
61  Y 1 1 A SER 31 ? HG   ? 
62  Y 1 1 A ILE 32 ? CG1  ? 
63  Y 1 1 A ILE 32 ? CG2  ? 
64  Y 1 1 A ILE 32 ? CD1  ? 
65  Y 1 1 A ILE 32 ? HB   ? 
66  Y 1 1 A ILE 32 ? HG12 ? 
67  Y 1 1 A ILE 32 ? HG13 ? 
68  Y 1 1 A ILE 32 ? HG21 ? 
69  Y 1 1 A ILE 32 ? HG22 ? 
70  Y 1 1 A ILE 32 ? HG23 ? 
71  Y 1 1 A ILE 32 ? HD11 ? 
72  Y 1 1 A ILE 32 ? HD12 ? 
73  Y 1 1 A ILE 32 ? HD13 ? 
74  Y 1 1 A ILE 33 ? CG1  ? 
75  Y 1 1 A ILE 33 ? CG2  ? 
76  Y 1 1 A ILE 33 ? CD1  ? 
77  Y 1 1 A ILE 33 ? HB   ? 
78  Y 1 1 A ILE 33 ? HG12 ? 
79  Y 1 1 A ILE 33 ? HG13 ? 
80  Y 1 1 A ILE 33 ? HG21 ? 
81  Y 1 1 A ILE 33 ? HG22 ? 
82  Y 1 1 A ILE 33 ? HG23 ? 
83  Y 1 1 A ILE 33 ? HD11 ? 
84  Y 1 1 A ILE 33 ? HD12 ? 
85  Y 1 1 A ILE 33 ? HD13 ? 
86  Y 1 1 A GLY 34 ? HA2  ? 
87  Y 1 1 A GLY 34 ? HA3  ? 
88  Y 1 1 A ILE 35 ? CG1  ? 
89  Y 1 1 A ILE 35 ? CG2  ? 
90  Y 1 1 A ILE 35 ? CD1  ? 
91  Y 1 1 A ILE 35 ? HB   ? 
92  Y 1 1 A ILE 35 ? HG12 ? 
93  Y 1 1 A ILE 35 ? HG13 ? 
94  Y 1 1 A ILE 35 ? HG21 ? 
95  Y 1 1 A ILE 35 ? HG22 ? 
96  Y 1 1 A ILE 35 ? HG23 ? 
97  Y 1 1 A ILE 35 ? HD11 ? 
98  Y 1 1 A ILE 35 ? HD12 ? 
99  Y 1 1 A ILE 35 ? HD13 ? 
100 Y 1 1 A LEU 36 ? CG   ? 
101 Y 1 1 A LEU 36 ? CD1  ? 
102 Y 1 1 A LEU 36 ? CD2  ? 
103 Y 1 1 A LEU 36 ? HB2  ? 
104 Y 1 1 A LEU 36 ? HB3  ? 
105 Y 1 1 A LEU 36 ? HG   ? 
106 Y 1 1 A LEU 36 ? HD11 ? 
107 Y 1 1 A LEU 36 ? HD12 ? 
108 Y 1 1 A LEU 36 ? HD13 ? 
109 Y 1 1 A LEU 36 ? HD21 ? 
110 Y 1 1 A LEU 36 ? HD22 ? 
111 Y 1 1 A LEU 36 ? HD23 ? 
112 Y 1 1 A HIS 37 ? CG   ? 
113 Y 1 1 A HIS 37 ? ND1  ? 
114 Y 1 1 A HIS 37 ? CD2  ? 
115 Y 1 1 A HIS 37 ? CE1  ? 
116 Y 1 1 A HIS 37 ? NE2  ? 
117 Y 1 1 A HIS 37 ? HB2  ? 
118 Y 1 1 A HIS 37 ? HB3  ? 
119 Y 1 1 A HIS 37 ? HD2  ? 
120 Y 1 1 A HIS 37 ? HE1  ? 
121 Y 1 1 A LEU 38 ? CG   ? 
122 Y 1 1 A LEU 38 ? CD1  ? 
123 Y 1 1 A LEU 38 ? CD2  ? 
124 Y 1 1 A LEU 38 ? HB2  ? 
125 Y 1 1 A LEU 38 ? HB3  ? 
126 Y 1 1 A LEU 38 ? HG   ? 
127 Y 1 1 A LEU 38 ? HD11 ? 
128 Y 1 1 A LEU 38 ? HD12 ? 
129 Y 1 1 A LEU 38 ? HD13 ? 
130 Y 1 1 A LEU 38 ? HD21 ? 
131 Y 1 1 A LEU 38 ? HD22 ? 
132 Y 1 1 A LEU 38 ? HD23 ? 
133 Y 1 1 A ILE 39 ? CG1  ? 
134 Y 1 1 A ILE 39 ? CG2  ? 
135 Y 1 1 A ILE 39 ? CD1  ? 
136 Y 1 1 A ILE 39 ? HB   ? 
137 Y 1 1 A ILE 39 ? HG12 ? 
138 Y 1 1 A ILE 39 ? HG13 ? 
139 Y 1 1 A ILE 39 ? HG21 ? 
140 Y 1 1 A ILE 39 ? HG22 ? 
141 Y 1 1 A ILE 39 ? HG23 ? 
142 Y 1 1 A ILE 39 ? HD11 ? 
143 Y 1 1 A ILE 39 ? HD12 ? 
144 Y 1 1 A ILE 39 ? HD13 ? 
145 Y 1 1 A LEU 40 ? CG   ? 
146 Y 1 1 A LEU 40 ? CD1  ? 
147 Y 1 1 A LEU 40 ? CD2  ? 
148 Y 1 1 A LEU 40 ? HB2  ? 
149 Y 1 1 A LEU 40 ? HB3  ? 
150 Y 1 1 A LEU 40 ? HG   ? 
151 Y 1 1 A LEU 40 ? HD11 ? 
152 Y 1 1 A LEU 40 ? HD12 ? 
153 Y 1 1 A LEU 40 ? HD13 ? 
154 Y 1 1 A LEU 40 ? HD21 ? 
155 Y 1 1 A LEU 40 ? HD22 ? 
156 Y 1 1 A LEU 40 ? HD23 ? 
157 Y 1 1 A TRP 41 ? CG   ? 
158 Y 1 1 A TRP 41 ? CD1  ? 
159 Y 1 1 A TRP 41 ? CD2  ? 
160 Y 1 1 A TRP 41 ? NE1  ? 
161 Y 1 1 A TRP 41 ? CE2  ? 
162 Y 1 1 A TRP 41 ? CE3  ? 
163 Y 1 1 A TRP 41 ? CZ2  ? 
164 Y 1 1 A TRP 41 ? CZ3  ? 
165 Y 1 1 A TRP 41 ? CH2  ? 
166 Y 1 1 A TRP 41 ? HB2  ? 
167 Y 1 1 A TRP 41 ? HB3  ? 
168 Y 1 1 A TRP 41 ? HD1  ? 
169 Y 1 1 A TRP 41 ? HE1  ? 
170 Y 1 1 A TRP 41 ? HE3  ? 
171 Y 1 1 A TRP 41 ? HZ2  ? 
172 Y 1 1 A TRP 41 ? HZ3  ? 
173 Y 1 1 A TRP 41 ? HH2  ? 
174 Y 1 1 A ILE 42 ? CG1  ? 
175 Y 1 1 A ILE 42 ? CG2  ? 
176 Y 1 1 A ILE 42 ? CD1  ? 
177 Y 1 1 A ILE 42 ? HB   ? 
178 Y 1 1 A ILE 42 ? HG12 ? 
179 Y 1 1 A ILE 42 ? HG13 ? 
180 Y 1 1 A ILE 42 ? HG21 ? 
181 Y 1 1 A ILE 42 ? HG22 ? 
182 Y 1 1 A ILE 42 ? HG23 ? 
183 Y 1 1 A ILE 42 ? HD11 ? 
184 Y 1 1 A ILE 42 ? HD12 ? 
185 Y 1 1 A ILE 42 ? HD13 ? 
186 Y 1 1 A LEU 43 ? CG   ? 
187 Y 1 1 A LEU 43 ? CD1  ? 
188 Y 1 1 A LEU 43 ? CD2  ? 
189 Y 1 1 A LEU 43 ? HB2  ? 
190 Y 1 1 A LEU 43 ? HB3  ? 
191 Y 1 1 A LEU 43 ? HG   ? 
192 Y 1 1 A LEU 43 ? HD11 ? 
193 Y 1 1 A LEU 43 ? HD12 ? 
194 Y 1 1 A LEU 43 ? HD13 ? 
195 Y 1 1 A LEU 43 ? HD21 ? 
196 Y 1 1 A LEU 43 ? HD22 ? 
197 Y 1 1 A LEU 43 ? HD23 ? 
198 Y 1 1 A ASP 44 ? CG   ? 
199 Y 1 1 A ASP 44 ? OD1  ? 
200 Y 1 1 A ASP 44 ? OD2  ? 
201 Y 1 1 A ASP 44 ? HB2  ? 
202 Y 1 1 A ASP 44 ? HB3  ? 
203 Y 1 1 A ARG 45 ? CG   ? 
204 Y 1 1 A ARG 45 ? CD   ? 
205 Y 1 1 A ARG 45 ? NE   ? 
206 Y 1 1 A ARG 45 ? CZ   ? 
207 Y 1 1 A ARG 45 ? NH1  ? 
208 Y 1 1 A ARG 45 ? NH2  ? 
209 Y 1 1 A ARG 45 ? HB2  ? 
210 Y 1 1 A ARG 45 ? HB3  ? 
211 Y 1 1 A ARG 45 ? HG2  ? 
212 Y 1 1 A ARG 45 ? HG3  ? 
213 Y 1 1 A ARG 45 ? HD2  ? 
214 Y 1 1 A ARG 45 ? HD3  ? 
215 Y 1 1 A ARG 45 ? HE   ? 
216 Y 1 1 A ARG 45 ? HH11 ? 
217 Y 1 1 A ARG 45 ? HH12 ? 
218 Y 1 1 A ARG 45 ? HH21 ? 
219 Y 1 1 A ARG 45 ? HH22 ? 
220 Y 1 1 A LEU 46 ? CG   ? 
221 Y 1 1 A LEU 46 ? CD1  ? 
222 Y 1 1 A LEU 46 ? CD2  ? 
223 Y 1 1 A LEU 46 ? HB2  ? 
224 Y 1 1 A LEU 46 ? HB3  ? 
225 Y 1 1 A LEU 46 ? HG   ? 
226 Y 1 1 A LEU 46 ? HD11 ? 
227 Y 1 1 A LEU 46 ? HD12 ? 
228 Y 1 1 A LEU 46 ? HD13 ? 
229 Y 1 1 A LEU 46 ? HD21 ? 
230 Y 1 1 A LEU 46 ? HD22 ? 
231 Y 1 1 A LEU 46 ? HD23 ? 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
