BMRB Entry 16639

Name: Structure of a complex between domain V of beta2-glycoprotein I and the fourth ligand-binding module from LDLR determined with Haddock.
Published: 2010-05-05

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PDB ID: 2kri
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR16639
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: Structure of a complex between domain V of beta2-glycoprotein I and the fourth ligand-binding module from LDLR determined with Haddock. PubMed: 20223219

Deposition date: 2009-12-18 Original release date: 2010-05-05

Authors: Beglova, Natalia

Citation: Lee, Chang-Jin; De Biasio, Alfredo; Beglova, Natalia. "Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids." Structure (Cambridge, MA, U. S.) 18, 366-376 (2010).

Assembly members:
beta2GPI, polymer, 85 residues, 9366.987 Da.
LDLR, polymer, 40 residues, 4181.480 Da.
CA, non-polymer, 40.078 Da.

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):
beta2GPI: GSCKLPVKKATVVYQGERVK IQEKFKNGMLHGDKVSFFCK NKEKKCSYTEDAQCIDGTIE VPKCFKEHSSLAFWKTDASD VKPCA
LDLR: TCGPASFQCNSSTCIPQLWA CDNDPDCEDGSDEWPQRCRG

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1
heteronucl_T1_relaxation
- heteronuclear_R1_list_1
heteronucl_T2_relaxation
- heteronuclear_R2_list_1

Data type	Count
15N chemical shifts	104
1H chemical shifts	104
T1 relaxation values	95
T2 relaxation values	95

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Entity Assembly ID	Entity Name	Entity ID
1	beta2GPI	1
2	LDLR	2
3	Calcium ion	3

1	THR	CYS	GLY	PRO	ALA	SER	PHE	GLN	CYS	ASN
2	SER	SER	THR	CYS	ILE	PRO	GLN	LEU	TRP	ALA
3	CYS	ASP	ASN	ASP	PRO	ASP	CYS	GLU	ASP	GLY
4	SER	ASP	GLU	TRP	PRO	GLN	ARG	CYS	ARG	GLY

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-15N HSQC	sample_2	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HN(CO)CA	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_2	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_2	isotropic	sample_conditions_1
3D HN(CO)CA	sample_2	isotropic	sample_conditions_1

Biological Magnetic Resonance Data Bank

BMRB Entry 16639

Title: Structure of a complex between domain V of beta2-glycoprotein I and the fourth ligand-binding module from LDLR determined with Haddock. PubMed: 20223219

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	THR	CYS	GLY	PRO	ALA	SER	PHE	GLN	CYS	ASN
2	SER	SER	THR	CYS	ILE	PRO	GLN	LEU	TRP	ALA
3	CYS	ASP	ASN	ASP	PRO	ASP	CYS	GLU	ASP	GLY
4	SER	ASP	GLU	TRP	PRO	GLN	ARG	CYS	ARG	GLY

1	THR	CYS	GLY	PRO	ALA	SER	PHE	GLN	CYS	ASN
2	SER	SER	THR	CYS	ILE	PRO	GLN	LEU	TRP	ALA
3	CYS	ASP	ASN	ASP	PRO	ASP	CYS	GLU	ASP	GLY
4	SER	ASP	GLU	TRP	PRO	GLN	ARG	CYS	ARG	GLY

1	THR	CYS	GLY	PRO	ALA	SER	PHE	GLN	CYS	ASN
2	SER	SER	THR	CYS	ILE	PRO	GLN	LEU	TRP	ALA
3	CYS	ASP	ASN	ASP	PRO	ASP	CYS	GLU	ASP	GLY
4	SER	ASP	GLU	TRP	PRO	GLN	ARG	CYS	ARG	GLY