BMRB Entry 16851
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PDB ID: 2kwf
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR16851
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Title: The structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1 PubMed: 24682819
Deposition date: 2010-04-08 Original release date: 2012-08-02
Authors: Denis, Christopher; Chitayat, Seth; Plevin, Michael; Liu, Shuang; Spencer, Holly; Ikura, Mitsuhiko; LeBrun, David; Smith, Steven
Citation: Denis, Christopher; Langelaan, David; Kirlin, Alyssa; Chitayat, Seth; Munro, Kim; Spencer, Holly; LeBrun, David; Smith, Steven. "Functional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300." Nucleic Acids Res. ., .-. (2014).
Assembly members:
KIX, polymer, 87 residues, 10353.954 Da.
ETAD1, polymer, 19 residues, 2021.198 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
KIX: GVRKGWHEHVTQDLRSHLVH
KLVQAIFPTPDPAALKDRRM
ENLVAYAKKVEGDMYESANS
RDEYYHLLAEKIYKIQKELE
EKRRSRL
ETAD1: GSGTDKELSDLLDFSAMFS
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 438 |
| 15N chemical shifts | 112 |
| 1H chemical shifts | 656 |
Additional metadata:
Related Database Links:
| BMRB | 18314 18315 18694 18695 16467 |
| PDB | 1KDX 1SB0 2AGH 2KWF 2LQH 2LQI 2LXS 2LXT 2KNH |
| DBJ | BAE06125 BAG65526 BAI45616 BAC26095 BAC38116 BAE21912 BAE21989 BAE25324 |
| GB | AAB28651 AAC08447 AAC51331 AAC51770 AAH72594 AAA42115 AAA58632 AAA60311 AAB32662 AAB62389 |
| PRF | 1923401A 2208360B |
| REF | NP_001020603 NP_001073315 NP_001157494 NP_001247644 NP_004371 NP_001071353 NP_001077431 NP_001077436 NP_001187118 NP_001187247 |
| SP | P45481 Q6JHU9 Q92793 P15884 P51514 Q60722 Q61286 Q99081 |
| TPG | DAA15549 DAA01129 DAA25320 |
| EMBL | CAA46052 CAA62868 CAD89914 CAF92364 CAG00972 |
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