BMRB Entry 16853

Name: NMR structure of the transmembrane and cytoplasmic domains of human CD4
Published: 2012-08-02

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PDB ID: 2klu
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR16853
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: NMR structure of the transmembrane and cytoplasmic domains of human CD4 PubMed: 18035040

Deposition date: 2010-04-09 Original release date: 2012-08-02

Authors: Wittlich, Marc; Willbold, Dieter

Citation: Wittlich, Marc; Koenig, Bernd; Hoffmann, Silke; Willbold, Dieter. "Structural characterization of the transmembrane and cytoplasmic domains of human CD4." Biochim. Biophys. Acta 1768, 2949-2960 (2007).

Assembly members:
CD4, polymer, 70 residues, 7850.4 Da.
DPC, non-polymer, 389.445 Da.

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):
CD4: GPLVPRGSMALIVLGGVAGL LLFIGLGIFFSVRSRHRRRQ AERMSQIKRLLSEKKTSQSP HRFQKTHSPI

Data sets:

assigned_chemical_shifts
- CD4mut_BMRB

Data type	Count
13C chemical shifts	329
15N chemical shifts	68
1H chemical shifts	529

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Entity Assembly ID	Entity Name	Entity ID
1	CD4mut	1
2	micelle	2

1	GLY	PRO	LEU	VAL	PRO	ARG	GLY	SER	MET	ALA
2	LEU	ILE	VAL	LEU	GLY	GLY	VAL	ALA	GLY	LEU
3	LEU	LEU	PHE	ILE	GLY	LEU	GLY	ILE	PHE	PHE
4	SER	VAL	ARG	SER	ARG	HIS	ARG	ARG	ARG	GLN
5	ALA	GLU	ARG	MET	SER	GLN	ILE	LYS	ARG	LEU
6	LEU	SER	GLU	LYS	LYS	THR	SER	GLN	SER	PRO
7	HIS	ARG	PHE	GLN	LYS	THR	HIS	SER	PRO	ILE

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC	sample_1	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HBHA(CO)NH	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_1	isotropic	sample_conditions_1
3D HCCH-COSY	sample_1	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_1	isotropic	sample_conditions_1

Biological Magnetic Resonance Data Bank

BMRB Entry 16853

Title: NMR structure of the transmembrane and cytoplasmic domains of human CD4 PubMed: 18035040

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	GLY	PRO	LEU	VAL	PRO	ARG	GLY	SER	MET	ALA
2	LEU	ILE	VAL	LEU	GLY	GLY	VAL	ALA	GLY	LEU
3	LEU	LEU	PHE	ILE	GLY	LEU	GLY	ILE	PHE	PHE
4	SER	VAL	ARG	SER	ARG	HIS	ARG	ARG	ARG	GLN
5	ALA	GLU	ARG	MET	SER	GLN	ILE	LYS	ARG	LEU
6	LEU	SER	GLU	LYS	LYS	THR	SER	GLN	SER	PRO
7	HIS	ARG	PHE	GLN	LYS	THR	HIS	SER	PRO	ILE

1	GLY	PRO	LEU	VAL	PRO	ARG	GLY	SER	MET	ALA
2	LEU	ILE	VAL	LEU	GLY	GLY	VAL	ALA	GLY	LEU
3	LEU	LEU	PHE	ILE	GLY	LEU	GLY	ILE	PHE	PHE
4	SER	VAL	ARG	SER	ARG	HIS	ARG	ARG	ARG	GLN
5	ALA	GLU	ARG	MET	SER	GLN	ILE	LYS	ARG	LEU
6	LEU	SER	GLU	LYS	LYS	THR	SER	GLN	SER	PRO
7	HIS	ARG	PHE	GLN	LYS	THR	HIS	SER	PRO	ILE

1	GLY	PRO	LEU	VAL	PRO	ARG	GLY	SER	MET	ALA
2	LEU	ILE	VAL	LEU	GLY	GLY	VAL	ALA	GLY	LEU
3	LEU	LEU	PHE	ILE	GLY	LEU	GLY	ILE	PHE	PHE
4	SER	VAL	ARG	SER	ARG	HIS	ARG	ARG	ARG	GLN
5	ALA	GLU	ARG	MET	SER	GLN	ILE	LYS	ARG	LEU
6	LEU	SER	GLU	LYS	LYS	THR	SER	GLN	SER	PRO
7	HIS	ARG	PHE	GLN	LYS	THR	HIS	SER	PRO	ILE