BMRB Entry 17392

Name: NMR Solution structures of CBP bromodomain with small molucule J28
Published: 2011-02-09

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PDB ID: 2l84
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR17392
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: NMR Solution structures of CBP bromodomain with small molucule J28 PubMed: 21513889

Deposition date: 2011-01-03 Original release date: 2011-02-09

Authors: Borah, Jagat; Mujtaba, Shiraz; Karakikes, Ioannis; Zeng, Lei; Muller, Michaela; Patel, Jigneshkumar; Moshkina, Natasha; Morohashi, Keita; Zhang, Weijia; Gerona-Navarro, Guillermo; Hajjar, Roger; Zhou, Ming-Ming

Citation: Borah, Jagat; Mujtaba, Shiraz; Karakikes, Ioannis; Zeng, Lei; Muller, Michaela; Patel, Jigneshkumar; Moshkina, Natasha; Morohashi, Keita; Zhang, Weijia; Gerona-Navarro, Guillermo; Hajjar, Roger; Zhou, Ming-Ming. "A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes." Chem. Biol. 18, 531-541 (2011).

Assembly members:
entity_1, polymer, 121 residues, 14418.670 Da.
J28, non-polymer, 335.378 Da.

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):
entity_1: GSHMRKKIFKPEELRQALMP TLEALYRQDPESLPFRQPVD PQLLGIPDYFDIVKNPMDLS TIKRKLDTGQYQEPWQYVDD VWLMFNNAWLYNRKTSRVYK FCSKLAEVFEQEIDPVMQSL G

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list

Data type	Count
13C chemical shifts	442
15N chemical shifts	122
1H chemical shifts	849

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Entity Assembly ID	Entity Name	Entity ID
1	CBP bromodomain	1
2	J28	2

Name	Sample	Sample state	Sample conditions
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HN(CO)CACB	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_2	isotropic	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_2	isotropic	sample_conditions_1
3D 13C-Edited-13C/15N-filtered NOESY	sample_2	isotropic	sample_conditions_1

BMRB	17393
PDB	1JSP 2D82 2L84 2L85 2RNY 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K 4N3W 4N4F 4NR4 4NR5 4NR6 4NR7 4NYV 4NYW 4NYX 4OUF 4TQN 4TS8
DBJ	BAE06125 BAG65526 BAI45616
GB	AAB28651 AAC51331 AAC51770 AAH72594 AAI72737
PRF	1923401A
REF	NP_001020603 NP_001073315 NP_001157494 NP_001247644 NP_004371
SP	P45481 Q6JHU9 Q92793
TPG	DAA15549

Biological Magnetic Resonance Data Bank

BMRB Entry 17392

Title: NMR Solution structures of CBP bromodomain with small molucule J28 PubMed: 21513889

Additional metadata:

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Entities:

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