BMRB Entry 17569

Name: Solution structure of the ADD domain of ATRX complexed with histone tail H3 1-15 K9me3
Published: 2011-06-16

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PDB ID: 2lbm
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, SPARTA
BMRB Entry DOI: doi:10.13018/BMR17569
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: Solution structure of the ADD domain of ATRX complexed with histone tail H3 1-15 K9me3 PubMed: 21666677

Deposition date: 2011-04-08 Original release date: 2011-06-16

Authors: Eustermann, Sebastian; Yang, Ji-Chun; Neuhaus, David

Citation: Eustermann, Sebastian; Yang, Ji-Chun; Law, Martin; Amos, Rachel; Chapman, Lynda; Jelinska, Clare; Garrick, David; Clynes, David; Gibbons, Richard; Rhodes, Daniela; Higgs, Douglas; Neuhaus, David. "Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin." Nat. Struct. Mol. Biol. 18, 777-782 (2011).

Assembly members:
ATRX_ADD_domain, polymer, 142 residues, 16274.673 Da.
H3_tail_1-15_K9me3, polymer, 15 residues, 1607.892 Da.
ZN, non-polymer, 65.409 Da.

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):
ATRX_ADD_domain: GAMADKRGDGLHGIVSCTAC GQQVNHFQKDSIYRHPSLQV LICKNCFKYYMSDDISRDSD GMDEQCRWCAEGGNLICCDF CHNAFCKKCILRNLGRKELS TIMDENNQWYCYICHPEPLL DLVTACNSVFENLEQLLQQN KK
H3_tail_1-15_K9me3: ARTKQTARXSTGGKA

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	393
15N chemical shifts	148
1H chemical shifts	949

Additional metadata:

Assembly
Samples and Experiments
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Entity Assembly ID	Entity Name	Entity ID
1	ATRX_ADD_domain	1
2	H3_tail_1-15_K9me3	2
3	ZN1_1	3
4	ZN1_2	3
5	ZN1_3	3

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC aliphatic (constant-time)	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC aromatic (constant-time)	sample_1	isotropic	sample_conditions_1
2D 1H-1H NOESY (13C-H rejected in F1 and F2)	sample_2	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HN(CO)CA	sample_1	isotropic	sample_conditions_1
3D HBHA(CO)NH	sample_1	isotropic	sample_conditions_1
3D H[C]CH-TOCSY	sample_1	isotropic	sample_conditions_1
3D [H]CCH-TOCSY	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_1	isotropic	sample_conditions_1
2D 1H-1H TOCSY (13C-H rejected in F1 and F2)	sample_2	isotropic	sample_conditions_1
2D 1H-1H NOESY (15N-H rejected in F2)	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_2	isotropic	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_2	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic (rejected 13C-H in F1, 12C-H in F3)	sample_2	isotropic	sample_conditions_1
2D 1H-1H NOESY (13C-H rejected F1, 12C-H rejected F2)	sample_2	isotropic	sample_conditions_1
2D 1H-1H NOESY (13C-H and 15N-H rejected in F1 and F2)	sample_1	isotropic	sample_conditions_1

BMRB	15001
PDB	2JM1 2LBM 2LD1
DBJ	BAC28096 BAC40142 BAC81110 BAC81111 BAC81112
EMBL	CAB90351 CAI40710 CAI42674 CAI42675 CAI43115
GB	AAB40698 AAB40699 AAB40700 AAB49969 AAB49970
REF	NP_000480 NP_001009018 NP_033556 NP_612114 XP_001099671
SP	P46100 Q61687 Q7YQM3 Q7YQM4
TPG	DAA12976 DAA12977

Biological Magnetic Resonance Data Bank

BMRB Entry 17569

Title: Solution structure of the ADD domain of ATRX complexed with histone tail H3 1-15 K9me3 PubMed: 21666677

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