BMRB Entry 17623

Name: MODEL OF HUMAN U2AF65 TANDEM RRM1 AND RRM2 DOMAINS WITH EIGHT-SITE URIDINE BINDING
Published: 2011-08-03

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PDB ID: 2yh1
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR17623
MolProbity Validation Chart

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Nicholas Rego and David Koes
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: MODEL OF HUMAN U2AF65 TANDEM RRM1 AND RRM2 DOMAINS WITH EIGHT-SITE URIDINE BINDING

Deposition date: 2011-05-04 Original release date: 2011-08-03

Authors: Mackereth, C.; Madl, T.; Simon, B.; Zanier, K.; Gasch, A.; Sattler, Michael

Citation: Mackereth, C.; Madl, T.; Bonnal, S.; Simon, B.; Zanier, K.; Gasch, A.; Rybin, V.; Valcarcel, J.; Sattler, Michael. "Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF" Nature ., .-..

Assembly members:
HUMAN_U2AF65, polymer, 198 residues, 21491.534 Da.
5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP)-3', polymer, 9 residues, 2774.53744 Da.

Natural source: Common Name: HUMAN Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: chemical synthesis Host organism: unknown

Entity Sequences (FASTA):
HUMAN_U2AF65: GAMARRLYVGNIPFGITEEA MMDFFNAQMRLGGLTQAPGN PVLAVQINQDKNFAFLEFRS VDETTQAMAFDGIIFQGQSL KIRRPHDYQPLPGMSENPSV YVPGVVSTVVPDSAHKLFIG GLPNYLNDDQVKELLTSFGP LKAFNLVKDSATGLSKGYAF CEYVDINVTDQAIAGLNGMQ LGDKKLLVQRASVGAKNA
5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP)-3': UUUUUUUUU

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	375
15N chemical shifts	184
1H chemical shifts	914

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Assembly
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Entity Assembly ID	Entity Name	Entity ID
1	HUMAN U2AF65	1
2	5'-R(UPUPUPUPUPUPUPUP*UP)-3'	2

Name	Sample	Sample state	Sample conditions
1H	sample_1	solution	sample_conditions_1
15N HSQC (PRE)	sample_1	solution	sample_conditions_1
15N TROSY (HN-N RDC)	sample_1	solution	sample_conditions_1
3D HNCO (N-CO RDC)	sample_1	solution	sample_conditions_1

UNP	U2AF2_HUMAN
BMRB	17622
PDB	2YH0 2YH1 2YH1
DBJ	BAC37309 BAG70075 BAG70201 BAI45669
EMBL	CAA45409 CAA45874 CAA45875 CAF97922
GB	AAH07487 AAH08740 AAH30574 AAH43071 AAH44032
PRF	1805352A
REF	NP_001001217 NP_001012496 NP_001025127 NP_001068804 NP_001080595
SP	P26368 P26369
TPG	DAA19368

Biological Magnetic Resonance Data Bank

BMRB Entry 17623

Title: MODEL OF HUMAN U2AF65 TANDEM RRM1 AND RRM2 DOMAINS WITH EIGHT-SITE URIDINE BINDING

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