BMRB Entry 17632
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PDB ID: 2lct
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR17632
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Title: Solution structure of the Vav1 SH2 domain complexed with a Syk-derived doubly phosphorylated peptide PubMed: 21606197
Deposition date: 2011-05-09 Original release date: 2011-06-03
Authors: Chen, Chih-Hong; Gorenstein, Nina; Post, Carol
Citation: Chen, Chih-Hong; Martin, Victoria; Gorenstein, Nina; Geahlen, Robert; Post, Carol Beth. "Two closely-spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav." Mol. Cell. Biol. 31, 2984-2996 (2011).
Assembly members:
entity_1, polymer, 107 residues, 12335.253 Da.
entity_2, polymer, 13 residues, 1674.475 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
entity_1: GHMQDLSVHLWYAGPMERAG
AESILANRSDGTFLVRQRVK
DAAEFAISIKYNVEVKHIKI
MTAEGLYRITEKKAFRGLTE
LVEFYQQNSLKDCFKSLDTT
LQFPFKE
entity_2: DTEVXESPXADPE
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 355 |
| 15N chemical shifts | 95 |
| 1H chemical shifts | 771 |
Additional metadata:
Related Database Links:
| BMRB | 19423 |
| PDB | 2CRH 2LCT 2MC1 2ROR |
| DBJ | BAG36112 BAG62721 BAJ21026 |
| EMBL | CAA58783 |
| GB | AAC25011 AAH13361 AAI23647 AIC59346 EAW69057 |
| REF | NP_001071542 NP_001245135 NP_001245136 NP_005419 XP_002801087 |
| SP | P15498 Q08DN7 |
| TPG | DAA27902 |
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