BMRB Entry 18002
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PDB ID: 2lko
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR18002
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Title: Structural Basis of Phosphoinositide Binding to Kindlin-2 Pleckstrin Homology Domain in Regulating Integrin Activation PubMed: 22030399
Deposition date: 2011-10-17 Original release date: 2011-11-21
Authors: Liu, Jianmin; Fukuda, Koichi; Xu, Zhen
Citation: Liu, Jianmin; Fukuda, Koichi; Xu, Zhen; Ma, Yan-Qing; Hirbawi, Jamila; Mao, Xian; Wu, Chuanyue; Plow, Edward; Qin, Jun. "Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation." J. Biol. Chem. 286, 43334-43342 (2011).
Assembly members:
Kindlin-2, polymer, 138 residues, 15722.256 Da.
4IP, non-polymer, 500.075 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
Kindlin-2: GSHMGDITSIPELADYIKVF
KPKKLTLKGYKQYWCTFKDT
SISCYKSKEESSGTPAHQMN
LRGCEVTPDVNISGQKFNIK
LLIPVAEGMNEIWLRCDNEK
QYAHWMAACRLASKGKTMAD
SSYNLEVQNILSFLKMQH
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 377 |
| 15N chemical shifts | 129 |
| 1H chemical shifts | 669 |
Additional metadata:
Related Database Links:
| PDB | 2LKO 4F7H |
| DBJ | BAE38850 BAF84427 |
| EMBL | CAA80852 CAD61925 |
| GB | AAH17327 AAH33436 AAH83876 AAI51293 AAN75823 |
| REF | NP_001011915 NP_001094734 NP_001128471 NP_001128472 NP_001253248 |
| SP | Q8CIB5 Q96AC1 |
| TPG | DAA25234 |
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