BMRB Entry 18236
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR18236
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Title: Backbone and sidechain 13C, 15N, and 1H assignments of cruzain in complex with K777 PubMed: 23181936
Deposition date: 2012-02-01 Original release date: 2014-04-22
Authors: Lee, Gregory; Balouch, Eamon; Craik, Charles
Citation: Lee, Gregory; Balouch, Eaman; Goetz, David; Lazic, Ana; McKerrow, James; Craik, Charles. "Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy." Biochemistry 51, 10087-10098 (2012).
Assembly members:
cruzain, polymer, 215 residues, 22703.2 Da.
D1R, non-polymer, 576.749 Da.
Natural source: Common Name: Trypanosoma cruzi Taxonomy ID: 5693 Superkingdom: Eukaryota Kingdom: not available Genus/species: Trypanosoma cruzi
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
cruzain: APAAVDWRARGAVTAVKDQG
QCGSCWAFSAIGNVECQWFL
AGHPLTNLSEQMLVSCDKTD
SGCSGGLMNNAFEWIVQENN
GAVYTEDSYPYASGEGISPP
CTTSGHTVGATITGHVELPQ
DEAQIAAWLAVNGPVAVAVD
ASSWMTYTGGVMTSCVSEQL
DHGVLLVGYNDSAAVPYWII
KNSWTTQWGEEGYIRIAKGS
NQCLVKEEASSAVVG
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 632 |
| 15N chemical shifts | 182 |
| 1H chemical shifts | 205 |
Additional metadata:
Related Database Links:
| GB | 2OZ2_A AAA30181 AAB41118 AAB41119 AAC00067 AAF75546 |
| PDB | 1AIM 1EWL 1EWM 1EWO 1EWP 1F29 1F2A 1F2B 1F2C 1ME3 1ME4 1U9Q 2AIM 2OZ2 3HD3 3I06 3IUT 3KKU 3LXS 4KLB 4PI3 4QH6 4W5B 4W5C 4XUI |
| DBJ | BAA96735 BAA96736 BAA96737 |
| REF | XP_804236 XP_805951 XP_818578 XP_818579 XP_820174 |
| SP | P25779 |
Download simulated HSQC data in one of the following formats:
CSV: Backbone
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SPARKY: Backbone
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