BMRB Entry 18314
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PDB ID: 2lqh
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR18314
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Title: NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2b3l conformation) PubMed: 22474372
Deposition date: 2012-03-06 Original release date: 2012-05-08
Authors: Wang, Feng; Marshall, Christopher; Yamamoto, Kazuo; Li, Guang-Yao; Gasmi-Seabrook, Genevieve; Okada, Hitoshi; Mak, Tak; Ikura, Mitsuhiko
Citation: Wang, Feng; Marshall, Christopher; Yamamoto, Kazuo; Li, Guang-Yao; Gasmi-Seabrook, Genevieve; Okada, Hitoshi; Mak, Tak; Ikura, Mitsuhiko. "Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment." Proc. Natl. Acad. Sci. U.S.A. 109, 6078-6083 (2012).
Assembly members:
entity_1, polymer, 87 residues, 10353.954 Da.
entity_2, polymer, 52 residues, 5208.538 Da.
Natural source: Common Name: Hosue mouse Taxonomy ID: 10090 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Mus musculus
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
entity_1: GVRKGWHEHVTQDLRSHLVH
KLVQAIFPTPDPAALKDRRM
ENLVAYAKKVEGDMYESANS
RDEYYHLLAEKIYKIQKELE
EKRRSRL
entity_2: GSMSHYGNQTLQDLLTSDSL
SHSDGGGSGGGSGGGSLECD
MESIIRSELMDA
- assigned_chemical_shifts
Data type | Count |
13C chemical shifts | 512 |
15N chemical shifts | 124 |
1H chemical shifts | 860 |
Additional metadata:
Related Database Links:
BMRB | 16851 18315 18694 18695 18315 |
PDB | 1KDX 1SB0 2AGH 2KWF 2LQH 2LQI 2LXS 2LXT |
DBJ | BAE06125 BAG65526 BAI45616 |
GB | AAB28651 AAC08447 AAC51331 AAC51770 AAH72594 |
PRF | 1923401A |
REF | NP_001020603 NP_001073315 NP_001157494 NP_001247644 NP_004371 |
SP | P45481 Q6JHU9 Q92793 |
TPG | DAA15549 |
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