BMRB Entry 18439

Name: solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide
Published: 2012-06-05

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PDB ID: 2lsp
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR18439
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide PubMed: 22645123

Deposition date: 2012-05-03 Original release date: 2012-06-05

Authors: Zhang, Guangtao; Liu, Ruijie; Zhong, Yifei; Plotnikov, Alexander; Zhang, Weijia; Rusinova, Elena; Gerona-Nevarro, Guillermo; Moshkina, Natasha; Joshua, Jennifer; Chuang, Peter; Ohlmeyer, Michael; He, John Cijiang

Citation: Zhang, Guangtao; Liu, Ruijie; Zhong, Yifei; Plotnikov, Alexander; Zhang, Weijia; Zeng, Lei; Rusinova, Elena; Gerona-Nevarro, Guillermo; Moshkina, Natasha; Joshua, Jennifer; Chuang, Peter; Ohlmeyer, Michael; He, John Cijiang; Zhou, Ming-Ming. "Down-regulation of NF-B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition." J. Biol. Chem. 287, 28840-28851 (2012).

Assembly members:
entity_1, polymer, 13 residues, 1663.968 Da.
entity_2, polymer, 128 residues, 14842.159 Da.

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: chemical synthesis

Entity Sequences (FASTA):
entity_1: RTYETFXSIMKKS
entity_2: KDVPDSQQHPAPEKSSKVSE QLKCCSGILKEMFAKKHAAY AWPFYKPVDVEALGLHDYCD IIKHPMDMSTIKSKLEAREY RDAQEFGADVRLMFSNCYKY NPPDHEVVAMARKLQDVFEM RFAKMPDE

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	444
15N chemical shifts	117
1H chemical shifts	874

Additional metadata:

Assembly
Samples and Experiments
Software
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Entity Assembly ID	Entity Name	Entity ID
1	NF-kB-K310ac peptide	1
2	BRD4 second bromodomain	2

Name	Sample	Sample state	Sample conditions
3D HNCACB	sample_2	isotropic	sample_conditions_1
3D HN(CO)CACB	sample_2	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_2	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_1	isotropic	sample_conditions_1
3D 13C-Edited-15N/13C filtered NOESY	sample_1	isotropic	sample_conditions_1

BMRB	15057 19738
PDB	2I8N 2LSP 2MJV 2OUO 2YEM 3JVL 3JVM 4KV4
REF	XP_004761195 XP_006524755 XP_006524756 XP_008763395

Biological Magnetic Resonance Data Bank

BMRB Entry 18439

Title: solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide PubMed: 22645123

Additional metadata:

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Entities:

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