BMRB Entry 18663
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PDB ID: 4b6v
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR18663
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Title: The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety PubMed: 23431134
Deposition date: 2012-08-15 Original release date: 2013-02-28
Authors: Osborne, M.; Volpon, Laurent; Kornblatt, J.; Culjkovic-kraljcic, B.; Baguet, A.; Borden, K.; Borden, A.
Citation: Osborne, Michael; Volpon, Laurent; Kornblatt, Jack; Culjkovic-Kraljacic, Biljana; Baguet, Aurelie; Borden, Katherine. "eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition." Proc. Natl. Acad. Sci. U.S.A. 110, 3877-3882 (2013).
Assembly members:
EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_4E_TYPE, polymer, 207 residues, 22831.0043 Da.
Natural source: Common Name: Mouse Taxonomy ID: 10090 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Mus musculus
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_4E_TYPE: MALPPAAAPPGANEPLDKAL
SALPPEPGGVPLHSPWTFWL
DRSLPGATAAECASNLKKIY
TVQTVQIFWSVYNNIPPVTS
LPLRCSYHLMRGERRPLWEE
ESNAKGGVWKMKVPKDSTST
VWKELLLATIGEQFTDCAAA
DDEIIGVSVSVRDREDVVQV
WNVNASLVGEATVLEKIHQL
LPHIAFKAVFYKPHEEHHAF
EGGRGKH
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 620 |
| 15N chemical shifts | 207 |
| 1H chemical shifts | 1327 |
Additional metadata:
Related Database Links:
| UNP | Q9DBB5.1 IF4E3_MOUSE |
| BMRB | 18667 |
| PDB | 4B6U 4B6V |
| DBJ | BAB23780 BAB24928 |
| GB | AAH27014 AAI68936 AAT45741 EDK99365 EDL91436 |
| REF | NP_001100082 NP_080105 XP_005547668 XP_005547669 XP_005547670 |
| SP | Q9DBB5 |
| TPG | DAA17098 |
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