BMRB Entry 18792
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PDB ID: 2m03
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR18792
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Title: Solution structure of BCL-xL determined with selective isotope labelling of I,L,V sidechains PubMed: 23340338
Deposition date: 2012-10-19 Original release date: 2013-01-22
Authors: Viacava Follis, Ariele; Royappa, Grace; Kriwacki, Richard
Citation: Follis, Ariele Viacava; Chipuk, Jerry; Fisher, John; Yun, Mi-Kyung; Grace, Christy; Nourse, Amanda; Baran, Katherine; Ou, Li; Min, Lie; White, Stephen; Green, Douglas; Kriwacki, Richard. "PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis." Nat. Chem. Biol. 9, 163-168 (2013).
Assembly members:
BCL-xL_apo, polymer, 181 residues, 20252.496 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
BCL-xL_apo: MSMAMSQSNRELVVDFLSYK
LSQKGYSWSQFSDVEENRTE
APEGTESEAVKQALREAGDE
FELRYRRAFSDLTSQLHITP
GTAYQSFEQVVNELFRDGVN
WGRIVAFFSFGGALCVESVD
KEMQVLVSRIAAWMATYLND
HLEPWIQENGGWDTFVELYG
NNAAAESRKGQERLEHHHHH
H
- assigned_chemical_shifts
Data type | Count |
13C chemical shifts | 536 |
15N chemical shifts | 171 |
1H chemical shifts | 343 |
Additional metadata:
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