BMRB Entry 19153
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PDB ID: 2m6t
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR19153
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Title: NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R
Deposition date: 2013-04-09 Original release date: 2014-10-13
Authors: Strickland, Madeleine; Williams, Chris; Richards, Emily; Minnall, Leanne; Crump, Matthew; Frago, Susana; Hughes, Jennifer; Garner, Lee; Hoppe, Hans-Jurgen; Rezgui, Dellel; Zaccheo, Oliver; Prince, Stuart; Hassan, Andrew; Whittaker, Sara
Citation: Frago, Susana; Strickland, Madeleine; Hughes, Jennifer; Williams, Christopher; Garner, Lee; Hoppe, Hans-Jurgen; Rezgui, Dellel; Zaccheo, Oliver; Prince, Stuart; Crump, Matthew; Hassan, Andrew. "Directed evolution of structurally selected IGF2R domain 11 binding loop residues generates an IGF2 super-antagonist" EMBO J. ., .-..
Assembly members:
IGF2R, polymer, 142 residues, 15433.671 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
IGF2R: MKSNEHDDCQVTNPSTGHLF
DLSSLSGRAGFTAAYAKGWG
VYMSICGENENCPPGVGACF
GQTRISVGKANKRLRYVDQV
LQLVYKDGSPCPSKSGLSYK
SVISFVCRPEAGPTNRPMLI
SLDKQTCTLFFSWHTPLACE
LA
- assigned_chemical_shifts
- heteronucl_NOEs
- heteronucl_T1_relaxation
- heteronucl_T2_relaxation
| Data type | Count |
| 1H chemical shifts | 955 |
| 13C chemical shifts | 597 |
| 15N chemical shifts | 151 |
| heteronuclear NOE values | 266 |
| T1 relaxation values | 284 |
| T2 relaxation values | 284 |
Additional metadata:
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