BMRB Entry 19290
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PDB ID: 4bs2
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR19290
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Title: NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA PubMed: 24240615
Deposition date: 2013-06-07 Original release date: 2013-06-28
Authors: Lukavsky, Peter; Daujotyte, D.; Tollervey, J.; Ule, J.; Stuani, C.; Buratti, E.; Baralle, F.; Damberger, F.; Allain, F.
Citation: Lukavsky, Peter; Daujotyte, Dalia; Tollervey, James; Ule, Jernej; Stuani, Cristiana; Buratti, Emanuele; Baralle, Francisco; Damberger, Fred; Allain, Frederic H-T. "Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43." Nat. Struct. Mol. Biol. 20, 1443-1449 (2013).
Assembly members:
TAR_DNA-BINDING_PROTEIN_43, polymer, 174 residues, 19955.5578 Da.
5'-R(*GP*UP*GP*UP*GP*AP*AP*UP*GP*AP*AP*UP)-3', polymer, 12 residues, 3933.29822 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
TAR_DNA-BINDING_PROTEIN_43: GSHMASKTSDLIVLGLPWKT
TEQDLKEYFSTFGEVLMVQV
KKDLKTGHSKGFGFVRFTEY
ETQVKVMSQRHMIDGRWCDC
KLPNSKQSQDEPLRSRKVFV
GRCTEDMTEDELREFFSQYG
DVMDVFIPKPFRAFAFVTFA
DDQIAQSLCGEDLIIKGISV
HISNAEPKHNSNRQ
5'-R(*GP*UP*GP*UP*GP*AP*AP*UP*GP*AP*AP*UP)-3': GUGUGAAUGAAU
- assigned_chemical_shifts
Data type | Count |
13C chemical shifts | 864 |
15N chemical shifts | 182 |
1H chemical shifts | 1327 |
31P chemical shifts | 11 |
Additional metadata:
Related Database Links:
UNP | TADBP_HUMAN |
PDB | 4BS2 |
DBJ | BAD96474 BAE87159 BAG35326 BAG58707 BAG61425 |
EMBL | CAB43367 CAG38565 CAH92854 CAL37794 |
GB | AAA70033 AAH71657 AAH95435 ABO32290 ABO32291 |
REF | NP_001127597 NP_031401 XP_001102660 XP_002750326 XP_003274288 |
SP | Q13148 Q5R5W2 |
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