BMRB Entry 19614

Name: The basic-helix-loop-helix region of the transcriptional repressor HES-1 is preorganized to bind DNA
Published: 2014-02-03

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PDB ID: 2mh3
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR19614
MolProbity Validation Chart

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Nicholas Rego and David Koes
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: The basic-helix-loop-helix region of the transcriptional repressor HES-1 is preorganized to bind DNA PubMed: 24403087

Deposition date: 2013-11-15 Original release date: 2014-02-03

Authors: Wienk, Hans; Popovic, Matija; Coglievina, Maristella; Boelens, Rolf; Pongor, Sandor; Pintar, Alessandro

Citation: Popovic, Matija; Wienk, Hans; Coglievina, Maristella; Boelens, Rolf; Pongor, Sandor; Pintar, Alessandro. "The basic helix-loop-helix region of the transcriptional repressor hairy and enhancer of split 1 is preorganized to bind DNA." Proteins 82, 537-545 (2014).

Assembly members:
entity, polymer, 70 residues, 8227.798 Da.

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):
entity: MKPKTASEHRKSSKPIMEKR RRARINESLSQLKTLILDAL KKDSSRHSKLEKADILEMTV KHLRNLQRAQ

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	604
15N chemical shifts	142
1H chemical shifts	976

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Entity Assembly ID	Entity Name	Entity ID
1	HES-1_1	1
2	HES-1_2	1

1	MET	LYS	PRO	LYS	THR	ALA	SER	GLU	HIS	ARG
2	LYS	SER	SER	LYS	PRO	ILE	MET	GLU	LYS	ARG
3	ARG	ARG	ALA	ARG	ILE	ASN	GLU	SER	LEU	SER
4	GLN	LEU	LYS	THR	LEU	ILE	LEU	ASP	ALA	LEU
5	LYS	LYS	ASP	SER	SER	ARG	HIS	SER	LYS	LEU
6	GLU	LYS	ALA	ASP	ILE	LEU	GLU	MET	THR	VAL
7	LYS	HIS	LEU	ARG	ASN	LEU	GLN	ARG	ALA	GLN

Name	Sample	Sample state	Sample conditions
triple resonance assignment	sample_1	isotropic	sample_conditions_1
relaxation	sample_1	isotropic	sample_conditions_1
DNA titration	sample_1	isotropic	sample_conditions_1
NOESY	sample_1	isotropic	sample_conditions_1

PDB	2MH3
DBJ	BAA02682 BAA03931 BAA91149 BAE21226 BAE21713
EMBL	CAA65998 CAG08099 CAG46641 CAJ82991 CDQ79517
GB	AAA41307 AAA65220 AAA79185 AAF73060 AAH18375
PRF	1905315A
REF	NP_001011194 NP_001029850 NP_001079386 NP_001081396 NP_001098313
SP	P35428 Q04666 Q14469 Q3ZBG4 Q5PPM5
TPG	DAA33369

Biological Magnetic Resonance Data Bank

BMRB Entry 19614

Title: The basic-helix-loop-helix region of the transcriptional repressor HES-1 is preorganized to bind DNA PubMed: 24403087

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	MET	LYS	PRO	LYS	THR	ALA	SER	GLU	HIS	ARG
2	LYS	SER	SER	LYS	PRO	ILE	MET	GLU	LYS	ARG
3	ARG	ARG	ALA	ARG	ILE	ASN	GLU	SER	LEU	SER
4	GLN	LEU	LYS	THR	LEU	ILE	LEU	ASP	ALA	LEU
5	LYS	LYS	ASP	SER	SER	ARG	HIS	SER	LYS	LEU
6	GLU	LYS	ALA	ASP	ILE	LEU	GLU	MET	THR	VAL
7	LYS	HIS	LEU	ARG	ASN	LEU	GLN	ARG	ALA	GLN

1	MET	LYS	PRO	LYS	THR	ALA	SER	GLU	HIS	ARG
2	LYS	SER	SER	LYS	PRO	ILE	MET	GLU	LYS	ARG
3	ARG	ARG	ALA	ARG	ILE	ASN	GLU	SER	LEU	SER
4	GLN	LEU	LYS	THR	LEU	ILE	LEU	ASP	ALA	LEU
5	LYS	LYS	ASP	SER	SER	ARG	HIS	SER	LYS	LEU
6	GLU	LYS	ALA	ASP	ILE	LEU	GLU	MET	THR	VAL
7	LYS	HIS	LEU	ARG	ASN	LEU	GLN	ARG	ALA	GLN

1	MET	LYS	PRO	LYS	THR	ALA	SER	GLU	HIS	ARG
2	LYS	SER	SER	LYS	PRO	ILE	MET	GLU	LYS	ARG
3	ARG	ARG	ALA	ARG	ILE	ASN	GLU	SER	LEU	SER
4	GLN	LEU	LYS	THR	LEU	ILE	LEU	ASP	ALA	LEU
5	LYS	LYS	ASP	SER	SER	ARG	HIS	SER	LYS	LEU
6	GLU	LYS	ALA	ASP	ILE	LEU	GLU	MET	THR	VAL
7	LYS	HIS	LEU	ARG	ASN	LEU	GLN	ARG	ALA	GLN