BMRB Entry 19738
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PDB ID: 2mjv
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR19738
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Title: Solution structures of second bromodomain of Brd4 with Di-acetylated Twist peptide PubMed: 24525235
Deposition date: 2014-01-16 Original release date: 2014-03-17
Authors: Zeng, Lei; Zhou, Ming-Ming
Citation: Shi, Jian; Wang, Yifan; Zeng, Lei; Wu, Yadi; Deng, Jiong; Zhang, Qiang; Lin, Yiwei; Li, Junlin; Kang, Tiebang; Tao, Min; Rusinova, Elena; Zhang, Guangtao; Wang, Chi; Zhu, Haining; Yao, Jun; Zeng, Yi-Xin; Evers, B.; Zhou, Ming-Ming; Zhou, Binhua. "Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer" Cancer Cell 25, 210-225 (2014).
Assembly members:
entity_1, polymer, 12 residues, 1300.477 Da.
entity_2, polymer, 128 residues, 14842.159 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
entity_1: SPAQGXRGXKSA
entity_2: KDVPDSQQHPAPEKSSKVSE
QLKCCSGILKEMFAKKHAAY
AWPFYKPVDVEALGLHDYCD
IIKHPMDMSTIKSKLEAREY
RDAQEFGADVRLMFSNCYKY
NPPDHEVVAMARKLQDVFEM
RFAKMPDE
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 454 |
| 15N chemical shifts | 118 |
| 1H chemical shifts | 874 |
Additional metadata:
Related Database Links:
| BMRB | 15057 18439 |
| PDB | 2I8N 2LSP 2MJV 2OUO 2YEM 3JVL 3JVM 4KV4 |
| REF | XP_004761195 XP_006524755 XP_006524756 XP_008763395 |
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