BMRB Entry 19816
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PDB ID: 2mle
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR19816
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Title: NMR structure of the C-domain of troponin C bound to the anchoring region of troponin I PubMed: 18803402
Deposition date: 2014-02-26 Original release date: 2014-03-10
Authors: Robertson, Ian; Baryshnikova, Olga; Mercier, Pascal; Sykes, Brian
Citation: Baryshnikova, Olga; Robertson, Ian; Mercier, Pascal; Sykes, Brian. "The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I." Biochemistry 47, 10950-10960 (2008).
Assembly members:
cCTnC, polymer, 72 residues, 8369.260 Da.
CALCIUM ION, non-polymer, 40.078 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
cCTnC: MGKSEEELSDLFRMFDKNAD
GYIDLDELKIMLQATGETIT
EDDIEELMKDGDKNNDGRID
YDEFLEFMKGVE
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 403 |
| 13C chemical shifts | 216 |
| 15N chemical shifts | 70 |
Additional metadata:
Related Database Links:
| BMRB | 15385 15388 15400 15427 16752 17243 17440 19817 25120 |
| PDB | 1AJ4 1DTL 1FI5 1IH0 1J1D 1J1E 1LA0 1OZS 1SBJ 1SCV 2JT0 2JT3 2JT8 2JTZ 2KDH 2L98 2MLE 2MLF 3CTN |
| DBJ | BAA02369 BAG36483 |
| EMBL | CAA30736 CAG46663 CAG46683 |
| GB | AAA36772 AAA37492 AAA37493 AAA48654 AAB91994 |
| PIR | TPHUCC |
| PRF | 1510257A 750650A |
| REF | NP_001029277 NP_001029523 NP_001123715 NP_001272501 NP_001291793 |
| SP | P02591 P09860 P19123 P63315 P63316 |
| TPG | DAA16908 |
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