BMRB Entry 19939
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PDB ID: 2moe
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR19939
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Title: Solution structure of MBD4 methyl-cytosine binding domain bound to methylated DNA PubMed: 25183517
Deposition date: 2014-04-24 Original release date: 2014-09-05
Authors: Williams, David; Walavalkar, Ninad
Citation: Walavalkar, Ninad; Cramer, Jason; Buchwald, William; Scarsdale, Neel; Williams, David. "Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches" Nucleic Acids Res. ., .-. (2014).
Assembly members:
MBD4mbd, polymer, 71 residues, 8088.318 Da.
DNAfor, polymer, 10 residues, Formula weight is not available
DNArev, polymer, 10 residues, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
MBD4mbd: GSTECRKSVPCGWERVVKQR
LFGKTAGRFDVYFISPQGLK
FRSKSSLANYLHKNGETSLK
PEDFDFTVLSK
DNAfor: GGATXGGCTC
DNArev: GAGCXGATCC
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 291 |
| 1H chemical shifts | 526 |
| 15N chemical shifts | 75 |
Additional metadata:
Related Database Links:
| PDB | 2MOE 4LG7 |
| DBJ | BAE02211 BAG64144 BAK62846 |
| EMBL | CAG29301 CAH89518 |
| GB | AAC68879 AAD22195 AAD50374 AAH11752 AAM00008 |
| REF | NP_001127160 NP_001263199 NP_001263200 NP_001263201 NP_001267403 |
| SP | O95243 |
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