BMRB Entry 25232
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PDB ID: 2mut
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR25232
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Title: Solution structure of the F231L mutant ERCC1-XPF dimerization region PubMed: 26085086
Deposition date: 2014-09-17 Original release date: 2015-06-22
Authors: Faridounnia, Maryam; Wienk, Hans; Kovacic, Lidija; Folkers, Gert; Jaspers, Nicolaas; Kaptein, Robert; Hoeijmakers, Jan; Boelens, Rolf
Citation: Faridounnia, Maryam; Wienk, Hans; Kovacic, Lidija; Folkers, Gert; Jaspers, Nicolaas; Boelens, Rolf. "The Cerebro-Oculo-Facio-Skeletal (COFS) Syndrome point mutation F231L in the ERCC1 DNA repair protein causes dissociation of the ERCC1-XPF complex" J. Biol. Chem. ., .-. (2015).
Assembly members:
entity_1, polymer, 96 residues, 10985.764 Da.
entity_2, polymer, 84 residues, 9230.592 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
entity_1: RIRRRYNMADLLMEKLEQDL
VSRVTECLTTVKSVNKTDSQ
TLLTTFGSLEQLIAASREDL
ALCPGLGPQKARRLFDVLHE
PFLKVPGGLEHHHHHH
entity_2: MDSETLPESEKYNPGPQDFL
LKMPGVNAKNCRSLMHHVKN
IAELAALSQDELTSILGNAA
NAKQLYDFIHTSFAEVVSKG
KGKK
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 695 |
| 15N chemical shifts | 172 |
| 1H chemical shifts | 1173 |
Additional metadata:
Related Database Links:
| PDB | 1Z00 2A1J 2MUT |
| DBJ | BAG37398 BAG52472 |
| GB | AAA35810 AAA52394 AAC16253 AAH08930 AAM34796 |
| PRF | 1403276A |
| REF | NP_001181860 NP_001974 XP_003817569 XP_003915760 XP_003915761 |
| SP | P07992 |
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