BMRB Entry 25694
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PDB ID: 2n55
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR25694
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Title: Structure of constitutively monomeric CXCL12 in complex with the CXCR4 N-terminus PubMed: 27058821
Deposition date: 2015-07-07 Original release date: 2016-04-25
Authors: Ziarek, Joshua; Peterson, Francis; Volkman, Brian
Citation: Smith, Emmanuel; Nevins, Amanda; Qiao, Zhen; Liu, Yan; Getschman, Anthony; Vankayala, Sai; Kemp, M. Trent; Peterson, Francis; Li, Rongshi; Volkman, Brian; Chen, Yu. "Structure-Based Identification of Novel Ligands Targeting Multiple Sites within a Chemokine-G-Protein-Coupled-Receptor Interface" J. Med. Chem. 59, 4342-4351 (2016).
Assembly members:
entity_1, polymer, 70 residues, 8146.729 Da.
entity_2, polymer, 40 residues, 4518.798 Da.
Natural source: Common Name: human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
entity_1: GMKPVSLSYRCPCRFFESHV
ARANVKHLKILNTPNCALQI
VARLKNNNRQVCIDPKCKWC
QEYLEKALNK
entity_2: GSMEGISIYTSDNYTEEMGS
GDYDSMKEPAFREENANFNK
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 452 |
| 15N chemical shifts | 110 |
| 1H chemical shifts | 753 |
Additional metadata:
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