BMRB Entry 34131

Name: Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6
Published: 2017-12-04

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PDB ID: 5nwm
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR34131
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Nicholas Rego and David Koes
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6 PubMed: 29203888

Deposition date: 2017-05-06 Original release date: 2017-12-04

Authors: Russo, L.; Becker, S.; Griesinger, C.

Citation: Russo, L.; Giller, K.; Pfitzner, E.; Griesinger, C.; Becker, S.. "Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6" Sci. Rep. 7, 16845-16845 (2017).

Assembly members:
entity_1, polymer, 132 residues, 14811.774 Da.
entity_2, polymer, 32 residues, 3452.837 Da.

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):
entity_1: GHMTGVESFMTKQDTTGKII SIDTSSLRAAGRTGWEDLVR KCIYAFFQPQGREPSYARQL FQEVMTRGTASSPSYRFILN DGTMLSAHTRCKLCYPQSPD MQPFIMGIHIIDREHSGLSP QDDTNSGMSIPR
entity_2: GTWIGEDIFPPLLPPTEQDL TKLLLEGQGESG

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	645
15N chemical shifts	164
1H chemical shifts	1072

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Entity Assembly ID	Entity Name	Entity ID
1	entity_1	1
2	entity_2	2

Samples:

sample_3: HEPES 50 mM; sodium chloride 150 mM; D2O 10%; STAT6 1 mM; NCoA1, [U-99% 13C; U-99% 15N], 0.7 mM

sample_4: HEPES 50 mM; sodium chloride 150 mM; D2O 10%; STAT6, [U-99% 15N], 1 mM; NCoA1 0.7 mM

sample_5: HEPES 50 mM; sodium chloride 150 mM; D2O 10%; STAT6 1 mM; NCoA1, [U-99% 15N], 0.7 mM

sample_6: HEPES 50 mM; sodium chloride 150 mM; D2O 10%; STAT6, [U-99% 15N], 1 mM

sample_7: HEPES 50 mM; sodium chloride 150 mM; D2O 100%; STAT6, [U-99% 13C; U-99% 15N], 1 mM; NCoA1 0.7 mM

sample_8: HEPES 50 mM; sodium chloride 150 mM; D2O 100%; STAT6 1 mM; NCoA1, [U-99% 13C; U-99% 15N], 0.7 mM

sample_1: HEPES 50 mM; sodium chloride 150 mM; D2O 10%; STAT6, [U-99% 13C; U-99% 15N], 1 mM

sample_2: HEPES 50 mM; sodium chloride 150 mM; D2O 10%; STAT6, [U-99% 13C; U-99% 15N], 1 mM; NCoA1 0.7 mM

sample_conditions_1: ionic strength: 150 mM; pH: 7.0; pressure: 1 atm; temperature: 309 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	not available	sample_conditions_1
2D 1H-13C HSQC aliphatic	sample_1	not available	sample_conditions_1
3D CBCA(CO)NH	sample_1	not available	sample_conditions_1
3D HNCA	sample_1	not available	sample_conditions_1
3D 1H-15N TOCSY	sample_1	not available	sample_conditions_1
3D 1H-15N NOESY	sample_1	not available	sample_conditions_1
2D 1H-15N HSQC	sample_2	not available	sample_conditions_1
2D 1H-13C HSQC aliphatic	sample_2	not available	sample_conditions_1
2D 1H-13C HSQC aromatic	sample_2	not available	sample_conditions_1
3D CBCA(CO)NH	sample_2	not available	sample_conditions_1
3D HNCO	sample_2	not available	sample_conditions_1
3D HNCA	sample_2	not available	sample_conditions_1
3D 1H-15N NOESY	sample_2	not available	sample_conditions_1
3D 1H-15N TOCSY	sample_2	not available	sample_conditions_1
3D 1H-15N TOCSY	sample_3	not available	sample_conditions_1
3D 1H-15N NOESY	sample_3	not available	sample_conditions_1
2D 1H-15N HSQC	sample_3	not available	sample_conditions_1
3D HNCACB	sample_2	not available	sample_conditions_1
3D HCCH-TOCSY	sample_7	not available	sample_conditions_1
3D HNHA	sample_1	not available	sample_conditions_1
3D HNHA	sample_2	not available	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_7	not available	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_7	not available	sample_conditions_1
3D HNCA	sample_3	not available	sample_conditions_1
3D HNCO	sample_3	not available	sample_conditions_1
3D CBCA(CO)NH	sample_3	not available	sample_conditions_1
2D 1H-13C HSQC aromatic	sample_3	not available	sample_conditions_1
2D 1H-13C HSQC aliphatic	sample_3	not available	sample_conditions_1
3D HCCH-TOCSY	sample_8	not available	sample_conditions_1
3D HNHA	sample_3	not available	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_8	not available	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_8	not available	sample_conditions_1
2D 1H-15N HSQC	sample_5	not available	sample_conditions_1
2D 1H-15N HSQC	sample_4	not available	sample_conditions_1
2D 1H-15N HSQC	sample_6	not available	sample_conditions_1
3D 1H,13C-edited/12C-filter NOESY	sample_7	not available	sample_conditions_1

Download simulated HSQC data in one of the following formats:
CSV: Backbone or all simulated shifts
SPARKY: Backbone or all simulated shifts

Biological Magnetic Resonance Data Bank

BMRB Entry 34131

Title: Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6 PubMed: 29203888

Additional metadata:

Assembly:

Entities:

Samples:

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