BMRB Entry 34496
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR34496
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Title: Ca2+-bound Calmodulin mutant N53I PubMed: 32317284
Deposition date: 2020-03-06 Original release date: 2020-04-27
Authors: Holt, C.; Nielsen, L.; Lau, K.; Brohus, M.; Sorensen, A.; Larsen, K.; Sommer, C.; Petegem, F.; Overgaard, M.; Wimmer, R.
Citation: Holt, C.; Hamborg, L.; Lau, K.; Brohus, M.; Sorensen, A.; Larsen, K.; Sommer, C.; Petegem, F.; Overgaard, M.; Wimmer, R.. "The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-domain, altering its interaction with the cardiac ryanodine receptor" J. Biol. Chem. ., .-. (2020).
Assembly members:
entity_1, polymer, 148 residues, 16720.404 Da.
entity_CA, non-polymer, 40.078 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli BL21(DE3)
Entity Sequences (FASTA):
entity_1: ADQLTEEQIAEFKEAFSLFD
KDGDGTITTKELGTVMRSLG
QNPTEAELQDMIIEVDADGN
GTIDFPEFLTMMARKMKDTD
SEEEIREAFRVFDKDGNGYI
SAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEE
FVQMMTAK
- assigned_chemical_shifts
- heteronucl_NOEs
- heteronucl_T1_relaxation
- heteronucl_T2_relaxation
| Data type | Count |
| 13C chemical shifts | 631 |
| 15N chemical shifts | 157 |
| 1H chemical shifts | 992 |
| T1 relaxation values | 141 |
| T2 relaxation values | 143 |
| heteronuclear NOE values | 143 |
Additional metadata:
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