BMRB Entry 36077
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PDB ID: 5xi9
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR36077
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Title: Solution structure for human HSP70 substrate binding domain PubMed: 29495458
Deposition date: 2017-04-26 Original release date: 2018-05-14
Authors: Hoshikawa, M.; Tochio, N.; Tate, S.
Citation: Umehara, Kohei; Hoshikawa, Miho; Tochio, Naoya; Tate, Shin-Ichi. "Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication" Molecules 23, E528-E528 (2018).
Assembly members:
Heat shock 70 kDa protein 1A, polymer, 185 residues, 20323.885 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
Heat shock 70 kDa protein 1A: HMGDKSENVQDLLLLDVAPL
SLGLETAGGVMTALIKRNST
IPTKQTQIFTTYSDNQPGVL
IQVYEGERAMTKDNNLLGRF
ELSGIPPAPRGVPQIEVTFD
IDANGILNVTATDKSTGKAN
KITITNDKGRLSKEEIERMV
QEAEKYKAEDEVQRERVSAK
NALESYAFNMKSAVEDEGLK
GKISE
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 781 |
| 15N chemical shifts | 197 |
| 1H chemical shifts | 1136 |
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