BMRB Entry 4262
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PDB ID: 1bzf
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR4262
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Title: NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE
Deposition date: 1998-10-30 Original release date: 2000-05-22
Authors: POLSHAKOV, V.; BIRDSALL, B.; FRENKIEL, T.; GARGARO, A.; FEENEY, J.
Citation: POLSHAKOV, V.; BIRDSALL, B.; FRENKIEL, T.; GARGARO, A.; FEENEY, J.. "Structure and dynamics in solution of the complex of Lactobillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate"" Protein Sci. 8, 467-481 (1999).
Assembly members:
DIHYDROFOLATE REDUCTASE, polymer, 162 residues, 18300 Da.
TMQ, non-polymer, 370.426 Da.
Natural source: Common Name: Lactobacillus casei Taxonomy ID: 1582 Superkingdom: Bacteria Kingdom: not available Genus/species: Lactobacillus casei
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
DIHYDROFOLATE REDUCTASE: TAFLWAQDRDGLIGKDGHLP
WHLPDDLHYFRAQTVGKIMV
VGRRTYESFPKRPLPERTNV
VLTHQEDYQAQGAVVVHDVA
AVFAYAKQHPDQELVIAGGA
QIFTAFKDDVDTLLVTRLAG
SFEGDTKMIPLNWDDFTKVS
SRTVEDTNPALTHTYEVWQK
KA
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 1082 |
| 15N chemical shifts | 168 |
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