BMRB Entry 4617
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR4617
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Title: Structure of hetero complex of non structural protein (NS) of hepatitis C virus (HCV) and synthetic peptidic compound PubMed: 10716920
Deposition date: 2000-01-17 Original release date: 2001-03-08
Authors: Barbato, G.; Cicero, D.; Cordier, F.; Narjes, F.; Gerlach, B.; Sambucini, S.; Grzesiek, S.; Matassa, V.; DeFrancesco, R.; Bazzo, R.
Citation: Barbato, G.; Cicero, D.; Cordier, F.; Narjes, F.; Gerlach, B.; Sambucini, S.; Grzesiek, S.; Matassa, V.; DeFrancesco, R.; Bazzo, R.. "Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain" EMBO J. 19, 1195-1206 (2000).
Assembly members:
serine protease, polymer, 186 residues, Formula weight is not available
modified tripeptide inhibitor, polymer, 3 residues, Formula weight is not available
ZN, non-polymer, 65.409 Da.
Natural source: Common Name: HCV Taxonomy ID: 11105 Superkingdom: Viruses Kingdom: not available Genus/species: Hepacivirus Hepatitis C virus
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
serine protease: APITAYSQQTRGLLGCIITS
LTGRDKNQVEGEVQVVSTAT
QSFLATCVNGVCWTVYHGAG
SKTLAGPKGPITQMYTNVDQ
DLVGWQAPPGARSLTPCTCG
SSDLYLVTRHADVIPVRRRG
DSRGSLLSPRPVSYLKGSSG
GPLLCPSGHAVGIFRAAVCT
RGVAKAVDFVPVESMETTMR
ASKKKK
modified tripeptide inhibitor: ELX
- assigned_chemical_shifts
- coupling_constants
| Data type | Count |
| 13C chemical shifts | 268 |
| coupling constants | 91 |