BMRB Entry 50265

Name: NMR backbone resonance assignment of TREM2 transmembrane helix in complex with the partner protein DAP12
Published: 2020-06-08

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR50265

NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
NMR-STAR v2.1 text file (deprecated)
XML gzip file.
RDF gzip file.
All files associated with the entry

Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

Select model:

I am color blind

Download raw data. Direct link to this display. Help

Title: NMR backbone resonance assignment of TREM2 transmembrane helix in complex with the partner protein DAP12 PubMed: 32830336

Deposition date: 2020-05-08 Original release date: 2020-06-08

Authors: Steiner, Andrea; Hagn, Franz

Citation: Steiner, Andrea; Schlepckow, Kai; Brunner, Bettina; Steiner, Harald; Haass, Christian; Hagn, Franz. "gamma-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics" EMBO J. 39, e104247-e104247 (2020).

Assembly members:
entity_1, polymer, 49 residues, Formula weight is not available
entity_2, polymer, 50 residues, Formula weight is not available

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):
entity_1: GSGRSLLEGEIPFPPTSILL LLACIFLIKILAASALWAAA WHGQKPGTH
entity_2: GLRPVQAQAQSDSSCSTVSP GVLAGIVMGDLVLTVLIALA VYFLGRLVPR

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	91
15N chemical shifts	34
1H chemical shifts	34

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
Hide all

Entity Assembly ID	Entity Name	Entity ID
1	TREM2	1
2	DAP12	2

1	GLY	LEU	ARG	PRO	VAL	GLN	ALA	GLN	ALA	GLN
2	SER	ASP	SER	SER	CYS	SER	THR	VAL	SER	PRO
3	GLY	VAL	LEU	ALA	GLY	ILE	VAL	MET	GLY	ASP
4	LEU	VAL	LEU	THR	VAL	LEU	ILE	ALA	LEU	ALA
5	VAL	TYR	PHE	LEU	GLY	ARG	LEU	VAL	PRO	ARG

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HN(CO)CA	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1

UNP	Q9NZC2
UniProt	O43914

Biological Magnetic Resonance Data Bank

BMRB Entry 50265

Title: NMR backbone resonance assignment of TREM2 transmembrane helix in complex with the partner protein DAP12 PubMed: 32830336

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	GLY	LEU	ARG	PRO	VAL	GLN	ALA	GLN	ALA	GLN
2	SER	ASP	SER	SER	CYS	SER	THR	VAL	SER	PRO
3	GLY	VAL	LEU	ALA	GLY	ILE	VAL	MET	GLY	ASP
4	LEU	VAL	LEU	THR	VAL	LEU	ILE	ALA	LEU	ALA
5	VAL	TYR	PHE	LEU	GLY	ARG	LEU	VAL	PRO	ARG

1	GLY	LEU	ARG	PRO	VAL	GLN	ALA	GLN	ALA	GLN
2	SER	ASP	SER	SER	CYS	SER	THR	VAL	SER	PRO
3	GLY	VAL	LEU	ALA	GLY	ILE	VAL	MET	GLY	ASP
4	LEU	VAL	LEU	THR	VAL	LEU	ILE	ALA	LEU	ALA
5	VAL	TYR	PHE	LEU	GLY	ARG	LEU	VAL	PRO	ARG

1	GLY	LEU	ARG	PRO	VAL	GLN	ALA	GLN	ALA	GLN
2	SER	ASP	SER	SER	CYS	SER	THR	VAL	SER	PRO
3	GLY	VAL	LEU	ALA	GLY	ILE	VAL	MET	GLY	ASP
4	LEU	VAL	LEU	THR	VAL	LEU	ILE	ALA	LEU	ALA
5	VAL	TYR	PHE	LEU	GLY	ARG	LEU	VAL	PRO	ARG