BMRB Entry 5987

Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR5987

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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: Interaction of the TAZ1 domain of CREB-binding protein with the activation domain of CITED2: Regulation by competition between intrinsically unstructured ligands for non-identical binding sites PubMed: 14594809

Deposition date: 2003-10-28 Original release date: 2004-02-13

Authors: De Guzman, Roberto; Martinez-Yamout, Maria; Dyson, H. Jane; Wright, Peter

Citation: De Guzman, Roberto; Martinez-Yamout, Maria; Dyson, H. Jane; Wright, Peter. "Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: Regulation by competition between intrinsically unstructured ligands for non-identical binding sites" J. Biol. Chem. 279, 3042-3049 (2004).

Assembly members:
CITED2 C-terminal activation domain, polymer, 51 residues, Formula weight is not available
CBP TAZ1 domain, polymer, 100 residues, Formula weight is not available
ZN, non-polymer, 65.409 Da.

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: recombinant technology

Entity Sequences (FASTA):
CITED2 C-terminal activation domain: MTDFIDEEVLMSLVIEMGLD RIKELPELWLGQNEFDFMTD FVCKQQPSRVS
CBP TAZ1 domain: ATGPTADPEKRKLIQQQLVL LLHAHKCQRREQANGEVRAC SLPHCRTMKNVLNHMTHCQA GKACQVAHCASSRQIISHWK NCTRHDCPVCLPLKNASDKR

Data sets:

assigned_chemical_shifts
- shift_set_1
- shift_set_2

Data type	Count
1H chemical shifts	923
13C chemical shifts	481
15N chemical shifts	145

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Entity Assembly ID	Entity Name	Entity ID
1	CITED2 CAD	1
2	CBP TAZ1	2
3	ZINC (II) ION, 1	3
4	ZINC (II) ION, 2	3
5	ZINC (II) ION, 3	3

1	ALA	THR	GLY	PRO	THR	ALA	ASP	PRO	GLU	LYS
2	ARG	LYS	LEU	ILE	GLN	GLN	GLN	LEU	VAL	LEU
3	LEU	LEU	HIS	ALA	HIS	LYS	CYS	GLN	ARG	ARG
4	GLU	GLN	ALA	ASN	GLY	GLU	VAL	ARG	ALA	CYS
5	SER	LEU	PRO	HIS	CYS	ARG	THR	MET	LYS	ASN
6	VAL	LEU	ASN	HIS	MET	THR	HIS	CYS	GLN	ALA
7	GLY	LYS	ALA	CYS	GLN	VAL	ALA	HIS	CYS	ALA
8	SER	SER	ARG	GLN	ILE	ILE	SER	HIS	TRP	LYS
9	ASN	CYS	THR	ARG	HIS	ASP	CYS	PRO	VAL	CYS
10	LEU	PRO	LEU	LYS	ASN	ALA	SER	ASP	LYS	ARG

SWISS-PROT	P45481 Q92793
REF	NP_596872 XP_001095225 NP_001073315 NP_004371 NP_001020603
PRF	1923401A
GenBank	AAC51770 AAH72594 AAC08447 AAC51331 AAB28651
DBJ	BAG65526 BAE06125
PDB	1U2N 1L8C 1R8U
BMRB	5327 6268

Biological Magnetic Resonance Data Bank

BMRB Entry 5987

Title: Interaction of the TAZ1 domain of CREB-binding protein with the activation domain of CITED2: Regulation by competition between intrinsically unstructured ligands for non-identical binding sites PubMed: 14594809

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	ALA	THR	GLY	PRO	THR	ALA	ASP	PRO	GLU	LYS
2	ARG	LYS	LEU	ILE	GLN	GLN	GLN	LEU	VAL	LEU
3	LEU	LEU	HIS	ALA	HIS	LYS	CYS	GLN	ARG	ARG
4	GLU	GLN	ALA	ASN	GLY	GLU	VAL	ARG	ALA	CYS
5	SER	LEU	PRO	HIS	CYS	ARG	THR	MET	LYS	ASN
6	VAL	LEU	ASN	HIS	MET	THR	HIS	CYS	GLN	ALA
7	GLY	LYS	ALA	CYS	GLN	VAL	ALA	HIS	CYS	ALA
8	SER	SER	ARG	GLN	ILE	ILE	SER	HIS	TRP	LYS
9	ASN	CYS	THR	ARG	HIS	ASP	CYS	PRO	VAL	CYS
10	LEU	PRO	LEU	LYS	ASN	ALA	SER	ASP	LYS	ARG

Name	Sample	Sample state	Sample conditions
3D HNCA	not available	not available	cond_1
3D CBCACONH	not available	not available	cond_1
3D HNCACB	not available	not available	cond_1
3D HCCH-TOCSY	not available	not available	cond_1
3D HCCH-COSY	not available	not available	cond_1
3D 1H-15N NOESY	not available	not available	cond_1
3D 1H-13C NOESY	not available	not available	cond_1
2D HSQC	not available	not available	cond_1
2D 1H-13C HMQC	not available	not available	cond_1

1	ALA	THR	GLY	PRO	THR	ALA	ASP	PRO	GLU	LYS
2	ARG	LYS	LEU	ILE	GLN	GLN	GLN	LEU	VAL	LEU
3	LEU	LEU	HIS	ALA	HIS	LYS	CYS	GLN	ARG	ARG
4	GLU	GLN	ALA	ASN	GLY	GLU	VAL	ARG	ALA	CYS
5	SER	LEU	PRO	HIS	CYS	ARG	THR	MET	LYS	ASN
6	VAL	LEU	ASN	HIS	MET	THR	HIS	CYS	GLN	ALA
7	GLY	LYS	ALA	CYS	GLN	VAL	ALA	HIS	CYS	ALA
8	SER	SER	ARG	GLN	ILE	ILE	SER	HIS	TRP	LYS
9	ASN	CYS	THR	ARG	HIS	ASP	CYS	PRO	VAL	CYS
10	LEU	PRO	LEU	LYS	ASN	ALA	SER	ASP	LYS	ARG

1	ALA	THR	GLY	PRO	THR	ALA	ASP	PRO	GLU	LYS
2	ARG	LYS	LEU	ILE	GLN	GLN	GLN	LEU	VAL	LEU
3	LEU	LEU	HIS	ALA	HIS	LYS	CYS	GLN	ARG	ARG
4	GLU	GLN	ALA	ASN	GLY	GLU	VAL	ARG	ALA	CYS
5	SER	LEU	PRO	HIS	CYS	ARG	THR	MET	LYS	ASN
6	VAL	LEU	ASN	HIS	MET	THR	HIS	CYS	GLN	ALA
7	GLY	LYS	ALA	CYS	GLN	VAL	ALA	HIS	CYS	ALA
8	SER	SER	ARG	GLN	ILE	ILE	SER	HIS	TRP	LYS
9	ASN	CYS	THR	ARG	HIS	ASP	CYS	PRO	VAL	CYS
10	LEU	PRO	LEU	LYS	ASN	ALA	SER	ASP	LYS	ARG