BMRB Entry 5123

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR5123

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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: Characterization of the Structure and Dynamics of Amyloidogenic Variants of Human Lysozyme by NMR Spectroscopy PubMed: 11714920

Deposition date: 2001-08-27 Original release date: 2002-01-25

Authors: Chamberlain, Aaron; Receveur, Veronique; Spencer, Andrew; Redfield, Christina; Dobson, Christopher

Citation: Chamberlain, Aaron; Receveur, Veronique; Spencer, Andrew; Redfield, Christina; Dobson, Christopher. "Characterization of the Structure and Dynamics of Amyloidogenic Variants of Human Lysozyme by NMR Spectroscopy" Protein Sci. 10, 2525-2530 (2001).

Assembly members:
lysozyme, polymer, 130 residues, Formula weight is not available

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapien

Experimental source: Production method: recombinant technology Host organism: Aspergillus niger

Entity Sequences (FASTA):
lysozyme: KVFERCELARTLKRLGMDGY RGISLANWMCLAKWESGYNT RATNYNAGDRSTDYGIFQIN SRYWCNDGKTPGAVNACHLS CSALLQDNIADAVACAKRVV RDPQGIRAWVAWRNRCQNRD VRQYVQGCGV

Data sets:

assigned_chemical_shifts
- chemical_shift_set_1

Data type	Count
15N chemical shifts	123
1H chemical shifts	123

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	lysozyme	1

Entities:

Entity 1, lysozyme 130 residues - Formula weight is not available

1	LYS	VAL	PHE	GLU	ARG	CYS	GLU	LEU	ALA	ARG
2	THR	LEU	LYS	ARG	LEU	GLY	MET	ASP	GLY	TYR
3	ARG	GLY	ILE	SER	LEU	ALA	ASN	TRP	MET	CYS
4	LEU	ALA	LYS	TRP	GLU	SER	GLY	TYR	ASN	THR
5	ARG	ALA	THR	ASN	TYR	ASN	ALA	GLY	ASP	ARG
6	SER	THR	ASP	TYR	GLY	ILE	PHE	GLN	ILE	ASN
7	SER	ARG	TYR	TRP	CYS	ASN	ASP	GLY	LYS	THR
8	PRO	GLY	ALA	VAL	ASN	ALA	CYS	HIS	LEU	SER
9	CYS	SER	ALA	LEU	LEU	GLN	ASP	ASN	ILE	ALA
10	ASP	ALA	VAL	ALA	CYS	ALA	LYS	ARG	VAL	VAL
11	ARG	ASP	PRO	GLN	GLY	ILE	ARG	ALA	TRP	VAL
12	ALA	TRP	ARG	ASN	ARG	CYS	GLN	ASN	ARG	ASP
13	VAL	ARG	GLN	TYR	VAL	GLN	GLY	CYS	GLY	VAL

Samples:

sample: lysozyme0.8 – 1.2 mM; HCl mM; H2O 100%

condition: pH: 5.0; temperature: 310 K

Experiments:

Name	Sample	Sample state	Sample conditions
3D NOESY	not available	not available	not available
HSQC	not available	not available	not available
COSY	not available	not available	not available

Software:

No software information available

NMR spectrometers:

unknown unknown 0 MHz

Related Database Links:

BMRB	2542 5124 5125 5130 5142 76
PDB	133L 134L 1B5U 1B5V 1B5W 1B5X 1B5Y 1B5Z 1B7L 1B7M 1B7N 1B7O 1B7P 1B7Q 1B7R 1B7S 1BB3 1BB4 1BB5 1C43 1C45 1C46 1C7P 1CJ6 1CJ7 1CJ8 1CJ9 1CKC 1CKD 1CKF 1CKG 1CKH 1D6P 1D6Q 1DI3 1DI4 1DI5 1EQ4 1EQ5 1EQE 1GAY 1GAZ 1GB0 1GB2 1GB3 1GB5 1GB6 1GB7 1GB8 1GB9 1GBO 1GBW 1GBX 1GBY 1GBZ 1GDW 1GDX 1GE0 1GE1 1GE2 1GE3 1GE4 1GEV 1GEZ 1GF0 1GF3 1GF4 1GF5 1GF6 1GF7 1GF8 1GF9 1GFA 1GFE 1GFG 1GFH 1GFJ 1GFK 1GFR 1GFT 1GFU 1GFV 1HNL 1I1Z 1I20 1I22 1INU 1IOC 1IP1 1IP2 1IP3 1IP4 1IP5 1IP6 1IP7 1IWT 1IWU 1IWV 1IWW 1IWX 1IWY 1IWZ 1IX0 1IY3 1IY4 1JKA 1JKB 1JKC 1JKD 1JSF 1JWR 1LAA 1LHH 1LHI 1LHJ 1LHK 1LHL 1LHM 1LOZ 1LYY 1LZ1 1LZ4 1LZ5 1LZR 1LZS 1OP9 1OUA 1OUB 1OUC 1OUD 1OUE 1OUF 1OUG 1OUH 1OUI 1OUJ 1QSW 1RE2 1REM 1REX 1REY 1REZ 1TAY 1TBY 1TCY 1TDY 1UBZ 1W08 1WQM 1WQN 1WQO 1WQP 1WQQ 1WQR 1YAM 1YAN 1YAO 1YAP 1YAQ 207L 208L 2BQA 2BQB 2BQC 2BQD 2BQE 2BQF 2BQG 2BQH 2BQI 2BQJ 2BQK 2BQL 2BQM 2BQN 2BQO 2HEA 2HEB 2HEC 2HED 2HEE 2HEF 2LHM 2MEA 2MEB 2MEC 2MED 2MEE 2MEF 2MEG 2MEH 2MEI 2NWD 2ZIJ 2ZIK 2ZIL 2ZWB 3EBA 3FE0 3LHM 3LN2 4I0C 4ML7
DBJ	BAA00314 BAG34722 BAG73364
EMBL	CAA32175 CAA53144
GB	AAA36188 AAA59535 AAA59536 AAA72819 AAB26052
REF	NP_000230 NP_001009073 NP_001266591 XP_002823550 XP_003259554
SP	P61626 P61627 P61628 P79179 P79180
TPE	CDM98740 CDM98750 CDM98754

Download simulated HSQC data in one of the following formats:
CSV: Backbone or all simulated shifts
SPARKY: Backbone or all simulated shifts

1	LYS	VAL	PHE	GLU	ARG	CYS	GLU	LEU	ALA	ARG
2	THR	LEU	LYS	ARG	LEU	GLY	MET	ASP	GLY	TYR
3	ARG	GLY	ILE	SER	LEU	ALA	ASN	TRP	MET	CYS
4	LEU	ALA	LYS	TRP	GLU	SER	GLY	TYR	ASN	THR
5	ARG	ALA	THR	ASN	TYR	ASN	ALA	GLY	ASP	ARG
6	SER	THR	ASP	TYR	GLY	ILE	PHE	GLN	ILE	ASN
7	SER	ARG	TYR	TRP	CYS	ASN	ASP	GLY	LYS	THR
8	PRO	GLY	ALA	VAL	ASN	ALA	CYS	HIS	LEU	SER
9	CYS	SER	ALA	LEU	LEU	GLN	ASP	ASN	ILE	ALA
10	ASP	ALA	VAL	ALA	CYS	ALA	LYS	ARG	VAL	VAL
11	ARG	ASP	PRO	GLN	GLY	ILE	ARG	ALA	TRP	VAL
12	ALA	TRP	ARG	ASN	ARG	CYS	GLN	ASN	ARG	ASP
13	VAL	ARG	GLN	TYR	VAL	GLN	GLY	CYS	GLY	VAL

1	LYS	VAL	PHE	GLU	ARG	CYS	GLU	LEU	ALA	ARG
2	THR	LEU	LYS	ARG	LEU	GLY	MET	ASP	GLY	TYR
3	ARG	GLY	ILE	SER	LEU	ALA	ASN	TRP	MET	CYS
4	LEU	ALA	LYS	TRP	GLU	SER	GLY	TYR	ASN	THR
5	ARG	ALA	THR	ASN	TYR	ASN	ALA	GLY	ASP	ARG
6	SER	THR	ASP	TYR	GLY	ILE	PHE	GLN	ILE	ASN
7	SER	ARG	TYR	TRP	CYS	ASN	ASP	GLY	LYS	THR
8	PRO	GLY	ALA	VAL	ASN	ALA	CYS	HIS	LEU	SER
9	CYS	SER	ALA	LEU	LEU	GLN	ASP	ASN	ILE	ALA
10	ASP	ALA	VAL	ALA	CYS	ALA	LYS	ARG	VAL	VAL
11	ARG	ASP	PRO	GLN	GLY	ILE	ARG	ALA	TRP	VAL
12	ALA	TRP	ARG	ASN	ARG	CYS	GLN	ASN	ARG	ASP
13	VAL	ARG	GLN	TYR	VAL	GLN	GLY	CYS	GLY	VAL

1	LYS	VAL	PHE	GLU	ARG	CYS	GLU	LEU	ALA	ARG
2	THR	LEU	LYS	ARG	LEU	GLY	MET	ASP	GLY	TYR
3	ARG	GLY	ILE	SER	LEU	ALA	ASN	TRP	MET	CYS
4	LEU	ALA	LYS	TRP	GLU	SER	GLY	TYR	ASN	THR
5	ARG	ALA	THR	ASN	TYR	ASN	ALA	GLY	ASP	ARG
6	SER	THR	ASP	TYR	GLY	ILE	PHE	GLN	ILE	ASN
7	SER	ARG	TYR	TRP	CYS	ASN	ASP	GLY	LYS	THR
8	PRO	GLY	ALA	VAL	ASN	ALA	CYS	HIS	LEU	SER
9	CYS	SER	ALA	LEU	LEU	GLN	ASP	ASN	ILE	ALA
10	ASP	ALA	VAL	ALA	CYS	ALA	LYS	ARG	VAL	VAL
11	ARG	ASP	PRO	GLN	GLY	ILE	ARG	ALA	TRP	VAL
12	ALA	TRP	ARG	ASN	ARG	CYS	GLN	ASN	ARG	ASP
13	VAL	ARG	GLN	TYR	VAL	GLN	GLY	CYS	GLY	VAL