BMRB Entry 5198
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR5198
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Title: 1H, 13C, and 15N Chemical Shift Assignments for v107 in complex with vascular endothelial growth factor PubMed: 11866530
Deposition date: 2001-11-02 Original release date: 2002-05-07
Authors: Pan, Borlan; Li, Bing; Russell, Stephen; Tom, Jeffrey; Cochran, Andrea; Fairbrother, Wayne
Citation: Pan, Borlan; Li, Bing; Russell, Stephen; Tom, Jeffrey; Cochran, Andrea; Fairbrother, Wayne. "Solution Structure of a Phage-derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor " J. Mol. Biol. 316, 769-787 (2002).
Assembly members:
v107 peptide, polymer, 19 residues, 2343.0 Da.
vascular endothelial growth factor, polymer, 99 residues, 11625.4 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology
Entity Sequences (FASTA):
v107 peptide: GGNECDIARMWEWECFERL
vascular endothelial growth factor: HHEVVKFMDVYQRSYCHPIE
TLVDIFQEYPDEIEYIFKPS
CVPLMRCGGCCNDEGLECVP
TEESNITMQIMRIKPHQGQH
IGEMSFLQHNKCECRPKKD
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 122 |
| 13C chemical shifts | 82 |
| 15N chemical shifts | 18 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | VEGF subunit 1 | 2 |
| 2 | VEGF subunit 2 | 2 |
| 3 | v107 subunit 1 | 1 |
| 4 | v107 subunit 2 | 1 |
Entities:
Entity 2, VEGF subunit 1 99 residues - 11625.4 Da.
| 1 | HIS | HIS | GLU | VAL | VAL | LYS | PHE | MET | ASP | VAL | ||||
| 2 | TYR | GLN | ARG | SER | TYR | CYS | HIS | PRO | ILE | GLU | ||||
| 3 | THR | LEU | VAL | ASP | ILE | PHE | GLN | GLU | TYR | PRO | ||||
| 4 | ASP | GLU | ILE | GLU | TYR | ILE | PHE | LYS | PRO | SER | ||||
| 5 | CYS | VAL | PRO | LEU | MET | ARG | CYS | GLY | GLY | CYS | ||||
| 6 | CYS | ASN | ASP | GLU | GLY | LEU | GLU | CYS | VAL | PRO | ||||
| 7 | THR | GLU | GLU | SER | ASN | ILE | THR | MET | GLN | ILE | ||||
| 8 | MET | ARG | ILE | LYS | PRO | HIS | GLN | GLY | GLN | HIS | ||||
| 9 | ILE | GLY | GLU | MET | SER | PHE | LEU | GLN | HIS | ASN | ||||
| 10 | LYS | CYS | GLU | CYS | ARG | PRO | LYS | LYS | ASP |
Entity 1, v107 subunit 1 19 residues - 2343.0 Da.
| 1 | GLY | GLY | ASN | GLU | CYS | ASP | ILE | ALA | ARG | MET | ||||
| 2 | TRP | GLU | TRP | GLU | CYS | PHE | GLU | ARG | LEU |
Samples:
sample_1: v107 peptide, [U-98% 13C; U-98% 15N], 0.6 mM; vascular endothelial growth factor 0.9 mM
Cond_1: pH: 7.0; temperature: 308 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|
Software:
No software information available
NMR spectrometers:
- Bruker DRX 600 MHz
- Bruker DRX 800 MHz
Related Database Links:
| BMRB | 5186 5186 5185 |
| PDB | |
| DBJ | BAA78418 BAB68520 BAD92722 BAG70136 BAG70265 BAD92722 BAA78418 |
| EMBL | CAA09179 CAA44447 CAA57143 CAB82426 CAC19923 CAC19515 CAC19513 CAC19512 CAA44447 CAA09179 |
| GB | AAA35789 AAA36804 AAA36807 AAB47118 AAC63102 |
| PRF | 2105202A |
| REF | NP_001003175 NP_001009854 NP_001020537 NP_001020538 NP_001020539 NP_001020541 NP_001020540 NP_001020539 NP_001020538 NP_001020537 |
| SP | P15692 P49151 Q9MYV3 |
| SWISS-PROT | P15692 |
| GenBank | AAC63102 AAB47118 AAA36807 AAA36804 AAA35789 |
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